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普瑞巴林联合脉冲射频治疗带状疱疹后神经痛的临床效果李伟兴① 林冠林① 陈振明① 蔡振宇① 【摘要】 目的：探究普瑞巴林联合脉冲射频（PRF）治疗带状疱疹后神经痛（PHN）的临床效果。
方法：选取2021年3月—2022年9月厦门大学附属第一医院疼痛科收治的70例PHN患者，依据治疗方案差异分为的PRF组（采用普瑞巴林联合PRF治疗）与NB组[采用普瑞巴林联合神经阻滞（NB）]，各35例。
比较两组治疗前后疼痛程度、临床效果、睡眠质量及不良反应发生情况。
结果：治疗前，两组视觉模拟评分法（VAS）评分比较，差异无统计学意义（P>0.05）；治疗后 1周、4周及12周，两组VAS评分显著低于治疗前，且PRF组低于NB组，治疗后4周及12周，两组VAS评分显著低于治疗后1周，治疗后12周，两组VAS评分显著低于治疗后4周，差异有统计学意义（P<0.05）。
PRF组总有效率为94.29%，显著高于NB组的74.29%，差异有统计学意义（P<0.05）。
治疗前，两组匹兹堡睡眠质量指数（PSQI）评分比较，差异无统计学意义（P>0.05）；治疗后1周、4周及12周，两组PSQI评分显著低于治疗前，且PRF组低于NB组，治疗后4周及12周，两组PSQI评分显著低于治疗后1周，治疗后12周，两组PSQI评分显著低于治疗后4周，差异有统计学意义（P<0.05）。
PRF组不良反应发生率为17.14%，显著低于NB组的40.00%，差异有统计学意义（P<0.05）。
结论：普瑞巴林联合PRF治疗PHN具有确切的效果，可显著减轻患者疼痛，改善患者睡眠质量，同时不良反应发生较少。
【关键词】 带状疱疹后神经痛 普瑞巴林 脉冲射频 神经阻滞 视觉模拟评分法 匹兹堡睡眠质量指数 doi：10.14033/ki.cfmr.2023.31.010 文献标识码 B 文章编号 1674-6805（2023）31-0038-04 Clinical Effect of Pregabalin Combined with Pulsed Radiofrequency in the Treatment of Postherpetic Neuralgia/LI Weixing, LIN Guanlin, CHEN Zhenming, CAI Zhenyu. //Chinese and Foreign Medical Research, 2023, 21(31): 38-41 [Abstract] Objective: To explore the clinical effect of Pregabalin combined with pulsed radiofrequency (PRF) on postherpetic neuralgia (PHN). Method: A total of 70 PHN patients admitted to the Pain Department of the First Affiliated Hospital of Xiamen University from March 2021 to September 2022 were selected and divided into PRF group (treated with Pregabalin combined with PRF) and NB group [treated with Pregabalin combined with nerve block (NB)] according to the difference in treatment plans, with 35 cases in each group. The pain degree, clinical efficacy, sleep quality before and after treatment and adverse reactions were compared between the two groups. Result: Before treatment, there was no significant difference in visual analogue scale (VAS) scores between the two groups (P>0.05). At 1 week, 4 weeks and 12 weeks after treatment, VAS scores in two groups were significantly lower than those before treatment, and PRF group were lower than those in the NB group, at 4 weeks and 12 weeks after treatment, the VAS score of the two groups were significantly lower than that of 1 week after treatment, and at 12 weeks after treatment, the VAS scores of the two groups were significantly lower than that of 4 weeks after treatment, the differences were statistically significant (P<0.05). The total effective rate of PRF group was 94.29%, which was significantly higher than 74.29% of NB group, the difference was statistically significant (P<0.05). Before treatment, there was no significant difference in Pittsburgh sleep quality index (PSQI) scores between the two groups (P>0.05). At 1 week, 4 weeks and 12 weeks after treatment, PSQI scores in two groups were significantly lower than those before treatment, and PRF group were lower than those in NB group, at 4 weeks and 12 weeks after treatment, the PSQI scores of the two groups were significantly lower than that of 1 week after treatment, and at 12 weeks after treatment, the PSQI scores of the two groups were significantly lower than that of 4 weeks after treatment, the differences were statistically significant (P<0.05). The complication rate of PRF group was 17.14%, which was significantly lower than 40.00% of NB group, and the difference was statistically significant (P<0.05). Conclusion: Pregabalin combined with PRF in the treatment of PHN has a definite effect, which can significantly reduce pain and improve sleep quality of patients with fewer complications. [Key words] Postherpetic neuralgia Pregabalin Pulsed radiofrequency Nerve block Visual analogue scale Pittsburgh sleep quality index First-author's address: The First Affiliated Hospital of Xiamen University, Xiamen 361003, China①厦门大学附属第一医院 福建 厦门 361003通信作者：蔡振宇 带状疱疹（HZ）是水痘-带状疱疹病毒长期潜伏在背根神经节，其在人体免疫力较弱的时候活化，导致沿神经涉及的皮肤局部出现疱疹[1]。
临床医药文献杂志Journal of Clinical Medical2019 年第 6 卷第 27 期2019 Vol.6 No.2769脑卒中后中枢性疼痛采用普瑞巴林治疗的临床效果王云江1，王 晨2，梅 江3（1.新疆呼图壁县中医医院疼痛科，新疆 昌吉 831200；2.新疆呼图壁县人民医院中医科，新疆 昌吉 831200；3.新疆呼图壁县中医医院梅江中医整脊工作室，新疆 昌吉 831200）【摘要】目的 本次研究分析在脑卒中后中枢性疼痛患者治疗中采用普瑞巴林的临床治疗效果。
方法 本次研究样本从本院脑卒中后中枢性疼痛患者中选取，总共选取样本50例，研究时间从2015年1月～2018年10月，按照治疗方式的差异将所有患者分为两组，其中实验组患者采用普瑞巴林治疗，对照组患者采用加巴喷丁治疗，将两组患者临床效果进行比较。
结果 对比两组患者治疗后疼痛强度评分，以此作为临床治疗效果的对比依据，从数据统计结果上分析，实验组患者疼痛强度评分较低，并与对照组比较存在统计学差异（P ＜0.05）；对比两组患者治疗后负面情绪评分，并以此作为临床治疗质量的对比依据，从数据统计结果上分析，实验组负面情绪评分较为优异，并与对照组比较存在统计学差异（P ＜0.05）。
结论 本次研究证实，在脑卒中后中枢性疼痛患者治疗中采用普瑞巴，对患者临床疗效较好，为有效治疗方案。
【关键词】脑卒中；中枢性疼痛；普瑞巴林；临床效果【中图分类号】R743.3 【文献标识码】A 【文章编号】ISSN.2095-8242.2019.27.69.01脑卒中是中老年人的常见疾病，并且具有较高的发病率与致残率，而脑卒中后中枢性疼痛属于一种多发性的并发症状，患者临床表现为患侧肢体或者躯干之间伴有持续性疼痛症状，这种疼痛一般为针刺样或刀割样，患者一般难以忍受。
因而在长期的病痛折磨后，患者容易出现焦虑、抑郁等负面情绪。
在临床治疗中一般采用药物治疗方案，并取得了显著疗效。
普瑞巴林联合吗啡对癌性神经病理性疼痛患者VAS评分及睡
眠质量的影响
徐锋
【期刊名称】《河南医学研究》
【年(卷),期】2017(026)019
【摘要】目的研究普瑞巴林联合吗啡对癌性神经病理性疼痛(NCP)患者疼痛视觉模拟评分(VAS)及睡眠质量的影响.方法选取南阳南石医院收治的NCP患者54例,随机数表法分为两组,各27例.对照组接受吗啡治疗,观察组普瑞巴林+吗啡治疗,对比两组治疗前后VAS及MOS-SS睡眠量表评分变化.结果治疗后,观察组VAS评分低于对照组,差异有统计学意义(P＜0.05);观察组MOS-SS睡眠质量各维度评分优于对照组,差异有统计学意义(P＜0.05).结论普瑞巴林联合吗啡应用于癌性神经病理性疼痛患者,可降低VAS评分,提高患者睡眠质量.
【总页数】2页(P3587-3588)
【作者】徐锋
【作者单位】南阳南石医院疼痛科河南南阳473000
【正文语种】中文
【中图分类】R730.5
【相关文献】
1.普瑞巴林对癌性神经病理性疼痛患者睡眠和抑郁的疗效 [J], 陈惠萍;王琦;许燕玉;汪冬吟;甘惠贞
2.普瑞巴林与吗啡联合应用对癌性神经病理性疼痛的治疗效果 [J], 窦智;蒋宗滨;钟进才
3.普瑞巴林对癌性疼痛患者睡眠质量及吗啡不良反应的影响 [J], 匡燕;肖广莉;罗艳
4.超声引导下选择性神经根阻滞联合普瑞巴林对脑卒中后神经病理性疼痛视觉模拟评分及睡眠质量的影响 [J], 张玉
5.普瑞巴林联合吗啡对癌性神经病理性疼痛的治疗效果探究 [J], 何金莲
因版权原因，仅展示原文概要，查看原文内容请购买。
2021年5月第11卷第10期·临床医学·神经系统普瑞巴林在脑卒中后中枢神经痛治疗中的观察研究周 静 袁大华▲ 王玉凯 丁 楠广东省佛山市第一人民医院神经内科，广东佛山 528000[摘要] 目的 探究普瑞巴林在脑卒中后中枢神经痛治疗中的临床应用效果。
方法 回顾性选择2017年8月至2019年8月佛山市第一人民医院神经科收治的使用普瑞巴林的脑卒中后中枢神经痛患者40例为治疗组，选择同期使用奥卡西平的脑卒中后神经痛患者30例作为对照组。
两组均予以脑卒中规范化治疗，均治疗观察8周。
比较两组治疗前后疼痛、心理健康状况变化情况以及药物不良反应发生率。
结果 治疗前两组患者的平均每日疼痛评分量表分值（DPRS）比较，差异无统计学意义（P＞0.05），治疗4、8周后，治疗组的DPRS分值明显低于对照组（P＜0.05）。
治疗8周后，治疗组患者的焦虑（HAMA）、抑郁（HAMD）评分明显低于对照组（P＜0.05）。
治疗组的药物不良反应总发生率为5.26%，与对照组的2.63%比较，差异无统计学意义（P＞0.05）。
结论 普瑞巴林能够显著减轻脑卒中后中枢神经痛患者的疼痛感，并有助于消除不良情绪，且不会增加不良反应发生。
[关键词] 脑卒中；中枢神经痛；普瑞巴林；奥卡西平[中图分类号] R743.3 [文献标识码] A [文章编号] 2095-0616（2021）10-0184-04Observation and analysis of pregabalin in the treatment of post-stroke central neuropathic painZHOU Jing YUAN Dahua WANG Yukai DING NanDepartment of Neurology, the First People's Hospital of Foshan, Guangdong, Foshan 528000, China[Abstract] Objective To investigate the clinical application efficacy of pregabalin in the treatment of post-stroke central neuropathicpain. Methods Patients with post-stroke central neuropathic pain treated with pregabalin and admitted to the department of neurologyof the First People's Hospital of Foshan from August 2017 to August 2019 were retrospectively selected as the treatment group (n=40),and patients with post-stroke central neuropathic pain treated with oxcarbazepine in the same period were selected as the control group(n=30). Both groups were all given standardized treatment for stroke, and the treatment was observed for 8 weeks. The changes of pain,mental health and the incidence of adverse drug reactions were compared between the two groups before and after treatment. ResultsBefore treatment, there was no statistically significant difference in the average daily pain rating scale (DPRS) between the two groups ofpatients (P＞0.05). After 4 weeks and 8 weeks of treatment, the DPRS score of the treatment group was significantly lower than that ofthe control group (P＜0.05). After 8 weeks of treatment, the scores of anxiety (Hamilton anxietyscale, HAMA) and depression (Hamiltondepressive scale, HAMD) in the treatment group were significantly lower than those in the control group (P＜0.05). The incidence ofadverse drug reactions in the treatment group was 5.26%, which was not significantly different from 2.63% in the control group, withoutstatistically significant difference (P＞0.05). Conclusion Pregabalin can significantly reduce the post-stroke central neuropathicpain of patients and is conducive to eliminating adverse emotions without increasing the incidence of adverse reactions.[Key words] Stroke; Central neuropathic pain; Pregabalin; Oxcarbazepine脑卒中后中枢神经痛主要是指脑卒中发生后在没有精神因素、周围神经受损的情况下瘫痪侧肢体出现间断或持续的疼痛感，并伴有感觉异常的一种病理性神经疼痛[1]。
普瑞巴林联合经皮电刺激治疗带状疱疹后遗神经痛的疗效何云武;龙慧;邹聪;李威;李晴;汤永红;欧阳玲;周丽娜
【期刊名称】《中国康复》
【年(卷),期】2013(028)001
【摘要】目的:观察口服普瑞巴林联合经皮电刺激治疗腹部带状疱疹后遗神经痛(PHN)的临床效果.方法:腹部PHN患者52例,随机分为2组各26例.对照组口服普瑞巴林300mg,每天2次；观察组在此基础上给予患处经皮神经电刺激(TENS)治疗.用视觉模拟疼痛评分(VAS)和睡眠质量评分(QS)评价效果,并观察治疗后的不良反应.结果:治疗1、2、3及4周后,2组VAS和QS评分均显著下降(均P＜0.05),观察组降低较对照组更明显(均P＜0.05).2组不良反应比较差异无统计学意义.结论:口服普瑞巴林300mg联合TENS治疗可有效缓解腹部PHN,改善睡眠质量,且无明显不良反应.
【总页数】2页(P35-36)
【作者】何云武;龙慧;邹聪;李威;李晴;汤永红;欧阳玲;周丽娜
【作者单位】南华大学附属第二医院疼痛科,湖南衡阳421001
【正文语种】中文
【中图分类】R49;R752.12
【相关文献】
1.普瑞巴林联合经皮神经电刺激治疗卒中后疼痛疗效观察 [J], 陈建敏; 王志勇
2.梅花针联合普瑞巴林治疗带状疱疹后遗神经痛疗效研究 [J], 张辰;郭姗姗;谢川;
黄建辉;阮中迪
3.归芍颗粒、刺血拔罐法联合普瑞巴林对带状疱疹后遗神经痛患者的临床疗效 [J], 张丽芹;丁锋;矫英
4.自拟四虫益气养血汤联合普瑞巴林治疗带状疱疹后遗神经痛的临床疗效 [J], 孙岚
5.普瑞巴林联合高能红光治疗头面部带状疱疹后遗神经痛的疗效观察 [J], 周微因版权原因，仅展示原文概要，查看原文内容请购买。
普瑞巴林胶囊治疗脑卒中后丘脑痛的临床疗效目的探讨普瑞巴林对脑卒中后丘脑痛的疗效和安全性。
方法选择该院2012年6月—2015年3月住院及门诊的脑卒中后丘脑痛患者，共96例，按随机数字表法分三组：普瑞巴林组、加巴喷丁组、卡马西平缓释片组，每组32例，三组患者分别口服普瑞巴林胶囊、加巴喷丁胶囊、卡马西平缓释片治疗，期间停用其他镇痛药物。
所有患者于治疗前及治疗后1、2、4、8 周进行NRS评分及睡眠障碍评分，观察三组患者的不良反应。
结果普瑞巴林组在治疗后1周NRS 评分下降，且在此后各个时点下降明显（P＜0.05），与其他两组相比，在各个时间点差异均有统计学意义（P＜0.01）。
普瑞巴林组在治疗后1、2、4、8 周的睡眠障碍评分与治疗前比较差异有统计学意义（P＜0.05），且优于其他两组同期（P＜0.01）。
结论普瑞巴林可有效治疗脑卒中后丘脑痛，改善患者疼痛及睡眠障碍，不良反应少，药物耐受性良好。
[Abstract] Objective To study the effectiveness and safety for thalamic pain after Stroke treated with pregabalin. Methods 96 patients with thalamic pain from 2012 June to 2015 March were randomized equally into three groups：pregabalin group，gabapentin group and carbamazepine group，32cases in each group.After managed in accordance with the Guidelines for the Secondary Prevention of Stroke，each group received respective drugs，out of other analgesic drugs during treatment. The effects were evaluated with NRS and sleep disorder score before treatment and1，2，4，8weeks，while adverse effects were observed. Results The NRS of pregabalin group decreased in each time point （P＜0.05），and there was a significant difference between the three groups （P＜0.01）. The sleep disorder scores of pregabalin group before treatment and1，2，4，8weeks was different statistically（P＜0.05），and better than the other two groups（P＜0.01）.Conclusion Pregabalin can improve thalamic pain and sleep disorder of patients，with little adverse effects，and is well tolerated.[Key words] Pregabalin；Thalamic pain；Stroke丘腦卒中后丘脑痛并不少见，它也是最常见的中枢性疼痛[1]，多表现为病灶对侧肢体难以忍受的自发性疼痛，常引起睡眠障碍、焦虑和抑郁障碍，严重地影响了患者的生活质量[2]。
