胡必杰、何礼贤、张杏怡等 中华医院感染学杂志 中华医院感染学杂志.2001;11(13):177-180 胡必杰、何礼贤、张杏怡等.中华医院感染学杂志
Adapted with permission from: Gaynes R, et al. Clin Infect Dis. 2005;41:848-54
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Independent study of 8,244 P aeruginosa ICU isolates collected from 1994 to 2000 reported the following average susceptibilities2:
– Mortality/morbidity – Length of ICU and hospital stay – Healthcare costs
• No new antibiotic classes under development2
– Highlights the need to optimize existing classes of antimicrobials
– – – – – tobramycin, 87% imipenem, 83% amikacin, 90% piperacillin-tazobactam, 78% cefepime, 71%
1. Gaynes R, et al. Clin Infect Dis. 2005;41:848-854. 2. Neuhauser M, et al. JAMA. 2003;289:885-888.
• Resistance to antimicrobial agents is increasing among many gram-negative pathogens1 • Infection with resistant pathogens is associated with negative health outcomes3,4