Thrombin抑制剂_激动剂_MCE
- 格式：pdf
- 大小：239.00 KB
- 文档页数：2
www.MedChemExpress.cn
1Thrombin Thrombin is a serine protease that in humans is encoded by the F2gene. Thrombin is an intriguing coagulation protease demonstratingan array of effects on endothelial cells, vascular smooth muscle cells(VSMC), monocytes, and platelets, all of which are involved in thepathophysiology of atherosclerosis. There is mounting evidence thatthrombin acts as a powerful modulator of many processes likeregulation of vascular tone, permeability, migration and proliferationof VSMC, recruitment of monocytes into the atherosclerotic lesions,induction of diverse pro-inflammatory markers, and all of these arerelated to the progression of cardiovascular disease. Recent studies intransgenic mice models indicate that the deletion of the naturalthrombin inhibitor heparin cofactor II promotes an accelerated atherogenic state. The combined evidence points tothrombin as a pivotal contributor to vascular pathophysiology. Considering the clinical development of selectiveanticoagulants including direct thrombin inhibitors.Purity:>98%Clinical Data:Size:10mM x 1mL in DMSO,
2 mg, 5 mg, 10 mg, 50 mg, 100 mgPurity:98.65%Clinical Data:Phase 4Size:10mM x 1mL in DMSO,2 mg, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg,1 gPurity:99.85%Clinical Data:Phase 4Size:10mM x 1mL in DMSO,
2 mg, 5 mg, 10 mg, 50 mg, 100 mgPurity:>98%Clinical Data:Size:1 mg, 5 mgPurity:98.90%Clinical Data:Phase 4Size:
2 mg, 5 mg, 10 mg, 50 mg, 100 mgPurity::>98.00%Clinical Data:Phase 4Size:10mM x 1mL in DMSO,100 mg, 500 mgPurity:>98%Clinical Data:Size:10mM x 1mL in DMSO,
10 mg, 50 mg, 100 mgPurity:>98%Clinical Data:Size:10 mg, 50 mg, 100 mgPurity:>98%Clinical Data:Size:10mM x 1mL in DMSO,100 mg, 200 mgThrombin Inhibitors & ModulatorsBioactivity:AEBSF is a water soluble, irreversible serine protease inhibitor;inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin,and trypsin.Bioactivity:Argatroban is a direct, selective thrombin inhibitor.
Bioactivity:Argatroban monohydrate is a direct, selective thrombin inhibitor.Bioactivity:Bivalirudin Trifluoroacetate is a synthetic 20 residue peptide whichreversibly inhibits thrombin.Bioactivity:Dabigatran(BIB-953; BIBR 953ZW) is a reversible and selective, directthrombin inhibitor (DTI) with Ki value of 4.5 nM.Bioactivity:Dabigatran D4 hydrochloride is deuterium labeled Dabigatran, whichis a reversible and selective, direct thrombin inhibitor (DTI) with Kivalue of 4.5 nM.Bioactivity:Dabigatran etexilate(BIBR-1048) is the orally active prodrug ofdabigatran; Dabigatran is a reversible and selective, direct thrombininhibitor (DTI) with Ki value of 4.5 nM.Bioactivity:Dabigatran etexilate mesylate (BIBR 1048MS) is the orally activeprodrug of dabigatran. Dabigatran is a reversible and selective, directthrombin inhibitor (DTI) with Ki value of 4.5 nM.Bioactivity:ethyl ester of Dabigatran, which is an emerging oral anticoagulantwhich is a direct inhibitor of thrombin activity.2Tel: 4008203792Fax: 021-53700325Email: sales@MedChemExpress.cnAEBSF(Pefabloc SC)Cat. No.: HY-12821Argatroban(Argipidine; Acova)Cat. No.: HY-B0375Argatroban monohydrate(Argipidine monohydrate; Acova monohydrate)Cat. No.: HY-B0375ABivalirudin Trifluoroacetate(Bivalirudin)Cat. No.: HY-15664Dabigatran(BIBR 953; BIBR 953ZW; BIBR953; BIB-953)Cat. No.: HY-10163Dabigatran D4 hydrochloride (Pradaxa D4 hydrochloride; BIBR-953 D4 hydrochloride)Cat. No.: HY-10163ASDabigatran etexilate(Prazaxa; BIBR 1048; BIBR-1048)Cat. No.: HY-10274Dabigatran etexilate mesylate (Pradaxa; BIBR 1048MS; Dabigatran etexilate methanesulfonate)Cat. No.: HY-10274ADabigatran ethyl esterCat. No.: HY-17378
