BP_205_04A_Deconvolution-PART_1 [Compatibility Mode]

OM-USB-1208FS, OM-USB-1408FSU L ow Cost, MultifunctionUSB Devices with 4 Differential or 8 Single-Ended Analog Inputs U P rovides 12-Bit (OM-USB-1208FS) or 14-Bit (OM-USB-1408FS) Analog Input Resolution U M aximum Sampling Rates Ranging from 1.2 kS/s to 50 kS/s U 2 Analog Outputs U 16 Digital I/O Lines U O ne 32-Bit Counter Input Channel U N o External Power RequiredThe OM-USB-1208FS and OM-USB-1408FS dataacquisition modules offer four differential (DIFF) or eight single-ended (SE) analog inputs, two analog outputs, 16 digital I/O channels, and one counter input.These modules are USB 2.0 full speed voltage input data acquisition modules (fully compatible with both USB 1.1 and USB 2.0 ports). These are plug-and-play modules which draw power from the USB cable - no external power supply is required. All configurable options (including individual channel ranges) are software programmable, and the modules are fully software calibrated.Both modules feature eight analog voltage input channels that are processed through a single A/D converter. The analog inputs to the OM-USB-1208FS are software configurable for either eight 11-bit single-ended or four 12-bit differential inputs. The analog inputs to the OM-USB-1408FS are software configurable for either eight 13-bit single-ended or four 14-bit differential inputs.These modules have one 32-bit counter channel. The digital I/O channels are software programmable for input or output. Both models have two 12-bit analog outputs. The packaging for the OM-USB-1208FS and OM-USB-1408FS ensures ease of use in a variety of applications.OM-USB-1208FS shown actual size.The OM-USB-1208FS and OM-USB-1408FS data acquisition modules are supplied with TracerDAQsoftware which is a collection of four virtual instrument applications used to graphically display and store input data and generate output signals:• S trip Chart—Log and graph values acquire from analog inputs, digital inputs, temperature inputs and counter inputs• O scilloscope—Display values acquired fromanalog inputs• F unction Generator—Generate waveforms for analog outputs•R ate Generator—Generate waveforms for counter outputsT racerDAQ PRO is an enhanced version of TracerDAQ. A comparison of some of the features included in TracerDAQ vs TracerDAQ PRO is shown on the next page.TracerDAQ Pro Strip Chartwith Measurements.TracerDAQ Strip Chart.digital input, event counter digital input, event counter Time-of-Day Triggering No YesMath Channel No YesFeatures ComparisonSOFTWAREOM-USB-1208FS and OM-USB-1408FS modules ship with an impressive array of software, including the new TracerDAQ®, a full-featured, out-of-the-box data logging, viewing, and analysis application. Driver support and detailed example programs are included for Universal Library programming libraries for Microsoft® Visual Studio® programming languages, and other languages, including DASYLab®, and ULx for NI LabVIEW®(comprehensive library of Vls and example programs compatible with 32-bit and 64-bit LabVIEW v8.5 through 2013) and InstaCal™ installation, calibration andtest utility - powerful solutions for programmers and nonprogrammers alike. These modules operate under Microsoft Windows® XP (32-bit only) and VIST A/7/8 (32-bit and 64-bit) operating systems.ANALOG INPUTOM-USB 1208FS: These devices provide eight, 11-bit single-ended analog inputs or four, 12-bit differential analog inputs.OM-USB 1408FS: These devices provide eight, 13-bit single-ended analog inputs or four, 14-bit differential analog inputs.All devices support software selectable ranges that provide inputs from ±1V to ±20V in a differential configuration, and ±10V in a single-ended configuration.OM-USB-1408FS8 SE/4 DIFF48 kS/s max2±6.0 mA per Pin1GENERAL INFORMATIONSAMPLING RATE: When scanning continuously to computer memory (hardware-paced mode), theOM-USB-1208FS can sample at a maximum of50 kS/s, and the OM-USB-1408FS can sample ata maximum of 48 kS/s.CHANNEL-GAIN QUEUEThe channel-gain queue feature lets you configure a list of channels and gains for each scan. Each channel can have a different gain setting. The gain settings are stored in a channel-gain queue list that is written to local memory on the device.The OM-USB-1208FS and OM-USB-1408FS channel-gain queue can contain up to 16 channels listed in any order.ANALOG OUTPUTThe maximum analog output update rate for all devices depends on several factors, including USB port speed. Both devices offer two 12-bit analog outputs with a range of 0V to 4.096V.When updating continuously from computer memory (hardware-paced mode), one analog output updates at a maximum rate of 10 kS/s; two analog outputs update simultaneously at a maximum rate of 5 kS/s each. DIGITAL I/OAll devices provide 16 TTL-level digital I/O lines. Digital I/O can be programmed on each 8-bit port (Port A and Port B) for either input (default) or output.EVENT COUNTER INPUTEach device supports one 32-bit TTL-level counter that accepts inputs up to 1 MHz.SPECIFICATIONSANALOG INPUTA/D Converter Type: Successive approximation Channels: 8 single-ended (SE) or 4 differential (DIFF), software programmableInput Common-Mode Voltage Range for Linear Operation:SE Mode: CHx to GND, ±10V maxDIFF Mode: CHx to GND, -10V min, 20V max Absolute Maximum Input Voltage: CHx to GND,±28V maxInput Impedance: 122 kΩRanges: Software selectable on a per-channel basis SE Mode: ±10VD IFF Mode: ±20V, ±10V, ±5V, ±4V, ±2.5V, ±2.0V,±1.25V, ±1.0VThroughput: Maximum throughput scanning to computer memory depends on the computer being used. Software Paced: 250 S/s typ, system-dependentHardware Paced:OM-USB-1208FS: 50 kS/sOM-USB-1408FS: 48 kS/sChannel Gain Queue: Up to 16 elements, software-selectable channel and rangeResolution:OM-USB-1208FS:DIFF: 12 bits, no missing codesSE: 11 bitsOM-USB-1408FS:DIFF: 14 bits, no missing codesSE: 13 bitsCAL Accuracy (OM-USB-1208FS Only):CAL = 2.5 V, ±36.25 mV maxIntegral Linearity ErrorOM-USB-1208FS: ±1 least significant bit (LSB) typ OM-USB-1408FS: ±2 LSB typDifferential Linearity Error: ±0.5 LSB typ Repeatability: ±1 LSB typCAL Current (OM-USB-1208FS Only):Source: 5 mA maxSink: 20 μA min, 100 μA typ2.5VREF Accuracy (OM-USB 1408FS Only):±36.25 mV max2.5VREF Output Current (OM-USB 1408FS Only): Source: 5 mA maxSink: 20 μA min, 100 μA typTrigger Source (Software-Selectable):External Digital: TRIG_INClock Source: Internal; External (SYNC), rising edgetriggeredANALOG OUTPUTNumber of Channels: 2Output Range: 0V to 4.096V, 1 mV per LSB Resolution: 12 bits, 1 in 4096Throughput: Maximum throughput scanning to computer memory depends on the computer being used S oftware Paced: 250 S/s single channel typ, system-dependentHardware Paced:Single Channel: 10 kS/sDual Channel: 5 kS/s Power On and Reset VoltageOM-USB-1208FS: Initializes to 000h codeO M-USB-1408FS: 0V, ±20 mV typ, initializes to 000h codeOutput Drive (Each D/A OUT): 15 mASlew Rate: 0.8V/μs typAccuracy (All Values are ±): 0V to 4.096V: 4.0 LSB typ, 45.0 LSB maxAnalog Output Accuracy Components(All Values are ±): 0V to 4.096V% of FSR: 0.1 typ, 0.9 maxGain Error at Full Scale: 4.0 mV typ, 36.0 mV max Offset: 1.0 mV typ, 9.0 mV max% of at Full Offset Scale ±2V0.2 4 9.766 13.766Least Significant Bit- Least Significant Bit-DIGITAL I/O Digital Type: CMOSNumber of I/O: 16 (Port A0 through A7, Port B0 through B7)Configuration: 2 banks of 8Pull Up/Pull-Down Configuration: All pins pulled up to 5V through 47 kΩ resistors (default); change to pull-down using internal user-configurable jumpers.Input High Voltage: 2.0V min, 5.5V absolute max Input Low Voltage: 0.8V max, -0.5V absolute min,0V recommended minOutput High Voltage (IOH = -6.0 mA): 3.84V min Output Low Voltage (IOL = 6.0 mA): 0.33V max Power On and Reset State: InputEXTERNAL TRIGGERTrigger Source: External digital, TRIG_INTrigger Mode: Edge sensitive; software-selectable for CMOS-compatible rising or falling edgeTrigger Latency: 10 μs maxTrigger Pulse Width: 1 μs minInput Type: Schmitt trigger, 47 kΩ pull-down to ground Schmitt Trigger Hysteresis: 1.01V typ, 0.6V min, 1.5V maxInput High Voltage Threshold: 2.43V typ, 1.9V min, 3.1V maxInput High Voltage Limit: 5.5V absolute maxInput Low Voltage Threshold: 1.42V typ, 1.0V min, 2.0V maxInput Low Voltage Limit: -0.5V absolute min, 0V recommended min EXTERNAL CLOCK INPUT/OUTPUTPin Name: SYNCPin Type: BidirectionalDirection (Software-Selectable):I nput (Default): Receives A/D clock from external source; active on rising edgeO utput: Outputs internal A/D clock; active on rising edgeInput Clock Rate:OM-USB-1208FS: 50 kHz, maxOM-USB-1408FS: 48 kHz, maxClock Pulse Width:Input Mode: 1 μs minOutput Mode: 5 μs minInput Type: Schmitt trigger, 47 kΩ pull-down to ground Schmitt Trigger Hysteresis: 1.01V typ, 0.6V min, 1.5V maxInput High Voltage Threshold: 2.43V typ, 1.9V min, 3.1V maxInput High Voltage Limit: 5.5V absolute maxInput Low Voltage Threshold: 1.42V typ, 1.0V min, 2.0V maxInput Low Voltage Limit: -0.5V absolute min,0V recommended minOutput High Voltage: 4.4V min (IOH = –50 μA),3.80V min (IOH = –8 mA)Output Low Voltage: 0.1V max (IOL = 50 μA),OM-USB-1408FSshown actual size.Ordering Example: OM-USB-1208FS 12-bit voltage input USB data acquisition module (4 DE/8 SE analog input channels, 16 digital I/O, 1 counter, 2 analog outputs) and OCW-1, OMEGACARE SM extends standard 1-year warranty to a total of 2 years.Input Type: Schmitt trigger, 47 k Ω pull-down to ground Input Source: CTR screw terminal Resolution: 32 bitsMaximum Input Frequency: 1 MHz High Pulse Width: 500 ns min Low Pulse Width: 500 ns minSchmidt Trigger Hysteresis: 1.01V typ, 0.6V min, 1.5V maxInput High Voltage Threshold: 2.43V typ, 1.9V min, 3.1V maxInput High Voltage Limit: 5.5V absolute maxInput Low Voltage Threshold: 1.42V typ, 1.0V min, 2.0V maxInput Low Voltage Limit: -0.5V absolute min, 0V recommended minPOWERSupply Current: 80 mA (total current requirement; includes up to 10 mA for the status LED)+5V USB Power Available: C onnected to Self-Powered Hub: 4.5V min, 5.25V max C onnected to Bus-Powered Hub: 4.1V min, 5.25V maxOutput Current (total amount of current that can be sourced from the USB 5 V , analog outputs and digital outputs): C onnected to Self-Powered Hub or Externally Powered Root Port Hub: 420 mA maxConnected to Bus-Powered Hub: 20 mA max NON-VOLATILE MEMORY EEPROM: 1024 bytesGENERALOperating Temperature Range: 0 to 70°C (32 to 158°F), 0 to 90% RH non-condensing Storage Temperature Range: -40 to 70°C (-40 to 158°F), 0 to 90% RH non-condensing Communications: USB 2.0 Hi-speed mode (480 Mbps) is recommended; otherwise USB 1.1 full-speed mode (12 Mbps)Microcontroller Type: High performance 32-bit RISC Signal I/O Connector Type: Screw terminal USB Cable Length: 3 m (9.84') max Dimensions: 79 L x 82 W x 27 mm H (3.10 x 3.20 x 1.05") Weight: 91 g (3.2 oz)TracerDAQ Pro Strip Chartwith Measurements.TracerDAQ Strip Chart.OMEGACARE SM extended warranty program is available for models shown on this page. Ask your sales representative for full details when placing an order. OMEGACARE SM covers parts,labor and equivalent loaners.。

lInstructions for Use: Flexible Inspection Scope Kit-USB Brand Name of ProductFlexible Inspection Scope Kit - USB Generic Name of ProductFlexible Inspection Scope Kit - USB Product Code Number(s)FIS-007U, FIS-007USK, FIS-007UB, CT-101, CT-102Intended UseFor visually inspecting items.Range of Applications for ProductEnhance visual inspection by providing lighted magnification, image capture and the option for documentation in hard-to-see crevices, channels, and lumens in areas of instruments that are not visible to the unaided eye.Key Specifications of Product Flexible Inspection Scope- FIS-007U∙CT-101 1.90 mm OD and 110 cm length∙CT-102 1.06 mm OD and 110 cm length∙Opticalo Resolution format:o CT-102 1.06 mm: 40,000 pixels (or 200- x 200 pixels)o CT-101 1.90 mm: 160,000 pixels (or 400- x 400 pixels)o Field of View: 120° in airo Angle of view: 0°USB Control Module: Control Module housing Camera processor and LEDillumination:∙Dimensions: 5.25- x 3.90- x 1.85 inches∙Weight: 1.20 pounds ∙Digital Inspection Scope Connection∙Illumination Control- LED in the Control Module∙Power Cycle∙USB Camera Cable∙Easily change from small and large diameter scopes.Light Settings:There are four light settings operated by one button.Blinking Light (Indicates transmitting video data):∙Splash proof (IPX5 Rating)∙No external power needed.Flexible Inspection Scope Software Requirements:∙Compatible with Windows 10 Operating systems.∙USB flash drive includes software.Unpacking Flexible Inspection Scope:Carefully inspect for shipping damage. If there is any damage contact the shipping carrier and Heatlhmarkcustomer service 800-521-6224 immediately.USB Control Module: (Fig. 1).1.Digital Inspection Scope Connection 2.Illumination Control 3.Power Cycle B (Type C) on the right side of the boxFigure 1Flexible Inspection Scope™: (Fig. 2).∙CT-101 1.90 mm O.D. and 110 cm length ∙CT-102 1.06 mm O.D. and 110 cm lengthLarge1.90 mmSmall 1.06 mmFigure 2Flexible Inspection Scope™ Features3214Light/Illumination Settings: (Fig. 3).∙Five (5) light settingso Light on control indicats setting levelo Fifth setting is OFF∙Press light button to advance to next setting.∙Fifth setting turns the light OFF.Figure 3Power Cycle ButtonPress button to RESET camera (Fig. 4).Figure 41.Flexible Inspection Scope™ Plug (Fig. 5).Contains camera video connection as well as LED Light for illumination.1Figure 52.Flexible Working Length (Fig. 6).The portion of the Flexible Inspection Scope™ that is inserted into an item during visual inspection.The measuring scale markings on the Flexible Working Length are in centimeters (accuracy = ± 0.5 cm)2Figure 63.Distal Camera (Fig. 7).Distal portion of Flexible Inspection Scope™ that contains the camera lens3Figure 7SOFTWARE INSTALLATION:Note: This section is done only once when connecting the scope to the computer for the first time.∙System Requirements: MS Windows 10∙Install the Flexible Inspection Scope™ Software from the USB flash drive on a computer.Note: If you have any IT policies that may block this installation, please contact your IT team to give access to Healthmark scope viewer to install.1. Insert the USB Flash drive into your computer, and double click on the Healthmark Scope Viewer installer package to begin installation.2. The “Welcome to the Healthmark Scope Viewer Setup Wizard” screen pops up. Click on Next.3. Select the first tab Typical or setup type of your choice, click Next.4. Click Install and wait for installation to complete.5. Click Finish.STARTING SOFTWARE & CONNECTING SCOPE TO PC:(Fig 8).1.Open the Windows PC viewer software.2.Connect the Control Module to PC using USB Cable.3.Plug the Flexible Inspection Scope into the Control Module.4.In the viewer software, click Settings and Select USB Video Device, click on the desiredresolution, select the preferred Video Output Format, and then Click OK.5.Press the Power Cycle Button.Figure 86.Now you can start using the scope.Verifing OperationFollowing the steps listed below will ensure the proper use and performance of the Flexible Inspection Scope™. The Flexile Inspection Scope™ can be checked for normal operation by connecting it as described in the Startup section of this IFU.Normal operation includes:∙An image appearing on your computer monitor or HDMI Monitor.∙ A blinking light on Control Module near the Power Cycle button that indicates the image feed is transmitting.∙White light emitting from the distal end of the Digital Inspection Scope.∙An LED light on the control module top panel that indicates the light intensity of the device. Using SoftwareHealthmark Scope Viewer Software (Fig. 9).1.Capture button: Captures a Reference Image and saves it to the Reference Image folder.2.Main Image Window: Displays the image from the camera.3.Reference Image Window: Displays a reference image.4.Clear Button: Removes the image from the Reference image window.5.Open Reference Image button: Allows selection of a reference image from the Reference Imagefolder.6.Settings Button: Click to select the video camera and resolution settings.7.File Location Button: Click to change location where captured images are being saved.8.File Location Window: Shows the file path where captured images are being saved currently.9.Capture Image Button: Captures images and adds them to the File Location selected by the user(as shown in the File Location Window).10.Capture Video button: Click to record video. Click again to stop recording video.11.File Prefix: Type in text that you would like included in the file name of Captured Images.Figure 9Selecting Video Device or CameraFollow the directions below to select the video device or camera used to capture images using the Flexible Inspection Scope™ Viewer Software. (Fig. 10).1.Click Settings button in the lower left of the Scope Viewer software to display a list of videodevices or cameras being detected by your computer2.Select a device for capturing images using the Scope Viewera.The example below shows a webcam and USB Video Device in the Settings box. Select theUSB Video Device for the Flexible Inspection Scope™.b.You can also select your preferred Video Output Format from the dropdown box3.Click OK to view the selected Video Device.231Figure 10Capturing Still PicturesFollow the instructions for capturing still pictures from the Main Image Window.Select the Capture Image button. (Fig. 11).Figure 11Note: When an image is captured, “Image Captured” in red text will flash on the lower portion of the screen and a new file will appear in the Files Location.Capturing Video ImagesFollow the instructions below for capturing video from the Main Image Window.1.Select the Capture Video Button (Fig. 12).Figure 122.When the video is recording “Recording…” in red text will appear toward the bottom of thesoftware window.3.To stop recording, click Stop Capture. (Fig. 13).Figure 13Setting File PrefixFollowing the steps below allows you to create a file prefix that will appear after the underscore of image file names save to the File Location specified by the user.1.Click in the field next to File Prefix.2.Enter the characters that you would like to be included in the file name. (Fig 14).Figure 14Setting Location for Saved FilesFollowing the steps below allows you to set the file location of saved images using the Scope Viewer software.1.Click the File Location button.2.Select the file location you want to save captured images. (Fig 15).Figure 15Displaying Reference ImageThere are two ways to display a still image in the Reference Image Window on the Scope Viewer software.1.To display an image currently being displayed in the Main Image Window, click the Capture button. Note: The images will be saved in a file folder titled Reference Images in the designated File Location that the user specified in the File Location field. (Fig. 16).Figure 162.To display a saved image in the Reference Image Window from your File Location:a.Click the Open Reference Image button (Fig. 16 above).b.Select the file you want to display (Fig. 17 below).c.Click the OK Button, to display the image in the Reference Image Window. (Fig. 17).Figure 17Switching to a Different Flexible Inspection Scope™ on the Control Module:1.Press the Power button on the Control Module once.2.Disconnect the current Flexible Inspection Scope from the Control Module.3.Repeat the steps in the “STARTING SOFTWARE & CONNECTING SCOPE TO PC” procedure.Inserting Scope in ItemFigure 1Rotating Device to Avoid ObstacleFigure 2 Performing InspectionWipe down the Flexible Inspection Scope™ with a compatible wipe. Follow the manufacturer’s (Mfr.’s)Instructions for Use (IFU) for appropriate wipe usage. Click here to see the Chemical Compatibility Chart(PDF) for approved cleaning.The Flexible Inspection Scope™ is made of the same material as other common endoscopes. Any wipe,solution, or low temperature (≤ 60 °C [140 °F]) method intended for the reprocessing of endoscopes is likelycompatible with the Generation II Flexible Inspection Scope™ Catheters if used according to the productlabeling.Solutions Containing (Flexible Inspection Scope Only)Alcohol Ethoxylates Neutral or Near-Neutral pH DetergentsEnzymatic Cleaning Solutions Enzymatic DetergentsSodium Borated, Decahydrate Tetrapotassium PyrophosphateFlexible Inspection Scope™ has a fluid ingress protection rating of IPX7 (Waterproof) and can withstandimmersion in fluid up to one (1)-meter in depth for up to 30 minutes.Control Module USB has a fluid ingress protection rating of IPX5 (Water resistant) and can withstand asustained, low pressure water jet spray for up to three minutes.For Thorough Cleaning: CablesFollow the cleaning agent Mfr.’s IFU.1.Unplug and disconnect all components from the Control box prior to cleaning.2.Do not submerge or soak the cable for disinfection (cable is not waterproof).3.Wipe thoroughly with non-linting wipe moistened with facility approved neutral detergent. Use theappropriate brushes with detergent solution to remove any residues from areas that cannot bereached with the wipes.For Thorough Cleaning: Control Module1.Unplug and disconnect all components from the Control box prior to cleaning.2.Do not submerge or soak the cable for disinfection (Control Box is not waterproof).3.Wipe thoroughly with non-linting wipe moistened with facility approved neutral detergent. Use theappropriate brushes with detergent solution to remove any residues from areas that cannot bereached with the wipes.Note: Do NOT soak. Control Module and cables are not waterproof and should not be immersed.N/ACleaning –AutomatedDisinfection Control Module and CablesThese may be cleaned with alcohol based disinfectant wipes.Compatible agents (wipes and solutions) for disinfecting Flexible Inspection Scope™ and ControlModule:∙Hydrogen peroxide∙Isopropyl alcohol (IPA)∙Sodium hypochlorite (Bleach)∙Ortho-phenylphenol∙Quaternary ammonium.High-Level Disinfection (Flexible Inspection Scope™ Only)∙Select only disinfecting solutions listed in the compatible disinfecting methods.∙Follow all recommendations regarding health-hazards, dispensing, measuring, and storage from the Mfr. of cleaning and disinfecting agents.∙Soak the Flexible Inspection Scope™ in selected disinfecting solution per Mfr.’s IFU.∙Rinse the Flexible Inspection Scope™ with critical (sterile) water, again, following the disinfecting solutions Mfr.’s instructions.Reprocessing Chemical Compatibility Chart (PDF): Click here.。

斯派曼 Bertan 品牌 205B 系列高压电源，提供 1kV 至 50kV 可调的高压输出。

采用低噪声、线性拓扑技术，使得输出极低的纹波规格。

15W 至 30W 电源内有极性可逆设计，提供正极性或负极性任一输出极性。

205B系列有电弧和短路保护。

具有卓越的调节规格以及杰出的稳定性能。

典型应用高压绝缘试验测试C RT 测试静电电子束系统一般实验室使用选项RF隔离 (浮地) 输出规格输入电压：115Vac, ±10%, 50/60Hz @ 1A230Vac,±10%,50/*********输入电压通过开关选择输出电压：见 “型号选择” 表输出极性：所有电源设计为可逆极性输出电流：见 “型号选择” 表电压调节：输入：在指定输入电压范围内，≤ 额定输出电压的50ppm/0.001%。

负载：满负载变化，≤ 额定输出电压的 0.005%。

电流调节：在满输出电压时，内部设置限制为额定电流的 105%。

在零输出电压时，最大输出电流在其他电压设置必须成线性降至最大的 30%。

稳定性：在 0.5 小时预热之后，≤0.01%/小时，每 8 小时 0.02%。

精确度：电流监测：±(读数的 0.5% + 最大值的 0.25%)远程编程：±(设定值的 0.1% + 最大值的0.1%)电压监测：±(读数的 0.1% + 最大值的 0.1%)前面板表：电压 ±(设定值的 0.1% + 最大值的 0.1%)电流 ±(设定值的 0.25% + 最大值的 0.25%) 前面板控制：±(设定值的 0.25% + 最大值的 0.05%)工作温度：0°C 至 +50°C存储温度：-40°C 至 +85°C湿度：20% 至 85% 相对湿度，无冷凝。

输入电源连接器：IEC320 EMI 滤波/ 输入连接器，提供一根可分离的电源线。

SPECIFICA TIONSNI cDAQ™-91811-Slot, Ethernet CompactDAQ ChassisDefinitionsWarranted specifications describe the performance of a model under stated operating conditions and are covered by the model warranty.Characteristics describe values that are relevant to the use of the model under stated operating conditions but are not covered by the model warranty.•Typical specifications describe the expected performance met by a majority of the models.•Nominal specifications describe parameters and attributes that may be useful in operation. Specifications are Typical unless otherwise noted.ConditionsSpecifications are valid at 25 °C unless otherwise noted.Analog InputInput FIFO size127 samplesMaximum sample rate1Determined by the C Series moduleTiming accuracy250 ppm of sample rateTiming resolution212.5 nsNumber of channels supported Determined by the C Series module 1Performance dependent on type of installed C Series module and number of channels in the task.2Does not include group delay. For more information, refer to the documentation for each C Series module.Analog OutputNumber of channels supportedHardware-timed taskOnboard regeneration16Non-regeneration Determined by the C Series module Non-hardware-timed task Determined by the C Series module Maximum update rateOnboard regeneration 1.6 MS/s (multi-channel, aggregate)Non-regeneration Determined by the C Series module Timing accuracy50 ppm of sample rateTiming resolution12.5 nsOutput FIFO sizeOnboard regeneration8,191 samples shared among channels used Non-regeneration127 samplesAO waveform modes Non-periodic waveform,periodic waveform regeneration mode fromonboard memory,periodic waveform regeneration from hostbuffer including dynamic updateDigital Waveform CharacteristicsWaveform acquisition (DI) FIFOParallel modules511 samplesSerial modules63 samplesWaveform generation (DO) FIFOParallel modules2,047 samplesSerial modules63 samplesDigital input sample clock frequencyStreaming to application memory System-dependentFinite0 MHz to 10 MHz2| | NI cDAQ-9181 SpecificationsDigital output sample clock frequencyStreaming from application memory System-dependentRegeneration from FIFO0 MHz to 10 MHzFinite0 MHz to 10 MHzTiming accuracy50 ppmGeneral-Purpose Counters/TimersNumber of counters/timers4Resolution32 bitsCounter measurements Edge counting, pulse, semi-period, period,two-edge separation, pulse widthPosition measurements X1, X2, X4 quadrature encoding withChannel Z reloading; two-pulse encoding Output applications Pulse, pulse train with dynamic updates,frequency division, equivalent time sampling Internal base clocks80 MHz, 20 MHz, 100 kHzExternal base clock frequency0 MHz to 20 MHzBase clock accuracy50 ppmOutput frequency0 MHz to 20 MHzInputs Gate, Source, HW_Arm, Aux, A, B, Z,Up_DownRouting options for inputs Any module PFI, analog trigger, many internalsignalsFIFO Dedicated 127-sample FIFOFrequency GeneratorNumber of channels1Base clocks20 MHz, 10 MHz, 100 kHzDivisors 1 to 16 (integers)Base clock accuracy50 ppmOutput Any module PFI terminalNI cDAQ-9181 Specifications| © National Instruments| 3Module PFI CharacteristicsFunctionality Static digital input, static digital output, timinginput, and timing outputTiming output sources3Many analog input, analog output, counter,digital input, and digital output timing signals Timing input frequency0 MHz to 20 MHzTiming output frequency0 MHz to 20 MHzDigital TriggersSource Any module PFI terminalPolarity Software-selectable for most signalsAnalog input function Start Trigger, Reference Trigger,Pause Trigger, Sample Clock,Sample Clock TimebaseAnalog output function Start Trigger, Pause Trigger, Sample Clock,Sample Clock TimebaseCounter/timer function Gate, Source, HW_Arm, Aux, A, B, Z,Up_DownModule I/O StatesAt power-on Module-dependent. Refer to the documentationfor each C Series module.Network InterfaceNetwork protocols TCP/IP, UDPNetwork ports used HTTP:80 (configuration only), TCP:3580;UDP:5353 (configuration only), TCP:5353(configuration only); TCP:31415; UDP:7865(configuration only), UDP:8473 (configurationonly)Network IP configuration DHCP + Link-Local, DHCP, Static,Link-Local3Actual available signals are dependent on type of installed C Series module.4| | NI cDAQ-9181 SpecificationsHigh-performance data streams6Data stream types available Analog input, analog output, digital input,digital output, counter/timer input,counter/timer output, NI-XNET4Default MTU size1500 bytesEthernetNetwork interface100 Base-TX, full-duplex; 100 Base-TX,half-duplex; 10 Base-T, full-duplex; 10 Base-T,half-duplexCommunication rates10/100 Mbps, auto-negotiatedMaximum cabling distance100 m/segmentPower RequirementsCaution The protection provided by the NI cDAQ-9181 chassis can be impaired ifit is used in a manner not described in the NI cDAQ-9181/9184/9188/9191 UserManual.Note Some C Series modules have additional power requirements. For moreinformation about C Series module power requirements, refer to the documentationfor each C Series module.Note Sleep mode for C Series modules is not supported in the NI cDAQ-9181.V oltage input range9 V to 30 VMaximum power consumption5 5 W4When a session is active, CAN or LIN (NI-XNET) C Series modules use a total of two data streams regardless of the number of NI-XNET modules in the chassis.5Includes maximum 1 W module load per slot across rated temperature and product variations.NI cDAQ-9181 Specifications| © National Instruments| 5Note The maximum power consumption specification is based on a fully populatedsystem running a high-stress application at elevated ambient temperature and withall C Series modules consuming the maximum allowed power.Power input connector 2 positions 3.5 mm pitch mini-combicon screwterminal with screw flanges, Phoenix Contact1727566Power input mating connector Sauro CTF020V8, Phoenix Contact 1714977,or equivalentPhysical CharacteristicsWeight (unloaded)Approx. 470 g (16.6 oz)Dimensions (unloaded)194.0 mm × 88.7 mm × 33.6 mm(7.64 in. × 3.49 in. × 1.32 in.) Refer to thefollowing figure.Screw-terminal wiringGauge0.5 mm 2 to 2.1 mm2 (20 AWG to 14 AWG)copper conductor wireWire strip length 6 mm (0.24 in.) of insulation stripped from theendTemperature rating85 °CTorque for screw terminals0.20 N · m to 0.25 N · m (1.8 lb · in. to2.2 lb · in.)Wires per screw terminal One wire per screw terminalConnector securementSecurement type Screw flanges providedTorque for screw flanges0.20 N · m to 0.25 N · m (1.8 lb · in. to2.2 lb · in.)If you need to clean the chassis, wipe it with a dry towel.6| | NI cDAQ-9181 SpecificationsFigure 1. NI cDAQ-9181 DimensionsSafety VoltagesConnect only voltages that are within these limits.V terminal to C terminal30 V maximum, Measurement Category IMeasurement Category I is for measurements performed on circuits not directly connected to the electrical distribution system referred to as MAINS voltage. MAINS is a hazardous live electrical supply system that powers equipment. This category is for measurements of voltages from specially protected secondary circuits. Such voltage measurements include signal levels,special equipment, limited-energy parts of equipment, circuits powered by regulated low-voltage sources, and electronics.Caution Do not connect the system to signals or use for measurements withinMeasurement Categories II, III, or IV .NI cDAQ-9181 Specifications | © National Instruments | 7Note Measurement Categories CAT I and CAT O (Other) are equivalent. These testand measurement circuits are not intended for direct connection to the MAINsbuilding installations of Measurement Categories CAT II, CAT III, or CAT IV.Environmental0 °C to 55 °COperating temperature (IEC 60068-2-1and IEC 60068-2-2)Caution To maintain product performance and accuracy specifications when theambient temperature is between 45 and 55 °C, you must mount the chassishorizontally to a metal panel or surface using the screw holes or the panel mount kit.Measure the ambient temperature at each side of the CompactDAQ system 63.5 mm(2.5 in.) from the side and 25.4 mm (1.0 in.) from the rear cover of the system. Forfurther information about mounting configurations, go to /info and enterthe Info Code cdaqmounting.Storage temperature (IEC 60068-2-1 and-10 °C to 70 °CIEC 60068-2-2)Ingress protection IP 30Operating humidity (IEC 60068-2-56)10% to 90% RH, noncondensingStorage humidity (IEC 60068-2-56)5% to 95% RH, noncondensingPollution Degree (IEC 60664)2Maximum altitude5,000 mIndoor use only.Hazardous LocationsU.S. (UL)Class I, Division 2, Groups A, B, C, D, T4;Class I, Zone 2, AEx nA IIC T4Canada (C-UL)Class I, Division 2, Groups A, B, C, D, T4;Class I, Zone 2, Ex nA IIC T4Europe (ATEX) and International (IECEx)Ex nA IIC T4 Gc8| | NI cDAQ-9181 SpecificationsShock and VibrationTo meet these specifications, you must direct mount the NI cDAQ-9181 system and affix ferrules to the ends of the terminal lines.Operational shock30 g peak, half-sine, 11 ms pulse (Tested inaccordance with IEC 60068-2-27. Test profiledeveloped in accordance withMIL-PRF-28800F.)Random vibrationOperating 5 Hz to 500 Hz, 0.3 g rmsNon-operating 5 Hz to 500 Hz, 2.4 g rms (Tested in accordancewith IEC 60068-2-64. Non-operating testprofile exceeds the requirements ofMIL PRF-28800F, Class 3.)Safety and Hazardous Locations StandardsThis product is designed to meet the requirements of the following electrical equipment safety standards for measurement, control, and laboratory use:•IEC 61010-1, EN 61010-1•UL 61010-1, CSA C22.2 No. 61010-1•EN 60079-0:2012, EN 60079-15:2010•IEC 60079-0: Ed 6, IEC 60079-15; Ed 4•UL 60079-0; Ed 6, UL 60079-15; Ed 4•CSA 60079-0:2011, CSA 60079-15:2012Note For UL and other safety certifications, refer to the product label or the OnlineProduct Certification section.Electromagnetic CompatibilityThis product meets the requirements of the following EMC standards for electrical equipment for measurement, control, and laboratory use:•EN 61326-1 (IEC 61326-1): Class A emissions; Basic immunity•EN 55011 (CISPR 11): Group 1, Class A emissions•EN 55022 (CISPR 22): Class A emissions•EN 55024 (CISPR 24): Immunity•AS/NZS CISPR 11: Group 1, Class A emissions•AS/NZS CISPR 22: Class A emissionsNI cDAQ-9181 Specifications| © National Instruments| 9•FCC 47 CFR Part 15B: Class A emissions•ICES-001: Class A emissionsNote In the United States (per FCC 47 CFR), Class A equipment is intended foruse in commercial, light-industrial, and heavy-industrial locations. In Europe,Canada, Australia and New Zealand (per CISPR 11) Class A equipment is intendedfor use only in heavy-industrial locations.Note Group 1 equipment (per CISPR 11) is any industrial, scientific, or medicalequipment that does not intentionally generate radio frequency energy for thetreatment of material or inspection/analysis purposes.Note For EMC declarations and certifications, and additional information, refer tothe Online Product Certification section.CE ComplianceThis product meets the essential requirements of applicable European Directives, as follows:•2014/35/EU; Low-V oltage Directive (safety)•2014/30/EU; Electromagnetic Compatibility Directive (EMC)•2014/34/EU; Potentially Explosive Atmospheres (ATEX)Online Product CertificationRefer to the product Declaration of Conformity (DoC) for additional regulatory compliance information. To obtain product certifications and the DoC for this product, visit / certification, search by model number or product line, and click the appropriate link in the Certification column.Environmental ManagementNI is committed to designing and manufacturing products in an environmentally responsible manner. NI recognizes that eliminating certain hazardous substances from our products is beneficial to the environment and to NI customers.For additional environmental information, refer to the Minimize Our Environmental Impact web page at /environment. This page contains the environmental regulations and directives with which NI complies, as well as other environmental information not included in this document.10| | NI cDAQ-9181 SpecificationsWaste Electrical and Electronic Equipment (WEEE) EU Customers At the end of the product life cycle, all NI products must bedisposed of according to local laws and regulations. For more information abouthow to recycle NI products in your region, visit /environment/weee.电子信息产品污染控制管理办法（中国RoHS）中国客户National Instruments符合中国电子信息产品中限制使用某些有害物质指令(RoHS)。

到DT-3可抑制胃癌细胞AGS增殖的现象,细胞划痕愈合实验证实DT-3还具有抑制胃癌细胞AGS迁移的能力㊂用Western blotting实验和相关分析,可得出PKGIα在胃癌细胞中表达增高,PKGIα和NF-κB p-p65密切相关的结果,推测DT-3可能通过抑制PKGIα的蛋白表达降低NF-κB p65Ser536位点的磷酸化从而抑制胃癌细胞AGS的增殖和迁移㊂此外,我们课题组前期也发现某些信号通路的关键信号分子的磷酸化同样影响胃癌细胞的增殖和迁移[11];如前文所述[5],一项肾细胞癌研究表明可通过调节NF-κB p65 Ser536位点的磷酸化来激活NF-κB通路而在肿瘤发生发展中发挥关键作用,这与本实验在胃癌中的研究意义一致㊂本研究发现,DT-3是有效的抑制剂,通过抑制PKGIα信号通路,可以有效抑制胃癌细胞增殖㊁迁移㊂然而,本研究只在细胞层面进行了体外试验,从基础应用成果到投入临床转化这个过程,应在未来的临床前研究中仔细验证㊂ʌ参考文献ɔ[1]㊀郑荣寿,张思维,孙可欣,等.2016年中国恶性肿瘤流行情况分析[J].中华肿瘤杂志,2023,45(3):212-220. [2]㊀Pang J,Li G,Qian H,et al.Secretory typeⅡcGMP-de-pendent protein kinase blocks activation of PDGFRβviaSer254in gastric cancer cells[J].Cell Biol Int,2022,46(5):747-754.[3]㊀Soltek S,Karakhanova S,Golovastova M,et al.Anti-tumorproperties of the cGMP/protein kinase G inhibitor DT3inpancreatic adenocarcinoma[J].Naunyn Schmiedebergs ArchPharmacol,2015,388(11):1121-1128.[4]㊀Motolani A,Martin M,Sun M,et al.Phosphorylation of theregulators,a complex facet of NF-κB signaling in cancer[J].Biomolecules,2020,11(1):15.[5]㊀Wang Y,Su J,Wang Y,et al.The interaction of YBX1withG3BP1promotes renal cell carcinoma cell metastasis via YBX1/G3BP1-SPP1-NF-κB signaling axis[J].Exp Clin Cancer Res,2019,38(1):386.[6]㊀Hutter C,Zenklusen JC.The cancer genome atlas:creatinglasting value beyond its data[J].Cell,2018,173(2):283-285.[7]㊀Lanczky A,Gyorffy B.Web-based survival analysis tool tai-lored for medical research(KMplot):development and im-plementation[J].Med Internet Res,2021,23(7):e27633.[8]㊀Li C,Tang Z,Zhang W,et al.GEPIA2021:integrating multi-ple deconvolution-based analysis into GEPIA[J].Nucleic Acids Res,2021,49(W1):242-246.[9]㊀Hu K,Zheng QM,Wang YP,et al.Clinical and prognosticfeatures of E-cadherin in adenocarcinoma of the esopha-gogastric junction patients[J].Eur Cancer Prev,2023,32(2):119-125.[10]㊀谭林,王骞,屈伟明,等.胃癌组织中幽门螺杆菌感染和p-p65㊁EMT相关蛋白的表达及临床意义[J].现代消化及介入诊疗,2019,24(11):1245-1251.[11]㊀朱亚清,李春辉,何涛,等.ANP对胃癌MGC-803细胞增殖迁移的影响及机制的研究[J].河北医学,2020,26(12):1943-1947.ʌ文章编号ɔ1006-6233(2024)04-0560-05STAT3的多态性在HPV16所致宫颈癌发生中的作用张荷敏,㊀余㊀燕,㊀刘艳筠(联勤保障部队第九〇〇医院仓山院区妇科,㊀福建㊀福州㊀350000)ʌ摘㊀要ɔ目的:研究人乳头状瘤病毒16(HPV16)所致宫颈癌发生过程中转录活化子3(STAT3)多态性的作用㊂方法:回顾性选取2019年至2023年入院的34例宫颈癌患者为观察对象,将其设为A组,选取同一时期入院的54例宫颈上皮内瘤变患者将其设为B组,同时选取同一时期入院的80例慢性宫颈炎患者将其设为C组㊂HPV16E6蛋白测定方式主要为免疫组化㊁聚合酶链反应(PCR)-反向点杂交法,STAT3测定方式主要为PCR法,STAT3基因C1697G多态性测定方式主要为PCR-制片段长度多态性(RFLP),比较并分析三组患者E6蛋白㊁STAT3蛋白阳性表达率与STAT3基因多态性表达情况㊂结果:与B㊁C组相比,A组患者E6㊁STAT3蛋白阳性表达率明显更高,差异有统计学意义(P<0.0167);相比C组患者,B组患者E6蛋白㊁STAT3蛋白阳性表达率明显更高,差异有统计学意义(P<0.0167)㊂相比C组患者,A㊁B组患者G/G型构成比明显更低,C/C型构成比明显更高,差异有统计学意义(P<0. 0167);相比B组患者,A组患者G/G型构成比明显更低,C/C型构成比明显更高,差异有统计学意义㊃065㊃ʌ基金项目ɔ福建省卫生健康行业科研项目,(编号:21A200189)(P<0.0167);三组患者G/C型构成比差异无统计学意义(P>0.0167)㊂结论:HPV16所致宫颈癌发生及发展过程中STAT3及其多态性可能有重要作用㊂ʌ关键词ɔ㊀宫颈癌;㊀基因多态性;㊀转录活化子3;㊀人乳头状瘤病毒16ʌ文献标识码ɔ㊀A㊀㊀㊀㊀㊀ʌdoiɔ10.3969/j.issn.1006-6233.2024.04.06The Role of STAT3Polymorphism in the Developmentof Cervical Cancer Caused by HPV16ZHANG Hemin,YU Yan,LIU Yanyun (Cangshan Branch of the900th Hospital of the Joint Logistic Support Force,Fujian Fuzhou350000,China)ʌAbstractɔObjective:To investigate the role of signal transducer and activator of transcription3 (STAT3)polymorphism in the development of cervical cancer caused by human papillomavirus16(HPV16). Methods:A retrospective study was conducted on34patients with cervical cancer who were admitted to the hospital from2019to2023.They were assigned to Group A.Another54patients with cervical intraepithelial neoplasia and80patients with chronic cervicitis admitted to the hospital during the same period were assigned to Groups B and C,respectively.The expression of HPV16E6protein was detected by immunohistochemistry and polymerase chain reaction(PCR)-reverse dot blot hybridization.The expression of STAT3protein was detected by PCR,and the polymorphism of STAT3gene C1697G was detected by PCR-restriction fragment length polymorphism(RFLP).The expression rates of E6and STAT3proteins and the genotypes of STAT3 gene polymorphism in the three groups were compared and analyzed.Results:The positive expression rates of E6and STAT3proteins in Group A were significantly higher than those in Groups B and C(P<0.0167).The positive expression rates of E6and STAT3proteins in Group B were significantly higher than those in Group C (P<0.0167).The frequency of the G/G genotype in Groups A and B was significantly lower than that in Group C,and the frequency of the C/C genotype was significantly higher than that in Group C(P<0.0167). The frequency of the G/G genotype in Group A was significantly lower than that in Group B,and the frequen-cy of the C/C genotype was significantly higher than that in Group B(P<0.0167).There was no significant difference in the frequency of the G/C genotype among the three groups(P>0.0167).Conclusion:STAT3 and its polymorphism may play an important role in the development and progression of cervical cancer caused by HPV16.ʌKey wordsɔ㊀Cervical cancer;㊀Gene polymorphism;㊀Signal transducer and activator of transcription 3;㊀Human papillomavirus16㊀㊀宫颈癌作为肿瘤病症,对患者身心健康有严重影响,甚至危及生命㊂宫颈癌患者早期症状存在隐匿性,大部分患者临床确诊时已为中晚期阶段,预后质量均较低,且已经丧失最佳治疗时机[1]㊂现阶段,宫颈癌发生机理尚未完全明确,临床检查缺乏特异性㊁敏感性的诊断方式,所以对其发生的相关分子机制予以分析,明确新型分泌标志物对提升宫颈癌诊断准确性十分重要[2]㊂相关报道提出,宫颈癌诱发因素主要为人乳头状瘤病毒(human papilloma virus,HPV)感染[3]㊂细胞分化㊁增殖㊁凋亡及血管形成等一系列环节中转录活化子(signal transducer and activator of transcription, STAT)均有参与,且与肿瘤发生有着密切联系[4]㊂本研究以34例宫颈癌患者㊁80例慢性宫颈炎患者㊁54例宫颈上皮内瘤变患者为观察对象,分析HPV16所致宫颈癌发生过程中STAT3多态性的作用㊂1㊀资料与方法1.1㊀一般资料:观察对象为2019年至2023年入联勤保障部队第九〇〇医院的34例宫颈癌患者为观察对象,将其设为A组,选取同一时期入院的54例宫颈上皮内瘤变患者将其设为B组,同时选取同一时期收治的80例慢性宫颈炎患者将其设为C组㊂纳入标准:①与‘妇产科学“[5]中宫颈癌㊁宫颈上皮内瘤变㊁慢性宫颈炎诊断标准相符;②依从性好,可配合相关检查;③资料完整㊂排除标准:①合并有其它恶性肿瘤㊁感染性疾病等可影响研究开展病症者;②中途转院者;③伴精神病症者㊂A组患者年龄28~63(46.08ʃ6.34)岁;病㊃165㊃程1个月至2年(7.75ʃ1.48)个月㊂B组患者年龄28 ~64(46.19ʃ6.47)岁;病程1~23月(7.68ʃ1.51)月㊂C组患者年龄28~65(46.25ʃ6.56)岁;病程1~25月(7.72ʃ1.56)月㊂三组患者年龄㊁病程等资料差异无显著性(P>0.05),有可比性㊂本研究经联勤保障部队第九〇〇医院医学伦理委员会批准(20221004)㊂1.2㊀方㊀法1.2.1㊀HPV16E6蛋白检测:首先,将术后切除保存的新鲜组织样本制备为石蜡组织,然后进行切片并HE染色,上述操作完成之后对HPV亚型予以分型测定,检测方式为聚合酶链反应(Polymerase Chain Reac-tion,PCR)-反向点杂交法;其次,标本内HPV16E6蛋白表达水平测定方式为免疫组化Supervision TM二步法,予以切片处理并染色,染色完成之后双盲阅片,阳性细胞染色表现以显示棕黄色颗粒为判断标准,表达部位以细胞核为主,镜下染色完成之后,对阳性细胞及其染色情况予以半定量评分评价,细胞着色深浅程度划分为不同类型,第1个类型为无色(0分)㊁第2个类型为浅黄色(1分)㊁第3个类型为棕黄色(2分)㊁第4个类型为棕褐色(3分),>2分代表阳性,0~1分代表阴性㊂1.2.2㊀STAT3基因检测:对病理组织标本予以制作及备用,采集病理组织5cmˑ5cm,选取10%甲醛对病理组织予以固定处理,固定完成之后进行石蜡包埋处理,最后予以切片处理,切片厚度3μm,予以HE染色, STAT3基因型经PCR检测,对STAT3引物予以构建,上游㊁下游引物分别为5'-GAACTCCCTGAAAAGCTA-AAGC-3'㊁5'-GTTGGGCTCAAATACGGTGG-3',参照基因为β球蛋白基因(350bp),使用1.5mmoL/L氯化镁㊁50mmoL/L氯化钾㊁2μL上游引物㊁2μL下游引物㊁25U DNA聚合物及相应缓冲液,反应条件:预变性处理于94ħ环境下进行,时间控制在5min左右,同时将变形时间控制在30s左右,于63ħ环境下予以退火处理,时间控制在30s左右,然后于72ħ环境下延伸,时间控制在30s左右,循环35次之后于72ħ环境下延伸,时间控制在5min左右,分析PCR扩增产物的基因型,分析方式选取1.5%琼脂糖凝胶电泳技术;除此之外,经PCR-制片段长度多态性(restriction fragment length polymorphism,RFLP)对STAT3基因C1697G的多态性予以分析㊂1.3㊀统计学方法:采用SPSS20.0软件,计量资料用均数ʃ标准差( xʃs)表示,同组内治疗前后比较,采用配对t检验;两组间比较采用独立样本t检验,P<0.05为差异有统计学意义;计数资料以n(%)表示,采用χ2检验,若组间总体差异有统计学意义时(P<0.05),需要进一步两两比较时,对检验水准进行Bonferroni校正,即P'<0.0167时认为差异有统计学意义㊂2㊀结㊀果2.1㊀三组患者STAT3㊁E6蛋白表达情况比较:三组患者的STAT3㊁E6蛋白的阳性表达率差异有统计学意义(χ2STAT3=68.665,P STAT3=0.000;χ2E6=69.202, P E6=0.000)㊂与B㊁C组相比,A组患者E6㊁STAT3蛋白阳性表达率明显更高,差异有统计学意义(P<0. 0167);相比C组患者,B组患者STAT3蛋白㊁E6蛋白阳性表达率明显更高,差异有统计学意义(P<0. 0167)㊂见表1㊂表1㊀三组患者STAT3E6蛋白阳性表达情况比较n(%)组别n STAT3E6A组3428(82.35)26(76.47)B组5424(44.44)①26(48.15)①C组804(5.00)②③2(2.50)②③㊀㊀注:A㊁B组比较,①P<0.0167;A㊁C组比较,②P<0.0167;B㊁C组比较,③P<0.01672.2㊀三组患者STAT3基因多态性构成比比较:三组患者STAT3基因多态性构成比差异有统计学意义(χ2 =89.737,P=0.000)㊂相比C组患者,A㊁B组患者G/G型的构成比明显更低,C/C型的构成比明显更高,构成比的差异有统计学意义(P<0.0167);相比B组患者,A组患者G/G型构成比明显更低,C/C型构成比明显更高,构成比的差异有统计学意义(P<0.0167);三组患者G/C型构成比的差异无统计学意义(P>0.0167)㊂见表2㊂㊃265㊃表2㊀三组患者STAT3基因多态性构成比比较n (%)组别n G /G 型C /C 型G /C 型A 组342(5.88)28(82.35)4(11.77)B 组5432(59.26)①14(25.93)①8(14.81)C 组8074(92.50)②③2(2.50)②③4(5.00)㊀㊀注:A ㊁B 组比较,①P<0.0167;A ㊁C 组比较,②P<0.0167;B ㊁C 组比较,③P<0.01673㊀讨㊀论宫颈癌作为一种妇科恶性肿瘤,患病人数呈逐年增加趋势,已经成为妇科中高发肿瘤,发病率仅次于乳腺癌,且发病人群越来越年轻㊂相关报道提出,宫颈上皮增生不典型患者与宫颈癌患者HPV 感染几率相对较高,且绝大多数宫颈癌存在HPV -DNA ,HPV 感染与宫颈上皮内瘤变㊁宫颈癌的发生联系紧密,且是宫颈癌病变重要因素[6]㊂现阶段,感染HPV 的人数呈逐年增多趋势,宫颈癌患病人数也随之上升,但除了HPV 感染之外,卫生习惯㊁饮食习惯等一系列外界因素在宫颈癌发病中也发挥着重要作用,提示宫颈癌的发生是一系列致癌因素共同所致[7]㊂STAT 作为一种转录因子,对细胞信号转导具有介导作用,其作为JAK -STAT 信号转导途径中一个不可或缺的环节,初始转导位置主要为细胞表面受体,与特异性DNA 相结合之后,可对子序列启动产生促进作用,且信号能够朝着细胞核转导与调控基因表达,不仅参与了细胞分化㊁增殖及凋亡,还参与了血管形成,致使肿瘤加速形成[8]㊂11号染色体为STAT3的重要来源,其具备的功能相对而言较为复杂,且STAT3信号转导途径在机体免疫调节㊁器官形成㊁胚胎发育中具有重要作用;同时,致癌蛋白感染一旦发生,可对STAT3产生激活作用,并对凋亡抑制基因Mcl -1㊁Bcl -XL 产生上调作用,在此基础上对细胞凋亡产生抑制的同时,激活启动因子,最终对肿瘤血管生成产生促进作用;除此之外,STAT3组成性活化可在很大程度上阻断凋亡细胞的持续性恶化,进一步增大肿瘤细胞增殖量,加快血管形成,对STAT3表达予以阻断可在很大程度上提升肿瘤治疗效果[9-10]㊂本研究中,A 组患者STAT3蛋白㊁E6蛋白阳性表达率明显高于B ㊁C 组,差异有显著性(P<0.0167)㊂相关研究显示,STAT3组成性活化可在很大程度上抑制细胞凋亡,进一步增大细胞增殖量并加快细胞恶性转化与血管形成,因此对其予以有效抑制可能是治疗宫颈癌㊁子宫内膜癌患者的重要靶点[11]㊂针对STAT3的致癌作用,本研究对HPV16E6蛋白与STAT3在不同程度宫颈病变组织内的表达情况进行了综合分析,结果显示由慢性宫颈炎患者随疾病进展发展为宫颈上皮内瘤变,最终进展至宫颈癌过程中E6及STAT3蛋白阳性表达率明显升高㊂同时,相关报道提出,HPV16E6与STAT3于宫颈癌内的表达明显相关,所以恶性肿瘤转化过程中两者之间存在一定联系[2]㊂基因多态性作为医学研究热点之一,一个基因多态性出现变化之后可能造成其他基因型出现变化,在此基础上诱发相关病症,病症诊断中可将基因多态性作为参考依据,并可辅助用于判断预后状况㊂STAT3基因多态性主要分为3个类型,第1个类型为G /G 型,第2个类型为C /C 型,第3个类型为G /C 型;本研究中,相比C 组患者,A ㊁B 组患者G /G 型构成比明显更低,C /C 型构成比明显更高,构成比的差异有统计学意义(P <0.0167);相比B 组患者,A 组患者G /G 型构成比明显更低,C /C 型构成比明显更高,构成比的差异有统计学意义(P <0.0167),提示宫颈癌发生风险随HPV 感染风险升高而升高,疾病程度越重C /C 基因构成比越高,且宫颈癌发病率也随之增加㊂高和平等[12]在相关研究中显示,宫颈癌患者STAT3基因C /C 型构成比随着宫颈病变程度加重而随之增加,G /G 型占比随着G /G 型构成比而随之下降,提示STAT3与宫颈癌之间可能联系紧密,而C /C 基因型与HPV 感染发生的风险可能处于正相关关系㊂STAT3基因一旦发生突变状况,不仅会导致宫颈癌发病率升高,还会在很大程度上增大HPV 感染风险,且HPV 感染一旦出现,不仅会进一步激活STAT3信号通路,还会促使E6㊁E7致癌蛋白通路出现介导功效,是诱发宫颈癌的主要原因,致癌蛋白通过一系列途径可对细胞恶化㊁增殖与血管形成产生促进作用,提示STAT3可能参与了宫颈癌发生及发展,可将其作为宫颈癌诊断的参考指标㊂HPV16所致宫颈癌发生及发展过程中STAT3及其多态性有重要作用,临床检查工作中可作为辅助诊断指标,并为治疗方案的制定提供参考依据㊂但是,受病例数少㊁选择主观性强等因素影响,结果有待验证㊂㊃365㊃ʌ参考文献ɔ[1]㊀雷声云,吕海利,郑春艳.STAT3基因多态性与女性人乳头瘤病毒感染及宫颈病变的关系[J].中国微生态学杂志,2021,33(11):1313-1316,1325.[2]㊀范怡冰.宫颈分泌物中Stat3和Survivin的测定在宫颈病变筛查中的价值[J].中国妇幼健康研究,2018,29(9): 1123-1128.[3]㊀刘琳,沈攀,张力忆,等.宫颈病变内高危型HPV感染与Th细胞分化㊁细胞异常增殖的相关性[J].海南医学院学报,2018,24(3):315-318.[4]㊀莫小亮,覃桂荣,蒋晓莉,等.STAT3及其多态性在HPV16所致宫颈癌发生过程中的作用研究[J].中国当代医药, 2021,28(1):16-19,26.[5]㊀谢幸,孔北华,段涛.妇产科学[M].第9版.北京:人民卫生出版社,2018.278-279.[6]㊀张梦,马冬,袁腾,等.miR-135a-5p㊁GATA3和STAT3在宫颈癌中的表达及其相关性[J].肿瘤防治研究,2019,46(4):338-344.[7]㊀Gauri S,Gaurav V,Yogesh S,et al.Deregulation of microR-NAs Let-7a and miR-21mediate aberrant STAT3signalingduring human papillomavirus-induced cervical carcinogene-sis:role of E6oncoprotein[J].BMC Cancer,2019,14(6): 635-642.[8]㊀张英,邓丽娜,徐传彬.STAT3基因多态性与HPV感染及宫颈病变的关系[J].检验医学与临床,2017,14(21): 3211-3213.[9]㊀Lin W,Bowen S,Junpeng L,et al.STAT3exerts pro-tumorand anti-autophagy roles in cervical cancer[J].DiagnosticPathology,2022,17(1):258-264.[10]㊀Adrian K,Antons M,Lugo N S,et al.STAT3is a potentialtherapeutic target in cervical cancer(257)[J].GynecologicOncology,2022,166(11):259-265.[11]㊀张慧蓉,申东翔,罗敏,等.STAT3对宫颈癌HeLa细胞的增殖㊁凋亡及自噬的影响[J].实用医学杂志,2018,34(16):2653-2658.[12]㊀高和平,朱姗姗,徐福霞,等.STAT3在HPV16/18相关宫颈癌中的致病机制研究[J].中国优生与遗传杂志,2021,29(8):1083-1087.ʌ文章编号ɔ1006-6233(2024)04-0564-06慢性阻塞性肺疾病合并睡眠呼吸暂停综合征老年患者肺部感染气道炎性损伤及血清SAA CRP水平变化意义付晓培1,㊀时靖峰1,㊀腾小宝1,㊀韩明锋1,㊀曹冠亚1,㊀解明然2(1.安徽省阜阳市第二人民医院,㊀安徽㊀阜阳㊀2360152.安徽省立医院/中国科学技术大学附属第一医院胸外科,㊀安徽㊀合肥㊀230001)ʌ摘㊀要ɔ目的:探讨慢性阻塞性肺疾病(COPD)合并睡眠呼吸暂停综合征(OSAS)老年患者肺部感染㊁气道炎性损伤及血清淀粉样蛋白A(SAA)㊁C-反应蛋白(CRP)水平变化的意义㊂方法:选择2021年1月至2023年6月我院收治的120例老年COPD合并OSAS患者纳入COPD合并OSAS组,另选取本院同期收治的120例老年COPD患者纳入单纯COPD组㊂比较COPD合并OSAS组和单纯COPD组肺部感染检出率㊁血清IL-6㊁IL-10㊁IL-1β㊁COX-2和CRP㊁SAA水平;比较肺部感染和未感染患者血清指标水平;ROC分析血清CRP㊁SAA水平对COPD合并OSAS患者肺部感染的评估效能㊂结果:COPD 合并OSAS组肺部感染检出率为28.33%,高于单纯COPD组的17.50%(P<0.05);COPD合并OSAS组血清IL-6㊁IL-10㊁IL-1β㊁COX-2和血清CRP㊁SAA水平均高于单纯COPD组(P<0.05);肺部感染COPD合并OSAS患者血清CRP㊁SAA水平均显著高于未感染患者(P<0.05);ROC分析显示,血清CRP㊁SAA评估老年COPD合并OSAS患者肺部感染的AUC分别为0.834㊁0.894,联合检测评估肺部感染的AUC为0.929(P<0.05)㊂结论:老年COPD合并OSAS患者血清CRP㊁SAA和气道炎性损伤指标水平呈现异常升高趋势,血清CRP㊁SAA联合检测对老年COPD合并OSAS患者肺部感染具有最佳评估效能㊂ʌ关键词ɔ㊀慢性阻塞性肺疾病;㊀老㊀年;㊀睡眠呼吸暂停综合征;㊀肺部感染;㊀气道炎性损伤;㊀淀粉样蛋白Aʌ文献标识码ɔ㊀A㊀㊀㊀㊀㊀ʌdoiɔ10.3969/j.issn.1006-6233.2024.04.07㊃465㊃ʌ基金项目ɔ安徽省重点研究与开发计划项目,(编号:202004j07020017)。

UL Recognized UL Standard 1077Component Recognition Program as Protectors,Supplementary (Guide QVNU2,File E75596)UL Standard 508Switches,Industrial Control (Guide NRNT2,File E148683)CSA CertifiedComponent Supplementary Protector under Class 3215 30,FIle 047848 0 000CSA Standard C22.2 No. 235VDE CertifiedEN60934,VDE 0642 under File No.10537Agency CertificationsNotes for T able A:1DC and 1Ø 277 Volt ratings are 1 or 2 poles breaking. 3Ø Ratings are 3 poles breaking.2 Requires branch circuit backup with a UL LISTED Type K5 or RK5 fuse rated 15A minimum and no more than 4 times full load amps not to exceed 150A for 250 Volt rating and 125A for 277and 480 Volt ratings.3 UL Recognition and CSA Certification at 480 Volts refers to 3 and 4 pole versions, used only in a 3Ø wye connected circuit or 2 pole versions connected with 2 poles breaking 1Ø and backedup with series fusing per note 2.Table A:Lists UL Recognized and CSA and VDE Certified configurations and performance capabilities as a Component Supplementary Protector.ElectricalCURRENT RA TINGCIRCUITMAX FULL LOAD WITH WITHOUT (Inc) WITH (Icn) WITHOUTCONFIGURA TIONRA TINGFREQUENCYPHASEAMPSBACKUP FUSEBACKUP FUSEBACKUP FUSEBACKUP FUSE65DC ---0.02 - 50 ---500050001500125/25050/60 1 and 30.02 - 50 ---3000 --- ---25050/60 1 and 30.02 - 505000 ---5000150027750/6010.02 - 505000 --- --- ---480 Y 50/60 1 and 30.02 - 305000---------65DC ---0.02 - 5025050/60 1 and 30.02 - 5027750/6010.02 - 50480 Y50/6030.02 - 30480 Y 50/6010.02 - 30SWITCH ONL Y UL / CSAVDED-SERIES TABLE A: COMPONENT SUPPLEMENTARY PROTECTORVOLT AGEINTERRUPTING CAPACITY (AMPS)SERIESDesigned for snap-on-back panel rail mounting on either a 35mm x 7.5mm, or a 35mm x 15mm Symmetrical Din Rail,allowing rapid and simple mounting and removal of the breaker.It features recessed, wire-ready, touch-proof, shock-resistant ter-minals, suitable for automatic screwdriver assembly, as well as "Dead Front" construction characteristics.Available with a Visi-Rocker two-color actuator, which can be specified to indicate either the ON or the TRIPPED/OFF mode,or solid color rocker or handle type actuators. All actuator types fit in the same industry standard panel cutouts.0.02 - 50 amps, up to 480 VAC or 65 VDC, 1 - 4 poles (Handle),1 - 3 poles (Rocker), with a choice of time delays.Number of PolesRocker Type: 1-3; Handle Type: 1-4 Internal Circuit Config. Switch Only and Series Trip with cur-rent or voltage trip coils.WeighApproximately 128 grams/pole (Approximately 4.57 ounces/pole)Standard Colors Housing - Black; Actuator - See Ordering Scheme.MountingMounts on a standard 35mmSymmetrical DIN Rail (35 x 7.5 or 35x 15mm per DIN EN5002).MechanicalElectricalPhysicalEndurance10,000 ON-OFF operations @ 6 per minute; with rated Current and Voltage.Trip FreeAll D-Series Circuit Breakers will trip on overload,even when actuator is forcibly held in the ON position.Trip IndicationThe operating actuator moves posi-tively to the OFF position when an overload causes the breaker to trip.Designed and tested in accordance with requirements of specifi-cation MIL-PRF-55629 & MIL-STD-202 as follows:Shock Withstands 100 Gs,6ms,sawtoothwhile carrying rated current per Method 213,Test Condition "I".Instantaneous and ultra-short curves tested @ 90% of rated current.Vibration Withstands 0.060" excursion from10-55 Hz,and 10 Gs 55-500 Hz,at rated current per Method 204C,Test Condition A. Instantaneous and ultra-short curves tested at 90% of rated current.Moisture Resistance Method 106D,i.e.,ten 24-hourcycles @ + 25°C to +65°C,80-98%RH.Salt Spray Method 101,Condition A (90-95%RH @ 5% NaCl Solution,96 hrs).Thermal Shock Method 107D,Condition A (Fivecycles @ -55°C to +25°C to +85°C to +25°C).Operating Temperature -40°C to +85°CEnvironmental020 0.0200250.0250300.0300500.050075 0.0750800.0800850.0852100.1002150.1502200.2002250.2502300.3002350.3502400.4002450.450250 0.5002550.5502600.6002650.6502700.7002750.7502800.8002850.850410 1.000512 1.250413 1.300414 1.400415 1.500517 1.750420 2.000522 2.250425 2.500527 2.750430 3.000532 3.250435 3.500436 3.600440 4.000445 4.500547 4.750450 5.000455 5.500460 6.000465 6.5004707.0005727.2504757.5004808.0004858.5004909.0004959.500610 10.00071010.50061111.00071111.50061212.00071212.50061313.00061414.000615 15.00061616.00061717.00061818.00061919.00062020.00062121.00062222.000623 23.00062424.00062525.00062626.00062727.00062828.00062929.00063030.00063232.00063535.00064040.00064545.00065050.000A06 6 DC, 5 DC A1212 DC, 10 DC A1818 DC, 15 DC A2424 DC, 20 DC A3232 DC, 25 DC A4848 DC, 40 DC A6565 DC, 55 DC J06 6 AC, 5 AC J1212 AC, 10 AC J1818 AC, 15 ACJ2424 AC, 20 AC J4848 AC, 40 AC K20120 AC, 65 AC L40240 AC, 130 AC10Agency Approval8Actuator Color8 ACTUATOR COLOR & LEGEND Actuator orVisi-Color Marking: Marking Color: Single Color Visi-Rocker Color:I-O ON-OFF Dual Rocker/Handle (Actuator Black)8White A B 1Black White Black C D 2White n/a Red F G 3White Red Green H J 4White Green Blue K L 5White Blue Y ellow M N 6Black Y ellow Gray P Q 7Black Gray OrangeRS8Black Orange10 AGENCY APPROVAL C UL Recognized & CSA Certified D VDE Certified, UL Recognized & CSA Certified9 MOUNTING/VOLTAGEMOUNTING STYLE VOLTAGE Threaded Insert 16-32 x 0.195 inches< 300C 96-32 X 0.195 inches ≥300 2ISO M3 x 5mm< 300D 9ISO M3 x 5mm ≥3007 TERMINAL1#10 Screw & Pressure Plate for Direct Wire Connection 2#10 Screw without Pressure Plate3 POLES 1One2Two 3Three4Four5 FREQUENCY & DELA Y 03DC 50/60Hz, Switch Only 105DC Instantaneous 11DC Ultra Short 12DC Short 14DC Medium 16DC Long20550/60Hz Instantaneous 2150/60Hz Ultra Short 2250/60Hz Short 2450/60Hz Medium2650/60Hz Long32DC, 50/60Hz Short 34DC, 50/60Hz Medium 36DC, 50/60Hz Long42650/60Hz Short, Hi-Inrush 44650/60Hz Medium, Hi-Inrush 46650/60Hz Long, Hi-Inrush 527DC, Short,Hi-Inrush 547DC,Medium, Hi-Inrush 567DC, Long, Hi-Inrush4 CIRCUITA0 Switch Only (No Coil) 4B0Series Trip (Current)C0Series Trip (Voltage)1 SERIES D6Current Rating4Circuit3Poles2Actuator9Mounting/Voltage7Terminal5Frequency & Delay1SeriesNotes:1 Handle breakers available up to four poles. Rocker breakers available up to three poles.2Actuator Code:A: Multi-pole units factory assembled with common handle tie.B: Handle location as viewed from front of breaker:2 pole - left pole3 pole - center pole4 pole - two handles at center poles3Multipole rocker breakers have one rocker per breaker, as viewed from the front of thepanel. Two pole - left pole. Three pole - center pole 4≤30A, select Current Rating code 630. 31-50A, select Current Rating code 650.5Voltage coil only available with delay codes 10 & 20.6Available to 50A max with circuit code BO only.7Available to 50A (UL/CSA), 30A (VDE) with circuit code BO only.8Color shown is visi and legend with remainder of rocker black.9≥300V: Three pole breaker 3Ø or 2 pole breaker 1Ø, UL/CSA limited to 30 FLA max.10VDE Approval requires Dual (I-O, ON-OFF) or I-O markings6 CURRENT RATING (AMPERES)OR VOLTAGE COIL (VOLTS, MIN. TRIP RATING)5P0LE 3P0LE 2P0LE 1SERIES TRIP (2 TERM'S.)LINELINEROCKER ACTUATOR INDICATE "ON"HANDLE ACTUATORSWITCH ONL Y (2 TERM'S.)#10-32 SCREW AND PRESSURE PLA TE PER TERMINAL"MULTI-POLE IDENTIFICATION SCHEMENotes:1All dimensions are in inches [millimeters].2T olerance ±.015 [.38] unless otherwise specified.3-POLE(DF3) 3-POLE(DC3)REMOVALASSEMBL YNotes:1All dimensions are in inches [millimeters].2T olerance ±.015 [.38] unless otherwise specified.3Dimensions apply to all variations shown. Notice that circuit breaker line and load termi-nal orientation on indicate OFF is opposite of indicate ON.4For pole orientation with horizontal legend, rotate front view clockwise 90°.Notes:1All dimensions are in inches [millimeters].2T olerance ±.010 [.25] unless otherwise specified.。

1Product Overview1.1FeaturesThe following are key features of the MSC050SDA120S device:Low forward voltageLow leakage currentNo reverse recovery current/no forward recoveryAvalanche energy ratedRoHS compliant1.2BenefitsThe following are benefits of the MSC050SDA120S device:High switching frequencyLow switching lossesLow noise (EMI) switchingHigher reliability systemsIncreased system power density1.3ApplicationsThe MSC050SDA120S device is designed for the following applications:Power factor correction (PFC)Anti-parallel diodeSwitch-mode power supplyInverters/convertersMotor controllersFreewheeling diodeSwitch-mode power supplyInverters/convertersSnubber/clamp diode2Device SpecificationsThis section details the specifications for the MSC050SDA120S device.2.1Absolute Maximum RatingsThe following table shows the absolute maximum ratings for the MSC050SDA120S device. All ratings atT= 25 °C unless otherwise specified.CTable 1 • Absolute Maximum RatingsSymbol Parameter Ratings UnitV R Maximum DC reverse voltage1200VV RRM Maximum peak repetitive reverse voltageV RWM Maximum working peak reverse voltageI F Maximum DC forward current T = 25 °CC109AT = 135 °CC49T = 145 °CC41154I FRM Repetitive peak forward surge current (T = 25 °C, t = 8.3C pms, half sine wave)290I FSM Non-repetitive forward surge current (T = 25 °C, t = 8.3C pms, half sine wave)P tot Power dissipation T = 25 °CC429WT = 110 °CC186T , TJ STG Operating junction and storage temperature range–55 to 175°CT L Lead temperature for 10 seconds300100mJE AS Single-pulse avalanche energy (starting T = 25 °C, L = 0.08JmH, peak I = 50 A)LThe following table shows the thermal and mechanical characteristics of the MSC050SDA120S Device.Table 2 • Thermal and Mechanical CharacteristicsSymbol Characteristic Min Typ Max UnitRθJC Junction-to-case thermal resistance0.240.35°C/WWt Package weight0.14oz3.9g2.2Electrical PerformanceThe following table shows the static characteristics of the MSC050SDA120S device.Table 3 • Static CharacteristicsSymbol Characteristic Test Conditions Min Typ Max UnitV F Forward voltage I = 50 A, T = 25 °CF J 1.5 1.8VI = 50 A, T = 175 °CF J 2.1I RM Reverse leakage current V = 1200 V, T = 25 °CR J15200μAV = 1200 V, T = 175 °CR J250Q C Total capacitive charge V = 600 V, T = 25 °CR J224nCC J Junction capacitance V = 400 V, T = 25 °C, ƒ = 1 MHzR J246pFJunction capacitance V = 800 V, T = 25 °C, ƒ = 1 MHzR J1822.3Performance CurvesThis section shows the typical performance curves for the MSC050SDA120S device.Figure 1 • Maximum Transient Thermal ImpedanceFigure 2 • Forward Current vs. Forward Voltage Figure 3 • Max Forward Current vs. Case TempFigure 2 • Forward Current vs. Forward Voltage Figure 3 • Max Forward Current vs. Case TempFigure 4 • Max Power Dissipation vs. Case Temp Figure 5 • Reverse Current vs. Reverse VoltageFigure 6 • Total Capacitive Charge vs. Reverse Voltage Figure 7 • Junction Capacitance vs. Reverse VoltageThis section outlines the package specification for the MSC050SDA120S device.3.1Package Outline DrawingThis section shows the TO-268 package drawing of the MSC050SDA120S device.Figure 8 • Package Outline DrawingThe following table lists the TO-268 dimensions and should be used in conjunction with the PackageOutline Drawing.Table 4 • TO-268 DimensionsSymbol Min (mm)Max (mm)Min (in.)Max (in.)A 4.90 5.100.1930.201B15.8516.200.6240.638C18.7019.100.7360.752D 1.00 1.250.0390.049E13.8014.000.5430.551F13.3013.600.5240.535G 2.70 2.900.1060.114H 1.15 1.450.0450.057I 1.95 2.210.0770.087J0.94 1.400.0370.055Symbol Min (mm)Max (mm)Min (in.)Max (in.) K 2.40 2.700.0940.106L0.400.600.0160.024M 1.45 1.600.0570.063N0.000.180.0000.007O12.4012.700.4880.500P 5.45 BSC (nom.)0.215 BSC (nom.) Terminal 1CathodeTerminal 2CathodeTerminal 3AnodeTerminal 4CathodeMicrosemi HeadquartersOne Enterprise, Aliso Viejo,CA 92656 USAWithin the USA: +1 (800) 713-4113Outside the USA: +1 (949) 380-6100Sales: +1 (949) 380-6136Fax: +1 (949) 215-4996Email:***************************© 2019 Microsemi. All rights reserved. Microsemi and the Microsemi logo are trademarks of Microsemi Corporation. All other trademarks and service marks are the property of their respective owners.Microsemi makes no warranty, representation, or guarantee regarding the information contained herein or the suitability of its products and services for any particular purpose, nor does Microsemi assume any liability whatsoever arising out of the application or use of any product or circuit. The products sold hereunder and any other products sold by Microsemi have been subject to limited testing and should not be used in conjunction with mission-critical equipment or applications. Any performance specifications are believed to be reliable but are not verified, and Buyer must conduct and complete all performance and other testing of the products, alone and together with, or installed in, any end-products. Buyer shall not rely on any data and performance specifications or parameters provided by Microsemi. It is the Buyer's responsibility to independently determine suitability of any products and to test and verify the same. The information provided by Microsemi hereunder is provided "as is, where is" and with all faults, and the entire risk associated with such information is entirely with the Buyer. Microsemi does not grant, explicitly or implicitly, to any party any patent rights, licenses, or any other IP rights, whether with regard to such information itself or anything described by such information. Information provided in this document is proprietary to Microsemi, and Microsemi reserves the right to make any changes to the information in this document or to any products and services at any time without notice.Microsemi, a wholly owned subsidiary of Microchip Technology Inc. (Nasdaq: MCHP), offers a comprehensive portfolio of semiconductor and system solutions for aerospace & defense, communications, data center and industrial markets. Products include high-performance and radiation-hardened analog mixed-signal integrated circuits, FPGAs, SoCs and ASICs; power management products; timing and synchronization devices and precise time solutions, setting the world's standard for time; voice processing devices; RF solutions; discrete components; enterprise storage and communication solutions; security technologies and scalable anti-tamper products; Ethernet solutions; Power-over-Ethernet ICs and midspans; as well as custom design capabilities and services. Microsemi is headquartered in Aliso Viejo, California, and has approximately 4,800 employees globally. Learn more at www. .053-4091 | January 2019 | Preliminary。