DOI：10.19368/ki.2096-1782.2023.08.097生长抑素和奥曲肽在治疗急性胰腺炎中的应用张腾1，刘风青1，王建2，张吉霞1，吴莉1，曹相敬31.山东中医药大学附属医院大学城医院消化内科，山东济南250300；2.山东中医药大学附属医院大学城医院麻醉科，山东济南250300；3.山东中医药大学附属医院大学城医院科教科，山东济南250300 [摘要]目的探究生长抑素和奥曲肽在治疗急性胰腺炎中的效果。
方法选取2020年1月—2023年1月山东中医药大学附属医院大学城医院收治的90例急性胰腺炎患者为研究对象。
以抽签法分为参照组和研究组，每组45例。
参照组采用生长抑素治疗，研究组采用生长抑素联合奥曲肽治疗。
对比两组临床疗效、血液流变学指标、实验室检查结果。
结果研究组临床总有效率为95.55%高于参照组的82.22%，差异有统计学意义（χ2=4.050，P<0.05）。
治疗后，研究组血淀粉酶、白细胞计数指标低于参照组，白蛋白高于参照组，差异有统计学意义（P<0.05）。
治疗后，研究组IL-8、IL-15、TNF-α等炎症反应指标均低于参照组，差异有统计学意义（P<0.05）。
治疗后，研究组全血比黏度（高切）、血浆比黏度、血小板粘附率低于参照组，差异有统计学意义（P<0.05）。
结论生长抑素与奥曲肽联合应用，有利于提高急性胰腺炎患者的临床总有效率，并且还可减轻其机体的炎症反应，有助于改善其血液流变学指标。
同时，相较于单独用药而言，联合用药在促进血淀粉酶、白细胞计数等实验室指标恢复正常方面作用突出。
[关键词]急性胰腺炎；生长抑素；奥曲肽；炎症反应；血液流变学；血淀粉酶[中图分类号]R4 [文献标识码]A [文章编号]2096-1782（2023）04(b)-0097-05Application of Somatostatin and Octreotide in the Treatment of Acute Pan⁃creatitisZHANG Teng1, LIU Fengqing1, WANG Jian2, ZHANG Jixia1, WU Li1, CAO Xiangjing31.Department of Gastroenterology, University Town Hospital, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, 250300 China;2.Department of Anesthesiology, University Town Hospi‐tal, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, 250300 China;3.Department of Science and Education, University Town Hospital, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, 250300 China[Abstract] Objective To explore the effect of somatostatin and octreotide in the treatment of acute pancreatitis.Methods From January 2020 to January 2023 90 patients with acute pancreatitis admitted to the University City Hos‐pital of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine were selected as the research object. They were divided into reference group and study group by drawing lots, with 45 cases in each group. The ref‐erence group was treated with somatostatin, the study group was treated with somatostatin combined with octreotide. Clinical efficacy, hemorheological indexes and laboratory examination results were compared between the two group.Results The total clinical effective rate of the study group was 95.55 %, which was higher than 82.22 % of the refer‐ence group, and the difference was statistically significant (χ2=4.050, P<0.05). After treatment, the blood amylase and white blood cell count indexes of the study group were lower than those of the reference group, and the albumin was higher than that of the reference group, the differences were statistically significant (P<0.05). After treatment, the in‐flammatory response indexes such as IL-8, IL-15 and TNF-α in the study group were smaller than those in the refer‐ence group, and the difference was statistically significant (P<0.05). After treatment, the whole blood specific viscosity (high shear), plasma specific viscosity and platelet adhesion rate in the study group were lower than those in the refer‐[基金项目]科技发展计划项目（201820026）。
