灌注方法是等向性的,其独立于传感器方位。
The focus of this paper is to investigate the repeatability and robustness of VCEUS imaging for tracking perfusion changes in the healthy and injured kidney.
这篇文章主要致力于观察超声造影显像追踪正常及受损肾脏灌 注变化的可重复性及稳定性。
二Method
VCEUS utilizes a series of planar image acquisitions, capturing the non-linear second harmonic signal from microbubble (MB) contrast agents flowing in the vasculature. Tissue perfusion parameters (peak intensity, IPK; time-to-peak intensity, TPK; wash-in rate, WIR; area under curve, AUC) were derived from time-intensity curve data collected during in vitro flow phantom studies and in vivo animal studies of healthy and injured kidney.
• 容积超声造影显像可以作为一种监测血管损伤后肾脏灌注变 化的潜在手段。
Current methods for quantifying AKI are searching for bio-markers indicative of kidney injury such as positive fluctuations in serum creatinine .However, serum creatinine levels lack the sensitivity and specificity necessary for early detection . Due to the nephrotoxic nature of both CT and MR contrast agents, other standard perfusion imaging modalities are not suitable for diagnosis and monitoring of AKI. 目前确诊AKI的方法主要通过寻找血液中肾脏损害的生物标志物 ,例如血肌酐水平升高。但是血肌酐缺乏早期诊断的敏感性及 特异性。由于CT及MR造影本身存在肾毒性,而其他标准灌注显 像模式不适合诊断及监测AKI。