非小细胞肺癌三维适形放疗分割方式研究

作者简介：陈金梅（1983－），女，硕士，医师，主要从事肿瘤放射治疗工作。

E-mail ：cjm82@21cn．com 通讯作者：张纬建（1955－），男，主任医师，主要从事肿瘤放射治疗工作。

E-mail ：zwj9090@126．com 三维适形放疗与调强放疗在不同肺叶非小细胞肺癌中的剂量学研究陈金梅1，张纬建1，林育毅2，洪金省1，郭飞宝1（1．福建医科大学附属第一医院放疗科，福建福州350004；2．厦门市第二医院放疗科，福建厦门361021）摘要：目的比较不同肺叶非小细胞肺癌（NSCLC ）的调强放疗（IMRT ）和三维适形放疗（3DCRT ）的剂量学特点。

方法以肿瘤位于上叶（上叶组）及下叶（下叶组）的各10例接受根治性放疗的NSCLC 患者为研究对象，分别制定5野IMRT 计划及3 5野3DCRT 计划，应用剂量体积直方图评估两组治疗计划，分别比较上叶组、下叶组IMRT 与3DCRT 计划之间的剂量学参数。

结果1）上叶组、下叶组的IMRT 计划的以下指标优于相应的3DCRT 计划，差异均有统计学意义（P ＜0．05）：PTV 参数、适形指数、异质性指数、平均肺剂量及肺V10 V65、食管Dmean 及V55、心脏V40、食管的早晚期正常组织并发症发生率；2）IMRT 计划比3DCRT 计划平均降低了上叶组约2．7%的肺V5值及下叶组约1．1%的V5值，但差异无统计学意义（P ＞0．05）；3）与3DCRT 计划比较，上叶组、下叶组的IMRT 计划的食管V35、心脏Dmean 均较低，在上叶组的差异有统计学意义（P ＜0．05），在下叶组的差异无统计学意义（P ＞0．05）。

结论在NSCLC 的根治性放疗中，5野IMRT 较3DCRT 更能提高靶区的剂量分布均匀性，在保护正常组织器官方面也显示出较明显的优势；且IMRT 应用于上叶NSCLC 的优势有可能大于下叶者。

关键词：非小细胞肺癌；剂量学；调强放疗；三维适形放疗中图分类号：R734．2；R730．55文献标识码：A文章编号：1673－5412（2011）06－0499－04A Dosimetric Study of Three Dimensional Conformal Radiotherapy and Intensity ModulatedRadiotherapy for Different Pulmonary Lobes of Non-Small Cell Lung CancerChen Jinmei 1，Zhang Weijian 1，Lin Yuyi 2，Hong Jinsheng 1，Guo Feibao 1（1．Department of Radiotherapy ，the First Affiliated Hospital of Fujian Medical University ，Fuzhou 350004，China ；2．Department of Radiotherapy ，the Second Hospital of Xiamen ，Xiamen 361021，China ）Abstract ：ObjectiveTo compare the dosimetry characteristics of intensity modulated radiation therapy （IMRT ）and three dimensional con-formal radiotherapy （3DCRT ）with different pulmonary lobes of non-small cell lung cancer （NSCLC ）．Methods The study was performed tocompare IMRT and 3DCRT of 10patients with NSCLC in the upper lobes （the upper lobe group ）and 10patients with NSCLC in the lower lobes （the lower lobe group ）．All the patients would receive radical radiotherapy．In the IMRT plans ，five coplanar beams were designed．Three to five coplanar beams were designed for 3DCRT plans．The two series of plans were evaluated by the dose volume histogram．The differ-ences of dosimetry parameter were analyzed too．Results 1）The indices of IMRT plans were superior to the 3DCRT plans of NSCLC in the upper lobe group or the lower lobe group ，the difference was statistically significant （P ＜0．05），including the indices of PTV ，conformity in-dex ，heterogeneity index ，mean lung dose ，V10-V65of lung parenchyma ，V55and mean dose of esophagus ，V40of heart ，acute and late normal tissue complication probability of esophagus ；2）compared with the 3DCRT plans ，the average V5of lung was degraded about 2．7%in the up-per lobe group ，and 1．1%in the lower lobe group ，but the difference was not statistically significant （P ＞0．05）；3）compared with the 3DCRT plans ，the IMRT plans of NSCLC in the upper lobe group ，the difference of V35of esophagus and mean dose of heart were statistically significant （P ＜0．05），but of NSCLC in the lower lobe group ，the difference was not statistically significant （P ＞0．05）．Conclusion Forthe patients with NSCLC who received radical radiotherapy ，the five beam IMRT plans can have better dose uniformity and protect the normalorgan better than the 3DCRT plans．The application of IMRT for NSCLC located in the upper lobes may be superior to the lower lobes．Key words ：non-small cell lung cancer ；dosimetry ；intensity-modulated radiotherapy ；three-dimensional conformal radiotherapy随着三维适形放疗（three dimensional conformalradiotherapy ，3DCRT ）与调强放疗（intensity modulated radiotherapy ，IMRT ）在非小细胞肺癌（non-small celllung cancer ，NSCLC ）治疗中的应用日渐广泛，两种技术在NSCLC 治疗中应用的剂量学特点成为了研究的热点。