容积超声造影通过一系列的二维图像采集,捕捉流入脉管系统 的微气泡造影剂形成的非线性二次谐波信号。在体外流速模型 及体内正常/受损肾脏的动物研究中,收集来自时间-强度曲线 的组织灌注参数(峰强度、达峰值强度时间、內洗率、曲线下 面积)。
For the flow phantom studies, either the concentration of MB contrast agent was held constant (10 μL/L) with varying volumetric flow rates (10, 20, and 30 mL/min) or the flow rate was held constant (30 mL/min) and the contrast agent concentration was varied (5, 10, and 20 μL/L). 在体外流速模型研究中,保证微气泡浓度稳定(10 μL/L), 改变容积流速率(10, 20, and 30 mL/min),或者保证流速稳定 (30 mL/min),改变微气泡浓度(5, 10, and 20 μL/L)。
Figure 1a shows time-intensity curves for three different MB concent rations for a fixed volumetric flow rate. All three time-intensity curve s reach their peak intensity at the same time point。 图1a显示固定容积流速,改变微泡造影剂浓度所形成的时间强度曲线。三条时间强度曲线均在同一时间达到了峰强度。 The derived perfusion parameters from time-intensity curve data (i.e., IPK,TPK, WIR, and AUC) are described in Figure 1a. 从时间强度曲线中可以得出IPK/TPK/WRI/AUC等灌注参数。