DOI：10.16662/ki.1674-0742.2023.21.108不同年龄期传染性单核细胞增多症的临床资料分析吴炽勇，简方华，吴浩峰福建医科大学附属龙岩第一医院儿内科，福建龙岩364000［摘要］目的分析EB病毒（epstein-barr virus，EBV）相关儿童传染性单核细胞增多症（infectious mononucleo⁃sis，IM）的不同年龄期临床特征及实验室检查。
方法回顾性收集2020年1月—2021年12月在福建医科大学附属龙岩第一医院住院诊断为IM的78例患儿的临床资料，对比不同年龄段临床特征及实验室检查结果。
结果各年龄段患儿发热、咽扁桃体炎、颈部淋巴结肿大、肝肿大、脾肿大、皮疹、发热持续时间比较，差异无统计学意义（P>0.05）。
各年龄段眼睑浮肿比例分别为100.0%、22.2%、50.0%、11.1%，差异有统计学意义（χ2= 11.526，P<0.05）。
各年龄段外周血白细胞相比，差异有统计学意义（P<0.05），其他实验室检测指标比较，差异无统计学意义（P>0.05）。
符合实验室确诊IM依据的抗体谱1有58例（74.4%），且各年龄段血清抗EBV抗体谱类型比较，差异无统计学意义（P>0.05）。
结论儿童不同年龄期IM主要临床特征有少许差别，多数有发热、颈部淋巴结肿大、咽扁桃体炎，需结合相关实验室检查尤其血清EBV-DNA载量检测，并进行综合分析，及时诊断。
［关键词］EB病毒；传染性单核细胞增多症；儿童；临床特征；实验室检查结果［中图分类号］R725.1 ［文献标识码］A ［文章编号］1674-0742（2023）07(c)-0108-04Clinical Data Analysis of Infectious Mononucleosis at Different AgesWU Chiyong, JIAN Fanghua, WU HaofengDepartment of Pediatrics Medicine, Longyan First Hospital Affiliated to Fujian Medical University, Longyan, Fujian Province, 364000 China[Abstract] Objective To analyze the clinical features and laboratory tests of Epstein-Barr virus (EBV) associated in⁃fectious mononucleosis (IM) in children at different ages. Methods Clinical data of 78 children diagnosed with IM hospitalized in Longyan First Hospital Affiliated to Fujian Medical University from January 2020 to December 2021 were retrospectively collected, and clinical characteristics and laboratory test results of different ages were compared.Results There was no statistically significant difference in the duration of fever, pharyngeal tonsillitis, cervical lymph node enlargement, hepatomegaly, splenomegaly, rash and fever among children of different ages (P>0.05). The propor⁃tion of eyelid edema in each age group was 100.0%, 22.2%, 50.0% and 11.1%, respectively, and the difference was statistically significant (χ2=11.526, P<0.05). There were statistically significant differences in peripheral blood white blood cells among all age groups (P<0.05), but no statistically significant differences in other laboratory test indicators (P>0.05). There were 58 cases (74.4%) in accordance with the antibody spectrum based on laboratory diagnosis of IM, and there was no statistical significance in serum anti-EBV antibody spectrum types among different age groups (P> 0.05). Conclusion The main clinical features of IM in children of different ages are slightly different, most of them have fever, neck lymph node enlargement, and pharyngeal tonsillitis. Relevant laboratory tests, especially serum EBV-DNA load detection, should be combined with comprehensive analysis for timely diagnosis.[Key words] EB virus; Infectious mononucleosis; Children; Clinical features; Laboratory test results[作者简介] 吴炽勇（1976-），男，本科，副主任医师，研究方向为儿童重症及儿科常见疾病。
