Far-Ultraviolet Surveys of Globular Clusters Searching for the Products of Stellar Collisio

系统医学 2023 年 12 月第 8 卷第 24期分析三联、四联药物方案治疗胃溃疡的临床效果王昌盛1，陈兰2，廖小红21.广东药科大学附属第一医院药学部，广东广州510062；2.广东三九脑科医院药剂科，广东广州510510[摘要]目的探讨胃溃疡患者选择四联药物治疗后的临床效果。

方法选取2022年1月—2023年8月广东药科大学附属第一医院收治的76例胃溃疡患者为研究对象，依据投掷硬币法分组，参照组（38例）选择三联药物治疗，研究组（38例）选择四联药物治疗，比较两组治疗总有效率、胃灼痛评分、胃溃疡面积、上腹疼痛评分、临床症状改善时间。

结果研究组治疗总有效率为97.37%，明显高于参照组，差异有统计学意义（χ2= 6.176，P<0.05）。

治疗后，研究组胃灼痛评分、胃溃疡面积、上腹疼痛评分、临床症状改善时间均低于参照组，差异有统计学意义（P均<0.05）。

结论同三联药物比较，胃溃疡患者接受四联药物治疗，可显著提升临床效果，有效改善疾病症状，可促进胃溃疡患者的良好预后。

[关键词]胃溃疡；三联药物；四联药物；疗效[中图分类号]R573 [文献标识码]A [文章编号]2096-1782（2023）12(b)-0175-03 Clinical Effect of Triple and Quadruple Drug Regimens in the Treatment of Gastric UlcerWANG Changsheng1, CHEN Lan2, LIAO Xiaohong21.Department of Pharmacy, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guang⁃dong Province, 510062 China;2.Department of Pharmacy, Guangdong Sanjiu Brain Hospital, Guangzhou, Guangdong Province, 510510 China[Abstract] Objective To investigate the clinical effect of quadruple drug therapy in patients with gastric ulcer. Methods Seventy-six patients with gastric ulcer admitted to the First Affiliated Hospital of Guangdong Pharmaceuti⁃cal University from January 2022 to August 2023 were selected as the research object and divided into groups ac⁃cording to coin tossing method. The reference group (38 cases) received triple drug therapy, and the study group (38 cases) received quadruple drug therapy. The total effective rate, the score of heartburn pain, the area of gastric ulcer, the score of upper abdominal pain and the improvement time of clinical symptoms were compared between the two groups. Results The total effective rate of the study group was 97.37%, which was significantly higher than that of the reference group, and the difference was statistically significant (χ2=6.176, P<0.05). After treatment, the score of heartburn pain, the area of gastric ulcer, the score of upper abdominal pain and the improvement time of clinical symptoms in the study group were lower than those in the reference group, and the differences were statistically sig⁃nificant (all P<0.05). Conclusion Compared with triple drug, quadruple drug treatment for gastric ulcer patients can significantly improve the clinical effect, effectively improve the disease symptoms, and promote the good prognosis of patients with gastric ulcer.[Key words] Gastric ulcer; Triple drug; Quadruple drugs; Curative effect对于胃溃疡疾病而言，其属于一种胃肠道高发病[1-2]。

·综述·Chinese Journal of Animal Infectious Diseases中国动物传染病学报摘 要：干扰素刺激基因15（ISG15）是由病原微生物或干扰素诱导产生的一种大小为15 kDa 的泛素样蛋白。

在干扰素诱导的数百个干扰素刺激基因中，ISG15是诱导最强烈、最快的ISG 蛋白之一。

研究表明，ISG15对多种病毒具有抗病毒作用。

此外，ISG15在调节宿主损伤、DNA 修复，调节信号通路及抗原递呈中也发挥着重要的作用。

文章介绍了ISG15的概况，并阐述了近年来ISG15在抗病毒、免疫调节和调节宿主信号通路过程中的作用。

关键词：干扰素刺激基因15；抗病毒作用；免疫调节中图分类号：S852.4 文献标志码：A 文章编号：1674-6422（2023）06-0170-07Molecular Mechanism of Interferon-Stimulated Gene 15 Antiviral InfectionTANG Jingyu 1, DU Hanyu 1,2, JIA Nannan 1, TANG Aoxing 1, LIU Chuncao 1, ZHU Jie 1, MENGChunchun 1, LI Chuanfeng 1, LIU Guangqing 1(1. Shanghai V eterinary Research Institute, CAAS, Shanghai 200241, China; 2. Xinjiang Agricultural University, Xinjiang 830052, China)收稿日期：2021-11-02作者简介：国家重点研发计划项目（2016YFD0500108）；中国农业科学院创新工程项目作者简介：唐井玉，女，博士研究生，预防兽医学专业通信作者：刘光清，E-mail：**************.cn干扰素刺激基因15抗病毒感染的分子机制唐井玉1，杜汉宇1,2，贾楠楠1，汤傲星1，刘春草1，朱 杰1，孟春春1，李传峰1，刘光清1（1.中国农业科学院上海兽医研究所 小动物传染病预防与控制创新团队，上海200241；2.新疆农业大学，乌鲁木齐830052）2023,31(6):170-176Abstract: Interferon-stimulated gene 15 (ISG15) is a ubiquitin-like protein of approximately 15 kDa induced by pathogenic microorganisms or interferons. Among the hundreds of interferon-stimulated genes induced by interferons, ISG15 is one of the most strongly and fastest induced ISG proteins. Studies have shown that ISG15 has antiviral effects against a variety of viruses. In addition, ISG15 plays an important role in regulating host damage, DNA repair, and regulating signaling pathways and antigen delivery. The article presented an overview of ISG15 and described the role of ISG15 in the process of antiviral, immunomodulation and regulation of host signaling pathways in recent years.Key words: Interferon-stimulated gene 15; antiviral infection; immunomodulation先天性免疫应答是抵抗入侵病原体的第一道防线，病原体可以通过宿主模式识别受体来感知。

53--植物保护·园艺园林　引用格式： 马俊青，袁国军，龚东风，等. 环境因子及栽培措施对核桃细菌性黑斑病的影响[J]. 湖南农业科学，2024（2）：53-59.　DOI:10.16498/ki.hnnykx.2024.002.011核桃（Juglansregia L.）又名胡桃，种仁含油量高，可生食，亦可榨油食用，木材坚实，是很好的硬木材料，目前在南欧、北非、东亚、美国和南美西部广泛种植。

核桃仁不仅含油量高，还含有蛋白质和多种生物活性成分，包括酚类化合物、胆固醇、生育酚和膳食纤维等[1]。

核桃叶制成的茶有血液清洁效果，有增强身体体质的作用。

绿色外果皮是核桃加工的副产品，含有一些具有抗氧化和抗微生物 作用的化合物，其研究也逐渐受到重视[2]。

核桃黑斑病（Walnut blight ）是世界范围内核桃最具破坏性的 细菌性病害之一[3]，国内外学者关于引起核桃细菌性黑斑病的病原报道主要涉及树生黄单胞菌胡桃变种（Xanthomonas arboricola pv. juglandis ）[4-7]、核桃黄极 毛杆菌（Xanthomonas campestris pv. juglandis ）[8-9]、成团泛菌（Pantoea agglomerans ）以及上述细菌的复合报道[10]。

韩国地区为变黄假单胞菌（Pseudomonas 环境因子及栽培措施对核桃细菌性黑斑病的影响 马俊青，袁国军，龚东风，卢绍辉 （河南省林业科学研究院，河南 郑州 450008）摘要： 为找出核桃黑斑病的发生与核桃品种、生长环境以及栽培措施之间的关系，调查了17个核桃品种的病情指数，生长地的海拔、地形坡度、降雨量、温度、郁闭度、地面覆盖率等环境因子，以及灌溉次数、防治次数、是否清园等栽培措施，采用主成分分析法和相关性方法分析了环境因子、栽培措施与核桃细菌性黑斑病发生的关系。

结果表明：（1）根据17个核桃品种的病情指数得出中强特勒、辽核1号、西扶为抗病品种；（2）发现核桃黑斑病病情指数与郁闭度、防治次数和是否清园具有强相关性，郁闭度为正相关，防治次数和是否清园为负相关，平均温度、地面覆盖率与病情指数为负相关。

细胞培养用青霉素-链霉素产品简介：细胞培养用青霉素-链霉素(Penicillin-Streptomycin for Cell Culture)为粉剂，是最常用的细胞培养用抗生素(即通常所谓的双抗)。

在细胞培养液中推荐的青霉素的工作浓度为100U/ml ，链霉素的工作浓度为0.1mg/ml 。

一个包装的细胞培养用青霉素-链霉素可以配制80L 细胞培养液。

保存条件：室温保存。

4ºC 保存可以使用更长时间。

注意事项：开瓶后需防止受潮。

本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。

为了您的安全和健康，请穿实验服并戴一次性手套操作。

使用说明：细胞培养用青霉素-链霉素可以参考如下两种方法之一使用：1. 配制细胞培养液时加入细胞培养用青霉素-链霉素，然后再过滤除菌：配制细胞培养液时按照青霉素的工作浓度为100U/ml ，链霉素的工作浓度为0.1mg/ml 进行配制，配制完成后过滤除菌即可使用。

2. 配制青霉素-链霉素溶液(100X)母液，然后再添加到细胞培养液中：按照青霉素的含量为10KU/ml ，链霉素的含量为10mg/ml ，配制青霉素-链霉素溶液(100X)母液。

过滤除菌后即可按照100倍稀释加入到细胞培养液中使用。

配制的母液可以-20ºC 冻存。

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郭浩，白雪媛，陈宇，等. 人参醇溶蛋白提取工艺优化、结构表征及体外抗氧化活性分析[J]. 食品工业科技，2024，45（8）：1−10. doi:10.13386/j.issn1002-0306.2023070055GUO Hao, BAI Xueyuan, CHEN Yu, et al. Optimization of the Extraction Process, Structural Characterization and Antioxidant Activity of Ginseng Alcohol Soluble Proteins[J]. Science and Technology of Food Industry, 2024, 45(8): 1−10. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023070055· 特邀主编专栏—食品中天然产物提取分离、结构表征和生物活性（客座主编：杨栩、彭鑫） ·人参醇溶蛋白提取工艺优化、结构表征及体外抗氧化活性分析郭　浩，白雪媛，陈　宇，宋文博，刘　那，王思明*（长春中医药大学东北亚中医药研究院，吉林长春 130117）摘　要：为探讨人参中醇溶蛋白提取工艺，结构表征及体外抗氧化活性，本文以人参为研究对象，采用单因素实验和响应面试验探索人参醇溶蛋白的最佳提取工艺，以紫外吸收光谱法、红外分光光度分析法、氨基酸组成、微观结构观察等方法对人参醇溶蛋白进行结构表征，并对其在不同pH 条件下的体外抗氧化活性开展一系列研究。

通过测定DPPH 自由基清除能力、羟基自由基清除能力、铁离子还原能力，评价人参醇溶蛋白的体外抗氧化活性。

结果表明，人参中醇溶蛋白最佳提取工艺为：提取时间2 h 、提取料液比1:10 g/mL 、提取pH 为7，此时人参醇溶蛋白得率为0.319%，蛋白含量为75%。

盐酸克伦特罗检测方法的研究进展获奖科研报告论文摘要: 近年来, 食品安全受到社会高度重视, 盐酸克伦特罗在临床上用于支气管扩张, 可用于临床哮喘治疗, 支气管炎症治疗等, 属于肾上腺素兴奋剂。

在动物饲料中加入该物质能够提高瘦肉率, 因此很多不法商家利用该物质提高肉畜的品质, 然而残留于动物体内的该物质会导致食用人群出现不同程度的中毒, 甚至会出现中毒死亡。

目前, 国内外针对盐酸克伦特罗的含量研究, 包括高效液相色谱法, 气质联用, 气相色谱法, 酶联免疫测定法等多种方法。

在本次研究中我们针对近几年常用的检测方法对该物质进行方法检测研究。

关键字：盐酸克伦特罗;检测;方法;进展近年来, 随着社会经济建设的发展使得畜牧业也得到了相应的发展, 在生产过程中由于非法添加药物而导致兽药残留问题严重, 而兽药残留会严重危害到人们的身体健康, 因此人们高度重视食品安全问题。

在畜牧业中过量使用盐酸克伦特罗能够提高饲料转化率、提高瘦肉率, 但该物质属于兴奋类药物, 如果长期服用该药物可能会使人体出现头晕、四肢麻木、恶心等症状, 甚至危及生命。

因此, 我国明文规定畜牧业养殖不允许采用此物质, 但很多商家为牟取非法利益, 过量使用该物质导致消费者出现中毒的现象, 因此有必要针对盐酸克伦特罗的残留量进行检测分析, 在本次研究中我们针对几种检测方法进行比较, 能够对今后发展进行展望。

一、盐酸克伦特罗性质分析首先该物质是属于肾上腺素的激动剂, 也被称为是瘦肉精。

从药学上认为是双氯醇胺, 分子量為313.65, 在常温状态下是白色或微黄色的粉末状结构, 无臭, 味苦, 极易溶于水、乙醇、甲醇、微溶于丙酮、氯仿、不溶于苯。

其化学性质活泼, 可通过多种化学反应形成化合物。

二、检测方法当前针对该物质的检测方法包括生物、理化以及免疫学检测, 其中理化检测中包括高效液相分析、气质联用、毛细管电泳法;免疫学检测包括酶联免疫、滴金免疫层析、免疫荧光检测、放射性免疫等。