起搏介导的心室非同步 电-机械的非同步
左右心室不同步 左室间隔与游离壁不同步 左室游离壁不同部位的不同步
兰州大学第一医院
室间隔起搏的益处
• 获得尽可能的生理性室内传导,减少室间和 室内的电机械不同步
• His或His旁的起搏可以获得最为理想的心室 电传导, 由于操作上的困难和离房室瓣环较 近,易发生心房的远场感知
为什么出现了意外结果? DDD的优势为什么消失? 是VVI与DDD同样好? 还是DDD与VVI同样差?
兰州大学第一医院
进一步的研究发现……
• Danish I and Danish II Trials • DAVID Trial • MOST Sub-study
兰州大学第一医院
Danish I1 and Danish II2 研究结果
当DDD伴有较高比例的心室起搏时, 右室心尖部起搏造成的危害抵消了房室同步所带来的益处
DAVID
MOST Sub-Study
一个相同结论: 不必要的RV尖部起搏,是非常重要的HF和AF预测因子
Danish I
Danish II
兰州大学第一医院
Figure 9-1. Conduction of the impulse in the heart. The impulse originates in the sinus node (1), continues in the atrial wall (2), and is delayed in the atrioventricular (AV) node (3). Conduction within the ventricles is initially rapid within the rapid conduction system: His bundle (4), right and left bundle branches (5), and Purkinje fibers (6). The impulse is transferred from the rapid conduction system to the working myocardium in the Purkinje–myocardial junctions (7), which are located in the endocardium. Within the slowly conducting working myocardium, the impulse is conducted from endocardium to epicardium.