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PRODUCTION VISESVisesIntroduction to Design ...........................................66–67VMC/HMC Solutions ............................................68–69Ball Lock® Mounting System ...............................70–71Production Vises4" (100 mm) Production Vises ................................72–736" (150 mm) Production Vises .................................74–75Self Centering Vises .................................................764" (100 mm) ................................................................76–776" (150 mm) ................................................................78–79Accessories ......................................................................79Production Vise Columns 4" (100 mm) Production Vise4 Sided ...........................................................................803 Sided ...........................................................................816" (150 mm) Production Vise4 Sided ...........................................................................823 Sided ...........................................................................8312 Station Hex .................................................................8412 & 16 Station Multi Quads ..................................85–86Hydraulic Production Vises .....................................874" (100 mm) ...............................................................88–896" (150 mm) ...............................................................89–90Hydraulic Vise Columns ...........................................914" (100 mm) 4 sided ........................................................924" (100 mm) 3 sided ........................................................936" (150 mm) 4 sided ........................................................946" (150 mm) 3 sided ........................................................95Column Subplates ..........................................................96Hydraulic Vise Accessories......................................97–98Vise Accessories ...............................................99–104Jaw Selections ..................................................99–101Ball Lock® Shanks/Plates .....................................102–103Sine Fixture Keys/T-Slot Nuts .....................................104Cast Iron Shop Vises ......................................105–106Bock Quick Change FixturingIntroduction ..................................................................107System Overview .................................................108–109Twin Vises ........................................................................110Jaw System .....................................................................111 Twin Vise Data ................................................................112Locator Plates .................................................................113DexLoc™ Locator Pins ...................................................113 Mono-Quad System (114)5-Axis Production VisesIntroduction ...................................................................115Self Centering .................................................................116Jaws /Accessories ................................................117–118Fixed .................................................................................119Jaws/Accessories .......................................................120Quick Clamping Block .................................................121Super Compact Clamp .................................................122Jaws/Accessories ...............................................123–124Vise with Reversible and Interchangeable Inserts ...125Jaws/Accessories .......................................................125Pallet Clamps .. (126)P R O D U C T I O N V I S E SWORKHOLDING SOLUTIONS GROUPPRODUCTION VISESJergens Production Vise SystemFastest Quick Change Jaw SystemMaximum Holding Power• Jaws machined to the contour of your workpiece maximizing holding force.6" (150mm) MonoQuad4" (100mm) MonoQuad• Quick change reverseable soft jaws • Single station adapter plate included• Multiple base designs to meet any requirementDual Station VisesSelf-Centering VisesWORKHOLDING SOLUTIONS GROUPPRODUCTION VISESJergens Production VisesMachine “Pockets” into the vise jaws, in the shape of your workpiece.Benefit: Reduce set-up times and parts change overMultiple mounting base configurations Fully sealed lead screw assemblyBenefit: Lower maintenance Rigid construction with hardened and ground stainless steel railsBenefit: High accuracy and repeatabilityChip and fluid flow through baseBenefit: Easier to keep clean, no more cloggingWORKHOLDING SOLUTIONS GROUPPRODUCTION VISESVertical Machine SolutionsHydraulic Vise Pages 88–90Innovative compact design. Reduced set-up time.Internal Slide Assembly with Hydraulic Clamping Cylinder.Universal Base Production Vises Pages 73 & 75The mounting flange has slotted holes to allow Ball Lock ® Base Production Vises Pages 72 & 74The mounting flange is cut into a jigsaw pattern to allowvises to nest closely together. Designed for use with Jergens Ball Lock ®Mounting System.5-Axis production vises and accessories rigidly clamp parts without obstructing access to multiple part faces.Self Centering Vises (3 Base Styles)Pages 76–79Self-Centering vises provide quick, simple fixturing for concentric machining of different sized workpieces.Narrow Base Production Vises Pages 73 & 75The small footprint allows maximum density of vises on your Bock Brand Quick Change System Pages 107–114Bock Brand vises combine with alpha-numeric locator plates Indexer Systems Page 81Indexer solutions can be customized to yourrequirements. Choose either three or four sided columns.WORKHOLDING SOLUTIONS GROUPPRODUCTION VISES Horizontal Machine Solutions6-Sided Production Vise ColumnsPage 84Increase the number of parts per load, while maintaining a small footprint. Available with bases to fit directly onto 4-Sided Production Vise Multi-Columns Pages 85 & 86Multiple columns mounted on a single base provide 12 or 163-Sided Production Vise ColumnsPages 81 & 83For machining 3 faces of production parts on HMC's. Largespindle noses can access the workpiece.240° workpiece accessibility.Multi-Vise FixturesPages 73, 75, 77, 79 & 89T o maximize productivity, mount multiple narrow body visesonto a single fixture plate. Mount the fixture plate onto thetombstones with the Jergens Ball LockWORKHOLDING SOLUTIONS GROUP PRODUCTION VISESSystem accurately positionsThe Ball Lock System securely holds fixtureplates to subplates with up to 20,000 lbs (88kN)of hold-down force per shank.Ball Lock® Fixture Mounting System forThe Ball Lock® Mounting System provides a method of quickly and accurately locating fixtures onto machine tables. The Ball Lock Commonly Asked QuestionsQ. What is the Ball Lock®Mounting System?It is a means of locating and lockingtwo flat surfaces together, normally afixture plate to a sub-plate.Q. How does it lock?A. Inside the shank are three balls thatexpand into a tapered groove in thereceiver bushing. This action drawsthe plates together. The locking ballsare activated by turning a setscrew inthe head of the shank, which pushesWORKHOLDING SOLUTIONS GROUPPRODUCTION VISESUnmatched Setup Speedand Workholding FlexibilityQ. Is there a preferable location for System repeatability is improvedif the liners are located at opposite corners of a rectangular fixture plate. For consistency, we recommend locating the liner bushings at top left Q. What are the advantages of using with ¾" (18mm) of thread engagementrequires 10 turns to lock. On CNCmachines, the repeatability of fixturelocations makes indicating of thefixture unnecessary.Q. How do I recess the fixtureplatefor a clear surface ?A. Counterbore the fixture plate to adiameter large enough to allow easyQ. What if my plate is thinner thanthe recommended thickness?A. By adjusting the depth of thecounterbore for the receiver bushingin the subplate, you can still use theBall Lockquestions on this type of application,please call 1-877-426-2504.Q. Can I use the shanks in a heated0.38[10]0.96[24]3.438[87.5]1.683.00[73]1.22[30][190]7.50WORKHOLDING SOLUTIONS GROUPPRODUCTION VISESProduction Vises – 4" (100mm)Ball Lock ShankShankPart No.Wt.Part No.SizeMetric17/32" (4) Plcs [13.5]Slotted Mounting Holes:3.13[80]2.50[63.5]6.00[150]Mounting Holes (2) Plcs:17/32"[13.5]WORKHOLDING SOLUTIONS GROUPPRODUCTION VISESProduction Vises – 4" (100mm)traditional strap clamps. The narrow base has 2 locating holes for 12mm -slots shown on page 104. Recessed machine tables, tombstones, or columns. Maximize flexibility by utilizing0.50[12]4.50[114]4.00[100]10.00[248] 1.45[38]0.96[24]WORKHOLDING SOLUTIONS GROUPPRODUCTION VISESProduction Vises – 6" (150mm)MetricBall Lock ShankShank Part No.Wt.Part No.Size1.125[28]2.952[75]4.921[125]7.874[200]6.000[150]Mounting Holes:M10 x 1.5 T ap (6) Plcs2.50[63.5]3.875[100]7.874[200]Locating Holes:.6255 (4) PlcsFor Sine Fixture KeysWORKHOLDING SOLUTIONS GROUPProduction Vises – 6" (150mm)is easily mounted directly to machine tool tables. Slotted mounting holes will match almost any table slot pattern. can be mounted as a stand-alone vise or mounted to a fixture plate. The slim design allows a high density of vises on machine tables, tombstones, or columns. Maximize flexibility by utilizing the Jergens1.22"(31.0)ED MTG. HOLES3.370"(85.60)±0.001"(0.03)WORKHOLDING SOLUTIONS GROUPSelf-Centering Precision Production Vises• Shown in Universal Base, also available in Narrow Bases and Ball Lock Part Number Wt. (lbs)49471SC38WORKHOLDING SOLUTIONS GROUPSelf-Centering Vises – 4" (100mm)12"6"WORKHOLDING SOLUTIONS GROUP Self-Centering Vises – 6" (150mm)12"6"50m m 12" (300mm )WORKHOLDING SOLUTIONS GROUPSelf-Centering Vises – 6" (150mm)Part No.49442SC*Jergens Standard Jaws fully compatible, see complete selection on page o order Jergens Production Vise Jaws with Adjustable Gib Screw, use standard jaw part no. followed by "SC".WORKHOLDING SOLUTIONS GROUP Production Vise Columns – 4" (100mm)QWORKHOLDING SOLUTIONS GROUPcan be mounted onto most any indexer. Columns can be attached directly to an indexer or become Jergens Technical Service for help designing Production Vise Columns – 4" (100mm)Mounting Wt. Ball Lock Shank Pattern 2* (lbs) Part No. Sizen/a 125 49602 20mm x 1"100mm 115 — —Mounting Wt. Ball Lock Shank Tri-column design allows upWORKHOLDING SOLUTIONS GROUP Production Vise Columns – 6" (150mm)QWORKHOLDING SOLUTIONS GROUPProduction Vise Columns – 6" (150mm)Mounting Wt. Ball Lock Shank Pattern 2* (lbs) Part No. Size252 49602 20mm x 1"266 49612 25mm x 1"100mm 240——Tri-column design allows upJBall Lock Mtg. PatternBall Lock Mtg. PatternWORKHOLDING SOLUTIONS GROUPProduction Vise ColumnsQK Ball Lock Mtg. PatternQKBall Lock Mtg. PatternWORKHOLDING SOLUTIONS GROUPPRODUCTION VISESProduction Vise ColumnsMtg. PatternK QQKBall Lock Mtg. PatternWORKHOLDING SOLUTIONS GROUPPRODUCTION VISESProduction Vise ColumnsWORKHOLDING SOLUTIONS GROUPPRODUCTION VISESHydraulic Production Vises• Innovative compact design • Internal hydraulics• 4,700 lbs (2,100 Kg) clamping force • Operates on lower input pressure • Fully machinable jaws• Fastest quick-change jaw system • Hardened stainless steel wear rails •Easy-Flow ™base designJergens hydraulic vises are available in 3 different base configurations. They offer the same unique features as Jergens manual vises.Technical Specifications:Hydraulic Clamping Stroke: 1/4" (6.3mm)Operating Volume: 0.4 Cu In (6.7 cm 3)Maximum Input Pressure: 4000 P .S.I. (275 bar)Minimum Input Pressure: 500 P .S.I. (35 bar)Input Port: #4 SAE (7/16-20 UNF-2B)Clamping Force (lbs) = Input Pressure x 1.19Clamping Force (Kg) = Input Pressure Bars x 7.67Operation:Using the Jergens Hydraulic Vise handle part number 49445, tighten vise jaws so the workpieces touch the fixed jaw. Next, turn the handle back 1/2 turn and activate the hydraulic cylinder. Hydraulic Power Sources AvailableClamping ForceInput PressureClamping ForcePSIBarslbskgf500 35 595 268 1,000 70 1,190 5376.0012.002.50[63.5]3.125[80] 6.00[150]17/32" (4) Plcs [13.5]Slotted Mounting Holes:Mounting Holes :17/32" (2) Plcs [13.5]WORKHOLDING SOLUTIONS GROUPPRODUCTION VISESHydraulic Production Vises – 4" (100mm)Mounting Holes:ap (6) PlcsMOUNTING HOLES (6) Plcs:3.938[100]LOCATING HOLES:.6255 (6) PlcsWORKHOLDING SOLUTIONS GROUPPRODUCTION VISESHydraulic Production Vises – 4" (100mm)Part Wt. N umber lbs/Kg49487 30/14Part Wt. N umber lbs/KgPart Wt.PRODUCTION VISESWORKHOLDING SOLUTIONS GROUP Hydraulic Production Vises – 6" (150mm)12.006.00PRODUCTION VISES WORKHOLDING SOLUTIONS GROUPHydraulic Vise Column(150mm) sizes,Fully Machinable and ReversibleMore workholding flexibility per jaw set.Hydraulic Vise Column Kits Include:Shown with base forSee page 98 for Air PoweredHydraulic PumpPRODUCTION VISESWORKHOLDING SOLUTIONS GROUP Hydraulic Vise Tooling Columns – 4" (100mm)PRODUCTION VISES WORKHOLDING SOLUTIONS GROUPHydraulic Vise Tooling ColumnsPRODUCTION VISESWORKHOLDING SOLUTIONS GROUP Hydraulic Vise Tooling Columns – 6" (150mm)Hydraulic Vise Tooling ColumnsHydraulic Vise Tooling Columns Standard Subplates35°TANK PRESSURE PORT1/4 NPT PORTS3.411.0260.091.0662.750.650.9380.375 AREA FOR TANK LINE LOCATION0.60 AREA FOR PRESSURE LINE LOCATION2.752 3/8"M5 X 0.8 TAP THRU (4) PLACES7/32 DRILL THRU (4) PLACESPTPORTPatent No. 3839866Hydraulic Production Vise AccessoriesPart Number61725HandlePart Number49445Handle for Hydraulic Vises, 4" Rotary Hydraulic UnionDual Passage, Ports 1/4 NPTPressure (psi) Bars Torque (in. lbs) Part Number61755 Performance Curve*(0.655)1000 2000 3000 4000 5000 (69) (138) (207) (276) (345)OUTPUT PRESSURE, PSI (BAR)Part Number61759Hydraulic Production Vise AccessoriesKit Includes61755 36:1 Pump61643 Remote four-way zero-leakageLow Pressure Air HoseHose I.D.1/4" 3/8" 1/2"HosePart Number 61106 61108 61110FittingPart Number 61107 61109 61111Hydraulic HoseHigh pressure hose is supplied assembled and to lengths indicated. Lengths are measured from end of coupling to end of coupling. Hose is 3/8" ID and available in 4000 psi or 7000 psi rating. 3/8" female tubing fittings on each end.N ipple1/8 NPT Male 619501/4 NPT Male 61905 619511/4 NPT Female61954 Air couplers have checks on sleeves only.Adapter for BSP1/4 Male NPT 1/4 NPT x 1/4 T 1/4 Female BSP 60221Adapters & ElbowsJergens Production Vise SystemThe clamping system Completely sealed lead screw Hard coated base made of high-strength, light-weight, aluminum extrusion. Guideway Rails made of hardened stainless steel.Aluminum jaws can be completely milled, therefore Aluminum or steel jaws suitable for milling:Extra Wide Jaws Full Face Vise PlateDual Station with Hard JawSingle Workpiece with Hard JawsProduction Vise JawsQuick Change Fixture PlateProduction Vise Accessoriesinclude two moveable jaws and one fixed jaw.Vise Conversion PlatesVise HandlesHard Jaw Carriers With Steel Inserts*Part No.Vise Size49442 4"/100mm Machinable Soft Jaws(Standard Sets included with Vises)Vise Work StopClearance holes for holddown (2) PlcsClearance holefor holddownStandard ShankJigsaw Fixture PlateMultiple Vise Fixture PlateProduction Vise Ball Lock ®Accessories – InchShank49601 49601-S 49602 49602-S 49611 49611-S49612 49612-SProduction Vise Ball Lock® Accessories – MetricJigsaw Fixture PlateClearance holefor holddownStandardShank Multiple Vise Fixture PlateClearance holes forholddown (2) PlcsProduction Vise Accessories Locate subplates or fixture plates to Tmachine tables. Available in inch sizes for 1/2"to 7/8" slots, and in metric sizes for 12mm to22mm slots.T-Slot NutsWORKHOLDING SOLUTIONS GROUPCast Iron Shop VisesCharacteristicsMade of close grained high tensile cast iron. Jaws ground and Hardened 55±3 HRC. Swivel base provided with positive locking and adjustable through 360°. Adjusts work piece to its center. Opposite threads for quick and accurate centering.CharacteristicsMade of close grained hightensile cast iron. Jaws ground and Hardened 55±3 HRC. Adjusts workpiece to its center. Opposite threads for quick and accurate centering. This is a low profile vise.T echnical DataPart Jaw Width Jaw Opening N umber Inch mm Inch mm Inch mm Inch mm Inch mm Inch mm 110080 2 50 2 50 110081 4 100 4 100 T echnical DataPartJaw Width Jaw OpeningNumber Inch mm Inch mm Inch mm Inch mm Inch mm Inch mm 110085 3 75 5 127 110086 4 100 4 100WORKHOLDING SOLUTIONS GROUPCharacteristicsManufactured from close grained high tensile cast iron. Swivel is full 360°. This is very useful for heavy duty milling jobs. Vise is low height for maximum clearances. Jaws are fully ground and precision with parallelism of 0.0012 (30 microns) the hardness of jaws is 55±33 HRC.T echnical DataPart Jaw Width Jaw Opening Jaw Depth N umber Inch mm Inch mm Inch mm Inch mm Inch mm Inch mm T echnical DataPartJaw Width Jaw Opening Jaw DepthNumber Inch mm Inch mm Inch mm Inch mm Inch mm Inch mm 110250 6 150 7 1/2 188 1 1/2 CharacteristicsManufactured from graded cast iron and precisionground. These vises have a needle bearing thrust collar. Vise jaws are in pairs and replaceable.Cast Iron Shop VisesMilling Machine Vises with Swivel Base (Heavy Duty)Machine VisesWORKHOLDING SOLUTIONS GROUP JERGENS-BOCK QUICK CHANGE S YS TEMFASTPRODUCTIVE by reducing spindle down-time to aminimum. The combination of short setup times, theability to move setups away from the machine andfast loading keeps your spindle cutting, not waiting.WORKHOLDING SOLUTIONS GROUPJERGENS -BOCK QUICK CHANGE S YS TEMwin Vise is the key component of the complete BockWorkholding system. A variety of body styles made from high-strength aluminum, ground steel guides, snap-on quick-change machinable aluminum jaws and a solid clamping screw and third hand mechanism System OverviewBock Locator Plate SystemBock Locator Plates are a great platform to quickly and accurately mount your T win Vises in a number of different positions. Locator/mounting holes with alpha-numeric identifiers and Bock’s DexLoc™ double-expanding locators give you +/- .0005" repeatability.DexLoc ™Locator PinsPatented DexLoc™ double-expanding locator pins allow for fast and accurate location of twin vises on locator plates.WORKHOLDING SOLUTIONS GROUP JERGENS-BOCK QUICK CHANGE S YS TEMHard-coated high-strength aluminum base for lighter WORKHOLDING SOLUTIONS GROUPJERGENS-BOCK QUICK CHANGE S YS TEMStraight basefor use on Bock Locator Plates or with toe clamps Slim-LineStandard interlockingGenerous cut-outs to prevent chip and coolant accumulationBock Twin Vise SystemThree different basestyles for your specificmounting needsWORKHOLDING SOLUTIONS GROUP JERGENS-BOCK QUICK CHANGE S YS TEM Bock Jaw SystemBock Machinable Jaws are made from high-strength aircraft grade anodized aluminum.Once machined to hold a specific part they become quick-change dedicated fixtures ideal for holding even complex shapes.STANDARD JAWS snap on and off in QUICK CHANGEFACE PLATEScan be convertedTALL JAWSto hold larger parts.123WORKHOLDING SOLUTIONS GROUP JERGENS-BOCK QUICK CHANGE S YS TEMBock Twin VisesScrew-on guideways made from hardened steelThird-hand function for fast sequential loading of partsExact positioning of center jaw using locator pins; removing center jaws allows the holding of one single large partAluminum jaws can be milled out to meet each part’s holding and locating requirements.Generous cut-outs to prevent chip and coolant accumulationStandard InterlockingStraight BaseSlim-LineWORKHOLDING SOLUTIONS GROUP JERGENS-BOCK QUICK CHANGE S YS TEM Bock Brand Locator Plate SystemBock Brand Locator PlatesDexLoc™ Locator PinsTo order DexLocWORKHOLDING SOLUTIONS GROUP JERGENS-BOCK QUICK CHANGE S YS TEMBock Mono-Quad System。
丙肝治疗最佳方案2016年，伴随着吉利德第三代丙肝药Epclusa以及默沙东Zepatier获批上市，丙肝治疗方案又多了很多新的选择，但是，很多患者仍然想知道哪种方案是丙肝治疗最佳方案，天健行公司将这些疑问一一解答如下：一、1b型丙肝治疗最佳方案是什么？是吉三（索非布韦sofosbuvir+维帕他韦velpatasvir）或者吉二（索非布韦sofosbuvir+雷迪帕韦ledipasvir）。
理由如下：根据2016最新版欧洲肝病协会（EASL）丙肝治疗指南，1b型丙肝治疗最佳方案，即推荐度为A1（最佳推荐）的方案是：吉二（索非布韦+雷迪帕韦）、吉三（索非布韦+维帕他韦）、Viekira Pak（ombitasvir+paritaprevir+ritonavir+dasabuvir）、Zepatier（elbasvir+grazoprevir）、欧盟组合（索非布韦+达卡他韦）根据2016最新版美国肝病协会（AASLD）丙肝治疗指南，1b型丙肝治疗最佳方案，即推荐度为IA（最佳推荐）的方案是：Zepatier（elbasvir+grazoprevir）、吉二（索非布韦+雷迪帕韦）、Viekira Pak（ombitasvir+paritaprevir+ritonavir+dasabuvir）、sofosbuvir+simeprevir、吉三（索非布韦+维帕他韦）。
需要特别注意的是，美肝会对于欧盟组合的推荐度是IB，即认为欧盟组合不是1b型丙肝的最佳治疗方案目前世界上只有吉一、吉二、欧盟组合和吉三有仿制药上市。
吉二III期临床试验数据（代号ION-1,2,3,4和GS-US-337-0113）、欧盟组合III期临床试验数据（代号ALLY-2,3）和吉三III期临床试验数据（代号ASTRAL-1,2,3,4）显示：吉二对于1型无肝硬化患者一个疗程治愈率约为95-100%；欧盟组合约为96.4-97.7%；吉三约为98-100%综上所述，我们认为1b型丙肝治疗最佳方案是吉三或者吉二二、2型丙肝治疗最佳方案是什么？是吉三（索非布韦sofosbuvir+维帕他韦velpatasvir）。
Clofarabine ；克罗拉滨；氯法拉滨产品编号：MB1061质量标准：>99%,BR包装规格：5MG ；25MG ；100MG产品形式：白色至类白色粉末基本信息简介：克罗拉滨 Clofarabine(Clolar; Clofarex)能抑制核苷酸还原酶，IC50为65 nM ，还能抑制DNA 聚合酶活性。
别名：(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine ；Clolar ； Clofarex物理性状及指标：外观：……………………白色至类白色粉末熔点：……………………202-205 °C(lit.)溶解性：…………………DMSO 60 mg/mL (197.57 mM)；Water Insoluble ；Ethanol Insoluble 纯度：………………………>99%,BR储存条件：2-8℃，避光防潮密闭干燥生物活性及研究进展Clofarabine 是一种第二代嘌呤核苷类似物，目前已被合成，以克服其局限性，并结合了氟达滨和cladribine 的最佳品质。
氯法拉滨通过抑制核苷酸还原酶和DNA 聚合酶的作用，从而耗尽细胞内用于DNA 复制的脱氧核苷三磷酸酯的数量。
与前体相比，氯法拉滨对脱氨基和磷解有更强的抵抗力，因此具有更好的稳定性和对脱氧胞苷激酶(deoxycytidine kinase, dCyd)的更高的亲和力，后者是核苷酸磷酸化的限速步骤。
自1993年第一阶段开始，研究了clofarabine 在血液学和固体恶性肿瘤患者中的应用，clofarabine 在成人急性白血病(包括急性髓细胞白血病(AML))中显示了单剂抗肿瘤活性。
在治疗成人急性髓性白血病和骨髓增生异常综合症中具有科研价值。
488 Scientific AbstractsSystemic sclerosis, myositis and related syndromes - aetiology, pathogenesis and animal modelsPOS0467 DERSIMELAGON, A NOVEL ORAL MELANOCORTIN1 RECEPTOR AGONIST, DEMONSTRATES DISEASE-MODIFYING EFFECTS IN PRECLINICAL MODELS OFSYSTEMIC SCLEROSISM. Kondo1, T. Suzuki1, Y. Kawano1, S. Kojima2, M. Miyashiro1, A. Matsumoto1, G. Kania3, P. Blyszczuk3, R. Ross4, P. Mulipa4, F. Del Galdo4, Y. Zhang5, J. H. W. Distler5. 1Mitsubishi T anabe Pharma Corporation, Research Unit/Immunology & Inflammation, Souyaku Innovative Research Division, Y okohama, Japan;2Mitsubishi T anabe Pharma Corporation, Discovery T echnology Laboratories, Souyaku Innovative Research Division, Y okohama, Japan;3University Hospital Zurich, University of Zurich, Center of Experimental Rheumatology, Department of Rheumatology, Schlieren, Switzerland;4University of Leeds, Leeds Instituteof Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, Leeds, United Kingdom;5Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Department of Internal Medicine 3—Rheumatology and Immunology, Erlangen, GermanyBackground: Activation of melanocortin 1 receptor (MC1R) is known to have broad anti-inflammatory and anti-fibrotic effects. The bleomycin (BLM)-induced skin fibrosis murine model is well-established for systemic sclerosis (SSc). α-mel-anocyte-stimulating hormone, an endogenous ligand of MC1R, inhibits skin fibro-sis and MC1R knock-out enhances skin fibrosis in this model. These pieces of evidence suggest that MC1R agonism has potential in the treatment of SSc. Objectives: Dersimelagon phosphate (MT-7117) is an investigational small molecule that is an orally administered, selective agonist for MC1R. The purpose of this study is to investigate the potential of MT-7117 as a therapeutic agent for SSc by evaluat-ing its efficacy and mechanism of action in complementary preclinical models. The expression and distribution of MC1R in the skin of SSc patients was investigated. Methods: The effects of MT-7117 on skin fibrosis and lung inflammation were eval-uated in BLM-induced SSc murine models that were optimized for prophylactic and therapeutic evaluation. Microarray-based gene expression analysis and serum pro-tein profiling were performed to investigate the mechanism of action of MT-7117 in the BLM-induced SSc models. The effect of MT-7117 on TGF-β-induced activation of human dermal fibroblasts was evaluated in vitro. Immunohistochemical analyses of MC1R expression in skin samples from SSc patients were performed. Results: Prophylactic treatment with MT-7117 (≥0.3 mg/kg/day p.o.) significantly inhibited the increase in collagen content of the skin, the serum level of sur-factant protein D, and the weight of the lungs from BLM-induced skin fibrosis and lung inflammation model. Therapeutic treatment with MT-7117 (≥3 mg/kg/ day p.o.) significantly suppressed skin thickening and the numbers of myofi-broblasts in pre-established BLM-induced skin fibrosis model. Gene array anal-ysis using the BLM-induced SSc model demonstrated changes in numerous categories related to macrophages, monocytes, and neutrophils, followed by endothelial cell-related categories after treatment with MT-7117. In the analy-sis that focused on biological functions, categories of inflammatory response, activation of antigen-presenting cells, angiogenesis, atherosclerosis, vascu-logenesis, and vaso-occlusion were suppressed by MT-7117. In the analysis that focused on molecular signaling pathways, triggering receptor expressed on myeloid cells-1, IL-6, and oncostatin M involved in inflammation, and perox-isome proliferator-activated receptor that is related to fibrosis were all affected by MT-7117. Serum protein profiling using BLM-induced SSc model revealed that multiple SSc-related biomarkers including P-selectin, osteoprotegerin, cys-tatin C, growth and differentiation factor-15 and S100A9 were suppressed by MT-7117. MT-7117 inhibited the activation of human dermal fibroblasts by sup-pressing TGF-β-induced ACTA2 (encoding α-smooth muscle actin) mRNA ele-vation in vitro. Immunohistochemical analyses showed that MC1R positivity was observed in 40 of 50 diffuse cutaneous SSc patients. MC1R was expressed by monocytes/macrophages, neutrophils, blood vessels (endothelial cells), fibro-blasts, and epidermis (keratinocytes) in the skin of SSc patients. Conclusion: MT-7117 demonstrates disease-modifying effects in preclinical mod-els of SSc. Investigations of its mechanism of action and target expression anal-yses indicate that MT-7117 exerts its positive effects by affecting the pathologies of inflammation, vascular dysfunction, and fibrosis through inflammatory cells, endothelial cells, and fibroblasts. In view of its potent beneficial impact on all these three main pathologies of SSc, MT-7117 is a potential therapeutic agent for the treatment of clinically challenging SSc, which has diverse and difficult to treat symp-toms. A phase 2 clinical trial investigating the efficacy and tolerability of MT-7117 in patients with early, progressive diffuse cutaneous SSc is currently in progress. Disclosure of Interests: Masahiro Kondo Employee of: Mitsubishi Tanabe Pharma Corporation, Tsuyoshi Suzuki Employee of: Mitsubishi Tanabe Pharma Corporation, Yuko Kawano Employee of: Mitsubishi Tanabe Pharma Corpora-tion, Shinji Kojima Employee of: Mitsubishi Tanabe Pharma Corporation, Masa-hiko Miyashiro Employee of: Mitsubishi Tanabe Pharma Corporation, Atsuhiro Matsumoto Employee of: Mitsubishi Tanabe Pharma Corporation, Gabriela Kania: None declared, Przemyslaw Blyszczuk: None declared, rebecca ross:None declared, Panji Mulipa: None declared, Francesco Del Galdo Grant/ research support from: Prof. F. Del Galdo received fees and research supportfrom Abbvie, AstraZeneca, Boehringer-Ingelheim, Capella, Chemomab, Kymab, Janssen and Mitsubishi-Tanabe., Yun Zhang: None declared, Jörg H.W. DistlerGrant/research support from: Prof. J.H.W. Distler received consulting fees, lec-ture fees, and/or honoraria from Actelion, Active Biotech, Anamar, ARXX, aTyr,Bayer Pharma, Boehringer Ingelheim, Celgene, Galapagos, GSK, Inventiva, JB Therapeutics, Medac, Pfizer, Sanofi-Aventis, RedX, RuiYi and UCB. J. H. W.Distler is stock owner of 4D Science and Scientific head of FibroCure.DOI: 10.1136/annrheumdis-2022-eular.29POS0468 EXTRACELLULAR VESICLES FROM SERUM OFMYOSITIS PATIENTS AS CIRCULATING BIOMARKERSAND DISEASE MEDIATORSS. Kivity1,2, H. Kravitz3, C. Cohen3, D. Margoulis3, M. Amar3, G. Kazimirsky3,D. Ozeri4, A. Dori5, C. Brodie3. 1Meir Medical Center, Rheumatology Unit, KefarSava, Israel;2T el Aviv University, Sackler faculty of Medicine, T el Aviv-Y afo, Israel;3Bar-Ilan University, The Mina and Everard Goodman Faculty of Life Sciences,Ramat Gan, Israel;4T el-HaShomer The Sheba Medical Center, ZabludowiczCenter for Autoimmune Disease, Ramat Gan, Israel;5T el-HaShomer The ShebaMedical Center, Department of Neurology, T alpiot Medical Leadership Program,Sackler Faculty of Medicine, T el Aviv University, Ramat Gan, IsraelBackground: Inflammatory myopathies (IM) are a heterogeneous group of disor-ders characterized by autoimmune inflammatory destruction of skeletal muscles.It is many times associated with lung, skin and joint involvement. Identifying bio-markers that can differentiate IM from other muscle disorders may elucidate the pathophysiology of IM, guide novel therapies, monitor disease activity/responseto treatments and predict prognosis. Exosomes are membrane-bound nanove-sicles with diameters of 30-150 nm that contain multiple proteins, nucleic acid,lipids and other molecules in a tissue- and cell-specific manner. Exosomes are secreted by a large variety of cells, play major roles in cell-cell interactions, andhave recently emerged as circulating biomarkers in a variety of pathological con-ditions, including several autoimmune diseases.Objectives: To characterize exosomes from serum of IM patients, analyze pro-tein expression and study their potential mediators of disease pathologies.Methods: Serum was collected from patients suffering from IM(n=5) and from patients suffering from Becker (BMD) and Duchenne (DMD) muscular dystro-phies (n=6). Exosomes were isolated by Exoquick precipitation and analyzedfor size distribution and by nanoparticle tracking analysis (NTA) and by Westernblot for exosome markers. The effects of the isolated EVs on human satellitecell proliferation and differentiation and macrophage activation were examined. Results: Exosomes from IM patients decreased human satellite cell proliferation (51%, P<0.01) and inhibited their myogenic differentiation as indicated by lower fusionindex (24% inhibition, P<0.01) and expression of myosin heavy chain (72% inhibi-tion, P<0.001). Similar results were obtained also with exosomes derived from DMDand BMD patients; however, their inhibitory effect were more pronounced on MyoG expression. T reatment of macrophages with exosomes from IM patients significantly increased the expression of IL-10 (3-fold, P<0.001), compared to exosomes of healthy controls and DMD patients. Another significant difference was in the expression of sig-naling molecules: Thus, exosomes from BMD patients increased the phosphorylationof Erk and p38, whereas a smaller effect was induced by IM exosomes.Conclusion: Exosomes from IM patients decrease satellite cell proliferationand myogenic differentiation compared to healthy exosomes. In addition, these exosomes increased the expression of IL-10 in macrophages. These effects areunique to exosomes of IM patients compared to muscular dystrophies. These promising results suggest that serum exosomes should be further investigatedas a novel biomarker with potential therapeutic implications.Disclosure of Interests: Shaye Kivity Speakers bureau: BI, Abbvie, Lilly, Pfizer, Janssen, Neopharm, Grant/research support from: Sobi, Haya Kravitz: None declared, Coral Cohen: None declared, Darya Margoulis: None declared, MosheAmar: None declared, Gila Kazimirsky: None declared, David Ozeri Speakers bureau: Neopharm, Consultant of: Abbvie, Amir Dori Grant/research supportfrom: Biogen, Chaya Brodie Grant/research support from: Biogen.DOI: 10.1136/annrheumdis-2022-eular.63POS0469 ENDOTHELIAL TO MESENCHYMAL TRANSITIONAND SENESCENCE ARE PART OF THE FIBROTICPATHOGENESIS IN SYSTEMIC SCLEROSISY. H. Chiu1,2, J. Spierings1, J. M. Van Laar1, J. De Vries-Bouwstra3, M. VanDijk4, R. Goldschmeding4. 1University Medical Center Utrecht, Departmentof Rheumatology and Clinical Immunology, Utrecht, Netherlands;2T ri-ServiceGeneral Hospital, Division of Rheumatology/Immunology/Allergy, T aipei, T aiwan, Republic of China;3Leiden University Medical Center, The Department of on December 24, 2023 by guest. Protected by copyright./ Ann Rheum Dis: first published as 10.1136/annrheumdis-2022-eular.29 on 23 May 2022. Downloaded from。
幸之素基础资料及使用方法幸之素是从天然蜂胶中提取的弱碱性PEP成分，经过科学配方精致而成的喷剂，不含酒精、不含麻醉剂，使用无刺激，绿色安全，可以长期用于男性生殖部位抑菌、延长房事时间，达到改善两性生活和谐度。
因此幸之素又有“幸福元素”之称。
幸之素 - 处方资料PEP：进口原料,巴西蜂胶中提取的生物活性因子。
醋酸氯己定：具有相当强的广谱抑菌、杀菌作用，可杀灭革兰氏阳性和阴性的细菌繁殖体。
甘油：婴儿用纳米级别，高纯度。
上述原料经科学工艺配伍，按照严格的制剂规范制成幸之素，用于配合临床治疗PE和生殖器抑菌。
本品对皮肤无刺激，无全身不良反应，成分中的甘油起到润滑护肤作用，喷后无须用水冲洗。
它起效时间快，局部喷抹吸收、干燥后，大约2 min即开始发生效应，抑菌同时降低阴茎敏感性。
幸之素 - 药理作用日本长野生命科学研究所医学研究科研究结果表明：幸之素喷剂经皮肤和粘膜吸收，尤其对粘膜具有一定的穿透力，可通过皮肤层感受器和神经末梢积聚，阻滞神经冲动激发和传导所需的离子流而稳定神经细胞膜，于是能够阻滞末梢神经纤维的传导，达到被药物涂抹局部皮肤、粘膜对感觉的敏感性降低的目的。
结论：幸之素可延长SSEP的潜伏期，提示对阴茎头背神经的感觉受体有局部脱敏作用，因而可用于早泄的治疗。
斯坦德科创医药独立第三方检测机构检测表明：依据WS/T650-2019《抗菌抑菌效果评价方法》，在实验条件下，幸之素液体原样作用2min对大肠杆菌（8099）的平均抑菌率>99.96%,有较强抑菌作用；对金黄色葡萄球菌(ATCC6538)的平均抑菌率>99.95%，有较强抑菌作用；对白色念珠菌(ATCC10231)的平均抑菌率>99.95%，有较强抑菌作用。
幸之素 - 安全性研究幸之素对雌性大鼠阴道给药，每日1次，连续给药7d，对大鼠阴道粘膜无明显刺激作用，为临床安全使用提供科学依据。
用药期间，幸之素组与溶剂组大鼠全身状况均无异常，阴道口也未见明显充血、红肿及异常分泌物流出，与空白对照组无区别;肉眼观察取出的阴道组织，各组均未见阴道粘膜有明显充血、水肿及出血点，各用药组与对照组无显著性差异。
上海生博AAV产品手册（2017版）一、AAV背景知识1.1AAV概况腺相关病毒(Adeno-associated virus，AAV)，是一类无包膜的细小病毒，属于微小病毒科(Parvoviridae)的依赖病毒属(Dependoparvovirus)，透射电镜(transmission electron microscope，TEM)下，AAV病毒本身呈二十面体结构。
AAV 基因组为约4.7kb的线性单链DNA(single strand DNA，ssDNA)，只含两个基因，Rep(Replication)基因和Cap(Capsid)基因。
AAV为目前发现的基因组最简单的复制缺陷型病毒，也因此，AAV被作为病毒载体广泛应用。
FIG1 AAV的3D构象图FIG2 AAV病毒颗粒的组分构成FIG1和FIG2文献出处：Mingozzi, F. and K.A. High.Blood, 2013. 122(1): p. 23-36.FIG3 AAV TEM图Zinn, E., et al.. Cell Rep, 2015. 12(6): p. 1056-68.1.2AAV的ITR区AAV基因组的5’和3 ’端各有一个长度为145bp的倒转重复序列(inverted terminal repeat，ITR)，是AAV复制和包装所必需的最少的自身序列。
ITR区富含GC(>80%)，可折叠为一个自我互补的T型发卡结构，其中的Rep蛋白结合位点(Rep binding elements，RBE)、RBE’和末端解链位点(terminal resolution site，TRS)是AAV 基因组的复制起始的关键。
另外ITR区还含有包装信号，是AAV整合、复制和包装所必须的顺式作用元件，并具有转录启动子活性。
FIG4 AAV基因组结构图Nance, M.E. and D. Duan. Hum Gene Ther, 2015. 26(12): p. 786-800.FIG5 AAV ITR区的二级结构图(以AAV2序列为例)Daya, S. and K.I. Berns. Clin Microbiol Rev, 2008. 21(4): p. 583-93.1.3AAV的ORFAAV含有两个开放阅读框(Open Reading Frame，ORF)，Rep基因和Cap基因。
菲林普利s型操作方法全文共四篇示例，供读者参考第一篇示例：菲林普利（Filnprel S）是一种常用的降压药物，广泛用于治疗高血压和心衰等疾病。
它通过抑制肾素-血管紧张素-醛固酮系统，减少血管紧张素II的生成，从而降低血压和减轻心脏负担。
在使用菲林普利时，正确的操作方法非常重要，可以帮助患者更好地发挥药物的疗效，减少副作用的发生。
一、服用方法1.按照医生或药师的建议服用。
一般情况下，成年人每天口服一次，每次剂量为5-20毫克，最大剂量不超过80毫克。
2.可以空腹或饭后服用，但应每天固定时间服用，避免漏服或忘记。
3.如有特殊情况，如忘记服药或服用次数不足，不要随意增加剂量或延长用药时间，应及时咨询医生或药师。
二、注意事项1.在服用菲林普利时，应避免饮酒。
酒精会增加菲林普利的副作用，同时影响药物的疗效。
2.患者在服用过程中应定期监测血压和肾功能，发现异常情况及时调整用药方案。
3.儿童、孕妇、哺乳期妇女和老年人使用菲林普利时，应遵循医生的处方和建议，避免药物的滥用和误用。
4.在服用菲林普利期间，应避免同时使用其他影响心血管系统的药物，以免发生药物相互作用。
5.如果服药过程中出现头晕、肌肉疼痛、皮疹等不良反应，应及时就医，而不是随意停药或调整剂量。
6.在使用菲林普利的饮食上应控制盐分摄入，避免高盐饮食对血压的影响。
三、药物存储1.药物应放置在干燥、阴凉处，避免阳光直射和潮湿环境。
2.药物应远离儿童和宠物，避免误食或误用。
3.药物瓶上的有效期应注意，过期药物应丢弃，避免使用失效药物对健康造成危害。
通过正确的操作方法和注意事项，可以更好地发挥菲林普利的疗效，减少副作用的发生，帮助患者有效控制高血压和心衰等疾病，改善生活质量。
建议患者在服用药物前务必咨询医生或药师，了解自己的病情和用药需求，遵循专业建议，确保药物的安全有效使用。
第二篇示例：菲林普利s型操作方法菲林普利s型是一种相对较为常见的电气化操作操纵材料的一种设备，它主要是通过控制开关来实现对电动机的启动和停止，以及方向的控制。
Version 1.0www.origine ORIGIN EFFECTS is a trademark of Origin E ects Limited and is a registered trademarkin the United States, United Kingdom and the EU.The ORIGIN EFFECTS Totem Device is a trade mark of Origin E ects Limited and is a registered trademarkin the United States and United Kingdom.HALCYON is a trademark of Origin E ects Limited and is a registered trademark in the United States.All other product names and trademarks are the propertyof their respective owners and are hereby acknowledged.KLON® and CENTAUR® are registered trademarks of KLON, LLC.Origin E ects has no a liation with KLON, LLC.No part of this publication may be reproduced in any form or by any means, whethermechanical or electronic, without the written permission of Origin E ects Limited.Origin E ects Limited reserves the right to change the features and specifications describedherein without notice or obligation. Origin E ects Limited cannot be held responsible for any loss or damage arising directly or indirectly from any error or omission in this manual.PLEASE READ ALL INSTRUCTIONS, PAY ATTENTION TO SAFETY WARNINGS.© Origin E ects Limited 2023IMPORT ANT:This product is designed to be powered from a 9VDC, >200mApower supply with 2.1mm centre-negative barrel connector.ContentsIntroducing the Halcyon Gold Overdrive (4)Connecting the Halcyon Gold Overdrive. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Controls (5)Sample Settings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Appendix A: Physical Specification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Appendix B: Performance Specification. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Appendix C: Connector Pin Out . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Appendix D: Safety Notices . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Appendix E: Warranty . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10The Halcyon Gold Overdrive is a versatile drive pedal featuring our proprietary Adaptive Circuitry. This unique design allows it to adapt its voicing in response to pick attack and volume changes, making it one of the most dynamic and interactive overdrives out there. While it is based on a certain rare and sought-after pedal, this is more than just a clone. Even though we went to great lengths to recreate the exact characteristics of unobtain-able vintage diodes, we didn’t stop there. We have also built in some innovative features that go way beyond the capabilities of the original pedal.We based this pedal on the Klon® Centaur® because it’s an all-time classic. Its clarity, dynamics and unique clean blend make it an excellent choice for players who like their overdrive pedals to have a more natural quality, capable of pushing the front end of any great amp. The all-too-frequently used term “transparent overdrive” really started with the Centaur® – and it thoroughly deserves that reputation.The Halcyon Gold Overdrive picks up where the Klon® leaves o , adding even more playability to this players’ favourite. The signature mid-hump now responds to playing dynamics and volume knob changes, and we’ve included our own smoother, more neutral voicing too. Add in an adjustable DRY control and you have an undeniably classic sound with way more variety.Key Features:• Adaptive circuitry responds to volume changes and playing dynamics• Based on the iconic Klon® Centaur®• DRY level control for extra tweakability• Voice switch o ers two flavours of mid push and drive• Ultra-high input impedance• High-quality bu ered bypass• Premium components throughout• Designed and built in England9VDC:INSTR:AMP:ControlsADAPT SWITCH:Position O:Position II:The e ect will be more prominent with higher setting on the DRIVE knob.Position I: Less adaptive than Position II. This setting still responds well to dynamics and volumechanges but maintains some bass and treble roll-o , perfect for keeping the low end tight and preventing feedback with high-gain tones.NOTE: Because the mid hump of the original Klon® Centaur®incre ase s with highe r gain, the Halcyon Gold Overdrive’s Adaptive behaviour will be more noticeable the higher you set the DRIVE control. This means you can turn the DRIVE up higher than is typical for Klon® users, then roll the guitar volume back to get the flatterclean boost tones that the pedal is known for.Controls (continued)ADAPT SWITCH (suggestion): To hear the ADAPT switch in action, set the DRIVE above 10 o’clock, select Position II, play some licks, then roll down your guitar volume to a clean tone and select Position O. You will hear a big di erence between the adaptive and stock clean tones!VOICE SWITCH: The VOICE switch gives you the ability to select either the classic Klon® mid hump or a smoother, more balanced tone. The KLN setting has the standard resonant, focused mid peak of an original Klon. The MOD setting has a broader mid hump and a softer, more compressed clipping characteristic. The MOD setting is particularly well suited to single coil pickups, and higher gain tones paired with very clean amp sounds.DRIVE: Turn clockwise to increase the amount of overdrive. Lower settings should be used when boosting an amp on the edge of breakup. When used with ADAPT settings I and II, high DRIVE settings can sound more natural than a typical drive pedal and will work well with a completely clean amp. ADAPT settings I and II will be more prominent the higher you set the DRIVE control.LEVEL: Sets the output level from the pedal. Turn clockwise to push the input of your amp. Keep this control set lower when using higher DRIVE settings.TONE: Turn counterclockwise to roll o more high-end. Lower settings will result in a typical warm lead tone while higher settings will give a bright, cutting tone. With ADAPT settings I and II, the e ect of the TONE control is reduced as the pedal cleans up, getting you back to your core clean tone.DRY: The Centaur® circuit mixes some of your dry guitar signal with the pedal’s overdrive tone. This control sets the level of that dry signal. We have also made improvements to this dry path, changing the overload characteristics when stacking with other pedals. Turn clockwise to help maintain body, clarity and definition when used with an overdriven amp. Turn counterclockwise to remove the clean signal, which can help when using the pedal as a standalone overdrive into a clean amp.Sample SettingsAppendix A: Physical SpecificationAppendix B: Performance SpecificationAppendix C: Connector Pin Out Instrument & Ampli er 1/4” TS Sockets:Appendix D: Safety NoticesGeneral SafetyKeep these instructions and heed all warnings. Do not use this apparatus near water. Clean only with a dry cloth. Do not install near any heat sources such as radiators, heat registers, stoves or other apparatus (including amplifi ers) that produce heat. Refer all servicing to qualifi ed service personnel. When using an external power supply, use only attachments/accessories specifi ed by Origin Effects. Protect the power cord from being walked on or pinched particularly at plugs, convenience receptacles, and the point where they exit from the apparatus. Do not defeat the safety purpose of the polarised or grounding-type plug. A polarised plug has two blades with one wider than the other. A grounding type plug has two blades and a third grounding prong. The wide blade or the third prong are provided for your safety. If the provided plug does not fi t into your outlet, consult an electrician for replacement of the obsolete outlet. Unplug this apparatus during lightning storms or when unused for long periods of time.CAUTION! No user-servicable parts inside. In the event of damage to the unit service orrepair must be done by qualifi ed service personnel only.This Product is CE compliant.This product is UKCA compliant.The crossed out wheely bin symbol indicates this product is classified as Waste Electricaland Electronic Equipment (WEEE) in the European Union and should not be discardedwith household waste. Other territories may vary. Contact your local authority or OriginEffects for more information.This product conforms to the European Union’s directive 2011/EU on Restrictions ofHazardous Substances (RoHS).Evaluation of apparatus based on altitude not exceeding 2000m. There may be somepotential safety hazard if the apparatus is operated at altitude exceeding 2000m.WARNING: This product can expose you to chemicals including nickel, which is known to the State of California to cause cancer. For more information, go to RoHSAppendix E: WarrantyThis product is covered by a 2-year manufacturer’s warranty from the date of purchase. This applies only to original purchasers who have bought their product from an authorised Origin Effects dealer or directly from Origin Effects.All returns or servicing should be arranged through the original dealer. Proof of original ownership may be required in the form of a purchase receipt.For full warranty details visit /warranty.。
ESSENTIAL INFORMATIONFUEL TANK CAPACITY/FUEL RECOMMENDATIONS:Your fuel tank can accommodate 18.5gallons of gasoline.Your vehicle is designed to use “Premium”unleaded gasoline with an (R+M)/2 octane rating of 91 or higher for optimum performance.The use of gasolines with lower octane ratings may degrade performance.FUSES:If electrical components in your vehicle stop working,a fuse may have blown.(You’ll notice a broken wire within the fuse.) For information on changing fuses,please consult your Owner’s Guide.TIRE PRESSURE:Improperly inflated tires can affect vehicle handling and can fail suddenly,possibly resulting in loss of vehicle control.Check your tires for proper air pressure monthly;check the air pressure in your spare tire every six months.Always use an accurate tire pressure gauge.Check the tire pressure when tires are cold,after the vehicle has been parked for at least 3 hours or has been driven less than 3 miles.(As you drive,the temperature in the tire warms up,increasing the tire pressure.) Adjust the tire pressure to the recommended specifications found on the tire inflation placard.CHANGING THE TIRES:Your spare tire,jack and lug nut wrench are located under your trunk cargo cover.(On V8 Sport models,the lug nut wrench is attached to the jack assembly.To use the wrench,remove it from the jack and extend the shaft.) Your vehicle may have a temporary or full-size spare tire.The temporary spare tire for your vehicle is labeled as such.It is smaller than a regular tire and is designed for emergency use only.Drive cautiously and replace the temporary spare tire as soon as possible.If you get a flat tire while driving,do not apply the brake heavily.Instead,gradually decrease your speed.Hold the steering wheel firmly and slowly move to a safe place on the side of the road.ROADSIDE EMERGENCIES:To fully assist you if you should have a vehicle concern,Lincoln offers a complimentary roadside assistance program.This program is separate from the New Vehicle Limited Warranty.The service is available 24 hours a day,seven days a week for the Basic Warranty Period (Canada),or New Vehicle Limited Warranty period (U.S.) of four years or 80,000 km (50,000 miles).Roadside assistance will cover:Country:Phone Number:•Changing a flat tire United States (800) 521-4140•Lockout assistance Canada (800) 665-2006•Jump-starts•Towing of your vehicle •Limited fuel deliveryFor complete details on any roadside assistance concern,please consult the Roadside Emergencies or Customer Assistance chapters of your Owner’s Guide.Ford Motor Company Customer Relationship Center P .O.Box 6248,Dearborn,MI 481211-800-392-3673 (FORD)(TDD for the hearing impaired:1-800-232-5952)This Quick Reference Guide is not intended to replace your vehicle Owner’s Guide which contains more detailed information concerning the features of your vehicle,as well as important safety warnings designed to help reduce the risk of injury to you and your passengers.Please read your entire Owner’s Guide carefully as you begin learning about your new vehicle and refer to the appropriate sections when questions arise.5W4J-19G217-BA*F5W4J19G217BA*May 2004 First PrintingQuick Reference GuideLincoln LS Litho in U.S.A.LI NCOLN LS2005 QUI CK REFERENCE GUI DE2005 M O D E L L S Q U I C K R E F E R E N C E G U I D EAUDIO SYSTEMSPREMIUM AM/FM STEREO/CASSETTE SINGLE CDPOWER/VOLUME:Press the control to turn the system on or off;turn the control to raise or lower the volume.AM/FM/CD:In radio mode ,press this control to switch between AM,FM1 or FM2 modes.In tape or CD mode ,press this control to stop play and begin radio play.I f you’re returning from tape or radio play and have a CD in place,press CD to begin play of the first CD track.The CD will begin play where it stopped last.TUNE:In radio mode ,press the left arrow to move to the next frequency down the band;hold the arrow to move quickly through the frequencies.Press the right arrow to move to the next frequency up the band;hold the arrow to move quickly through the frequencies.SEEK:In radio mode ,press the left arrow to find the next listenable station down the frequency band;press the right arrow to find the next listenable station up the frequency band.In tape or CD mode ,press the left arrow to listen to the previous selection or track;press the right arrow to listen to the next selection or track.SCAN:In radio mode ,press SCAN to hear a brief sampling of all listenable stations;press again to stop scan mode.In tape or CD mode ,press SCAN to hear a brief sampling of all selections.To stop on a particular selection,press the control again.AUTO SET:Auto Set allows you to set strong radio stations without losing your original manually set preset stations.Please consult your Owner’s Guide for details.AB C DEF G HIJ K LABCDEFRDS/MUTE:The Radio Data System allows your audio system to receive station identification or program type from RDS-equipped FM radio stations.Please consult your Owner’s Guide for details.Press MUTE to silence the playing media;press again to return to normal levels.REWIND/FF:Press REW to reverse in tape or CD mode;press FF to fast-forward in tape or CD mode.COMPRESSION/SHUFFLE:To adjust the soft and loud passages of a CD for a more consistent listening level,press COMP;press again to deactivate.Press SHUF to play all CD tracks in random order;press again to deactivate.BALANCE/FADE:Press BAL and the left SEL arrow to shift sound to the left speakers;press the right arrow to shift sound to the right speakers.Press FADE and the right arrow of SEL to shift the sound to the front;press the left arrow to adjust the sound to the rear.BASS/TREBLE:Press BASS,then use the SEL control left arrow to decrease or the right arrow to increase the audio system’s bass component.Press TREB,then use the SEL control left arrow to decrease or the right arrow to increase the audio system’s treble component.TAPE: f a tape is already loaded into the system,press TAPE to begin tape play.CLOCK:Press the RDS control until SELECT HOUR or SELECT MINS is e the left arrow of the SEL control to decrease hours/minutes,or the right arrow of the SEL control to increase hours/minutes.GHIJKL MMAUDIOPHILE SATELLITE READY AM/FM STEREO IN-DASH SIX CD RADIOAM/FM:In radio mode ,press this control to switch between AM,FM1 or FM2 frequency bands.In CD mode ,press this control to stop CD play and begin radio play.CD/AUX:Press to access CD or AUX mode.RADIO MEMORY PRESETS:These controls can be used to select up to six preset AM stations and twelve FM stations (six in FM1 and six in FM2).Use the AM/FM control to select the frequency band;select the station of your choice.Press and hold a memory preset control until the sound returns,indicating the station has been stored.BALANCE/FADE:Press BAL,then use the SEL control to adjust sound between left and right speakers.Press FADE,then use SEL to adjust the sound between the front and rear speakers.BASS/TREBLE:Press the BASS or TREB control,then use the SEL control up arrow to increase or down arrow to decrease that audio component.CD REWIND/FF:Press and hold the REW control until the desired selection is reached;release to disengage rewind.Press and hold FF until the desired selection is reached;release to disengage fast-forward.SEEK:In radio mode ,press the left arrow to find the next listenable station down the frequency band.Press the right arrow to find the next listenable station up the frequency band.n CD mode ,press the left arrow to move to the previous track on the current disc;press the right arrow to move to the next selection on the current disc.DB CAE FG H I JKAB CDEFTUNE:In radio mode ,press the left arrow to move to the next frequency down the band;hold the arrow to move quickly through the frequencies.Press the right arrow to move to the next frequency up the band;hold the arrow to move quickly through the frequencies.I n CD mode ,press the left arrow to listen to the previous disc;the right arrow to listen to the next disc.SCAN:In radio mode ,press SCAN to hear a brief sampling of all listenable stations;press again to stop scan mode.n CD mode ,press SCAN to hear a brief sampling of all CD selections.To stop on a particular selection,press the control again.CD LOAD:Press the LOAD control and wait for the CD door to open.(Never attempt to force the door open manually.) You can choose which slot you’d like to load by pressing the desired preset number.(As an example – to load a CD into slot 2,press LOAD and then press preset 2.) I f you don’t specify a location,the system will choose the next available slot.The display will indicate “LOAD CD#”until the CD is loaded and “LOADING CD#”while the CD is loading.CLOCK:Press MENU until SELECT HOUR or SELECT MINS is e the up arrow of SEL to increase,or the down arrow to decrease the hours and minutes.Your system comes equipped with satellite ready capability.The kit to enable satellite reception is available through your Lincoln dealer.Detailed satellite instructions are included with the dealer installed satellite kit.Dealer installed satellite kit available only in the continental United States.GHIJKCLIMATE CONTROL SYSTEMDUAL AUTOMATIC TEMPERATURE CONTROL (If Equipped)DRIVER TEMP CONTROL:Press the up arrow for a warmer temperature;the down arrow for a cooler temperature.(I n single zone operation,this control manages the temperature of the entire vehicle.n dual zone,it manages the temperature of the driver’s side of the e AUTO to change zones.)FAN SPEED:To adjust the fan speed manually,press the up arrow to increase the speed;the down arrow to decrease the speed.To return to automatic fan operation,press AUTO.COOL DRIVER SEAT:Press to cool the driver’s seat.Press once for full cool,twice for medium cool and a third time for low cool.Press a fourth time to disengage.HEAT DRIVER SEAT:Press to heat the driver’s seat.Press once for full heat,twice for medium heat and a third time for low heat.Press a fourth time to disengage.AUTO (Automatic Temperature Control):Press AUTO and select the temperature you find most comfortable.The system will either heat or cool the vehicle based on your temperature selection.Press and hold AUTO for about two seconds to toggle between single zone and dual zone temperature control.MANUAL O V ERRIDE CONTROLS:These 3 buttons OFF ,,allow you to manually direct airflow.To return to full automatic control,press AUTO.OFF:Press to disengage Automatic Temperature Control.Press AUTO to resume automatic operation.AIRFLOW DIRECTION CONTROL:Press to toggle through various air distribution modes.DEFROST:Press to clear ice or fog from the windshield;the system will distribute outside air through the windshield defroster ducts and the demister outlets.DBCAFGHABCDEFCOOL PASSENGER SEAT:Press to cool the front passenger seat.Press once for full cool,twice for medium cool and a third time for low cool.Press a fourth time to disengage.HEAT PASSENGER SEAT:Press to heat the front passenger seat.Press once for full heat,twice for medium heat and a third time for low heat.Press a fourth time to disengage.PASSENGER TEMP CONTROL:Press the up arrow for a warmer temperature;the down arrow for a cooler temperature.REAR WINDOW DEFROST:Press to clear therear window and side view mirrors of thin ice or fog.Press again to turn the system off,or allow it to turn off automatically after a predetermined period of time.RECIRCULATED AIR:Press to manually engage or disengage the operation of recirculated air in all modes except defrost.A/C:Press to manually control the air conditioning;press again to disengage.Press AUTO for automatic operation.DISPLAY OUTSIDE TEMP:Press EXT to display the outside temperature.Press EXT again to return to interior temperature.°F/°C:Press to switch between Fahrenheit and Celsius.The buttons for the rear heated seats are located on each of the rear door armrests.Press the top of the button for high heat,the bottom of the button for low heat;push again to deactivate.G H JKLM NOPQIEIJKLMNOPQCAUTION:DO NOT USE CD WITH ADHESIVE LABEL**CDs with adhesive labels and irregularly shaped CDs may get stuck in the CD player.Homemade CDs should be identified with permanent felt tip marker rather than adhesive labels.INTERIOR FEATURESLI NCOLN LSCongratulations on acquiring a Lincoln LS.Your elegant new vehicle possesses many sophisticated features,from steering wheel mounted controls to the electronic parking brake.This Quick Reference Guide was designed to acquaint you with many of the features you’ll be using most.For detailed information,please consult your Owner’s Guide.12387654911121414113FUEL DOOR RELEASEPress the power fuel door release control on the instrument panel to open the fuel door.4TURN SIGNAL/WIPER WASHER CONTROLSFor a single wipe with no wash,tap the end of the stalk briefly.To increase the speed of the wipers,rotate the end of the control away from you;to decrease the speed,rotate the control toward you.To activate the washer,push and hold the end of the stalk;the wash cycle will continue for up to ten seconds,until released.After release there will be three clearing wipes.(The windshield wiper won’t cycle automatically if the washer fluid is low.)5SPEED CONTROLYour speed controls are located on the steering wheel.Press ON to enable speed control.(You must be traveling at or above 30 miles per hour.) Press SET+ and release to set a speed,then press and hold + or – to increase or decrease speed.Pressing RES will return your vehicle to a previously set speed.To disengage speed control,press OFF or depress the brake pedal.HEADLAMP CONTROLSTurn the control clockwise to the first position to turn on the parking lamps,license plate lamps and tail lamps.Turn to the second position to turn on the headlamps.Turn the control counterclockwise to initiate the autolamp system,which turns your exterior lamps on and off automatically,based on availabledaylight;the system also keeps the lights on for a short time after the ignition switch is turned to the OFF position.To turn on the foglamps,pull the headlamp control toward you.12INTERIOR TRUNK RELEASEPress the power trunk release control on the instrument panel to open the trunk.When valet parking,you can render the switch inoperable by locking the button with your master key;lock your glove box before giving the attendant the gray valet key.6CHECK ENGINE LIGHTSolid illumination indicates a system malfunction,an overheated engine,or may come on if the vehicle runs out of fuel.Blinking illumination means an engine misfire is occurring;have the vehicle serviced immediately.9MESSAGE CENTER (If Equipped)Your Message Center is located on your instrument cluster.With the ignition in the “run”position,the Message Center will display important vehicle information while constantly monitoring vehicle systems.I t will also notify you of potential vehicle problems by displaying a system warning message.Please consult your Owner’s Guide for details.10CLIMATE CONTROL SYSTEMPlease see the reverse side for details.8STEERING WHEEL AUDIO CONTROLS(I f your vehicle is equipped with the Navigation System,please refer to your Owner’s Guide for information.) Press MEDIA to select AM,FM1,FM2,TAPE,or CD (if equipped).Radio Presets:In AM,FM1 or FM2 mode,use the up or down arrow to select preset radio stations within the selected radio band.Tape Selection:Intape mode,press the up or down arrow to select the next or previous selection on the tape.CD Selection:In CD mode,press the up or down arrow to select the next or previous selection on the CD.Volume:Press VOL + or – in any mode to adjust the volume.Mute:Press this control to silence the playing media;press again to return to normal volume.ABS WARNING LIGHTf this light remains on or continues to flash,it means a malfunction has been detected;have the ABS serviced immediately.You can expect your normal braking system to continue to function unless the brake warning light remains illuminated.7101311HEATED / COOLED SEATS (If Equipped)Please see the reverse side for details.12AUDIO SYSTEMS/CLOCKSPlease see the reverse side to review the Premium AM/FM stereo/cassette single CD unit or the Audiophile Satellite Ready AM/FM stereo in-dash six-CD radio.If you have the Navigation System,please consult the Entertainment chapter of your Owner’s Guide for more information on navigation system features,or call 1-888-NAV-MAPS (1-888-628-6277).13ASHTRAYYour ashtray has an unusual feature - it has a drawer with a removable tray;the tray can be damaged if not used properly.To remove the tray,push the ashtray face and slide it open;pull the tray from the drawer to remove.(You’ll notice that the tray has a tight fit.Please take care not to damage the ashtray.) To install the tray,insert the tray into the drawer;push to close.14FRONT AND REAR WINDOW DEFROSTER CONTROLSPress the defrost control to clear ice or fog from the windshield.Press the rear defrost control to clear the rear window and side view mirrors of thin ice or fog.Press again to turn the system off,or allow it to turn off automatically after a predetermined period of time.ADDITIONAL FEATURESREMOTE ENTRY SYSTEMADVANCETRAC™ (If Equipped)The AdvanceTrac™ system automatically turns on when the engine is started.AdvanceTrac™ enhances your vehicle’s stability during maneuvers that require all available tire traction,like in wet/snowy/icy road conditions and/or when performing emergency maneuvers.ELECTRONIC PARKING BRAKETo set the parking brake,pull the lever up.To release the parking brake,make sure the ignition is turned to ON,depress the brake pedal,then gently push the parking brake lever down.HOMELINK ®WIRELESS CONTROL SYSTEM (If Equipped)This control,located on the driver’s visor,provides a convenient way to replace up to three hand-held transmitters with a single built-in device.This feature will learn the radio frequency codes of most current transmitters to operate garage doors,entry gates,security systems,entry door locks,and home or office lighting.For more information,contact HomeLink® at: or 1–800–355–3515.Press and release the “unlock”icon to unlock the driver’s door.Press and release again within five seconds to unlock all doors.Press and hold this control for more than two seconds in order to begin opening the windows and moonroof (if equipped).The control can then be released and the windows and moonroof will complete the opening operation.Press and release the “lock”icon to lock all doors and arm the perimeter alarm system.Press and release again within three seconds to confirm that all doors,trunk and hood are closed and locked.One chirp will confirm that all doors,hood and trunk are closed;two chirps will indicate that one or more access points have NOT been properly closed.Press the “open trunk”icon to open the trunk.Press the “alarm”icon to activate the alarm.Press it a second time to deactivate the alarm.9。
