GB 206952006 高效氯氟氰菊酯原药

高效氯氟氰菊酯结构式-概述说明以及解释1.引言1.1 概述随着农药行业的发展，高效氯氟氰菊酯作为一种新型的杀虫剂受到了广泛关注。

它具有较高的杀虫活性和较长的持效期，被广泛应用于农业生产中的害虫防治。

高效氯氟氰菊酯的化学结构独特，通过对害虫的神经细胞进行破坏，达到杀虫的效果。

同时，高效氯氟氰菊酯的制备方法也越来越成熟，使其生产成本逐渐降低，提高了农业生产的效益。

然而，随着高效氯氟氰菊酯的广泛使用，也引发了一些争议。

一方面，高效氯氟氰菊酯对害虫的杀灭效果显著，能有效减少农作物受害面积，提高农产品的质量和产量。

另一方面，高效氯氟氰菊酯也对环境和人体产生一定的影响。

长期以来，高效氯氟氰菊酯在环境中的残留问题备受关注，其超标使用不仅会对农田土壤和水源造成污染，还会对生态系统产生破坏。

此外，高效氯氟氰菊酯在农作物生长过程中的残留也可能对人体健康造成潜在风险。

因此，在广泛应用高效氯氟氰菊酯的同时，我们也需要重视其对环境和人体的影响，并积极探索替代品或绿色防治方式，以达到农业生产的可持续发展目标。

通过加强监管措施，合理使用农药，并注重环境保护与人体健康，我们可以更好地发挥高效氯氟氰菊酯的优势，为农业生产做出贡献。

文章结构是指文章的组织框架，它能够使读者便于阅读和理解文章内容。

本文主要包括以下几个部分：1. 引言：- 1.1 概述：介绍高效氯氟氰菊酯的基本背景和相关概念。

- 1.2 文章结构：说明文章的组织框架和各个部分的内容。

- 1.3 目的：阐明撰写本文的目的和意义。

2. 正文：- 2.1 高效氯氟氰菊酯的化学结构：详细介绍高效氯氟氰菊酯的化学结构、分子式以及分子量等相关信息。

- 2.2 高效氯氟氰菊酯的制备方法：探讨高效氯氟氰菊酯的制备工艺、原料选择、反应条件等方面的内容。

3. 结论：- 3.1 高效氯氟氰菊酯的应用前景：讨论高效氯氟氰菊酯在农业领域的广泛应用，以及未来的研究方向和发展趋势。

- 3.2 对环境和人体的影响：分析高效氯氟氰菊酯在使用和生命周期中可能对环境和人体带来的潜在影响，以及可能的防护措施和风险评估。

EUROPEAN COMMISSIONDIRECTORATE-GENERAL HEALTH & CONSUMER PROTECTIONDirectorate E - Public, animal and plant healthUnit E1 Legislation relating to crop products and animal nutritionlambda-cyhalothrin7572/VI/97-final25 January 2001Review report for the active substance lambda-cyhalothrin Finalised in the Standing Committee on Plant Health at its meeting on 19 October 2000 in view of the inclusion of lambda-cyhalothrin in Annex I of Directive 91/414/EEC1.Procedure followed for the re-evaluation processThis review report has been established as a result of the re-evaluation of lambda-cyhalothrin, made in the context of the work programme for review of existing active substances provided for in Article 8(2) of Directive 91/414/EEC concerning the placing of plant protection products on the market, with a view to the possible inclusion of this substance in Annex I to the Directive.Commission Regulation (EEC) No 3600/92(1) laying down the detailed rules for the implementation of the first stage of the programme of work referred to in Article 8(2) of Council Directive 91/414/EEC, as last amended by Regulation (EC) No 1972/992, has laid down the detailed rules on the procedure according to which the re-evaluation has to be carried out. lambda-Cyhalothrin is one of the 90 existing active substances covered by this Regulation. In accordance with the provisions of Article 4 of Regulation (EEC) No 3600/92, Zeneca Agrochemicals on 27 July 1993 and Stefes Pflanzenschutz GmbH on9 and 20 July 1993 notified to the Commission of their wish to secure the inclusion of the active substance lambda-cyhalothrin in Annex I to the Directive.In accordance with the provisions of Article 5 of Regulation (EEC) No 3600/92, the Commission, by its Regulation (EEC) No 933/94(3), as last amended by Regulation (EC) No 2230/95(4), designated Sweden as rapporteur Member State to carry out the assessment of lambda-cyhalothrin on the basis of the dossiers submitted by the notifiers. In the same Regulation, the Commission specified furthermore the deadline for the notifiers with regard to the submission to the rapporteur Member States of the dossiers required under Article 6(2) of1 OJ No L 366, 15.12.1992, p.10.2 OJ No L 244, 16.9.1999, p. 41.3 OJ No L 107, 28.04.1994, p.8.4 OJ No L 225, 22.09.1995, p.1.Regulation (EEC) No 3600/92, as well as for other parties with regard to further technical and scientific information; for lambda-cyhalothrin this deadline was 30 April 1995.Only Zeneca Agrochemicals submitted a dossier to the rapporteur Member State which was considered as complete. Stefes Pflanzenschutz GmbH did not submit a dossier.In accordance with the provisions of Article 7(1) of Regulation (EEC) No 3600/92, Sweden submitted on 12 June1996 to the Commission the report of its examination, hereafter referred to as the draft assessment report, including, as required, a recommendation concerning the possible inclusion of lambda-cyhalothrin in Annex I to the Directive. Moreover, in accordance with the same provisions, the Commission and the Member States received also the summary dossier on lambda-cyhalothrin from Zeneca Agrochemicals, on 31 July 1996.In accordance with the provisions of Article 7(3) of Regulation (EEC) No 3600/92, the Commission forwarded for consultation the draft assessment report to all the Member States as well as to Zeneca Agrochemicals being the main data submitter, on 24 June 1996.The Commission organised an intensive consultation of technical experts from a certain number of Member States, to review the draft assessment report and the comments received thereon (peer review), in particular on each of the following disciplines:-identity and physical /chemical properties ;-fate and behaviour in the environment ;-ecotoxicology ;-mammalian toxicology ;-residues and analytical methods ;-regulatory questions.The meetings for this consultation were organised on behalf of the Commission by the Pesticide Safety Directorate (PSD) in York, United Kingdom, from September to December 1996.The report of the peer review (i.e. full report)was circulated, for further consultation, to Member States and the main data submitter on 13 January 1997 for comments and further clarification.In accordance with the provisions of Article 7(3) of Regulation (EEC) No 3600/92, the dossier, the draft assessment report, the peer review report (i.e. full report)and the comments and clarifications on the remaining issues, received after the peer review were referred to the Standing Committee on Plant Health, and specialised working groups of this Committee, for final examination, with participation of experts from the 15 Member States. This final examination took place from February 1998 to August 2000, and was finalised in the meeting of the Standing Committee on 19 October 2000.The present review report contains the conclusions of this final examination; given the importance of the draft assessment report, the peer review report (i.e. full report) and the comments and clarifications submitted after the peer review as basic information for the final examination process, these documents are considered respectively as background documents A, B and C to this review report and are part of it.These documents were also submitted to the Scientific Committee for Plants for separate consultation. The report of this Committee was formally adopted on 29 February 20005).2. Purposes of this review reportThis review report, including the background documents and appendices thereto, have been developed and finalised in support of the Directive 2000/80/EC concerning the placing of plant protection products on the market, so as to consolidate that Annex and include a further active substance (lambda-cyhalothrin), and to assist the Member States in decisions on individual plant protection products containing lambda-cyhalothrin they have to take in accordance with the provisions of that Directive, and in particular the provisions of article 4(1) and the uniform principles laid down in Annex VI.This review report provides also for the evaluation required under Section A.2.(b) of the above mentioned uniform principles, as well as under several specific sections of part B of these principles. In these sections it is provided that Member States, in evaluating applications and granting authorisations, shall take into account the information concerning the active substance in Annex II of the directive, submitted for the purpose of inclusion of the active substance in Annex I, as well as the result of the evaluation of those data.In accordance with the provisions of Article 7(6) of Regulation (EEC) No 3600/92, Member States will keep available or make available this review report for consultation by any interested parties or will make it available to them on their specific request. Moreover the Commission will send a copy of this review report (not including the background documents) to all operators having notified for this active substance under Article 4(1) of this Regulation.The information in this review report is, at least partly, based on information which is confidential and/or protected under the provisions of Directive 91/414/EEC. It is therefore recommended that this review report would not be accepted to support any registration outside the context of Directive 91/414/EEC, e.g. in third countries, for which the applicant has not demonstrated to have regulatory access to the information on which this review report is based.3.Overall conclusion in the context of Directive 91/414/EECThe overall conclusion from the evaluation is that it may be expected that plant protection products containing lambda-cyhalothrin will fulfil the safety requirements laid down in Article 5(1)(a) and (b) of Directive 91/414/EEC. This conclusion is however subject to compliance with the particular requirements in sections 4, 5, 6 and 7 of this report, as well as to the implementation of the provisions of Article 4(1) and the uniform principles laid down in Annex VI of Directive 91/414/EEC, for each lambda-cyhalothrin containing plant protection product for which Member States will grant or review the authorisation.Furthermore, these conclusions were reached within the framework of a range of uses, which were proposed and supported by the main data submitter, as outlined in Background documentC of this report.5 Opinion of the scientific Committee on Plants regarding the inclusion of lambda-cyhalothrin in Annex I to Council Directive 91/414/EEC concerning the placing of plant protection products on the market. SCP/LAMBDA/002-Final.Extension of the use pattern beyond those reviewed will require an evaluation at Member State level in order to establish whether the proposed extensions of use can satisfy the requirements of Article 4(1) and of the uniform principles laid down in Annex VI of Directive 91/414/EEC. With particular regard to residues, the review has established that the residues arising from the proposed uses, consequent on application consistent with good plant protection practice, have no harmful effects on human or animal health. The Theoretical Maximum Daily Intake (TMDI; excluding water and products of animal origin) for a 60 kg adult is 30 % of the Acceptable Daily Intake (ADI), based on the FAO/WHO European Diet (August 1994). Provisional estimates of acute dietary exposure of adults and toddlers revealed that the Acute Reference Dose (ARfD) might be exceeded for few, individual commodities6. These possible exceedances should be addressed in the framework of Council Directive 90/642/EEC on the setting of maximum residues of pesticides in fruit and vegetables.The review has identified several acceptable exposure scenarios for operators, workers and bystanders, which require however to be confirmed for each plant protection product in accordance with the relevant sections of the above mentioned uniform principles.The review has also concluded that under the proposed and supported conditions of use there are no unacceptable effects on the environment, as provided for in Article 4 (1) (b) (iv) and (v) of Directive 91/414/EEC, provided that certain conditions are taken into account as detailed in section 6 of this report.4.Identity and Physical/chemical propertiesThe main identity and the physical/chemical properties of lambda-cyhalothrin are given in Appendix I.The active substance shall comply with the FAO specification and there seem not to be reasons for deviating from that specification; the FAO specification is given in Appendix I of this report. The review has established that for the active substance notified by the main data submitter Zeneca Agrochemicals, none of the manufacturing impurities considered are, on the basis of information currently available, of toxicological or environmental concern.5.Endpoints and related informationIn order to facilitate Member States, in granting or reviewing authorisations, to apply adequately the provisions of Article 4(1) of Directive 91/414/EEC and the uniform principles laid down in Annex VI of that Directive, the most important endpoints as identified during the re-evaluation process are set out under point 1 above. These endpoints are listed in Appendix II.6Adults: Spinach; Toddlers: Apples, pears, grapes, spinach. Worst case estimates on the basis of provisional residue data.6.Particular conditions to be taken into account on short term basis by MemberStates in relation to the granting of authorisations of plant protection products containing lambda-cyhalothrinOn the basis of the proposed and supported uses, the following particular issues have been identified as requiring particular and short term attention from all Member States, in the framework of any authorisations to be granted, varied or withdrawn, as appropriate:- Member States in granting authorisations must pay particular attention to the operator safety and must ensure that the conditions of authorisation include appropriate protective measures.- Member states should observe the acute dietary exposure situation of consumers in view of future revisions of Maximum Residue Levels.- For the protection of aquatic organisms, risk mitigation measures should be applied where appropriate.- For the protection of bees Member States should prescribe appropriate risk mitigation measures (e.g. buffer zones) if products containing lambda-cyhalothrin are applied at high doses.- Depending on crop and application rate, Member States should prescribe appropriate risk mitigation measures to avoid unacceptable effects on non-target arthropods when authorisations are granted for plant protection products containing this active substance.7.List of studies to be generatedNo further studies were identified which at this stage were considered necessary in relation to the inclusion of lambda-cyhalothrin in Annex I under the current inclusion conditions.Some endpoints however may require the generation or submission of additional studies to be submitted to the Member States in order to ensure authorisations for use under certain conditions. This may particularly be the case for- residue data supporting the current critical GAP, and- further laboratory and/or field studies on bees and non-target arthropods.rmation on studies with claimed data protectionFor information of any interested parties, Appendix III gives information about the studies for which the main data submitter has claimed data protection and which during the re-evaluation process were considered as essential with a view to annex I inclusion. This information is only given to facilitate the operation of the provisions of Article 13 of Directive 91/414/EEC in the Member States. It is based on the best information available to the Commission services at the time this review report was prepared; but it does not prejudice any rights or obligations of Member States or operators with regard to its uses in the implementation of the provisions of Article 13 of the Directive 91/414/EEC neither does it commit the Commission.9.Updating of this review reportThe technical information in this report may require to be updated from time to time in order to take account of technical and scientific developments as well as of the results of the examination of any information referred to the Commission in the framework of Articles 7, 10 or 11 of Directive 91/414/EEC. Such adaptations will be examined and finalised in the Standing Committee on Plant Health, in connection with any amendment of the inclusion conditions for lambda-cyhalothrin in Annex I of the Directive.APPENDIX IIdentity, physical and chemical properties lambda-CYHALOTHRINMelting point49.2 °C (322.4 K)Boiling point No measurable boiling point (decomposes) Appearance Beige solid without any characteristic odour (technicalgrade)Relative density 1.33 g/cm3 (1330 kg/m3) at 25 °CVapour pressure 2 · 10-7 Pa at 20 °C (extrapolated)Henry's law constant0.02 Pa⋅m3·mol-1 at 20 °CSolubility in water At 20 °C:pH 5: 4 · 10-3 mg/lpH 6.5: 5 · 10-3 mg/lpH 9.2: 4 · 10-3 mg/lSolubility in organic solvents At 21 °C:hexane, toluene, dichloromethane, methanol, acetoneand ethyl acetate: > 500 g/lPartition co-efficient (log P OW)log P OW = 7.0Hydrolytic stability (DT50)There is no significant hydrolysis at pH 5.2 and 6.9.After 7 days at pH 9.0, 43 – 45 % of PP321 remainsintact, thus half-life is approximately 7 days. Dissociation constant Not applicable0.092 (at wavelengths 270-290 nm)Quantum yield of direct photo-transformation in water:acetonitrileFlammability Flammability, in terms of flash point: 83 ± 2ºC(substance heated before test)Explosive properties Not explosive (expert judgement based on structure) UV/VIS absorption (max.)Two absorption maxima, at 210 nm and 275-280 nm,with an absorption tail up to 300 nm.Photostability (DT50)Indicated DT50 in water 13 days (latitudes 40 and 50°N).Average quantum yield at 270-290 nm 0.092.Calculated DT50 in European waters 5 days (summer) to75 days (winter).Calculated photochemical oxidative DT50 in air 4.1 h.10 November 2000APPENDIX IIEND POINTS AND RELATED INFORMATIONlambda-CYHALOTHRIN1 Toxicology and metabolismAbsorption, distribution, excretion and metabolism in mammalsRate and extent of absorption:Oral, < 2 d man, 50 %Distribution:Wide, with concentration in adipose tissuePotential for accumulation:Half-life: 23 dRate and extent of excretion: 2 d, 90 %Toxicologically significant compounds:ParentMetabolism in animals:Mainly by cleavage of ester bond and furthertransformation to conjugated metabolitesAcute toxicityRat LD50 oral:LD50 = 56 (f) - 79 (m) mg/kg bw R25 Rat LD50 dermal:LD50 = 632 (m) – 696 (f) mg/kg bw R21 Rat LC50 inhalation:LC50 = 0.06 mg/l R26 Skin irritation:Slight irritation. Non-irritant according to criteria. Eye irritation:Slight irritation. Non-irritant according to criteria.Sensitisation (test method used and result):Not sensitising at a 1% challenge dose. Higher doses not possible due to paraesthesiaGuinea pig maximisation testShort term toxicityTarget / critical effect:Organs liver, CNSLowest relevant oral NOAEL / NOEL:0.5 mg/kg bw/d, oral, 1 y dog Lowest relevant dermal NOAEL /NOEL:No study available10 November 2000 Lowest relevant inhalation NOAEL /NOEL:No study availableGenotoxicity NegativeLong term toxicity and carcinogenicityTarget / critical effect:LiverLowest relevant NOAEL:NOEL 1.7 mg/kg bw/d, 2 y rat (cyhalothrin) Carcinogenicity:NegativeReproductive toxicityTarget / critical effect - Reproduction:Negative. Parental, slightly reduced bw gain andslightly reduced bw gain of the pups.Lowest relevant reproductive NOAEL / NOEL:NOEL 1.5 mg/kg bw/d (parental) NOEL 1.5 mg/kg bw/d (foetal)Target / critical effect - Developmental toxicity:Negative. No treatment related embryotoxic or teratogenic effects were observed.Lowest relevant developmental NOAEL / NOEL:NOEL 10 mg/kg bw/d based on maternal toxicity (decreased bw gain and loss of limb coordination).Delayed neurotoxicity Not relevantOther toxicological studies NoneMedical data Information suppliedSummaryValue Study Safety factor ADI:0.005 mg/kgbw/d1 y dog100AOEL systemic:0.0025 mg/kgbw/d 1 y dog(50 % oral absorption)100AOEL inhalation:AOEL dermal:ARfD (acute reference dose):0.0075 mg/kg bw6-week oral dogstudy; NOEL0.75 mg/kg bw1001. Toxicology and metabolism10 November 2000 Dermal absorption12 % EC formulation, in-use dilution: 4 %, in vivo rat5 % EC formulation, in-use dilution: <0.3%, in vivoman5 % EC formulation, in-use dilution: 0.055%, in vitroman0.3% used for model calculations (concentrate anddilution) (See Doc. 5684/VI/97-app.4)23 November 20002 Fate and behaviour in the environment2.1 Fate and behaviour in soil Route of degradationAerobic:Mineralization after 100 days:Non-extractable residues after 100 days:Relevant metabolites above 10 % of applied active substance: name and/or code % of applied rate (range and maximum)Supplemental studies Anaerobic:Soil photolysis:NegligibleRemarks:Rate of degradationLaboratory studies7Compound XV: (RS)-α-cyano-3-(4-hydroxyphenoxy)benzyl-(Z)-(1RS)-cis-3-(2-chloro-3, 3, 3-trifluoropropenyl)-2, 2-dimethylcyclopropanecarboxylate. (IUPAC)8Compound Ia (cyclopropane acid): (Z)-3-(2-chloro-3, 3, 3-trifluoropropenyl)-2, 2-dimethylcyclopropanecarboxylic acid. (IUPAC)9Compound V: 3-phenoxybenzoic acid. (IUPAC)23 November 2000DT 50lab (20 °C, aerobic):DT 90lab (20 °C, aerobic):DT 50lab (10 °C, aerobic):DT 50lab (20 °C, anaerobic):Field studies (country or region)US and Germany:Detected in the upper 10 cm of soil,< 4 % below 5 cm depthDT 50f from soil dissipation studies:Germany: 6, 26, 28, 40 d (best fit model)US study I: 2, 37 d (best fit model)US study II: 19, 20, 21, 35 d (best fit model)Mean 23 d (n=10)DT 90f from soil dissipation studies:Germany: 68, 85, 92, 207 d (best fit model)US study I: approx. 30, > 279 d (graphical)US study II: 62, 67, 108, 117d (best fit model)Mean 112 days (n=10)Soil accumulation studies:Not submitted, not required Soil residue studies:Not submitted, not requiredRemarksUS study I used 14C-cyclopropane and 14C-phenyl label; bound residues as 22-32% after 115 days,and as 17-27% after 279 days.Adsorption/desorptionK f / K oc :K dpH dependence:Mobility10DT 50s for soil metabolite XV inserted as agreed by Working Group Legislation, October 2000. Data provided by CTB (The Netherlands), not evaluated by the RMS. DT 50s in original report were 4, 3 and 4 days but recalculated into the figures in the table by CTB, assuming first order kinetics (r 2 0.75-0.96).11Kom values for soil metabolite XV inserted as agreed by Working Group Legislation, October 2000. Data provided by CTB (The Netherlands), not evaluated by the RMS. Koc values in original report were 60000, 67000,68000, 75000, 78000 and 110000, but recalculated into the values in the table by CTB.23 November 2000Laboratory studies:Column leaching:No significant leachingAged residue leaching:No significant leachingField studies:Lysimeter/Field leaching studies:Not submitted, not requestedNo leaching in field dissipation studies Remarks:None2.2 Fate and behaviour in waterAbiotic degradationHydrolytic degradation:Relevant metabolites:Photolytic degradation:Relevant metabolites:Biological degradationReady biological degradability:Not submitted, not requestedWater/sediment study:DT50 water:DT50 whole system:DT90 water:DT90 whole system:Distribution in water / sediment systems (active substance)at 20 °C, 2 systems, pH 7.2-7.8:5 and 11 h15 and 7 days3.3 and4.6 days151 and 45 daysParent compound, as % of applied radioactivity in the two water/sed. systems:Day 0Day 1Day 7 Water72/4910/13 3.7/2.6 Sediment14/3070/3053/4312Compound Ia (cyclopropane acid): (Z)-3-(2-chloro-3, 3, 3-trifluoropropenyl)2, 2-dimethylcyclopropanecarboxylic acid. (IUPAC).13Compound IV: 3-phenoxybenzaldehyde. (IUPAC)14Compound V: 3-phenoxybenzoic acid. (IUPAC)23 November 2000(metabolites)Accumulation in water and/or sediment:Degradation in the saturated zone Not submitted, not requestedRemarks:None2.3 Fate and behaviour in airVolatilityVapour pressure: 2 · 10-7 Pa at 20 °C (extrapolated)Henry's law constant:0.02 Pa m3·mol-1 at 20 °CPhotolytic degradationDirect photolysis in air:Not submitted and not requested, but possibletheoretically due to absorption ”tail” to 300 nm. Photochemical oxidative degradation in air:DT50 4.1 h (calculated)Volatilisation:Volatilisation from soil not significant, fromleaves low rate of volatilisation observed (88% ofapplied amount remaining on leaves after 24hours).15Compound VI: 3-phenoxybenzylalcohol. (IUPAC)16Compound XV (hydroxylated lambda-cyhalothrin): (RS)-α-cyano-3-(4-hydroxyphenoxy)benzyl-(Z)-(1RS)-cis-3-(2-chloro-3, 3, 3-trifluoropropenyl)-2, 2-dimethylcyclopropanecarboxylate. (IUPAC)23 November 2000 Remarks:None24 October 2000 3 EcotoxicologyTerrestrial VertebratesAcute toxicity to mammals:LD50 = 20 mg/kg bw (mice)Acute toxicity to birds:LD50 > 3950 mg/kg bw (mallard duck)Dietary toxicity to birds:LC50 > 5300 mg/kg food (bobwhite quail) Reproductive toxicity to birds:NOEC > 30 mg/kg food (mallard duck)Short term oral toxicity to mammals:NOEL = 0.7 mg/kg bw/day (male rat, 90-day) Aquatic OrganismsAcute toxicity fish:Long term toxicity fish:Bioaccumulation fish:Acute toxicity invertebrate:Acute toxicity algae:Chronic toxicity sediment dwellingorganism:17Compound Ia (cyclopropane acid): (Z)-3-(2-chloro-3, 3, 3-trifluoropropenyl)2, 2-dimethylcyclopropanecarboxylic acid. (IUPAC).18Compound V: 3-phenoxybenzoic acid. (IUPAC)24 October 2000Results from mesocosm studies:Mesocosm study I (UK):Gammaridae most sensitive taxa:LOEC: 4 events of overspray at 0.17 g/haChironomidae, less sensitive:NOEC: 4 events of overspray at 1.7 g/ha Mesocosm study II (US):Insecta most sensitive taxa:NOAEC: 12 events of overspray at 0.017 g/ha +6 events of run-off at 0.05 g/haFish, L. macrochirus, and sedentary chironomidswere less sensitive:NOEC: 12 events of overspray at 1.7 g/ha + 6events of run-off at 5 g/haHoneybeesAcute oral toxicity:LD50 (48 h) = 0.91 µg/beeAcute contact toxicity:LD50 (48 h) = 0.038 µg/beeField study in cereals:Preliminary results indicate NOAEC = 20 g/haOther arthropod speciesFoliage dwellers:Rhopalosiphum padi LD50 (6 d) 0.004 µg/g bw, contact exposure Leptyphantes spp. (m)LD50 (6 d) 0.097 µg/g bw, contact exposure Leptyphantes spp. (f)LD50 (6 d) 0.132 µg/g bw, contact exposure Bathyphantes spp. (f)LD50 (6 d) 0.012 µg/g bw, contact exposure Oedothorax spp. (m)LD50 (6 d) 0.058 µg/g bw, contact exposure Panonychus ulmi LD50 (48 h) 1.9 g/haTyphlodromus pyri LD50 (48 h) 0.2 g/haEpisyrphus balteatus27% larval mortality after 6 days at 9 g/haSoil dwellers:Trechus quadristriatus LD50 (6 d) 12.1 µg/g bw, contact exposure Pterostichus melanarius23% mortality after 28 days at 7.5 g/ha Poecilus cupreus0-10% mortality after 28 days at 7.5 g/ha Pardosa sp.90% mortality after 14 days at 7.5 g/ha Pardosa spp.83-87% mortality after 14 days at 7.5 g/ha24 October 2000Field study, autumn application in cereals, UK, at 5 g/ha:Mean depression in abundance of affected species was 20-60% and lasted for 4-5 weeks.Field study, summer application in cereals, UK, at 7 g/ha:Mean depression in abundance of affected species was 75% and lasted for 27±6 days.Field study, summer application in cereals, UK, at 2.5, 5 and 10 g/ha:Depression in abundance of the species affected lasted for 1-7 weeks with no statistically significant effects remaining 7 weeks after spraying. Increased selectivity was seen at reduced rates.Field studies in non-European countries:Recovery after 3 weeks.EarthwormsAcute toxicity:LC50 (14 d) > 1000 mg/kg soilNOEC = 100 mg/kg soilReproductive toxicity:Not submitted, not requestedSoil micro-organismsNitrogen mineralization:< 21% effect on ammonification/nitrification at1.25 kg/haCarbon mineralization:No significant effects at 1.25 kg/haList of studies24 October 2000APPENDIX IIIlambda-CYHALOTHRINList of studies for which the main submitter has claimed data protection and which during the re-evaluation process were considered as essential for the evaluation with a view to Annex I inclusion19.B.1 Identity, B.2 Physical and chemical properties, B.3 Data on application and further information,B.4 Proposals for classification and labelling, B.5 Methods of analysis19List based on a detailed analysis from Sweden in its submission of XX/XX/XX (background document C).20 Reports received from the notifier at the date of finalisation of the present review report (not exhaustive).Annex point/ reference number Author(s)Year TitleSource (where different from company)Company, Report No.GLP or GEP status (where relevant)Published or notReports20 onprevious use ingranting nationalauthorizationsAII 2.9.1 AII 7.2.1.1Collis WMD andLeahey JP1984PP321: Hydrolysis in Water at pH 5, 7 and 9.ICI Report series RJ 0338B.GLP studyNot publishedAustria (18/7/91),Germany(25/10/90),UK (14/2/1990),the Netherlands.AII 2.9.2 AII 2.9.3 AII 7.2.1.2Moffatt F1994lambda-Cyhalothrin: Environmental Half-lifeand Quantum Yield for DirectPhototransformation in Aqueous Solution.Zeneca Report Series RJ 1617B.GLP studyNot publishedAII 2.9.2 AII 7.2.1.2Priestley DB andLeahey JP1988PP321: Aqueous Photolysis at pH 5.ICI Report Series RJ 0605B.GLP studyNot publishedGermany(25/10/90),the Netherlands.AII 2.10Hayes SE1998Lambda-cyhalothrin - calculation of half-life byreaction with atmospheric hydroxyl radicals.Zeneca G:\AOP+lambda-cyhalothrin.AOP.GLP not relevantNot publishedAII 4.1Duffin MR1994The determination of lambda-cyhalothrin andassociated impurities in technical material bycapillary gas chromatography.Zeneca Agrochemicals Analytical MethodPAM 721/3.Not GLP studyNot publishedAII 4.2Hadfield ST, SadlerJ andBolygo E 1989The determination of residues of PP321 in water following sampling by a solid-phaseextraction technique.ICI Agrochemical Residue Analytical MethodNumber 125b.Not GLP studyNot publishedAII 4.2Marsh JR1995Determination of lambda-cyhalothrin in humanblood.Zeneca Central Toxicology Laboratory ReportNo. CTL/R/1241.Not GLP studyNot publishedAII 4.2Ryan J and Sapiets A1993Lambda-cyhalothrin: Validation of a steppedmodel to determine residues in air.Zeneca Agrochemicals Jealott´s Hill ResearchStation Report No. RJ1525B.GLP studyNot published。

化学品安全数据单一、标识
四、急救措施
九、物理及化学性质
十、稳定及反应性
十三、处置考虑
注1：当产品为含有两种以上危险物质的混合物时，应依据其混合后的危险性，制作安全数据单。

注2：制造商/供应商应根据实际情况确保安全数据单所含信息的正确性，并适时更新。

注3：如由于产品特性而不存在或不可得某些信息时（如固体不存在沸点），应在表格中以“/”标识。

第1页，共5页Chemical Safety Data Sheet
Note 1: When products contain two or more hazardous substances, Safety Data Sheets should be prepared based on the risk of the mixture.
Note 2: Manufacturer / supplier should ensure the correctness of the information contained in the safety data sheets, and updated in a timely manner.
Note 3: As a result of product features without the existence of certain information (such as boiling point does not exist for the solid) in the table with "/" logo.。

高效氯氟氰菊酯—搜狗百科化学名称：3-(2-氯-3,3,3-三氟丙烯基)-2,2-二甲基环丙烷羧酸α-氰基-3-苯氧苄基酯曾用名：高效氯氟氰菊酯、毒特星、功乐、攻关、功千、功勋、功禾、功锐、功星、功令、功浚、功特、攻猎、功将、功倒、攻索、功高、攻害、功力、功灿、功卡、功灭、金功、银功、立功、顶渺、好功、美功、森功、闪功、展功、广功、澳功、捷功、尊功、领功、稳功、爱功、极功、硬功、迅功、神功、易攻、至功、胜功、炫功、玄宝功、傲功、扑功、强攻、强弩、当关、飞红、红箭、惊彩、彩地、日高防、高发、高兰、高福、共福、泰龙、彪、劲彪、彪戈、英瑞、连斗、斗盎、斗魁、雷帅、碧宝、喷金、金登、金菊、鑫碧、氟虎、暂星、铁骑、铁腕、美赛、赛镖、擒敌、更富、荣茂、闪点、万凯、万祥、万巧、巧克、巧杀、砍杀、统杀、统宁、冲锋、巅逢、封害、狂纵、多击、击破、击断、米格、翠浓、务农、天戟、天矛、天弓、天菊、无患、刚劲、劲跑、劲夫、胜夫、夫伏、强悍、强镇、丝抑、顶秀、希利、真迅、迅拿、迅奇、奇猛、怒猛、蔬香、添翼、力鼎、透拿、速征、森戈、稼尊、震死、植喜、傲申、跃成、方捕、朗穗、朗星、健祥、黑雾、诱敌、闪平、联扑、妙胜、东晟、定生、定剑、乐剑、重歼、射手、单挑、双盾、通惠、惠择、大康、小康、康夫、消卷、穿纵、丰野、稳定杀、四面击、好本事、好农夫、好渗达、好乐士、圣斗士、金锐宁、黄金甲、恒功清、见虫卡、专整虫、虫垮台、绿青丹、雷司令、如雷贯、功得乐、特鲁伊、华夏龙、寒风刀、秋风扫、死翘翘、洽益鹏、百千浪、百业新、金秋风扫、菜茶帮手、苏化正功、丰山农富、上格治服、瑞德丰瑞功。

分析方法：液谱法(Anal.Methods. Pestic. Plant Growth. Regul. 1984.13,9)理化性质纯品为白色固体，黄色至棕色粘稠油状液体(工业品)，沸点187－190℃/0.2mmHg，蒸气压约0.001mPa(20℃)，密度1.25(25℃)，溶解度水中0.004ppb(20℃)，溶于丙酮，二氯甲烷，甲醇，乙醚，乙酸乙酯，己烷，甲苯均>500g/L(20℃)，50℃黑暗处存放2年不分解，光下稳定，275℃分解，光下pH7－9缓慢分解，pH>9加快分解。

高效氯氰菊酯高效氯氰菊酯英文名：Betacypermethrin别称：高效氯氰菊酯、戊酸氰醚酯化学式：C22H19CL2NO3分子量：416.3熔点：64～71℃（峰值67℃）水溶性：51.5(5℃）、93.4(25℃）、276.0(35℃）μg/l。

高效氯氰菊酯，别称戊酸氰醚酯，是农业杀虫剂，主要防治农作物上发生的鳞翅目害虫，具有强毒性。

原药外观为白色至奶油色结晶体，易溶于芳烃、酮类和醇类。

一、高效氯氰菊酯的简介（一）、高效氯氰菊酯通用名称：Betacypermethrin英文别名：Cyano(3-phenoxyphenyl)methyl3-(2,2-dichloroethenyl)-2,2-dim ethylcyclopropanecarboxylate;beta-Cypermethrin中文名称：高效氯氰菊酯中文别名：2,2-二甲基-3-(2,2-二氯乙烯基)环丙烷羧酸-α-氰基-(3-苯氧基)苄酯;戊酸氰醚酯化学名称：2,2-二甲基-3-(2,2-二氯乙烯基）环丙烷羧酸-α-氰基-(3-苯氧基）-苄酯EINECS：265-898-0;分子式：C22H19CL2NO3分子量：415.07（二）、理化性质该品为两对外消旋体混合物，其顺反比约为2：3。

原药外观为白色至奶油色结晶体，易溶于芳烃、酮类和醇类。

常用制剂有45%乳油。

熔点：64～71℃（峰值67℃）。

蒸气压：180mPa(20℃）比重：1.32g/ml（理论值），0.66g/ml（结晶体，20℃）溶解度在pH=7的水中，51.5(5℃）、93.4(25℃）、276.0(35℃）μg/l（理论值），异丙醇11.5，二甲苯749.8，二氯甲烷3878，丙酮2102，乙酸乙酯1427，石油醚13.1（均为mg/ml,20℃）稳定性：150℃，空气及阳光下及在中性及微酸性介质中稳定。

碱存在下差向异构，强碱中水解。

毒性：工业品：大鼠急性经口LD50649mg/kg，急性经皮LD50>5000mg/kg，对兔有轻微皮肤和眼刺激。

氰戊菊酯检测国标
摘要：
1.氰戊菊酯简介
2.氰戊菊酯检测国标概述
3.氰戊菊酯检测国标的具体内容
4.氰戊菊酯检测国标的重要性
正文：
氰戊菊酯是一种有机磷农药，具有高效、低毒、广谱的特点，被广泛应用于农业生产中。

然而，由于其对人体和环境的潜在危害，需要对其进行检测以保证其安全使用。

为此，我国制定了氰戊菊酯检测国标。

氰戊菊酯检测国标主要包括以下几个方面：
1.样品采集：对于各种含有氰戊菊酯的农产品、土壤、水样等，需要按照一定的比例进行随机抽样，确保检测结果的代表性。

2.样品处理：根据样品的性质，选择适当的方法进行前处理，如样品粉碎、提取、净化等，以便于后续的检测分析。

3.检测方法：采用气相色谱法、液相色谱法等先进技术，对氰戊菊酯进行定性和定量分析，确保检测结果的准确性。

4.检测结果判定：根据氰戊菊酯检测国标中设定的标准限值，判断样品中氰戊菊酯的含量是否超标，从而判断其安全性。

氰戊菊酯检测国标对于保障我国农业生产的安全、生态环境的可持续发展以及人民生活水平的提高具有重要意义。

首先，通过检测国标，可以确保农产
品中氰戊菊酯的含量符合安全标准，避免对人体健康造成危害。

其次，对土壤和水体中氰戊菊酯的检测，有助于评估农业生态环境的状况，为农业政策制定提供科学依据。

最后，氰戊菊酯检测国标有助于推动有机磷农药产业的优化升级，促进农业生产的绿色、可持续发展。

中国高效氯氟氰菊酯行业分析显示，高效氯氟氰菊酯纯品为白色固体，工业品为淡黄色固体，易溶于丙酮、甲醇、醋酸乙酯、甲苯等多种有机溶剂，不溶于水。

常温下可稳定贮藏半年以上；日光下在水中半衰期20d；土壤中半衰期22～82d。

高效氯氟氰菊酯又称为三氟氯氟氰菊酯、功夫菊酯，是拟除虫菊酯类杀虫剂的代表性品种，是16个立体异构体中杀虫活性最高的一对异构体，主要用于果树、棉花、大豆等作物的害虫防治，具有安全生物易降解、药效高、杀虫谱广、持效期长、无残留物等特点。

高效氯氟氰菊酯产品剂型包括微乳剂、水乳剂、可湿性粉剂、微囊悬浮剂、水分散颗粒以及其他类型，有效浓度（EC）有25%、10%、5%、2。

5%等，在国内登记的高效氯氟氰菊酯制剂中，25%EC，2。

5%水乳剂是目前主流剂型。

而未来由于降低功夫菊酯对环境的危害，伴随环保监管日益严格，微囊悬浮剂有望成为行业主要发展趋势。

高效氯氟氰菊酯生产原料一般包括贲亭酸甲酯、三氟三氯乙烷、盐酸、间苯氧基苯甲醛、亚硫酰氯、三氟氯菊酸等，合成工艺流程通常包括三氟氯菊酸合成、三氟氯菊酰氯合成、氯氟氰原油合成以及高效氯氟氰菊酯合成等环节。

中国高效氯氟氰菊酯起步较晚，于2005年才实现规模化生产和应用。

近年来随市场持续发展，中国高效氯氟氰菊酯生产能力逐渐提升。

现阶段中国高效氯氟氰菊酯原药登记企业已达到40余家，实际生产企业包括江苏扬农、江苏春江润田、潍坊润农、广东立农生物等十余家。

受新冠肺炎疫情影响，2020年，中国高效氯氟氰菊酯企业开工率较低，目前中国高效氯氟氰菊酯年产能在6。

2千吨左右，其中大部分产品用于出口，中国也已成为全球高效氯氟氰菊酯主要生产和出口国。

且凭借其独特优势，高效氯氟氰菊酯在拟除虫菊酯类杀虫剂市场中一直保持领先地位。

现阶段中国高效氯氟氰菊酯主要生产企业情况从市场竞争方面来看，江苏扬农是中国高效氯氟氰菊酯市场龙头企业。

据了解，江苏扬农司是国内仿生农药行业规模最大的企业，拟除虫菊酯农药的产量和营业收入一直名列全国同类农药行业第一，被中国农药工业协会评为“中国农药百强企业”、中国农药出口十强企业。

氰戊菊酯检测国标
国家标准对氰戊菊酯的检测方法主要有以下几种：
1. 高效液相色谱法（HPLC）：基于氰戊菊酯在特定条件下在色谱柱中的分离和检测，可通过峰面积或峰高值来定量分析。

2. 气相色谱法（GC）：将样品中的氰戊菊酯挥发成气体，并通过气相色谱柱进行分离和检测，通常配合质谱联用，可提供更精确的检测结果。

3. 液相色谱串联质谱法（LC-MS/MS）：将氰戊菊酯通过液相色谱柱进行分离，然后通过串联质谱的方法进行检测和定量分析，具有高灵敏度和高选择性。

4. 免疫学方法：包括酶联免疫吸附试验（ELISA）和免疫层析试验等，利用特定的抗体与氰戊菊酯结合，通过颜色反应或线条显示来进行定性和定量分析。

这些方法均受到国家相关标准的约束和规范，如《残留农药最大残留限量》（GB2763）等。

在实际检测过程中，需要按照相应的标准操作和仪器设备要求进行检测，并参照标准确定样品中氰戊菊酯的含量是否符合国家标准。

氯氰菊酯是一种高效氯氟氰菊酯原药，是农业杀虫剂，主要防治农作物上发生的鳞翅目害虫，具有强毒性。

氯氰菊酯对昆虫有很高的胃毒性和触杀作用，选择性毒力强，具有较长的持效性，一旦同害虫接触，立即作用于中枢神经系统，导致其迅速死亡。

此外，氯氰菊酯也是一种环境污染物。

相比其他拟除虫菊酯类杀虫剂，氯氰菊酯不容易被光和空气降解。

氯氰菊酯的国标标准是GB/T 20695-2006,也称为高效氯氟氰菊酯原药。

GB/T 20695-2006是高效氯氟氰菊酯原药的标准，规定了高效氯氟氰菊酯原药的要求、试验方法以及标志、标签、包装、贮运。

该标准适用于由高效氯氟氰菊酯和生产中产生的杂质组成的高效氯氟氰菊酯原药。

数字作者：暂无来源：《营销界·农资与市场》 2021年第4期14种14种新有效成分获得国际标准化组织（ISO）农药通用名技术委员会临时批准的英文通用名，这也是目前为止今年获批的所有英文通用名。

在这14种新农药中，喹草酮、双唑草酮、环吡氟草酮、苯唑氟草酮、三唑磺草酮、辛菌胺均为我国自主研发的有效成分，彰显了我国农药创制水平大幅提升。

277万亩次今年小麦条锈病大流行风险高。

目前，小麦条锈病已在湖北、陕西、河南、甘肃、云南、四川、贵州、重庆等8个省份232个县区发生215万亩，为近10年来第三重发年份。

据悉，目前湖北、陕西、河南、四川等省已累计实施小麦条锈病防治面积277万亩次。

2项国家市场监督管理总局（国家标准化管理委员会）日前批准发布《高效氯氟氰菊酯原药》（标准编号：GB/T 20695—2021，代替GB/T 20695—2006）和《高效氯氟氰菊酯乳油》（标准编号：GB/T 20696—2021，代替GB/T 20696—2006）两项农药产品的新版国家标准，均将自2021年10月1日起实施。

221万亩次今年草地贪夜蛾呈重发态势。

草地贪夜蛾已在云南、广东、广西等西南、华南秋冬种玉米种植区累计发生164万亩，同比增加15%。

据悉，目前云南、广东、广西等省份已累计实施草地贪夜蛾防治面积221万亩次。

13.4%预计2021年全国玉米病虫害将偏重发生。

其中，玉米“三病一虫”发生面积4.4亿亩次，同比增加13.4%。

10类3月15日，淘宝发布了《淘宝网农药行业管理规范》变更公示通知。

本次变更中，新增了违禁农药名单、杀鼠剂类目准入要求等。

其中，违禁农药名单新增10类。

百树菊酯为非内吸性杀虫剂，具有触杀和胃毒作用。

作用于神经系统，击倒快，长残效。

能有效防治棉花、果树、蔬菜、禾谷类作物和其它作物上的鳞翅目、鞘翅目、半翅目和同翅目害虫，剂量为7.5-20g/ha。

也可以防治蝗虫，并可作为动物健康用品使用。

科标检测百树菊酯检测标准如下：
GB/T19372-2003饲料中除虫菊酯类农药残留量测定-气相色谱法
GB20695-2006高效氯氟氰菊酯原药
GB22619-2008联苯菊酯原药
GB22620-2008联苯菊酯乳油
GB/T27779-2011卫生杀虫剂安全使用准则拟除虫菊酯类
GB/T5009.106-2003植物性食品中二氯苯醚菊酯残留量的测定
GB6694-1998氰戊菊酯原药
GB6695-199820%氰戊菊酯乳油
科标化工以“专心、专业、专注“为宗旨，致力于实现研究和应用的对接，从而推动化工行业的发展。

高效氯氟氰菊酯原药（母液）产品登记动态
佚名
【期刊名称】《农化市场十日讯》
【年(卷),期】2007(000)003
【摘要】高效氯氟氰菊酯是近年来登记产品数较多的杀虫剂品种之一，其原药（母液）产品登记数也相应较多。

从1997年首家企业登记到2006年底，共有国内外35家企业登记37个产品，其中国外3家企业登记4个产品，国内32家企业登记33个产品。

按照企业所在省（直辖市）划分，江苏省19家19个产品，山东省3家4个产品，广东省3家3个产品，天津市2家2个产品，湖北省、湖南省、浙江省、安徽省、江西省各1家1个产品。

【总页数】1页(P28)
【正文语种】中文
【中图分类】S482.4
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