Application value of noninvasive ultrasound cardiac output monitor combined with PEWS in severe influenza of children/Jia Xiaohui 1, Liu Li 1, Wen Xiaobin 1, Shen Xiaojia 1, Liu Yan 1, Xiang Lijia 2, Zhang Haiyang 3, Zhou Qian 1, Jian Ding 1, Wang Lin 41Department of Pediatrics, Chengdu Second People's Hospital, Chengdu 610017, China; 2Department of Infection, Chengdu Second People's Hospital, Chengdu 610017, China; 3Department of Child Critical Care Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, China; 4Departmnet of Pediatrics, Chengdu Qingbaijiang District People's Hospital, Chengdu 610039, China Corresponding author: LiuLi,Email:********************[Abstract] Objective: Based on Logistics regression, a diagnosis and prediction model for severe influenza of children was established by applying pediatric early warning score (PEWS) and hemodynamic parameters of non-invasive ultrasonic cardiac output monitor, and to analyze the application value of that. Methods: Clinical data of 284 pediatric patients aged from 29 days to 4.9 years who were diagnosed as severe and (or) critical influenza in Chengdu Second People’s Hospital, West China Second University Hospital of Sichuan University and Chengdu Qingbaijiang District People’s Hospital from January 2019 to March 2023 were collected. They were divided into severe group and critical group according to the criteria of disease classification of <Influenza Diagnosis and Treatment Protocol (2019 edition)>. The correlation analysis and multi-factor Logistics regression analysis were performed after the PEWS, blood gas lactic acid and the parameter values of each module of the monitor for non-invasive ultrasonic cardiac output (CO) were completed. Results: There were significant differences in the measured values of PEWS, lactic acid, stroke output (SV), CO, cardiac index (CI), peripheral vascular resistance (SVR) and peripheral vascular resistance index (SVRI) between the severe group and the critical group, and the differences were statistically significant (t =29.581, 12.462, 9.595, 6.000, 2.872, 120.664, 9.967, P <0.05), respectively. The PEWS scores of pediatric patients with severe and critical influenza was positively correlated with SVR value, and was negatively correlated with SV value and CO value (r =0.330, -0.217, -0.192, P <0.05), respectively. The serum lactic acid level of pediatric patients with severe and critical influenza was positively correlated with SVR, and was negatively correlated with SV value and CO value of non-invasive heart[摘要] 目的：基于logistics回归，应用儿童早期预警评分及无创超声心输出量监测仪血流动力学参数建立预测重症流感儿童发生危重症的诊断预测模型，分析其应用价值。
