DOI：10-3969/j.ien-1672-770.2021.01.017•临床研究-神经内镜微创术结合LCFD术对高血压脑出血患者症状、预后及影响术后生活质量的Logistics分析刘胜华，周政，唐协林,黎乾科，刘怡东，赵超，肖奎，羊飞龙,何绍勇，罗静，夏湘平，叶勇强!摘要】目的研究神经内镜微创术结合腰大池持续引流（LCFD）术治疗高血压脑出血（HICH）的预后及其影响因素。
方法66例HICH患者随机分为观察组及对照组，每组33例。
观察组患者采用神经内镜微创术结合LCFD治疗，对照组患者采用标准骨瓣开颅血肿清除术结合LCFD治疗。
比较两组患者的手术相关指标，以及手术前后格拉斯哥昏迷量表（GCS）评分、格拉斯哥预后量表（GOS）评分、日常生活活动能力（ADL）评分、Epwoth嗜睡量表（ESS）评分和预后生活质量SF-6评分;分析影响术后预后的因素。
结果观察组患者的手术时间及术中出血量显著低于对照组，血肿清除率显著高于对照组;术后的GCS、GOS、ADL、ESS评分及SF-6评分显著高于对照组（均P<0.001）。
多因素分析显示，与子女同住、吸烟、饮酒、脑出血量、脑中线移位、脑出血到手术时间、破入脑室为脑出血预后的独立影响因素。
结论神经内镜微创术结合LCFD对HICH具有较好的疗效，患者的预后较好。
同时应及时对患者是否与子女同住、吸烟、饮酒及脑出血量、脑中线移位、脑出血到手术时间、破入脑室进行了解与监测（并早期开展康复治疗干预$!关键词】高血压脑出血；神经内镜微创术（腰大池持续引流；预后；影响因素!中图分类号】R651；R743.2【文献标志码】B【文章编号】1672-770（2021%01异080-5Logistics analysis on effect of neuroendoscopic minimally invasive surgery combined with LCFD on the symptoms,prognosis and quality of life of patients with HICH LIE Sheng-Hua,ZHOU Zheng,TANG Xie-Ho,etal Depagmef O Neurosurgers,Third A fi Oated Hospital f NortS Sichuan MedOal Collefe,Miaayang621100,China Corresponding authos：ZHOU ZhengAbstract:Objective Tc explore the eOect of neuroendoscopic m inimallg invasive suryet combined with lumbar cerebrospinal fluig drainage（LCFD）on the symptoms,prognosis and qualitu of life of patients withhyao'Wnsiveintracerebralgemortayc（HICH）.Methods66patienW with hypertensive intracerebrcl hemorrhage wererandomlg divided into observation youp and contrci youp,33cases in each youp.Patients in thc observation groupwere treated with endoscopic minimallg invasive suryet combined with LCFD,whilo patienW in thc contrci group weretreated with standard craniotomy combined with LCFD.Thc perioperative indexes,GCS,GOS,ADL,ESS scores andprognosis of thc two groups were compaed,and thc factors influencing the qualitu of life were analyzed.Results Thcoperation Uec and intraoperative blood loss of the observation youp were siynificanUg gwcr than those of thc contrciyoup,and the hematoma clearance rats was siynificanUg higher than that of the contrci youp；the Gksyow coma scale（GCS）,Glasyow outcome score%GOS）,activities of daily living scale（ADL）,Epworth sleepiness scale%ESS）scoresand SF-6scores of the observation group were significanUg higher than those of the contrci group（ai P<0.001）.Multivaiato analysis showed that tiving with chiion,smoking,drinking,amount of cerebral hemorrhage,midiincshift,Uec from cerebral hemorrhage to operation,rd ventricular rupture were independent prognostic factors.Conclusion Neuroendoscopic minieallg invasive suryet combined with LCFD has good curative eOect and goodprognosis in patients with hich.At the same tiee,we shouk tieelg understand and monitor whether the patients livewith theic children,smoking,drinking and the amount of inWacerebrai hemorrhage,midiinc shift of brain,the timefrom cerebral hemorrhage to operation,and break into ventricles,and cairy out earlg rehabiliition intervention.Key wo+s:hypertensive intracerebral hemorrhage；neuroendoscopic minieallg invasive suryet;LCFD；prognosis基金项目：四川省医学会科研课题计划（S15056）；绵阳市卫生健康委科技计划项目（201953）作者单位：621100绵阳#川北医学院附属三台医院神经外科（刘胜华，唐协林#黎乾科，刘怡东，赵超，肖奎，羊飞龙,何绍勇，罗静）；陆军军医大学第二附属医院神经外科（周政）；遵义医学院附属医院神经外科（夏湘平）；四川省资阳市第一人民医院神经外科（叶勇强）通信作者:周政,E-mail:biybrain126@高血压脑出血（hypeOensiveintyceybymemowhaye, HICH）主要是由于血压升高造成的局部脑血管壁破裂所致；随着发病后脑组织受压迫,局部缺血缺氧，造成脑组织及神经细胞损伤，甚至凋亡，进而导致相关运动区域的功能障碍，严重影响患者的生命质量⑴$超早期神经内镜微创术可对高血压脑出血灶的大部分%80%）血肿进行清除［2］;术后通过腰大池持续引流％lumbar cerebrospinal Iuid drainage, LCFD），对于患者的神经功能恢复具有重要的意义。
