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Jpn K okai Tokk yo K oho,JP09255561(1997)
(1998-07-20收稿)
口服结肠定位给药系统
周 宇综述 蒋雪涛*审校
(解放军第82医院 淮阴 223001)
摘要 本文综述了口服结肠定位给药系统的制备方法和辅料,包括时间依赖性结肠释药系统;可被结肠酶或细菌降解的结肠释药系统;pH依赖性结肠释药系统;压力控制结肠释药系统。并对其优缺点作了评价。
关键词 结肠定位释药;时间依赖;生物降解;p H依赖;压力控制
随着生物工程技术的发展,蛋白质类和肽类药物增多。这些药物在胃和小肠部位易被消化酶和胃肠道pH等因素破坏,因而稳定性差,吸收利用度亦差。结肠没有消化酶(蛋白酶),是蛋白质和肽类药物比较好的吸收部位,同时结肠输送缓慢,缺少运动刺激性,这就造成了一个有利于稳定和增强吸收的局部环境。如果口服这类药物后,使其在结肠部位释放,就可避免被
*第二军医大学药学院 上海 200433
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国外医学药学分册 1999年8月 第26卷第4期DOI:10.13220/ k i.ji p r.1999.04.010
