围绝经期抑郁症与孤啡肽及单胺类递质的相关性研究

针灸对围绝经期抑郁症单胺类神经递质影响的关联性研究作者：陈倩倩来源：《医学信息》2018年第12期摘要：单胺类神经递质属于中枢神经递质，是一类生物学活性比较广泛的物质，单胺类神经递质含量的平衡失调与围绝经期抑郁症的发病密切相关。

中医针灸治疗围绝经期抑郁症已取得很好的疗效，同时对单胺类神经递质具有调节作用，本文通过研究针灸、围绝经期抑郁症以及单胺类神经递质三者之间的关联性，进一步明确中医针灸治疗围绝经期抑郁症可能的机制之一，为临床治疗提供理论依据。

关键词：针灸；围绝经期抑郁症；单胺类神经递质中图分类号：R749.4 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.12.017文章编号：1006-1959（2018）12-0054-03Abstract：Monoamine neurotransmitter is a central neurotransmitter.It is a kind of widely biological substance.The imbalance of the content of monoamine neurotransmitter is closely related to the incidence of perimenopausal depressive disorder.In the treatment of perimenopausal depressive disorder，traditional Chinese medicine has achieved good curative effect and has a regulating effect on monoamine neurotransmitter.In this paper，the relationship between three cases of acupuncture，perimenopausal depressive disorder and monoamine neurotransmitter is studied，and one of the possible mechanisms of the treatment of perimenopausal depressive disorder in traditional Chinese medicine is further clarified.It provides a theoretical basis for clinical treatment.Key words：Acupuncture and moxibustion；Perimenopausal depressive disorder；Monoamine neurotransmitter围绝经期抑郁症（perimenopausal depressive disorder）主要为中老年女性多发，通常发生于绝经前后。

抑郁症患者接受治疗前后血浆单胺类神经递质代谢产物的差异肖红;姚辉;侯刚;李箕君;郭苏皖【期刊名称】《中国组织工程研究》【年(卷),期】2005(009)016【摘要】BACKGROUND: Monoamine hypothesis has been demonstrated by researches. However, the correlation between the metabolite of plasma monoamine neurotransmitter and anti-depression treatment in patients with depression has less been reported.OBJECTIVE: To study the effect of different drugs on metabolite of plaama monoamine neurotransmitter, and the correlation between the metabolite of plasma monoamine neurotransmitter and anti-depression treatment in patients with depression.DESIGN: Case controlled study.SETTING: Neurological Department and Brain Institute of Nanjing MedicalUniversity.PARTICIPANTS: Forty patients with depression hospitalized in Nanjing Brain Hospital (depression group) were diagnosed with the second revised edition of China classification of mental diseases(CCMD-2) and the tenth edition of International classification of diseases. And the total score of Hanmilton rating scale for depression(HAMD) was more than 17. Healthy voluntary blood donators in the control group were from Nanjing Municipal Central Blood Station( n = 20).INTERVENTIONS: Antidepressant was used in the depression for 4 weeks: fluoxetine 20 mg per day; 5-serotonin selective reuptake inhibitor (SSRI) paroxetine 20 mgper day; venlafaxime 50- 100 mg per day;5-serotonin and morepinephrine selective reuptake inhibitor(SNRI) fluvoxamine 50-100 mg per day. High performance liquid chromatograpy(HPLC)was used to measure the level of metabolite of plasma monoamine neurotransmitter in patients with depression before and 42 week after treatment, and the HAMD was used to evaluate clinical effect of the patients.MAIN OUTCOME MEASURES: The levels of metabolites of plasma monoamine neurotransmitters in patients with depression: 5-hydroxyindoleace tic acid(5-HIAA), 3-methoxy-4-hydroxyphenylglycol(MHPG) and homovani llic acid(HVA) were measured before and 4th week after treatment.RESULTS: The levels of 5-HIAA, MHPG and HVA of the metabolites of plasma monoamine neurotransmitters in patients with depression before treatment [ (20.3±14.6), (124.8±103.6), (54.7±32.1) μg/L] were all lower than those in the normal controlgroup[ (39.5±28.4), (334.5 ±107.3), (88.5±37.2) μg/L], with statistically significant differences (P＜0.05). After SSRI treatment, the 5-HIAA content[ (37.1±21.9)μg/L]was significantly increased as compared with that before treatment, whose difference indicated significant meaning ( P＜0.05), but the differences in MHPG and HVA had no significant meaning as compared with those before treatment(P＞0.05) . After SNRI treatment, 5-HIAA and MHPG contents [(35.4±25.2 ), (291.2±120.4) μg/L] both were significantly increased, which indicated significant difference as compared with those before treatment( P＜0.05); but HVA level had no significant changes.CONCLUSION:'The peripheral neurotransmitter metabolites in plasma can reflect their states in brain. The change of neurotransmittermetabolite in plasma can be regarded as an important reference index for the evaluation of depression.%,背景:抑郁症的单胺假说已得到很多研究证明,但是郁症患者血浆中单胺递质代谢产物与抗抑郁治疗的相关性研究较少报道.目的:探讨不同药物治疗抑郁症患者血浆中单胺递质代谢产物的差异,以及抗抑郁治疗与抑郁患者血浆中单胺递质代谢产物水平的相关性.设计:病例对照研究.单位:南京医科大学脑科研究所和精神科.对象:抑郁症组(n=40)为南京脑科医院住院抑郁症患者,汉密顿抑郁量表总分＞17.对照组(n=20)为南京市中心血站健康志愿献血者.干预:抑郁症组均用抗抑郁药治疗4周:氟西汀[20 mg/d,5-羟色胺重摄取抑制剂类];帕罗西汀(20 mg/d,5-羟色胺重摄取抑制剂类);万拉法新[20～100 mg/d,5-羟色胺、去甲肾上腺素双重摄取抑制剂类],氟伏沙明(50～100 mg/d,去甲肾上腺素双重摄取抑制剂类).用高效液相色谱法对抑郁症患者治疗前后血浆中单胺递质代谢产物水平进行测定,用汉密顿抑郁量表评定抑郁症患者的临床疗效.主要观察指标:抑郁症患者血浆中单胺递质代谢产物5-羟吲哚乙酸、3-甲基-4-羟基苯乙二醇、高香草酸的水平.结果:抑郁症患者治疗前血浆中5-羟吲哚乙酸、3-甲基-4-羟基苯乙二醇、高香草酸的水平[(20.3±14.6),(124.8±103.6),(54.7±32.1)μg/L]均低于正常对照组[(39.5±28.4),(334.5±107.3),(88.5±37.2)μg/L],差异有显著性(P＜0.05).经5-羟色胺重摄取抑制剂治疗的抑郁症患者,5-羟吲哚乙酸含量[(37.1±21.9)μg/L]与治疗前比较明显升高,差异有显著性(P＜0.05);3-甲基-4-羟基苯乙二醇和高香草酸与治疗前比较,差异无显著性(P＞0.05);经去甲肾上腺素双重摄取抑制剂治疗后,血浆中5-羟吲哚乙酸,3-甲基-4-羟基苯乙二醇含量[(35.4±25.2),(291.2±120.4)μg/L]均比治疗前升高,差异有显著性(P＜0.05);高香草酸水平无明显变化.结论:外周的单胺递质代谢产物可反映脑中单胺类神经递质的状态,血浆中单胺类递质的变化可作为抑郁症疗效评定的一个重要参考指标.【总页数】2页(P246-247)【作者】肖红;姚辉;侯刚;李箕君;郭苏皖【作者单位】南京医科大学脑科医院,研究所,江苏省南京市,210029;南京医科大学脑科医院,精神科,江苏省南京市,210029;南京医科大学脑科医院,精神科,江苏省南京市,210029;南京医科大学脑科医院,精神科,江苏省南京市,210029;南京医科大学脑科医院,精神科,江苏省南京市,210029【正文语种】中文【中图分类】R749.72【相关文献】1.抑郁症患者血浆白细胞介素与单胺代谢产物的研究 [J], 姚辉;肖红;张晓斌;侯钢2.抑郁症与血浆中单胺类神经递质代谢产物 [J], 肖红;姚辉;侯刚;李其军;郭苏皖;吴如金3.抑郁症患者抗抑郁治疗前后细胞免疫及单胺类神经递质代谢产物的变化特征 [J], 姚辉;陶领纲;张晓斌;沙维伟;侯钢;张志珺4.抑郁症和焦虑症患者血浆单胺类神经递质浓度对照研究 [J], 袁勇贵;张心保;张石宁5.应用抑郁症状快速评定量表评估抑郁症患者急性期治疗后残留症状的性别差异[J], 赵娜;王晓红;师晶晶;丰雷;朱雪泉;王刚;胡建因版权原因，仅展示原文概要，查看原文内容请购买。

分子生物学指标一、单胺递质及受体5—羟色胺(5—HT)：纹状体、额叶、海马区、杏仁核、中隔核5—羟色胺受体：与正常人相比,抑郁症患者脑中5-HT2A受体数下降。

突触后5—HT1D 受体敏感性明显下降，血小板5—HT受体密度和活动度升高。

①5 —HT1A受体和5—HT2A 受体功能不平衡导致抑郁。

②突触前5—HT自身受体功能亢进导致抑郁。

（血小板5 - H T ：通过检测血小板5 - HT来反映脑5 - H T有一定的理论依据：血小板和5 - HT神经细胞在发生来源、生化特征和5 - H T转运体等方面都有许多相同特性；血小板以与神经元突触相似的方式摄取和储存5 - HT 。

故血小板能用来作为中枢神经元终末5-H T代谢研究的模型物。

）去甲肾上腺素(NE)：抑郁症患者中枢神经系统中NE含量下降,则发生抑郁症。

情感性障碍患者、内因性抑郁症患者血浆中NE水平较高,并有溢流(Spillover)现象、交感神经兴奋性增高。

NE受体：抑郁症患者发病机制之一是突触后β受体超敏,反馈使突触前α2受体超敏,导致抑制NE的生成和释放、突触间隙NE数量下降。

多巴胺(DA)及受体:代谢产物：DOPAC、高香草酸(HA V)抑郁症发病与DA关联的两种学说,①认为抑郁症患者存在中脑边缘系统DA功能失调,②认为抑郁症患者可能存在多巴胺D1受体功能低下。

二、谷氨酸和γ-氨基丁酸抑郁症患者枕叶皮质GABA浓度与正常人相比明显偏低,而谷氨酸浓度均值则明显偏高。

GABA水平与同一脑区内的谷氨酸水平成反比。

Glu/GABA。

情感障碍患者谷氨酸系统异常, 额叶皮质N-甲基-D-天门冬氨酸( N M DA ) 受体下调, 局部脑区谷氨酸转化率有改变。

.应激可使海马兴奋性毒性氨基酸谷氨酸(Glu)含量增加，造成细胞外Glu堆积。

Glu与细胞突触后膜N-甲基-D-天(门) 冬氨酸(NMDA)受体结合，促进Ca2+内流，使细胞内Ca2+增加，Ca2+与CaM偶联并结合于胞浆中相应的位点上激活NOS，催化NO的生成。

抑郁发作患者与正常人血浆孤啡肽含量的对照研究王丽娜1，刘兰芬2，张敬悬2，赵贵芳2(1.山东大学医学院，山东济南250012；2.山东省精神卫生中心，山东济南250014)【摘要】目的：探讨抑郁发作患者血浆孤啡肽（OFQ ）水平的变化，为抑郁发作的起病、诊断、治疗等寻找新的生物学指标。

方法：筛选45例抑郁发作患者和31例正常人，应用放射免疫（RIA ）法分别测定其血浆OFQ 浓度，比较抑郁组与对照组血浆OFQ 水平，抑郁组OFQ 含量与各量表总分的相关性，分析相关的影响因素。

结果：①抑郁组血浆OFQ 水平显著高于对照组(t =4.65，P ＜0.01)。

②抑郁组OFQ 含量与HAMD 、MADRS 、HAMA 总分均呈显著正相关。

③血浆OFQ 含量的影响因素主要有家人的关心、睡眠状况、家庭和睦、自杀观念或未遂史和总病程。

结论：血浆OFQ 水平的变化可能与抑郁发作的发病机制相关并反映疾病的严重程度。

【关键词】抑郁发作；孤啡肽中图分类号:R395.2文献标识码:A文章编号:1005-3611(2009)01-0048-03A Control Study of Orphanin FQ in Patients with Depression and Health AdultsWANG Li-na ，LIU Lan-fen ，ZHANG Jing-xuan ，et al Medical College of Shandong University ，Jinan 250012，China【Abstract 】Objective ：To investigate the changes of plasma orphanin FQ (OFQ)level in patients with bipolar andunipolar depression.Methods ：45patients with depression and 31health adults were studied.The concentrations of plasma OFQ were measured by radioimmunoassay (RIA).Results ：①Compared with the healthy controls,the level of plasma OFQ was significantly higher in patients with depression (t =4.65，P ＜0.01).②The plasma OFQ level was positively correlated to HAMD,MADRS and HAMA.③Many factors affected the level of plasma OFQ,including insomnia,family relationship,history of suicide,etc.Conclusion ：The changes of plasma OFQ level may play a role in the pathogenesis of depression and reflect the severity of disease.【Key words 】Depression ；Orphanin FQ【基金项目】山东省卫生厅科研基金资助项目（2005HW115）通讯作者：刘兰芬孤啡肽(orphanin FQ ，OFQ)又称痛敏素(nociceptin)，是1995年发现的内源性类阿片活性肽[1，2]。

坤宁安对围绝经期抑郁模型大鼠单胺类递质的影响【摘要】目的：观察坤宁安对围绝经期抑郁模型大鼠单胺类神经递质的影响。

方法：鼠龄为12-14个月的雌性SD大鼠，采用孤养结合慢性轻度不可预见性应激造模法，以氟西汀、倍美力作对照药物，观测大鼠海马5-HT、NE含量。

结果：抑郁模型组大鼠海马5-HT、NE含量下降，坤宁安可提高抑郁模型大鼠海马的5-HT、NE的含量。

结论：坤宁安能够提高抑郁模型大鼠5-HT、NE的含量，可能是其治疗围绝经期抑郁症的机理之一。

【关键词】坤宁安；5-HT；NE围绝经期是女性抑郁症高发时期，不仅给患者本人带来痛苦，而且给其亲人、家属和社会带来无尽的困扰和沉重的负担。

本研究通过观察坤宁安对围绝经期抑郁模型大鼠单胺类神经递质的影响，探讨坤宁安抗抑郁的作用机制，以指导临床应用。

现将结果具体报道如下：1材料与方法1.1实验材料1.1.1实验动物：鼠龄为12-14个月的雌性SD大鼠，体重为280-350g，购自黑龙江中医药大学实验动物中心，室温18-22℃，除特别说明外，大鼠均自由饮水和摄食，自然光照，通风良好。

1.1.2实验药品、试剂与仪器：坤宁安汤剂（柴胡、桂枝、白芍、党参、牡蛎、当归、甘草等药物组成）：由黑龙江中医药大学附属二院饮片药局提供。

倍美力片:惠氏制药有限公司分装。

规格:0.625mg/片。

百忧解胶囊:.礼来苏州制药有限公司分装。

规格:20mg/粒。

5-HT、NE酶免试剂盒：美国R& D公司。

多功能酶标仪：Tecan GENios。

1.2实验方法1.2.1 造模：每天进行大鼠阴道脱落细胞检查[1]，选择无规则动情周期的大鼠作为实验动物。

将70只围绝经期大鼠随机分为7组：正常围绝经期对照组（对照组）、抑郁模型组（模型组）、倍美力治疗组（倍美力组）、氟西汀治疗组（氟西汀组）、中药低剂量治疗组（中药低剂量组）、中药中剂量治疗组（中药中剂量组）、中药高剂量治疗组（中药高剂量组）。

CJCM 中医临床研究 2020年第12卷第12期 中华医学·气证•神经精神 -35-滋水清肝饮对围绝经期抑郁症患者的临床疗效及对血清孤啡肽和5-羟色胺的影响Clinical effect of Zishui Qinggan Decoction on patients with perimenopause depression and its effect on serum orphan enkephalin and5-hydroxytryptamine韩艳平（承德市双滦区人民医院/承德市精神病院，河北承德，067001）中图分类号：R71文献标识码：A文章编号：1674-7860（2020）12-0035-证型：GA【摘要】目的：探讨滋水清肝饮对围绝经期抑郁症患者的临床疗效及对血清孤啡肽和5-羟色胺的影响。

方法：将2017年10月－2018年10月在承德市双滦区人民医院妇科治疗的86例围绝经期抑郁症患者随机分为两组，对照组采用黛力新治疗，观察组使用滋水清肝饮治疗，比较两组患者的临床疗效、血清孤啡肽和5-羟色胺变化、汉密顿抑郁量表（Hamilton Depression Scale，HAMD）评分变化。

结果：观察组治疗总有效率为95.35%（41/43），明显高于对照组的79.07%（34/43）（P＜0.05）；观察组治疗后1个月、2个月、3个月的血清孤啡肽明显高于对照组，而5-羟色胺明显低于对照组（P＜0.05）；观察组治疗1个月、2个月、3个月的HAMD评分明显低于对照组（P＜0.05）。

结论：滋水清肝饮对围绝经期抑郁症患者的临床疗效显著，能有效缓解抑郁症状，能有效改善脑部神经递质水平，提高5-羟色胺含量，具有积极的临床意义。

【关键词】围绝经期抑郁症；滋水清肝饮；临床疗效；血清孤啡肽；5-羟色胺【Abstract】Objective: To investigate the clinical effect of Zishui Qinggan Decoction (滋水清肝饮) on patients with perimenopause depression and its effect on serum orphan enkephalin and 5-hydroxytryptamine. Methods: 86 patients with perimenopause depression who were treated in our hospital from October 2017 to October 2018 were randomly divided into two groups. The control group was treated with dilixin, and the observation group was treated with Zishui Qinggan Decoction. The clinical efficacy, changes in serum orphan enkephalin and 5-hydroxyserotonin, and changes in HAMD score were compared between the two groups. Results: The effective rate of treatment in the observation group was 95.35%(41/43), which was significantly higher than that in the control group 79.07%(34/43) (P<0.05). The serum levels of the treatment group were significantly higher than those of the control group 1, 2 and 3 months after treatment, while the levels of 5-ht of the observation group were significantly lower than those of the control group (P<0.05). HAMD scores of the observation group 1, 2 and 3 months after treatment were significantly lower than those of the control group (P<0.05). Conclusion: Zishui Qinggan Decoction has a significant clinical effect on patients with depression in perimenopian period, which can effectively relieve depressive symptoms, improve the level of neurotransmitter in brain and increase the content of 5-hydroxytryptamine, and it has positive clinical significance.【Keywords】 Perimenopausal depression; Zishui Qinggan Decoction; Clinical efficacy; Serum orphan enkephalin; 5-HTdoi:10.3969/j.issn.1674-7860.2020.12.015围绝经期抑郁症属于围绝经期综合征的一种类型，表现为焦虑、抑郁、烦躁、内心不安、感情冷淡、记忆力减退、行动迟缓等一系列情感障碍症状，严重者甚至出现自残及自杀倾向，严重危害患者的健康。

围绝经期综合征患者焦虑抑郁症状与脑源性神经营养因子的关系朱红卫【期刊名称】《临床心身疾病杂志》【年(卷),期】2016(022)003【摘要】目的:探讨围绝经期综合征患者焦虑抑郁症状与脑源性神经营养因子的关系.方法:将30例围绝经期综合征伴焦虑抑郁症状患者设为实验组,抽取同期进行健康体检的围绝经期妇女30名设为对照组,实验组应用抗抑郁剂联合激素替代治疗,观察2周.于实验组治疗前后采用焦虑自评量表、抑郁自评量表总定焦虑抑郁状况,同时检测血清脑源性神经营养因子水平的变化.结果:治疗前实验组焦虑自评量表、抑郁自评量表总分均显著高于对照组(P＜0.01),血清脑源性神经营养因子水平显著低于对照组(P＜0.01);治疗后实验组焦虑自评量表、抑郁自评量表总分较治疗前显著下降(P＜0.01),但仍显著高于对照组(P＜0.01);血清脑源性神经营养因子水平较治疗前显著升高(P＜0.01),但仍显著低于对照组(P＜0.05).结论:围绝经期综合征患者焦虑抑郁症状与血清脑源性神经营养因子水平呈正相关,对患者应用抗抑郁剂联合激素替代治疗可有效缓解症状,改善焦虑抑郁情绪.【总页数】3页(P11-13)【作者】朱红卫【作者单位】476000河南·商丘商丘市妇幼保健院【正文语种】中文【中图分类】R588;R749.4;R749.92【相关文献】1.围绝经期综合征焦虑抑郁症状与脑源性神经营养因子的关系 [J], 单菲;槐中美;杨和增;谢国华2.穴位电刺激联合耳穴贴压对围绝经期综合征患者焦虑抑郁症状、生活质量及神经递质的影响 [J], 闫学花; 陈建军; 闫利荣; 杨泉林; 刘向娇; 苏心镜3.脑源性神经营养因子、肿瘤坏死因子-α和白细胞介素-6与慢性阻塞性肺疾病患者急性加重后抑郁及预后的关系 [J], 袁晓梅; 高新愿; 杨小花4.血清脑源性神经营养因子及C反应蛋白水平与精神分裂症患者认知功能的关系[J], 朱军;肖文焕;曹月梅5.血清脑源性神经营养因子水平与左心室射血分数降低的心力衰竭患者预后的关系研究 [J], 程小兵;罗娟娟;陈燕;潘文博;钟万生;韩卫星因版权原因，仅展示原文概要，查看原文内容请购买。

抑郁症患者抗抑郁治疗前后细胞免疫及单胺类神经递质代谢产物的变化特征姚辉;陶领纲;张晓斌;沙维伟;侯钢;张志珺【期刊名称】《中国组织工程研究》【年(卷),期】2004(008)015【摘要】背景:近期的研究表明细胞因子不但是免疫调节因子,而且具有广泛的中枢调节作用,对神经递质的合成和代谢产生影响.抑郁症的发病机制有着多种假说,但目前研究结果尚不一致.目的:探讨抑郁症患者抗抑郁剂治疗前后的细胞免疫及单胺类神经递质代谢产物的改变.设计:以诊断为依据的病例对照研究.地点、对象和方法:采用酶联免疫吸附法和高效液相电化学检测法,对南京医科大学脑科医院就诊的40例抑郁症患者在治疗前和抗抑郁药治疗4周后的血浆细胞因子白介素2(IL-2)和IL-6以及单胺代谢产物5-羟吲哚乙酸(5-hydroxyindoleacetic acid,5-HIAA)、3-甲基-4-羟-苯乙二醇(3-methoxy-4-hydroxyphenylglycol,MHPG)和高香草酸的水平进行测定,并以20例健康人作为对照组.主要观察指标:抑郁症患者治疗前后与对照组血浆IL-2,IL-6,5-HIAA,MHPG和高香草酸水平的比较;抑郁症患者治疗前后血浆IL-2,IL-6与5-HIAA,MHPG,高香草酸的相关性.结果:抑郁症组治疗前血浆IL-2,IL-6水平[(4.11±0.53),(41.08±4.85)μg/L]明显高于正常对照组[(3.24±0.53),(35.8l±4.32)μg/L](P＜0.01),经过4周抗抑郁剂治疗后,随着病情显著好转IL-2,IL-6水平较治疗前显著降低(P＜0.01);抑郁症组治疗前血浆5-HIAA,MHPG,高香草酸浓度显著低于正常对照组(P＜0.05),治疗后5-HIAA,MHPG 明显高于治疗前(P＜0.05);治疗前后血浆5-HIAA的差值与治疗前后IL-2,IL-6的差值均呈显著的负相关(r=-0.42,-0.36,P＜0.05).结论:抑郁症患者可能伴有免疫激活和炎症反应;抑郁症患者存在中枢5-羟色胺和去甲肾上腺素功能低下;IL-2,IL-6可影响中枢的5-羟色胺活动.%BACKGROUND: As indicated by the recent researches, cell factors are not only immunity regulation factors but also have wide central regulation reactions, which affect the synthesis and metabolism of neural transmitters. There are many hypotheses in the pathogenesis of depression; however, the results of recent researches were not accordance.OBJECTIVE: To discuss the variety of cell-mediated immunity and the metabolic products of monoamine neural transmitters in depression patients before and after therapy.DESIGN: A case control study on the basis of diagnosis.SETTING, PARTICIPANTS and INTERVENTION: Forty depression patients visited at brain hospital affiliated with Nanjing Medical University were selected in the study. The serous interleukin-2(IL-2), interleukin-6 (IL-6) and the metabolic products of monoamine, which were 5-hydroxyindoleacetic acid (5-HIAA), 3-methocy-4-hydroxyphenylglycol (MHPG) and homovanillic acid, were assayed before and 4-week after therapy by ELISA and high efficiency liquid electrochemical method, and 20 healthy subjects were selected in the control group.MAIN OUTCOME MEASURES: Comparison of serous levels of IL-2,IL-6, 5-HIAA, MHPG and homovanillic acid between the depression group (before and after therapy) and control group; the correlation of serous levels of IL-2, IL-6, 5-HIAA, MHPG and homovanillic acid in the depression group between before and after therapy.RESULTS: The levels of serous IL-2 and IL-6[ (4.11 ±0.53), (41.08 +4.85) μg/L] in t he depression group before therapy were significantly higher than those in the controlgroup[(3.24 +0.53), (35.81 +4.32) μg/L, P ＜0.01] . After 4-week therapy, the disease conditions improved significantly. The serous levels of IL-2 and IL-6 significantly decreased compared with that before therapy( P ＜ 0.01) . The serous levels of 5-HIAA, MHPG and homovanillic acid before therapy in the depression group were significantly lower than those in the control group (P ＜ 0.05 ), and the levels were significantly increased after therapy compared with the levels before therapy ( P ＜ 0.05) . There were negative correlations between the difference of serous 5-HIAA before and after therapy and those of IL-2 and IL-6( r =0.42,-0.36, P ＜0.05).CONCLUSION: There might be immunity activation and inflammation reaction complicated with depression. There are hypofunctions of central 5-hydroxytryptamine(5-HT) and norodrenalin existing in depression patients. IL-2 and IL-6 might affect the activities of central 5-HT.【总页数】2页(P2978-2979)【作者】姚辉;陶领纲;张晓斌;沙维伟;侯钢;张志珺【作者单位】南京医科大学附属脑科医院精神科,江苏省,南京市,210029;广西社会福利院精神科,广西壮族自治区,桂林市,541001;扬州市五台山医院精神科,江苏省,扬州市,225003;扬州市五台山医院精神科,江苏省,扬州市,225003;南京医科大学附属脑科医院精神科,江苏省,南京市,210029;南京医科大学附属脑科医院精神科,江苏省,南京市,210029【正文语种】中文【中图分类】R749【相关文献】1.伴有抑郁障碍的恶性血液病患者抗抑郁治疗前后细胞免疫及细胞因子的变化 [J], 赵蓓;孙若星;曹祥山;华晓莹;钱新瑜;周民;孙剑2.抑郁症与血浆中单胺类神经递质代谢产物 [J], 肖红;姚辉;侯刚;李其军;郭苏皖;吴如金3.抑郁症患者接受治疗前后血浆单胺类神经递质代谢产物的差异 [J], 肖红;姚辉;侯刚;李箕君;郭苏皖4.老年抑郁症患者抗抑郁治疗对血糖、血脂及机体代谢的影响 [J], 胡静;万静;林振东;范洪峰;陈冰容5.首发抑郁症患者抗抑郁治疗前后甲状腺功能的变化 [J], 聂峰因版权原因，仅展示原文概要，查看原文内容请购买。