银屑病与亚甲基四氢叶酸还原酶基因多态位点A677V关系的研究

中国人亚甲基四氢叶酸还原酶基因C677T多态性与脑梗死关系的Meta分析张涌;闫玲;张学君;易继湖【期刊名称】《中国慢性病预防与控制》【年(卷),期】2005(13)4【摘要】目的探讨我国人群亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与脑梗死的相关性。

方法通过文献检索收集脑梗死组和非脑梗死组的病例鄄对照研究,剔除不符合要求的文献,在全面文献回顾的基础上对各研究OR值进行Meta分析。

结果共有8篇符合条件的文献纳入分析,Meta分析结果表明,以CC基因型为参照,携带TT、TC基因型个体发生脑梗死的OR值分别为2.58和1.72,而携带至少一个突变基因型的个体发生脑梗死的OR值为1.98。

结论MTHFR基因C677T多态性与我国人群脑梗死易感性有关,纯合突变基因型是脑梗死的重要危险因素。

【总页数】3页(P155-157)【关键词】亚甲基四氢叶酸还原酶;脑梗死;多态性;Meta分析【作者】张涌;闫玲;张学君;易继湖【作者单位】济南市中心医院神经科;山东省职业卫生与职业病防治研究院【正文语种】中文【中图分类】R541.3【相关文献】1.中国人群母亲亚甲基四氢叶酸还原酶C677T多态性与后代DS关系的Meta分析 [J], 张福全;赵霞;刘一2.亚甲基四氢叶酸还原酶基因C677T多态性与中国人群糖尿病肾病相关性的Meta分析 [J], 孙亮;王松岚;史晓红;杨泽3.中国人群亚甲基四氢叶酸还原酶C677T多态性与急性淋巴细胞白血病关系的Meta分析 [J], 刘恩溢;黄琳;赵立波;刘一;杨巍;李玉珍4.中国人群5,10-亚甲基四氢叶酸还原酶基因C677T多态性与非综合征性唇腭裂关系的Meta分析 [J], 朱博;王达;杨博逸;刘宇岩;李永芳;孙贵范5.亚甲基四氢叶酸还原酶C677T基因位点多态性与股骨头坏死关系的Meta分析[J], 范思奇;曾平;赖崇荣;刘雄;;;;因版权原因，仅展示原文概要，查看原文内容请购买。

银屑病亚甲基四氢叶酸还原酶基因多态性与甲氨蝶呤疗效及不良反应的关系皮肖冰;王晓霞;王继辉;赖春颜【期刊名称】《皮肤性病诊疗学杂志》【年(卷),期】2014(21)3【摘要】To investigate the single nucleotide polymorphism of 5,10 methylenetet-rahydrofolate reductase ( MTHFR) gene in psoriatic patients, and its association with the efficacy and adverse effect of the long term therapy of low-dose methotrexate ( MTX) .Methods:MTHFR gene was performed by the polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP) in 120 patients and 100 heaIthy controIs.The clinical and laboratory data of 120 psoriatic patients were evaluated before treatment and at 1, 2, 4, 12 weeks after therapy.Efficacy and adverse effects of medication were analyzed.Results:There was no significant difference in the frenquency of MTHFR 677 CC, CT, TT between the psoriaticpatients(54.17%,32.50%、13.33%) and the healthy controls(43.00%, 45.00%, 12.00%) (χ² =3.70,P>0.05).The therapeutic effect of MTX in 105 patients were evaluated, there was no significant difference a-mong different gene type grou ps(χ²=1.45,P>0.05).There were 42 cases (42/120, 35.00%) presented with MTX related adverse effects.A significant difference in the frequency of 677 CC, CT, TT was found between the group with adverse effects and the group without adverse effects(χ²=17.26,P<0.05) , with ahigher percentage of CT and TT gene type in the adverse effects group than that in the group without adverse effects(χ²=17.05,P<0.05).Also, there was a signifi-cant difference between the group with adverse reaction of hepatic toxicity and the group without adverse effects(χ²=10.02,P<0.05), with a higher frequency of T mutant gene in the hepatic toxicity groupthan that in the group without hepatictoxicity(χ²=7.52,P<0.05).Conclusion:There was no relationship between the pathogenesis of psoriasis and the efficacy of MTX with the mutation of MTHFR gene 677C/T.However, MTHFR gene C677T mutation was probably one of genetic risk factors for the adverse effects of MTX such as hepatic toxicity.T mutant gene was the risk factor of the adverse effects of MTX.%目的：探讨银屑病患者亚甲基四氢叶酸还原酶（ MTHFR）基因C677C/T多态性及其与长期小剂量甲氨蝶呤（MTX）方案治疗的疗效和不良反应的相关性。

MTHFR基因多态性与银屑病的遗传易感性吴杰;栗玉珍;马虹宇;白静;陈峰;傅松滨【期刊名称】《国际遗传学杂志》【年(卷),期】2007(030)003【摘要】目的探讨亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase),MTHFR基因单核苷酸多态与中国北方地区银屑病的关系.方法针对123例寻常型银屑病患者和129名正常对照个体,分别用PCR-RFLP和AS-PCR的方法,分析C677T、G1793A和A1298C 3个多态位点基因型,并进行统计分析.结果在病例组中,MTHFR 677 C、T等位基因频率分别为45.13%、54.87%,1298A、C等位基因频率为88.37%、11.63%,1793G、A等位基因频率为95.12%、4.88%.在正常对照组中,677 C、T等位基因频率分别为44.96%、54.87%,1298A、C等位基因频率为86.44%、13.56%,1793G、A等位基因频率为96.12%、3.88%.经统计学分析,MTHFR C677T、A1298C、G1793A各多态位点基因型、等位基因频率在病例组和对照组中的分布差异无统计学性意义,C677T与A1298C基因型联合分析也未发现有统计学意义.结论 MTHFR基因的3个多态位点(C677T、A1298C、G1793A)与寻常型银屑病的易感性无明显的相关关系.【总页数】5页(P173-177)【作者】吴杰;栗玉珍;马虹宇;白静;陈峰;傅松滨【作者单位】150081,哈尔滨医科大学医学遗传学研究室;150081,哈尔滨医科大学附属第二医院皮肤科;150001,哈尔滨,黑龙江省医院检验科;150081,哈尔滨,黑龙江省普通高校医学遗传学重点实验室;150081,哈尔滨医科大学医学遗传学研究室;150081,哈尔滨医科大学医学遗传学研究室;150081,哈尔滨,黑龙江省生物医药工程重点实验室【正文语种】中文【中图分类】R75【相关文献】1.MTHFR基因和β纤维蛋白原455G/A基因多态性与脑梗死的遗传易感性 [J], 高海凤;李永秋;黎洁;马洪颖2.MTHFR C677T基因多态性与孤独症谱系障碍遗传易感性的Meta分析 [J], 李志君;孙擎;张晶;李环3.MTHFR C677T基因多态性与孤独症谱系障碍遗传易感性的Meta分析 [J], 李志君;孙擎;张晶;李环;;;;4.MTHFR基因多态性与妊高征的遗传易感性研究 [J], 王海燕;李才明;王筑;杨峰5.MTHFR基因多态性与非综合征性唇腭裂的遗传易感性 [J], 赵如冰;刀京晶;朱文丽;闫丽盈;李书琴;苏力;李勇因版权原因，仅展示原文概要，查看原文内容请购买。

新型亚甲基四氢叶酸还原酶单核苷酸多态性研究方法检测恶性血液病易感性【摘要】本研究探讨一种新型亚甲基四氢叶酸还原酶单核苷酸多态性(SNP)检测方法，并用其检测恶性血液病遗传易感性。

根据cDNA芯片原理制作一种目的基因芯片，利用双色荧光探针杂交进行SNP位点检测，测序法对该芯片检测结果的准确性进行验证,并以此对来自中国江苏地区的157例健康对照和127例恶性血液病患者(30例多发性骨髓瘤，28例非霍奇金淋巴瘤，22例急性淋巴细胞白血病，40例急性髓系白血病，7例慢性髓系白血病)的MTHFR基因C677T多态位点进行检测。

结果表明，为野生型、杂合型和突变型的叠加荧光分别显示为绿色、黄色和红色。

测序结果与芯片结果吻合。

677C和677T在病例和对照组的基因频率分别为%、%、%和%，差异有显着性。

677TT 基因型发生MM相对风险明显增加。

结论：本芯片检测方法准确、高通量且价格低廉，适用于大规模样本SNP调查；C677T多态改变影响恶性血液病的发病风险。

677TT基因型是MM的易感因素。

【关键词】单核苷酸多态性；基因芯片；双色荧光杂交；亚甲基四氢叶酸还原酶；恶性血液病A New Method for5,10-Methylenetetrahydrofolate Reductase Single Nucleotide Polymorphisms Genotyping Used to Study Susceptibility of Hematological MalignancyAbstractThe aim of this study was to set up a new method for 5,10- Methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphisms (SNP) genotyping, and to investigate the hereditary susceptibility of hematological malignancy. Prepared an aimed gene microarray based on cDNA microarray theory, dual- colorfluorescenece hybri- dization was used to detect SNP loci, and DNA sequencing was performed to confirm the results. The MTHFR C677T SNP loci of 157 controls and 127 patients with hematological malignancies (30 multiple myeloma, 28 non- Hodgkin′s lymphoma, 22 acute lymphoblastic leukemia, 40 acute myeloid leukemia, 7 chronic myeloid leukemia) from Jiangsu province were detected. The results showed that after overlapping, homozygous wild type, heterozygote type and homozygous mutant type yielded green, yellow and red fluorescence, respectively. DNA sequencing validated these results. The allele frequency of 677C and 677T in patients and controls were % and %, % and % respectively, showing statistically significant difference (χ2=, P=).677TT genotype showed a significantly higher risk of MM (OR=; 95%CI=; P=). Itis concluded that this microarray- based method is accurate, high- throughput and inexpensive, suitable for SNP genotyping in a large numbeer of individuals. C677T polymorphisms influence the risk of hematological malignancies. 677TT genotype is susceptive to MM.Key words single nucleotide polymorphism; gene microarray; dual- color fluorescenece hybridization;5,10- methylenetetrahydrofolate reductase; hematological malignancy 染色体DNA序列的某个位点上存在的单个碱基变化如果在人群中的发生频率超过1%，即为单核苷酸多态性。

亚甲基四氢叶酸还原酶基因多态性在妇产科领域的研究进展张亚丽，靳双玲△，张春燕，王国平【摘要】亚甲基四氢叶酸还原酶（MTHFR ）是参与机体叶酸代谢和DNA 甲基化的限速酶，参与体内多种生理生化反应。

MTHFR 基因突变有多种类型，C677T 位点突变是研究最多、最常见的突变类型。

该基因突变导致酶活性降低，进而影响叶酸代谢、DNA 合成及甲基化过程，最终增加该基因相关疾病的易感性。

由于MTHFR C677T 基因多态性存在地域和种族差异，导致同一疾病在不同地区和种族中出现不同的研究结果。

近年来随着基因多态性与相关疾病关注度增加，研究发现MTHFR C677T 基因多态性可致高同型半胱氨酸血症，使胚胎发育障碍并损伤血管内皮细胞，导致复发性流产及妊娠期高血压疾病，而妇科肿瘤的发生可能主要与DNA 甲基化受阻相关。

现就MTHFR C677T 基因多态性在妇产科领域的研究进展进行综述。

【关键词】亚甲基四氢叶酸还原酶（NADPH ）；多态现象，遗传；叶酸；妊娠并发症；生殖器肿瘤，女（雌）性Advances in Study of Methylenetetrahydrofolate Reductase Gene Polymorphisms in Obstetrics and Gynecology Field ZHANG Ya-li ，JIN Shuang-ling ，ZHANG Chun-yan ，WANG Guo-ping.Graduate College of Changzhi Medical College ，Changzhi 046000，Shanxi Province ，China （ZHANG Ya -li ，WANG Guo -ping ）；Department of Gynecology ，Heping Hospital Affiliated to Changzhi Medical College ，Changzhi 046000，Shanxi Province ，China （JIN Shuang-ling ，ZHANG Chun-yan ）Corresponding author ：JIN Shuang-ling ，E-mail ：************************【Abstract 】Methylenetetrahydrofolate reductase (MTHFR)is a rate limiting enzyme involved in folate metabolism and DNA methylation,which participates in a variety of physiological and biochemical reactions.There are many types of MTHFR gene mutation,but C677T is the most studied and common type of mutation.The gene mutation can decrease enzymatic activity,thereby affecting processes of folate metabolism,DNA synthesis and methylation,which increases susceptibilities to the gene-related disease utimately.Due to the regional and ethnic differences in MTHFR C677T gene polymorphism,the same disease has different results in different regions and races.In recently years,more and more attention has been paid to gene polymorphisms and related diseases.Researches revealed that polymorphisms of MTHFR C677T gene can lead to hyperhomocysteinemia,resulting in embryonic development disorder and damage to vascular endothelium ，which leads to recurrent abortion and hypertensive disorders of pregnancy,while the occurrence of gynecologic tumor may be mainly related to DNA methylation obstruction.This article presents an overview on advances in studies of MTHFR C677T gene polymorphisms in obstetrics and gynecology field.【Keywords 】Methylenetetrahydrofolate reductase (NADPH2);Polymorphism,genetic;Folic acid;Pregnancy complications;Genital neoplasms,female（J Int Obstet Gynecol ，2020,47：394-398）基金项目：吴阶平医学基金会项目[320.6750.18558（5）]作者单位：046000山西省长治市，长治医学院研究生院（张亚丽，王国平）；长治医学院附属和平医院妇科（靳双玲，张春燕）通信作者：靳双玲，E-mai ｌ：ｊ***********************△审校者·综述·叶酸也称维生素B9，属于水溶性维生素，是参与机体DNA 合成、蛋白质代谢、胚胎发育等生理生化过程不可或缺的物质。

5,10-亚甲基四氢叶酸还原酶基因多态性及补充叶酸与非综合征性唇腭裂的相关性唐银科;张业龙;简玉洛;闫喜英;翟晓梅【期刊名称】《中国组织工程研究》【年(卷),期】2011(015)015【摘要】背景:对于5,10-亚甲基四氢叶酸还原酶(5,10-methylene tetrahydrofolate reductase,MTHFR)基因C677T位点多态性与唇腭裂相关性的研究国内外结果不一,未见结合干预因素叶酸影响的相关报道.目的:探讨河南地区汉族人群MTHFR基因C677T位点多态性及补充叶酸与非综合征性唇腭裂的发病关系.方法:选取2008-09/2010-03在郑州大学第一附属医院及郑州市第一人民医院整形外科就诊的非综合征性唇腭裂患者110例,采用PCR-RFLP法检测外周血中MTHFR基因C677T位点基因型并与40例健康对照比较频数差异.同时结合母孕期是否补充叶酸进行统计学分析.结果与结论:病例组和对照组C677T基因型及等位基因频率比较差异均具有显著性意义(P < 0.01),且有家族史的患者TT基因型及T 等位基因频率高于无家族史患者(P < 0.05).对母孕期是否补充叶酸进行比较,发现非综合征性唇腭裂与叶酸摄入呈负相关(χ2=4.304,r=-0.169,P < 0.05).结果提示MTHFR基因C677T位点突变与河南汉族人群非综合征性唇腭裂的发生相关,母孕期补充叶酸能降低非综合征性唇腭裂的发病风险.%BACKGROUND: Results of correlation between 5, 10-methylenetetrahydrofolate reductase (MTHFR) C677T loci gene polymorphism and cleft are differ from China and aboard, and the influence of combined intervention factors folic acid has not reported.OBJECTIVE: To investigate the correlation between MTHFR C677Tloci gene polymorphism, folic acid supplementation and non-syndrome cleft lip and palate (NSCL/P) of Han population in HenanProvince.METHODS: Totally 110 cases with NSCL/P visited Department of Plastic Surgery, First Affiliated Hospital of Zhengzhou University or Department of Plastic Surgery, Zhengzhou First People's Hospital from September 2008 to March 2010 were selected. MTHFR C677T loci genes were detected by PCR-RFLP method, the frequency differences were compared with 40healthy controls. Simultaneously, the statistical analysis was performed combined with whether folic acid was supplemented at female pregnancy.RESULTS AND CONCLUSION: There were significance between the case group and control group in C677T genotype and gene frequency (P ＜ 0.01); in addition, TT genotype and gene frequency of cases with a family history was greater than that without a family history (P ＜ 0.05); comparing those with or without folic acid supplementation during pregnancy, there was a negative correlation between NSCL/P and folic acid supplementation (X2=4.304, y=0.169, P ＜ 0.05). The results suggest that MTHFR C677T mutation is associated with NSCL/P incidence in Henan Han population, and female pregnancy folic acid supplements can reduce the risk of NSCL/P.【总页数】4页(P2829-2832)【作者】唐银科;张业龙;简玉洛;闫喜英;翟晓梅【作者单位】郑州大学第一附属医院整形外科,河南省郑州市,450052;郑州市第一人民医院整形外科,河南省郑州市,450004;郑州市第一人民医院整形外科,河南省郑州市,450004;郑州市第一人民医院整形外科,河南省郑州市,450004;郑州大学第一附属医院整形外科,河南省郑州市,450052【正文语种】中文【中图分类】R318【相关文献】1.5,10-亚甲基四氢叶酸还原酶C677T基因多态性与不明原因复发性流产相关性的Meta分析 [J], 张丹;王韦韦;张宏秀2.5,10-亚甲基四氢叶酸还原酶C677T基因多态性与老年单纯收缩期高血压的相关性研究 [J], 张莹莹;梁蓉;麻仕利;郭绪昆3.5,10-亚甲基四氢叶酸还原酶基因多态性与同型半胱氨酸相关性研究 [J], 逯晓辉; 张彤; 王前明4.中国女性人群5,10-亚甲基四氢叶酸还原酶C677T基因多态性与原因不明复发性流产相关性的Meta分析 [J], 王根柱;王小营;寻志坤;孙强;邢百倩;李忠东5.中国女性人群5,10-亚甲基四氢叶酸还原酶C677T基因多态性与原因不明复发性流产相关性的Meta分析 [J], 王根柱;王小营;寻志坤;孙强;邢百倩;李忠东因版权原因，仅展示原文概要，查看原文内容请购买。

亚甲基四氢叶酸还原酶C677T基因多态性与2型糖尿病关系的病例对照研究商广芸;王宏宇;刘金波;袁平;周迎燕;李丽红【摘要】目的探讨亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与2型糖尿病(T2DM)的关系.方法选取226例T2DM患者(病例组)和194例健康对照个体(对照组),检测两组同型半胱氨酸水平,采用PCR-芯片杂交技术检测亚甲基四氢叶酸还原酶C677T多态位点基因型,计算等位基因频率并统计分析.结果 2组MTHFR 基因C677T位点基因型和等位基因频率比较,差异均无统计学意义(P＞0.05),MTHFR基因TT型同型半胱氨酸水平显著高于CC型及CT型.结论 MTHFR 基因C677T多态性影响同型半胱氨酸水平,但与T2DM的发病无明显的相关性.%Objective To examine the relationship between methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and type 2 diabetes mellitus(T2DM).Methods MTHFR gene C677T polymorphic sites were assayed in 226 T2DM and 194 healthy subjects by PCR-DNA microarray.Homosysteine levels were measured.And their genotype and allele frequency were statistically analyzed.Results There was no statistical significance in allele frequency and genotype of MTHFR gene C677T between the patients and healthy subjects(P ＞ 0.05).The homosysteine levels were obviously higher in TT genotype.Conclusion MTHFR gene C677T polymorphism is not a risk factor for patients with type 2 diabetes,but can effect homosysteine levels.【期刊名称】《医学研究杂志》【年(卷),期】2017(046)009【总页数】4页(P72-75)【关键词】2型糖尿病;亚甲基四氢叶酸还原酶;基因多态性【作者】商广芸;王宏宇;刘金波;袁平;周迎燕;李丽红【作者单位】100144 北京大学首钢医院血管医学科;100144 北京大学首钢医院血管医学科;100144 北京大学首钢医院血管医学科;100144 北京大学首钢医院血管医学科;100144 北京大学首钢医院血管医学科;100144 北京大学首钢医院血管医学科【正文语种】中文【中图分类】R446.1糖尿病是一种最常见的内分泌代谢疾病，其病因及发病机制十分复杂，涉及遗传、代谢、生活习惯、环境等多种因素。

中国5个民族亚甲基四氢叶酸还原酶基因多态性的研究于佳梅;王新春;陈白滨;张贵寅;李璞;孙艳阳;薛雅丽;杨焕杰【期刊名称】《人类学学报》【年(卷),期】1998(17)3【摘要】本文利用聚合酶链反应－限制性片段长度多态性（ＰＣＲ－ＲＦＬＰ）方法，检测了７９名汉族、３０名鄂伦春族、３１名鄂温克族、３１名达斡尔族、２９名壮族随机选择正常个体亚甲基四氢叶酸还原酶基因６７７位核苷酸多态性并加以比较。

结果表明，该位点多态频率具有种族差异，国内外１１个人群中，中国达斡尔族与汉族突变型等位基因Ｖ频率最高，分居第一位和第二位，提示亚洲人该频率偏高。

【总页数】5页(P242-246)【关键词】中国;PCR-RFLP;等位基因频率;MTHFR基因;多态性【作者】于佳梅;王新春;陈白滨;张贵寅;李璞;孙艳阳;薛雅丽;杨焕杰【作者单位】哈尔滨医科大学医学遗传学研究室【正文语种】中文【中图分类】Q982【相关文献】1.金港镇汉族女性亚甲基四氢叶酸还原酶与甲硫氨酸合成酶还原酶基因多态性研究[J], 黄巧红;鲁衍强;马少杰;薛琰;杨琦2.烟台市牟平区汉族女性亚甲基四氢叶酸还原酶和甲硫氨酸合成酶还原酶基因多态性分布研究 [J], 矫富燕;鲁衍强;李瑛;孙翠玉;于海萍;张巍伟;杨伟伟;孔飞飞;杨琦3.山东省莱芜市汉族女性5，10-亚甲基四氢叶酸还原酶与甲硫氨酸合成酶还原酶基因多态性研究 [J], 姜玉婵;鲁衍强;李瑛;刘晓玲;杨琦4.亚甲基四氢叶酸还原酶基因及甲硫氨酸合成酶基因多态性与口服叶酸治疗高同型半胱氨酸血症疗效的关系研究 [J], 田丹丹;张程达;王连珂;葛梦颍;侯全亮;吴越;李媛媛;张卫东5.湖北省利川市育龄妇女亚甲基四氢叶酸还原酶和甲硫氨酸合成酶还原酶基因多态性分布研究 [J], 许敏; 江鸿; 牟丹; 牟耀华; 蓝巧; 何铃钰; 覃露; 刘欣雨因版权原因，仅展示原文概要，查看原文内容请购买。

N5,10-亚甲基四氢叶酸还原酶基因多态性与脑血管病的关系研究邓美英;薛明战;张辉;乔晋;屈秋民;武成斌;李学成;鲁君亚;邓晓钟;高卫【期刊名称】《中国神经免疫学和神经病学杂志》【年(卷),期】2003(010)003【摘要】目的探讨N5,10-亚甲基四氢叶酸还原酶(MTHFR) 677C→T位点突变与晚发型脑血管病的关系. 方法采用多聚酶链反应-限制性内切酶片段长度多态性(PCR-RFLP)方法测定107例脑血管病患者及78例健康对照组MTHFR基因多态性. 结果 (1)两组MTHFR基因型频率分布差异有显著性(P＜0.01).患者组纯合子(T/T)突变频率(22.4%)较对照组(19.0%)升高,但统计学差异无显著性(P=0.057).杂合子(T/C)频率(61.7%)较对照组(41.8%)明显升高,差异有显著性(P＜0.01).脑血管病患者发生T等位基因型频率也较对照组显著升高,差异有显著性(P＜0.01).(2) MTHFR677C→T突变基因型的患者或T等位基因型患者患病的危险性较对照组显著增加,杂合子患病的危险性更大. 结论MTHFR677C→T位点突变增加脑血管病的危险性,可能是脑血管病的易感基因.【总页数】4页(P204-207)【作者】邓美英;薛明战;张辉;乔晋;屈秋民;武成斌;李学成;鲁君亚;邓晓钟;高卫【作者单位】西安交通大学第一医院,神经内科,陕西,西安,710061;西安交通大学第一医院,遗传研究室,陕西,西安,710061;西安交通大学第一医院,神经内科,陕西,西安,710061;西安交通大学第一医院,神经内科,陕西,西安,710061;西安交通大学第一医院,神经内科,陕西,西安,710061;西安交通大学第一医院,神经内科,陕西,西安,710061;西安交通大学第一医院,遗传研究室,陕西,西安,710061;航天714医院,陕西,西安,710100;航天714医院,陕西,西安,710100;航天714医院,陕西,西安,710100【正文语种】中文【中图分类】R743.3【相关文献】1.N5,10-亚甲基四氢叶酸还原酶基因多态性与宁夏地区汉族原发性高血压的关联性 [J], 刘海燕;马萍;徐清斌2.同型半胱氨酸代谢酶胱硫醚β-合成酶和N5,10-亚甲基四氢叶酸还原酶基因多态性与慢性肺源性心脏病的关系 [J], 杨芳;马五林;杨娜;运莉娜;王川川;赵双凤;李霞3.N5,10-亚甲基四氢叶酸还原酶基因多态与妊娠高血压综合征相关性的Meta分析 [J], 周波;时玥;时景璞4.N5,10-亚甲基四氢叶酸还原酶基因多态性与蒙古族原发性高血压病的关系 [J], 呼日勒;牛广明;赵世刚;张春雨;胡日乐;王智光;江名方5.N5,10-亚甲基四氢叶酸还原酶基因多态性与蒙古族原发性高血压及高血压合并脑血管病的关系 [J],因版权原因，仅展示原文概要，查看原文内容请购买。