专业课试卷 汉译英[1]

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汉译英:
目的 探讨术中保温对肺癌根治术患者中性粒细胞(PMNs)呼吸爆发的影
响。方法 32例全麻下行肺癌根治术患者,ASAⅡ或Ⅲ级,随机分为2组
(n=16):对照组(c组)和保温组(w组)。c组术中仅以毛毯等常规保温措
施保温;W组还使用加温毯和输液加温器保温,以维持术中核心体温不
低于基础值。静脉注射芬太尼、咪达唑仑、异丙酚和罗库溴铵行麻醉诱
导后气管插管,术中吸入异氟醚和氧化亚氮维持麻醉。于术前(基础值)、
术中(关胸前冲洗胸腔后即刻)和术毕(缝皮结束)采集外周静脉血,测定
血常规、PMNs活化率及其活性氧(ROS)产量。结果 与术前相比,2组术
中和术毕时WBC计数及PMNs百分比均升高(P<0.05),2组间WBC计数和
PMNs百分比差异无统计学意义。在刺激状态下(加入佛波酯):与术前相
比,2组术中、术毕时PMNs活化率均升高,w组术毕时ROS产量升高
(P<0.05),w组术毕时ROS产量高于c组(P<0.05);在静态下(加入磷酸
盐缓冲液):与术前相比,c组术中PMNs活化率和术中、术毕时ROS产量
均降低(P<0.05),w组术中PMNs活化率、术中及术毕ROS产量均高于c组
(P<0.05)。结论 肺癌根治术中保温可保持静态下活化PMNs的数量和ROS
产量,并增强刺激状态下PMNs的ROS产量,但对活化的PMNs数量无影响。
Objective To investigate the influence of intraoperative
thermostasis over respiratory burst of polymorphonuclear
neutrophils (PMNs) in patients undergoing radical operation for
lung cancer.Methods Thirty-two ASA Ⅱ or Ⅲ patients scheduled
for radical operation for lung cancer performed under general
anesthesia were randomized into 2 groups (n=16 each):control
group (C) and warming group (W).The patients were kept warm by
force-air warming system and fluid warming device as soon as the
patients were admitted to the operation room in group W .Rectal
and axillary temperature were continuously monitored as core and
surface temperature.Core temperature was maintained at
preoperative level (baseline).Anesthesia was induced with
midazolam, fentanyl and propofol.Tracheal intubation was
facilitated with rocuronium.Anesthesia was maintained with
isoflurane and nitroas oxide and intermittent i.v.boluses of
fentanyl,midazolam and vecuronium.Venous blood samples were
obtained before,during and at the end of surgery for normal blood
analysis and respiratory burst of PMNs which included activated
PMNs count and reactive oxygen species (ROS) production.Results
(1) WBC and PMN counts were significantly increased during and
after operation as compared with the baseline values before
operation in both groups and there was no significant difference
in WBC and PMN counts between the two groups.(2) PMA stimulation
resulted in higher intraoperative and postoperative activated PMN
count in both groups and higher postoperative ROS production in
group W. Postoperative ROS production was significantly higher
in group W than in group C.(3) Without stimulation activated PMN
count during operation and intra- and post-operative ROS
production were significantly decreased as compared with the
baseline values before operation in group C, while in group W there
was no significant difference in pre-, intra- and post-operative
activated PMN counts and ROS production.The intraoperative PMN
counts and intra- and post-operative ROS production were
significantly higher in group W than in group C.Conclusion
Intraoperative thermostasis can effectively maintain activated
PMN count and ROS production without stimulation and enhance ROS
production with stimulation in patients undergoing radical
operation for lung cancer.