ALK:J-ALEX更新,Brigatinib 后线
ROS1:Repotrectinib
C-met:Tepotinib,Capmatinib
RET:BLU-667
Her-2:吡咯替尼
B-raf:
NTRKs:
2020/4/30
4
主要内容
NCCN指南推荐检测八个基因+K-RAS
EGFR:
Med.2010;362:2380–8; Mok T, et al. N Engl J Med.2009; 361:947–57; Mitsudomi T, et al. Lancet Oncol.2010;11:121–8; Rosell R, et ncet Oncol.2012;13:239–46; Sequist LV, et
al. J Clin Oncol.2013;31:3327–34; Soria JC, et al. N Engl J Med. 2018 Jan 11;378(2):113-125. Wu YL, et al. Lancet Oncol.2014;15:213–22; Wu YL, et al. Ann Onc.2015; Ann
克服耐药:JNJ-372,U3-1402,
延缓耐药: RELAY研究,化疗+TKI,9291+A
EGFR-20插入: JNJ-372, TAK788
K-RAS:AMG510,曲美替尼+多西他赛
ALK:J-ALEX更新,Brigatinib 后线
ROS1:Repotrectinib
C-met:Tepotinib,Capmatinib
42
月
ARCHER-1050
中位数,月
HR(95% CI) p值