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• 1型糖尿病1,284 (4.5%), • 2型糖尿病8,560(30.0%), • 非糖尿病患者 18,704 例 (65.5%) • 2型糖尿病ESRD的发生率,随着年龄的增
加而显著增加(每年增加10.2% , P<0.0001).
EMMANUEL VILLAR, MD, PHD et al:
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非糖尿病肾病 (non-diabetic renal disease,NDRD)
• 回顾性研究:8%-81% • 小样本前瞻性研究:20%-30%
1.Eberhard R, Stephan RO. Nephropathy in patients with type 2 diabetes mellitus. NEJM, 1999, 341(15): 1127-y. Saudi J Kidney Dis Transplant, 2006, 17(4): 481490.
糖尿病肾病
北京协和医院 肾内科李学旺 2014年11月
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美国2型糖尿病患者中合并CKD的比 例可达40% ,中国64%
数据来自1999-2004年第4次美国国家 健康与营养调查
研究对象:年龄≥20岁的2型糖尿病患 者,n=1462
研究对象:上海市区年龄≥30岁的2型糖 尿病患者,n=1009
Kid Dis, 2007, 49(2 suppl 2): S1-S182
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不典型糖尿病肾损害
意大利的Fioretto等提出
• 肾小球轻微病变基础上,又包含以下任意 一项:
①严重的肾小管间质病变 ②严重的与大血管动脉粥样硬化相关的肾小动 脉玻璃样变 ③系膜区无或仅轻度增宽,但肾小球球性硬化 比例超过25%
( 最
World…
In cid en
5
对糖尿病和非糖尿病所致 ESRD发病率和患病率增长的预测
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USRDS: 2003 ADR. AJKD 42 (Suppl 5):S55, 2003
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Incidences, Treatments, Outcomes, and Sex Effect on Survival in Patients With End-Stage Renal Disease by Diabetes Status in Australia and New Zealand (1991–2005)
Koro CE, et al. Clin Ther;2009. 31:2608-2617
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Lu B, et al. J Diabetes & its Complications. 2008. 96-103
4
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资糖 料尿 )病
肾
病 在 终 末
期 肾 衰 竭
中 的 比 例
1.Fioretto P, Mauer M, et al. Patterns of renal injury in NIDDM patients with
microalbuminuria. Diabetologia, 1996, 39: 1569-1576. 2.徐鹏杰,李航,温昱冰,李学旺 中华肾脏病杂志, 2008
. (D) By electron microscopy, there is a paramesangial electron dense deposit typical of IgA nephropathy associated with mesangial sclerosis and mild uniform glomerular basement membrane thickening owing to underlying diabetic nephropathy. Original magnification, 3400 in A–C; 310,000 in D.
Sharma SG. Etal: Clin J Am Soc Nephrol 8: 1718–1724, October, 2013
Diabetic nephropathy with superimposed IgA nephropathy
(A) A glomerulus with moderate nodular mesangial sclerosis and glomerular basement membrane thickening exhibits mild segmental mesangial hypercellularity (staining with periodic acid–Schiff).
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Renal Biopsy Findings in Diabetes
• The Largest Single-Center Study of Renal Biopsy in Patients With Diabetes
• 620 patients who underwent kidney biopsy —227(37%)DN alone —226(36%)NDRD alone —164(27%)DN +NDRD
• 糖尿病肾小球病
Diabetic glomerulopathy,DG
National Kidney Foundation. KDOQI Clinical Practice Guigelines and Clinical
Practice Recommendations for Diabetes and Chronic Kidney Disease. Am J
DIABETES CARE, VOLUME 30, NUMBER 12, DECEMBER 2007
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关于糖尿病肾脏疾病
• 传统概念:糖尿病肾病
Diabetic nephropathy,DN
• 2007年K/DOQI指南的新概念:
• 糖尿病肾脏疾病
Diabetic kidney disease,DKD
(B) A representative glomerulus shows mesangial expansion by increased mesangial cell number and matrix (staining with hematoxylin and eosin)
(C) Immunofluorescencsta ining for IgA shows global mesangial immune deposits within the expanded mesangiume