- 73 -①北京核工业医院 北京 102413丁苯酞联合养血清脑颗粒治疗脑小血管病伴认知功能障碍的临床效果周扬①【摘要】 目的：分析丁苯酞联合养血清脑颗粒治疗脑小血管病伴认知功能下降患者的效果、安全性及对血管内皮功能的影响。
方法：选取2019年1月-2020年1月于本院就诊的脑小血管病伴认知功能下降患者90例，将其随机分为对照组（常规治疗）、研究1组（常规治疗+丁苯酞）、研究2组（常规治疗+丁苯酞+养血清脑颗粒），各30例。
比较三组治疗效果、安全性、治疗前后血管内皮功能指标。
结果：治疗后，各组MoCA 各项评分均较治疗前升高，研究1、2组除命名外其他各项评分均明显高于对照组，研究2组除命名外其他各项评分均明显高于研究1组（P <0.05）。
三组治疗期间不良反应发生率比较差异无统计学意义（χ2=0.900，P =0.638）。
治疗后，各组细胞间黏附分子-1（ICAM-1）、内皮素-1（ET-1）水平均较治疗前降低，研究1、2组ICAM-1、ET-1水平均明显低于对照组，研究2组ICAM-1、ET-1水平均明显低于研究1组（P <0.05）。
结论：丁苯酞联合养血清脑颗粒治疗脑小血管病伴认知功能下降患者的效果及安全性较好，可有效改善血管内皮功能及认知功能，具有一定的应用价值。
【关键词】 丁苯酞 养血清脑颗粒 脑小血管病 认知功能下降 安全性 血管内皮功能 doi：10.14033/ki.cfmr.2021.14.024文献标识码 B文章编号 1674-6805（2021）14-0073-04 Clinical Effect of Butylphthalide Combined with Yangxue Qingnao Granule in the Treatment of Cerebral Small Vessel Disease with Cognitive Dysfunction/ZHOU Yang. //Chinese and Foreign Medical Research, 2021, 19(14): 73-76 [Abstract] Objective: To analyze the effect and safety of Butylphthalide combined with Yangxue Qingnao Granule in the treatment of cerebral small vessel disease with cognitive dysfunction and its influence on vascular endothelial function. Method: From January 2019 to January 2020, 90 patients with cerebral small vessel disease with cognitive dysfunction were selected and randomly divided into the control group (routine treatment), the study 1 group (routine treatment+Butylphthalide) and the study 2 group (routine treatment+Butylphthalide+Yangxue Qingnao Granule), 30 cases in each group. The therapeutic effect, safety and vascular endothelial function indexes before and after treatment were compared among the three groups. Result: After treatment, the scores of MoCA in each group were higher than those before treatment, and the scores of other items except for naming in the study 1, 2 group were significantly higher than those in the control group, the scores of other items except for naming in the study 2 group were significantly higher than those in the study 1 group (P <0.05). There was no statistical significance in the incidence of adverse reactions among the three groups during treatment (χ2=0.900, P =0.638). After treatment, the levels of intercellular adhesion molecule-1 (ICAM-1) and endothelin-1 (ET-1) in all groups were lower than those before treatment, the levels of ICAM-1 and ET-1 in the study 1, 2 group were significantly lower than those in the control group, and the levels of ICAM-1 and ET-1 in the study 2 group were significantly lower than those in the study 1 group (P <0.05). Conclusion: Butylphthalide combined with Yangxue Qingnao Granule has good effect and safety in the treatment of cerebral small vessel disease with cognitive dysfunction, which can effectively improve vascular endothelial function and cognitive function, and has certain application value. [Key words] Butylphthalide Yangxue Qingnao Granule Cerebral small vessel disease Cognitive function decline Safety Vascular endothelial function First-author ’s address: Beijing Nuclear Industry Hospital, Beijing 102413, China 脑小血管病是一种临床常见的脑血管系统疾病，随着我国老龄化进程的加快，脑小血管病伴随的认知功能下降作为血管性认知功能的重要亚型疾病的发病率也随之逐年升高，但随着影像学科技的发展与进步，临床对于脑小血管病的预防、诊治的认知也进一步提高[1-2]。
