妊娠和Graves'病诊治郑芬萍【摘要】甲状腺激素是胎儿发育的重要激素,妊娠合并Graves'病 (GD)使得妊娠更加复杂化,而孕期甲状腺发生生理性变化,使孕期甲状腺疾病的诊断异于非妊娠妇女.本文就妊娠对GD发生风险的影响、早孕期甲状腺功能的变化及对甲亢诊断的影响,妊娠期GD的诊断和抗甲状腺药物的选择、孕前咨询及合并GD妇女的胎儿甲亢和甲减的风险做一综述.结合最新的研究结果,尤其指出,抗甲状腺药物在特殊的早孕周使用可能增加新生儿出生缺陷风险,这对于有怀孕打算的GD患者需要考虑在内.%Thyroid hormones are essential in fetal development,and Graves' disease (GD) may severely complicated with pregnancy.On the other hand,the physiological changes in thyroid function during pregnancy makes the diagnosis of thyroid disease different from non pregnant women.This review describes how pregnancy changes the risk ofGraves'disease,the change of thyroid function in early pregnancy,the diagnosis of Graves' disease during pregnancy,the selection of anti-thyroid drugs,as well as the consultation before pregnancy and the risks of fetal hyperthyroidism and bined with the latest literature,this review especially points out that the use of anti-thyroid drugs in special weeks of early pregnancy might increase the risk of birth defects,and which should be taken into consideration in woman with Graves' disease planning to be pregnant.【期刊名称】《医学与哲学》【年(卷),期】2018(039)004【总页数】5页(P18-21,24)【关键词】妊娠;Graves'病;抗甲状腺药物;孕前咨询【作者】郑芬萍【作者单位】浙江大学医学院附属邵逸夫医院内分泌科浙江杭州 310016【正文语种】中文【中图分类】R714.256在哺乳动物中，甲状腺激素对神经系统的发育尤为重要，孕期数月的甲状腺功能不足可以导致不可逆脑损伤。
