Time (hours)
Insulin aspart, t = 0 min Soluble human insulin, t = 0 min Soluble human insulin, t = 30 min (0.15 U/kg)
13
Plasma Insulin µU/ml)
Ideal Basal/Bolus Insulin Absorption Pattern
Failure of oral drugs
Diet and exercise:
Appetite Sensitizers and β-cell agents: regulation: lipid-lowering agents:
Insulins:
•Type 2 diabetes is preceded by impaired glucose tolerance and occurs when the beta-
75 Breakfast Lunch
Dinner
50
25
4:00
8:00
12:00
16:00
20:00
Time
24:00
4:00 8:00
10
Insulin aspart
Pro
Asp
Tyr Thr Asp
Phe Phe Gly
Arg Glu Gly
B30
Lys
B28
Cys
Thr
A21 Asn Cys
• 1型糖尿病的预防 • 1型糖尿病的逆转
7
Strategies to Achieve Improved Glycemic Control
8
Better Designed Insulins