普罗布考片说明书

降脂药普罗布考改善NASH大鼠肝脏脂肪变性的机制吴蓉;吴小翎;刘波;张伟;高静;肖晓秋;张霞【摘要】目的：探讨降脂药物普罗布考对非酒精性脂肪性肝炎大鼠肝脏病理、血清学指标的改善作用、对肝脏胆汁酸受体FXR及下游基因、蛋白SHP、SREBP-1C表达的影响。

方法雄性SD大鼠40只，随机平均分4组：（1）正常对照组，予普通饲料；（2）高脂组，予高脂饲料；（3）普罗布考对照组，予普通饲料及普罗布考灌胃（500 mg/kg· d-1）；（4）普罗布考干预组，予高脂饲料及普罗布考灌胃（500 mg/kg· d-1）。

15周后处死，检测各组大鼠血清转氨酶、血脂、胆汁酸，同时取肝组织，切片行HE染色及病理评分；RT-PCR及Western Blot 的方法检测肝组织FXR、SHP及SREBP-1C基因及蛋白的表达水平。

结果与高脂组比较，普罗布考干预组肝脏脂肪变性及炎症浸润程度明显减轻，血清ALT （126.40±52.56 vs 80.18±22.90 U/L，P<0.01）、AST（250.40±30.45 vs 179.45±41.14 U/L，P<0.01）及胆固醇（2.7±0.2 vs 2.4±0.3 mmo l/L，P<0.01）、游离脂肪酸（0.734±.0.11 vs 0.557±0.19 mmol/L，P<0.05），胆汁酸（48.3±11.6 vs 24.9±17.7μmol/L，P<0.01）的水平显著降低；FXR、SHP mRNA及蛋白表达水平显著上升（P<0.05），SREBP-1C mRNA及蛋白表达则显著降低（P<0.05）。

结论普罗布考改善NASH大鼠肝功及肝脏脂肪变性的作用与上调胆汁酸受体FXR的表达水平有关。

%Objective To determine the effects of probucol on serum parameters and liver histopathology in rats with non-alcoholic steatohepatitis (NASH) and explore the mechanisms. Methods Forty male Sprague-Dawley rats were randomly assigned into 4 equal groups, namely the normal control group (NC group) with a standard feeding, high-fat diet group (HD group) fed with a high-fat diet,probucol (500 mg/kg daily) control group (NP group) fed with standard diet, and probucol group fed with a high-fat diet (HP group). After 15 weeks of feeding, the rats were euthanized for histopathological inspection of the liver with HE staining and detection of farnesoid X receptor (FXR), SHP and SREBP-1C expressions using semi-quantitative RT-PCR and Western blotting. Results After the 15-week feeding, the rats in HP group had significantly lower levels of serum ALT, AST, cholesterol, bile acid, and free fatty acid than those in HD group (P<0.01 or 0.05). Compared with the normal control group, high-fat diet feeding resulted in significantly decreased mRNA and protein levels of FXR and SHP (P<0.05) and significantly increased SREBP-1C level (P<0.05). These high-fat diet-induced gene expression changes were reversed by probucol intervention (P<0.05). Conclusion Probucol treatment has beneficial effects on serum parameters, hepatic steatosis, and lobular inflammation in high-fat diet-induced NASH possibly by up-regulating FXR expression.【期刊名称】《南方医科大学学报》【年(卷),期】2014(000)005【总页数】5页(P731-735)【关键词】非酒精性脂肪性肝炎;普罗布考;法尼醇X受体;固醇调节元件结合蛋白1c【作者】吴蓉;吴小翎;刘波;张伟;高静;肖晓秋;张霞【作者单位】重庆医科大学附属第二医院消化内科，重庆 400010;重庆医科大学附属第二医院消化内科，重庆 400010;重庆医科大学附属第二医院消化内科，重庆 400010;重庆医科大学附属第二医院消化内科，重庆 400010;重庆医科大学附属第二医院病理科，重庆 400010;重庆医科大学生命科学研究院，重庆 400016;重庆医科大学附属第二医院消化内科，重庆 400010【正文语种】中文非酒精性脂肪性肝炎（NASH）是非酒精性脂肪性肝病（NAFLD）疾病谱之一，可能发展为肝硬化，甚至诱发肝细胞癌（HCC）［1］。

JOURNAL OF RARE AND UNCOMMON DISEASES, DEC. 2020,Vol.27, No.6, Total No.143111·短篇· 1 病例资料 患者，男，60岁2019年10月10日因常规体检，实验室检查：总胆固醇4.27m m o l/L，甘油三酯3.33mmol/L，低密度脂蛋白1.90mmol/L，甘油三酯高出正常值，医师建议调脂治疗，开具普罗布考片(颈复康药业集团有限公司，批号：930448)每次0.5g 一日两次。

2019年10月13日电话咨询门诊药房，服用普罗布考片后血压升高，是否停药。

患者自诉服用普罗布考经过，2019年10月10日晚餐时服用第一剂，半小时后感觉头晕、心慌、随测血压为150/85mmHg；10月11日服用普罗布考片第2天，上午服用后，血压达178/98mmHg，晚餐后服用，血压仍为178/98mmHg，随加用吲哒帕胺一片；10月12日服用服用普罗布考第3天，11点时测血压170/89～180/98mmHg,午觉后血压180/98mmHg，并伴心慌、头晕，仍加用吲哒帕胺一片，血压控制不稳定。

考虑患者对血压升高过程表述清晰，且确认血压的升高与饮食运动以及同服药物无相关性，药师建议停用普罗布考，正常服用吲达帕胺片，并每日早晚监测血压(每次测2～3遍，取平均值)。

10月15日随访，患者诉自10月13日停用普罗布考后无头晕，心慌症状，自测早晚血压平均值分别为137/76mmHg、132/75mmHg；10月14日自测早晚血压平均值分别为139/75mmHg、135/75mmHg，无其他不适症状。

2 讨 论 患者既往病史：患者2014年医院诊断高血压、糖尿病，规律服用吲哒帕胺2.5mg,日一次，血压控制在139/75～115/75mmHg；规律服用吡格列酮二甲双胍片，餐前血糖控制在5.8mmol/L左右，餐后血糖控制在7.0～7.8mmol/L；5年前医生建议服用阿托伐他汀10mg预防卒中，服用至今；2013年发生一次心慌，医院检查心功能指标正常，中医建议长期服用地奥心血康胶囊。

普罗布考的功能主治简介普罗布考是一种常用的药物，属于非处方药。

它具有多种功能和主治，可以有效地治疗一些常见疾病和症状。

本文将详细介绍普罗布考的功能主治。

功能主治以下是普罗布考的主要功能和主治：1.镇痛作用：普罗布考可对多种疼痛症状起到镇痛作用，如头痛、关节痛、牙痛等。

2.退烧作用：普罗布考能够降低体温，对发烧引起的不适症状有所缓解。

3.抗炎作用：普罗布考具有抗炎作用，能够减轻炎症引起的疼痛和不适感。

4.解热作用：普罗布考可以帮助降低体温，对各类热性疾病有较好的缓解作用。

5.缓解关节炎症状：普罗布考在治疗关节炎和风湿性关节炎方面较为常用，可以减轻关节疼痛和肿胀。

6.减轻月经痛症状：普罗布考可以在经期时减轻月经疼痛，并缓解相关不适症状。

7.缓解肌肉疼痛：普罗布考对肌肉疼痛、肌肉酸痛等症状也有一定的缓解作用。

8.治疗感冒和流感：普罗布考可用于缓解感冒和流感引起的全身症状，例如发热、头痛、鼻塞、喉咙痛等。

9.舒缓痛经和子宫痉挛：普罗布考可以缓解痛经引起的腹痛和子宫痉挛症状。

10.治疗关节运动损伤：普罗布考可用于治疗关节扭伤、肌肉拉伤、韧带损伤等运动损伤。

用法用量普罗布考的用法用量如下：•成人：每次口服1片，每日2~3次，饭后使用。

•儿童：请儿科医生指导使用方法和剂量。

注意事项使用普罗布考需注意以下事项：1.禁止超量使用：不可超过推荐的用量，以免对身体造成伤害。

2.避免长期使用：普罗布考被广泛认为是一种安全有效的药物，但长期或过量使用可能会导致一些副作用。

3.孕妇和哺乳期妇女慎用：孕妇和哺乳期妇女在使用前应咨询医生的指导。

4.慎重应用于儿童：儿童使用前要请医生指导，确保合适的用量。

5.注意药物过敏反应：如果对普罗布考或其他非处方药物过敏，应立即停止使用，并就医诊治。

6.与其他药物的相互作用：使用普罗布考时要避免与其他药物同时使用，以免产生相互作用。

结论普罗布考是一种非处方药，用于治疗多种常见疾病和症状。

它具有镇痛、退烧、抗炎、解热等功能，并且可用于治疗关节炎、月经痛、感冒、运动损伤等。

普罗布考对肾脏缺血再灌注损伤大鼠的保护作用及机制杨成;任星峰;彭隽【摘要】目的观察普罗布考对缺血再灌注大鼠肾脏氧化应激损伤的保护作用,同时探讨其作用机制.方法雄性SD大鼠30只,随机分为假手术组(S组)、缺血再灌注组(IR组)、普罗布考治疗组(P+IR组),每组10只.P+IR组大鼠每天用普罗布考(500 mg/kg)灌胃,S组和IR组大鼠每天用等量温开水灌胃.1周后制备肾缺血再灌注大鼠模型:3组大鼠都摘除右肾,IR组和P+IR组用无创动脉夹夹闭左侧肾动脉,30 min 后松夹恢复血流再灌注.再灌注后S组和IR组每天温开水灌胃,P+ IR组每天普罗布考灌胃,连续1周.1周后处死所有大鼠,留取血及肾组织标本,检测大鼠各项血液生化指标,观察肾组织病理学改变.结果与IR组相比,P+IR组血尿素氮(BUN)、血肌酐(SCr)、血脂水平明显降低(均 P<0.05),血清和肾组织中SOD活性明显上升、MDA 含量明显下降(均 P<0.05),肾组织病理损伤减轻,肾指数明显改善(P<0.05).结论普罗布考能提高缺血再灌注损伤大鼠血及肾组织中SOD活性,改善肾功能,降低血脂水平,减轻肾组织病理损伤,发挥肾脏保护作用.%Objective The aim of the study was to investigate the protective effect of probucol on oxidative stress injury in rats with ischemia-reperfusion injury(IRI)and its mechanism. Methods Thirty male Sprague-Dawley rats were randomly di-vided into sham operation group(S group),ischemia-reperfusion group(IR group),and probucol treatment group(probucol+IR group,P+IR group).Rats in the S and IR groups were fed with warm water every day,and rats in P+IR group were treated with probucol.After 1 week,rat model of renal ischemia and reperfusion was established.Right kidneys of the rats were re-moved.In IR and P+ IR groups,the left renal artery was clamped with a non-invasiveartery clamp,and after 30 minutes the blood vessels restored patency by loosening the clamp.After reperfusion,the S and IR groups were perfused with warm water every day,and the P+IR group was treated with probucol for 1 week.After 1 week,all the rats were sacrificed and the blood and kidney tissue specimens were taken.The blood biochemical indexes of the rats were measured,and the pathological changes of the kidneys were observed.Results The levels of blood urea nitrogen(BUN),serum creatinine(SCr)and blood lipids in P+ IR group were significantly lower than those in IR group(all P<0.05);in P+IR group,the level of superoxide dismutase(SOD)in serum and renal tissue was increased significantly(allP<0.05),meanwhile,the levels of malondialdehyde(MDA)were significantly decreased (P<0.05).In P+IR group,the pathological damage of kidney tissue was reduced,and renal index was significantlyimproved(P<0.05).Conclusion Probucol can increase the activity of SOD in blood and kidney of rats with IRI,improve renal function,reduce the level of blood lipids,reduce the pathological injury of renal tissue,and play a role in renal protection.【期刊名称】《华中科技大学学报（医学版）》【年(卷),期】2017(046)006【总页数】5页(P660-664)【关键词】普罗布考;肾脏;缺血再灌注;氧化应激【作者】杨成;任星峰;彭隽【作者单位】中国人民解放军武汉总医院肾内科,武汉 430070;中国人民解放军武汉总医院肾内科,武汉 430070;中国人民解放军武汉总医院肾内科,武汉 430070【正文语种】中文【中图分类】R691.6在日常生活中，各种突发事件、自然灾害以及战争伤导致的多器官损伤中，急性肾损伤(acute kidney injury，AKI)约占67%，其发病率和死亡率一直居高不下。

普罗布考片单次口服给药的人体药物代谢动力学研究_向
瑾
首先，普罗布考片在胃肠道中被吸收到血液中。

吸收速度较快，口服
给药后约15分钟就可达到最高浓度。

普罗布考片在胃肠道中主要经过被
动扩散的方式被吸收。

其吸收速度可以受到多种因素的影响，如药物的颗
粒大小、药物与食物的同时摄入、胃液pH值等等。

然后，普罗布考片被分布到全身各个组织。

由于它是一个亲脂性的药物，可以穿过血脑屏障和胎盘屏障，进入中枢神经系统和胎儿体内。

普罗
布考片主要以游离形式存在于体液中，结合蛋白质的比例约为90%。

普罗布考片的代谢主要发生在肝脏中。

它主要经过肝脏的酶系统进行
代谢，其中最重要的是细胞色素P450（CYP450）酶系统。

普罗布考片在
体内有两个主要的代谢途径：一个是芳香族羟化途径，通过CYP2D6酶参
与芳香族环的氧化反应；另一个是隐斑蛋白酯水解途径，通过酯酶将普罗
布考片转化为活性代谢物。

这两个代谢途径的产物都不活性，并且会进一
步被肾脏排泄。

最后，普罗布考片被排泄体外。

其主要通过肾脏的排泄，90%以上的
药物经过肾脏代谢和排泄。

根据研究，普罗布考片的半衰期约为3-6小时，也会受到个体差异和肾功能的影响。

综上所述，普罗布考片的口服给药的人体药物代谢动力学主要包括吸收、分布、代谢和排泄等过程。

了解普罗布考片的代谢动力学，可以帮助
我们更好地理解其在体内的药效学和药代动力学特征，为临床合理用药提
供依据。

• have certain genetic factors that a ect how the body breaks down clopidogrel tablets. Your doctor may do genetic tests to make sure • you may bruise and bleed more easily • you are more likely to have nose bleeds ® • take certain medicines, especially omeprazole (Prilosec ) or®esomeprazole (Nexium ). Your doctor may change the medicine you take for stomach acid problems while you take clopidogrel tablets.Read this Medication Guide before you start taking clopidogrel tablets and each time you get a re ll. There may be new information. This Medication Guide does not take the place of talking with your doctor about your medical condition or your treatment.What is the most important information I should know about clopidogrel tablets? 2. Clopidogrel tablets can cause bleeding which can be serious and can sometimes lead to death. Clopidogrel tablets are blood thinner medicine that lowers the chance of blood clots forming in your body. While you take clopidogrel tablets:clopidogrel tablets are right for you.1. Clopidogrel tablets may not work as well in people who:• aspirin, especially if you have had a stroke. Always talk to your doctor about whether you should take aspirin along with clopidogrel tablets to treat your condition.Especially tell your doctor if you take:• non-steroidal anti-in ammatory drugs (NSAIDs). Ask your doctor or pharmacist for a list of NSAID medicines if you are not sure. ®® • warfarin (Coumadin , Jantoven ).• selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs). Ask your doctor or pharmacist for a list of SSRI or SNRI medicines if you are not sure. • other antiplatelet agents• rifampin (used to treat severe infections)Taking clopidogrel tablets with certain other medicines may increase your risk of bleeding. • are breastfeeding or plan to breastfeed. It is not known if clopidogrelp asses into your breast milk. A decision should be made with your healthcare provider to avoid or discontinue breastfeeding when continuing clopidogrel tablets is needed.non-prescription medicines, vitamins and herbal supplements.Clopidogrel tablets may a ect the way other medicines work, and other medicines may a ect how clopidogrel tablets works. See “What is the most important information I should know about clopidogrel tablets?”Clopidogrel tablets may increase blood levels of other medicines such as ®repaglinide (Prandin ).Tell your doctor about all the medicines you take, including prescription, • have had an allergy or reaction to any medicine used to treat your disease. tablets will harm your unborn baby• are pregnant or plan to become pregnant. It is not known if clopidogrel Tell all of your doctors and your dentist that you are taking clopidogrel tablets. They should talk to the doctor who prescribed clopidogrel tablets for you before you have any surgery or invasive procedure.Clopidogrel tablets are a prescription medicine used to treat people who have any of the following:• a strokeWhat are clopidogrel tablets?• chest pain due to heart problems• poor circulation in their legs (peripheral arterial disease) Clopidogrel tablets are used alone or with aspirin to lower your chance of having another serious problem with your heart or blood vessels such as heart attack, stroke, or blood clot that can lead to death.It is not known if clopidogrel tablets are safe and e ective in children. • a heart attack Platelets are blood cells that help your blood clot normally. Clopidogrel tablets help to prevent platelets from sticking together and forming a clot that can block an artery.Medication Guide (kloe pid' oh grel)Clopidogrel Tablets, USP • blood in your urine (pink, red or brown urine) • vomit blood or your vomit looks like co ee groundsDo not stop taking clopidogrel tablets without talking to the doctor who prescribes it for you. People who stop taking clopidogrel tablets too soon have a higher risk of having a heart attack or dying. If you must stop clopidogrel tablets because of bleeding, your risk of a heart attack may be higher. • red or black stools (looks like tar)• it will take longer for any bleeding to stop• cough up blood or blood clots• bruises that happen without a known cause or get larger Call your doctor right away if you have any of these signs or symptoms of bleeding: • unexpected bleeding or bleeding that lasts a long time • have a history of bleeding problems• currently have a condition that causes bleeding, such as a stomach ulcer • plan to have surgery or a dental procedure. See “How should I take clopidogrel tablets?”What should I tell my doctor before taking clopidogrel tablets? Do not take clopidogrel tablets if you:• are allergic to clopidogrel or other ingredients in clopidogrel tablets. See the end of this lea et for a complete list of ingredients in clopidogrel tablets.Who should not take clopidogrel tablets? Before you take clopidogrel tablets, tell your doctor if you:• have a history of bowel (gastrointestinal) or stomach ulcers • Do not change your dose or stop taking clopidogrel tablets without talking to your doctor rst. Stopping clopidogrel tablets may increase your risk of heart attack or stroke.What are the possible side e ects of clopidogrel tablets? • If you miss a dose, take clopidogrel, as soon as you remember. If it is almost time for your next dose, skip the missed dose. Take the next dose at your regular time. Do not take 2 doses of clopidogrel tablets at the same time unless your doctor tells you to.Know the medicines you take. Keep a list of them to show your doctor or pharmacist when you get a new medicine.• If you take too much clopidogrel, call your doctor or go to the nearest emergency room right away.• Take clopidogrel tablets exactly as your doctor tells you.How should I take clopidogrel tablets?• Talk with your doctor about stopping your clopidogrel tablets before you have surgery. Your doctor may tell you to stop taking clopidogrel tablets at least 5 days before you have surgery to avoid excessive bleeding during surgery.• Take clopidogrel tablets with aspirin as instructed by your doctor.Tablet: colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, mannitol and microcrystalline cellulose.This Medication Guide summarizes the most important information about clopidogrel tablets. If you would like more information, talk to your doctor. Ask your doctor or pharmacist for information about clopidogrel tablets that was written for healthcare professionals.This Medication Guide has been approved by the U.S. Food and Drug Administration.Film coating: hypromellose 2910-5cP, polyethylene glycol 400 and titanium dioxide.Call your doctor for medical advice about side e ects. You may report side e ects to FDA at 1-800-FDA-1088.These are not all the possible side e ects of clopidogrel tablets. For more information, ask your doctor or pharmacist.• vision changes • persistent low blood sugar symptomsTell your doctor if you have any side e ect that bothers you or that does not go away. Tell your doctor if you develop an allergic reaction including skin reactions while taking clopidogrel tablets.How should I store clopidogrel tablets?• Store clopidogrel tablets at 20°-25°C (68°-77°F).Keep clopidogrel tablets and all medicines out of the reach of children. For more information, call 1-888-375-3784.General information about clopidogrel tabletsMedicines are sometimes used for purposes other than those listed in a Medication Guide. Do not take clopidogrel tablets for a condition for which it was not prescribed. Do not give clopidogrel tablets to other people, even if they have the same symptoms that you have. It may harm them.What are the ingredients in clopidogrel tablets? Active ingredient: clopidogrel bisulfate Inactive ingredients:All other trademarks are property of their respective owners.Rx onlySrikakulam - 532 409 INDIARevised: 09/2022Bachupally - 500 090 INDIAManufactured by:Dr. Reddy’s Laboratories Limited or• stroke • seizure • low amount of urine, or urine that is pink or has blood in it • stomach area (abdominal) pain • speech changes • nausea, vomiting, or diarrhea • headache • confusion • coma • fast heart rate or feeling short of breath • you feel tired or weak Clopidogrel tablets can cause serious side e ects including:• purplish spots (called purpura) on the skin or in the mouth (mucousmembranes) due to bleeding under the skin• your skin or the whites of your eyes are yellow (jaundice) • See “What is the most important information I should know about clopidogrel tablets?”• A blood clotting problem called Thrombotic Thrombocytopenic Purpura (TTP). TTP can happen with clopidogrel tablets, sometimes after a short time (less than 2 weeks). TTP is a blood clotting problem where blood clots form in blood vessels; and can happen anywhere in the body. TTP needs to be treated in a hospital right away, because it may cause death. Get medical help right away if you have any of these symptoms and they can not be explained by another medical condition: • your skin looks very pale • fever Dispense with Medication Guide available at:/medguide/clopidogreltabs.pdf150091544。

临床药师谈高脂血症用药编者按：高脂血症是由各种原因导致的血浆中的胆固醇、甘油三酯以及低密度脂蛋白水平升高和高密度脂蛋白过低的一种全身脂质代谢异常病，现代医学称之为血脂异常。

其发病是一个慢性过程，轻度高脂血症通常没有任何不舒服的感觉，因此很多人对高脂血症缺乏警惕，根本不把高脂血症当病看，最终导致各种严重疾患。

因此，高脂血症是名副其实的“隐形杀手”。

大量研究资料表明，高脂血症是脑卒中、冠心病、心肌梗死、猝死的高危因素，还会导致其他一些疾病。

积极有效的调血脂，是预防这些疾病的有效方式。

因此，我们要重视高脂血症的危害，并应采取积极的方式进行治疗。

为了让大家了解高脂血症，我们特邀请4位临床药师从血脂指标的解读和高脂血症危害、高脂血症的药物选择、高脂血症的用药指导和高脂血症的生活调理等方面进行解读。

血脂指标解读和高脂血症危害实例：一年一度的科室人员例行体检结果出来后，办公室年轻的小王看着手中的化验单发愁起来。

他的血脂化验单如下：血清甘油三脂：2.20mmol/L（参考值：0.56-1.70mmol/L）血清总胆固醇：4.55mmol/L（参考值：3.10-5.70mmol/L）高密度脂蛋白：0.93mmol/L（参考值：0.91-2.28mmol/L）低密度脂蛋白：1.97mmol/L（参考值：1.90-3.60mmol/L）小王还不到30岁，身体又不是很胖，血清甘油三脂怎么就高了呢？经向医师咨询后他才明白：造成高脂血症的祸首主要是不良的饮食习惯。

他总认为痛快地吃，痛快地喝，生活才带劲，平时喜欢吃菜油泡饭，吃夜宵喝啤酒……针对小王的血脂化验单，医师建议小王要控制饮食，改掉不良的生活习惯，并加强身体锻炼，即可将血脂水平调整过来。

解析（解放军169医院陆国忠）：虽然高脂血症这个词大家都非常熟悉，但日常生活中很多人并未真正认真对待它。

究其原因，是对高脂血症不全了解，对血脂指标也不甚了解。

血脂指标的解读（1）血脂指标血脂为血液中脂肪类物质的总称。

对乙酰氨基酚片【药品名称】通用名称：对乙酰氨基酚片英文名称：Paracetamol Tablets【成份】本品每片含主要成份对乙酰氨基酚0.3克。

辅科为淀粉、胶化淀粉、聚乙烯吡咯烷酮、硬脂酸、滑石粉、山梨酸钾、羟丙基甲基纤维素、三乙酸甘油酯。

【适应症】用于普通感冒或流行性感冒引起的发热，也用于缓解轻至中度疼痛如头痛、关节痛、偏头痛、牙痛、肌肉痛、神经痛、痛经。

【用法用量】口服。

4-6岁儿童，一次0.5片；7-12岁儿童，一次1片，12岁以上儿童及成人一次1-2片，若持续发热或疼痛，可间隔4-6小时重复用药一次，24小时内不得超过4次。

【不良反应】偶见皮疹、荨麻疹、药热及粒细胞减少。

长期大量用药会导致肝肾功能异常。

【禁忌】严重肝肾功能不全者禁用。

【注意事项】1.本品为对症治疗药，用于解热连续使用不超过3天，用于止痛不超过5天，症状未缓解请咨询医师或药师。

2.对阿司匹林过敏者慎用。

3.不能同时服用其他含有解热镇痛药的药品(如某些复方抗感冒药)。

4.肝肾功能不全者慎用。

5.孕妇及哺乳期妇女慎用。

6.服用本品期间不得饮酒或含有酒精的饮料。

7.对本品过敏者禁用，过敏体质者慎用。

8.本品性状发生改变时禁止使用。

9.请将本品放在儿童不能接触的地方。

10.儿童必须在成人监护下使用。

11.如正在使用其他药品，使用本品前请咨询医师或药师。

【特殊人群用药】儿童注意事项：3岁以下儿童因其肝、肾功能发育不全，应避免使用。

妊娠与哺乳期注意事项：本品可透过胎盘和在乳汁中分泌，故孕妇及哺乳期妇女不推荐使用。

老人注意事项：老年患者由于肝、肾功能发生减退，本品半衰期有所延长，易发生不良反应，应慎用或适当减量使用。

【药物相互作用】1. 应用巴比妥类(如苯巴比妥)或解痉药(如颠茄)的患者，长期应用本品可致肝损害。

2. 本品与氯霉素同服，可增强后者的毒性。

3. 如与其他药物同时使用可能会发生药物相互作用，详情请咨询医师或药师。

4. 长期规律的每日服用对乙酰氨基酚可增强华法林和其他香豆素类的抗凝作用，因而可增加出血风险；偶尔服用无显著影响。