布地奈德、硫酸特布他林、异丙托溴铵气雾剂联合雾化吸入治疗小儿喘息性支气管炎的效果观察

布地奈德、硫酸特布他林、异丙托溴铵气雾剂三联气泵雾化吸入治疗小儿喘息性支气管炎疗效观察【摘要】：目的观察分析喘息性支气管炎患儿雾化吸入布地奈德+硫酸特布他林+异丙托溴铵气雾剂的临床效果。

方法采用随机抽样法将我院2018年7月-2019年12月收治的喘息性支气管炎患儿86例分为相同例数的两组：对照组和研究组，每组各有患儿43例。

对照组给予常规综合治疗，研究组采用布地奈德+硫酸特布他林+异丙托溴铵气雾剂雾化吸入治疗，评估两组治疗效果。

结果研究组患儿的临床总有效率为97.67%，明显高于对照组的81.40%，差异有统计学意义（P＜0.05）。

与对照组比较，研究组患儿喘息改善时间、治疗时间均明显降低，差异有统计学意义（P＜0.05）。

结论雾化吸入布地奈德、硫酸特布他林、异丙托溴铵气雾剂可以明显提高喘息性支气管炎患儿的治疗效果，缩短治疗时间，具有在临床上大力推广及应用的价值。

【关键词】：小儿喘息性支气管炎；布地奈德；硫酸特布他林；异丙托溴铵气雾剂；应用效果Observation on the therapeutic effect of budesonide, terbutaline sulfate and ipratropium bromide on asthmatic bronchitis in children by triple air pump atomization inhalation【abstract 】: objective to observe and analyze the clinical effect of aerosol inhalation of budesonide + terbutaline sulfate + ipratropium bromide in children with asthmatic bronchitis.Methods a total of 86 children with asthmatic bronchitis admitted to our hospital from July 2018 to December 2019 were randomly pided into two groups with the same number of cases: the control group and the studygroup, with 43 cases in each group.The control group was given conventional comprehensive treatment, while the study group was treated with budesonide + terbutaline sulfate + ipratropium bromide aerosol inhalation, and the therapeutic effects of the two groups were evaluated.Results the total clinical effective rate of children in the study group was 97.67%, significantly higher than that of the control group (81.40%), and the difference was statistically significant (P < 0.05).Compared with the control group, the wheezing improvement time and treatment time of children in the study group were significantly reduced, and the difference was statistically significant (P < 0.05).Conclusion aerosol inhalation of budesonide, terbutaline sulfate and ipratropium bromide can significantly improve the therapeutic effect of children with asthmatic bronchitis and shorten the treatment time, which has the value of promoting and applying in clinical practice.【key words 】: asthmatic bronchitis in children;Budinned;Terbutaline sulfate;Ipratropium bromide aerosol;Application effect小儿喘息性支气管炎泛指一组因感染、过敏反应、化学刺激等致小儿出现以喘息为主要表现的急性支气管炎。

异丙托溴铵联合布地奈德、特布他林雾化吸入对支气管肺炎患儿细胞因子的影响车向郁【期刊名称】《海南医学院学报》【年(卷),期】2016(022)017【摘要】[ABSTRACT]Objective:To explore the clinical efficacy of aerosol inhalation of ipratropium bromide in combined with budesonide and terbutaline on bronchopneumonia in children and the effect on cytokines.Methods:A total of 70 children with bronchopneumonia who were admitted in our hospital were included in the study and randomized into the study group and the control group.The patients in the control group were given anti-infection,oxygen inhalation,cough and asthma relieving,aci-dosis correcting,mask+oxygen driven aerosol inhalation of budesonide (0.5 mg/time)and terbutaline (1.0 mg/time),withan&nbsp;oxygen flow rate of (5-7)L/min,(5-10)min every time,twice a day.On the above basis,the patients in the study group were given additional ipratropium bromide (1.0 mg/time).After 7 day treatment,the efficacy was evaluated.The levels of IL-6, TNF-α,CRP,and WBC before and after treatment were detected.PEF,FVC,and FEV1 before and after treatment were de-tected.The improvement of clinical symptoms and signs,and the occurrence of adverse reactions were observed.Results:The levels of IL-6,TNF-α,CRP,and WBC counting after treatment in the twogroups were significantly reduced when compared with that before treatment (P <0.05),and the reduced degree in the study group was significantly superior to that in the con-trol group (P <0.05).PEF,FVC,and FEV1 after treatment in the two groups were significantly improved when compared with before treatment (P <0.05),and the improved degree in the study group was significantly superior to that in the control group (P<0.05).After treatment,the cough and asthma relieving,and rale and DR shadow disappearing time in the study was significantly shorter than that in the control group (P <0.05).No severe adverse reactions occurred in the two groups,and the comparison between the two groups was not statistically significant (P >0.05).Conclusions:Ipratropium bromide in com-bination with budesonide and terbutaline in the treatment of bronchopneumonia in children can rapidly relieve the symptoms, and improve the cytokine level,with no obvious adverse reactions;therefore,it deserves to be widely recommended in the clin-ic.%目的：：探讨异丙托溴铵联合布地奈德、特布他林雾化吸入治疗小儿支气管肺炎临床疗效及对细胞因子的影响.方法：选取70例小儿支气管肺炎患儿为研究对象,随机分为研究组与对照组,对照组给予抗感染、吸氧、止咳平喘及纠正酸中毒等基础治疗,并采用布地奈德0．5 mg/次、特布他林1．0 mg/次联合面罩＋氧气驱动雾化吸入,氧流量为5~7L/min,每次5~10 min,2次/d,研究组在上述基础上联合异丙托溴铵1．0 mg/次吸入,两组均治疗7 d 进行疗效评价；检测治疗前后白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)、白细胞计数(WBC)水平；测定治疗前后肺功能,包括最高呼气流速(PEF)、用力肺活量(FVC)及第1秒最大呼气量(FEV1)；观察临床症状和体征改善情况及不良反应发生情况.结果：治疗后两组 IL-6、TNF-α、CRP 水平及 WBC 计数均降低,与治疗前比较,差异具有统计学意义(P ＜0．05),研究组优于对照组,差异有统计学意义(P ＜0．05)；治疗后两组 PEF、FVC、FEV1较治疗前改善,与治疗前比较差异显著(P ＜0．05),研究组优于对照组,差异有统计学意义(P ＜0．05)；治疗后研究组气喘缓解、止咳、啰音消失、胸片阴影消失等时间上均短于对照组,差异有统计学意义(P ＜0．05)；两组均未出现严重不良反应,两组比较,差异无统计学意义(P ＞0．05).结论：异丙托溴铵联合布地奈德、特布他林雾化吸入可快速缓解小儿支气管肺炎患儿症状,改善炎性因子水平,且无明显不良反应,值得临床推广.【总页数】4页(P1989-1991,1995)【作者】车向郁【作者单位】河北省邯郸市妇幼保健院，河北邯郸 056001【正文语种】中文【中图分类】R563.1【相关文献】1.布地奈德、特布他林、异丙托溴铵联合雾化吸入治疗小儿支气管肺炎疗效评价[J], 廖凤明2.布地奈德、特布他林联合异丙托溴铵雾化吸入疗法对6～12岁儿童喘息性支气管炎的治疗效果分析 [J], 袁小和; 陈蕊艳; 郑陈妹; 陆秋英3.异丙托溴铵联合布地奈德雾化吸入对支气管肺炎患儿血清细胞因子水平及肺功能的影响 [J], 林炜;吴炽勇;简方华4.异丙托溴铵联合布地奈德雾化吸入对小儿支气管肺炎患儿炎症因子及肺功能的影响 [J], 邱渺涞5.布地奈德联合特布他林、异丙托溴铵雾化吸入治疗小儿支气管肺炎的效果 [J], 杨静;刘霞因版权原因，仅展示原文概要，查看原文内容请购买。

布地奈德、硫酸特布他林、异丙托溴铵气雾剂联合雾化吸入治疗小儿喘息性支气管炎的效果观察刘华容【摘要】目的观察临床联合运用布地奈德、硫酸特布他林、异丙托溴铵气雾剂吸入治疗小儿喘息性支气管炎的效果及安全性.方法选择喘息性支气管炎患儿216例,随机分为观察组108例,对照组108例,两组均使用相同的抗感染、止咳平喘、吸氧等治疗.观察组加吸人用布地奈德混悬液、硫酸特布他林雾化液、异丙托溴铵气雾剂联合雾化吸入.对照组则使用地塞米松、α-糜蛋白酶雾化吸人.对两组的症状及体征得到明显改善的时间、总有效率及不良反应发生率进行比较.结果观察组在临床症状咳嗽以及喘息上明显改善的时间及肺部体征消失时间均较对照组短,差异有统计学意义[咳嗽:(4.32±1.41)d比(7.81±1.20)d,t=10.547,P=0.007;喘息:(3.15±0.92)d比(5.23±1.21)d,t=9.973,P=0.008;肺部体征:(3.47±1.12)d比(7.05±1.31)d,t=10.182,P=0.008];观察组总有效率为95.4％,对照组为78.7％,两组比较,差异有统计学意义(x2=13.295,P=0.000);观察组不良反应发生率为1.85％,对照组为2.78％,差异无统计学意义(x2=0.030,P=0.978).结论联合运用布地奈德、硫酸特布他林、异丙托溴铵气雾剂经压力雾化泵吸入治疗小儿喘息性支气管炎效果显著,且无明显不良反应,值得临床推广应用.【期刊名称】《中国医药导报》【年(卷),期】2014(011)001【总页数】4页(P76-78,82)【关键词】喘息性支气管炎;布地奈德;硫酸特布他林;异丙托溴铵;雾化吸入【作者】刘华容【作者单位】浙江衢化医院药剂科,浙江衢州324000【正文语种】中文【中图分类】R562.25喘息性支气管炎是3岁以内婴幼儿发病率较高的常见的呼吸系统疾病之一，多由感染引起，亦与自身免疫功能紊乱有关[1]。

在小儿呼吸系统疾病中喘息性支气管炎是临床多发且常见症，患病率高，病情发作后易引发一系列症状表现，如呼吸困难、刺激性干咳和肺通气障碍等[1]。

由于小儿年龄较小，机体功能处于发育状态，若临床治疗不及时，则能严重影响生长发育。

抗生素是临床常用药物，虽然在改善病情方面能取得较好效果，但长期应用易出现耐药性，治疗难度增加，临床应加强对药物的合理选择。

现就对药物雾化吸入疗法对6~12岁儿童喘息性支气管炎的治疗效果归纳如下。

1资料与方法1.1临床资料：以2018年2月~2019年4月为时限，取我院接收的小儿喘息性支气管炎患者90例为研究对象，以整群随机化方式分成两组。

对比组（n=45）女性16例，男性29例；年龄6~12岁，平均年龄（8.5±0.9）岁。

研究组（n=45）男性30例，女性15例；年龄6~12岁，平均年龄（9.4±0.6）岁。

对比两组临床资料P>0.05。

1.2入选与排除标准1.2.1入选标准：经血液检查均已确诊为喘息性支气管炎；年龄均<5岁；对于此次研究知晓同意并自愿签字。

1.2.2排除标准：伴肝肾等严重脏器功能异常；伴感染性病症；伴其他呼吸系统病症。

1.3治疗方法：给予对比组特布他林（成都华宇制药有限公司，国药准字H20010703，规格：1mL：0.25mg）联合布地奈德（湖北葛店人福药业有限责任公司，国药准字H20103795）雾化吸入治疗，向0.9%氯化钠注射液（宜昌三峡制药有限公司，国药准字H20123141，规格：100mL：0.9g）内加入特布他林、布地奈德，混合均匀后雾化吸入。

特布他林每次用药剂量为2.5~5mg，3~4次/d；布地奈德每次用药剂量为0.25~0.5mg，2次/d。

给予研究组特布他林、布地奈德、异丙托溴铵（山东京卫制药有限公司，国药准字H20120003，规格：20mL：5mg）共同雾化吸入治疗，特布他林、布地奈德的每日用药次数、每次用药剂量均参照对比组；异丙托溴布地奈德、特布他林联合异丙托溴铵雾化吸入疗法对6～12岁儿童喘息性支气管炎的治疗效果分析袁小和陈蕊艳郑陈妹陆秋英（广东省湛江市遂溪县妇幼保健院湛江524000）摘要：目的：以儿童喘息性支气管炎患者为例，取6~12岁，探究布地奈德、特布他林联合异丙托溴铵雾化吸入疗法的应用效果。

布地奈德混悬液联合硫酸特布他林雾化液吸入异丙托溴铵溶液治疗小儿喘息性支气管炎的临床效果刘霞;魏宗成【摘要】目的探析对小儿喘息性支气管炎以布地奈德混悬液联合硫酸特布他林雾化液、吸入异丙托溴铵溶液雾化吸入治疗的临床效果.方法选取本院在2017年9月至2018年7月期间收治的60例小儿喘息性支气管炎患儿,将其随机分为治疗组和对照组,各30例,两组均采取常规抗感染治疗+甲强龙静滴抗炎平喘,对照组在常规治疗后根据患儿的喘息严重程度分1～2次+盐酸丙卡特罗口服液治疗,治疗组在常规治疗后根据患儿的喘息严重程度分1～2次+吸入用布地奈德混悬液、硫酸特布他林雾化液、吸入异丙托溴安溶液进行治疗,比较两组患者治疗达到的临床效果及临床症状体征消失时间.结果治疗组治疗达到的总有效率为96.67％显著高于对照组73.33％,比较差异有统计学意义(P<0.05);治疗组喘息症状消失时间(3.67±0.52)d、肺部鸣音消失时间(4.08±1.21)d、咳嗽消失时间(4.52±1.27)d显著优于对照组,比较差异有统计学意义(P<0.05).结论对小儿喘息性支气管炎以布地奈德混悬液联合硫酸特布他林雾化液、吸入异丙托溴铵溶液雾化吸入治疗的临床效果明显,有效率高,快速改善临床症状,值得临床推广.【期刊名称】《当代医学》【年(卷),期】2019(025)016【总页数】2页(P176-177)【关键词】小儿喘息性支气管炎;布地奈德混悬液;硫酸特布他林雾化液;临床效果【作者】刘霞;魏宗成【作者单位】南京市浦口区中医院儿科,江苏南京 211800;南京市浦口区中医院人事科,江苏南京 211800【正文语种】中文喘息性支气管炎属于儿科十分常见的呼吸系统疾病，主要的患病人群以三岁以内的小儿为主，多由于感染导致，与自身免疫功能紊乱具有密切关系，发病前患儿多出现上呼吸道感染症状，发热或者不发热，伴有不同程度上的阵发性咳嗽症状，闻及肺部啰音，病程长且容易反复发作，有些会发展至哮喘，对患儿身体健康造成严重影响[1-2]。

特布他林、异丙托溴铵联合布地奈德雾化吸入治疗儿童支气管哮喘急性发作的疗效分析蓝颖艳【摘要】Objective To observe the special cloth He Lin, isopropyl bromide and budesonide atomization inhalation in the treatment of children with bronchial asthma in the treatment of acute episode of care. Methods 96 children with acute seizures were randomly divided into observation group and control group, two Methods were used, the clinical symptoms and signs were compared, the adverse reactions were observed.Results After 1 weeks of treatment, the observation group of cough, wheezing, wheezing disappearance time and hospitalization time were shorter than the control group (P<0.05). The total effective rate of the observation group (95.8%) was better than that of the control group (79.2%)(P<0.05).Conclusion Special cloth He Lin, isopropyl bromide and budesonide atomization inhalation in the treatment of acute asthmatic attack in children's care, the total efficiency is higher,with less adverse reactions worthy to be popularized and applied in clinical.%目的观察特布他林、异丙托溴铵联合布地奈德雾化吸入治疗儿童支气管哮喘急性发作的疗效.方法将96例符合标准的支气管哮喘急性发作患儿随机分为观察组和对照组,分别采用特布他林、异丙托溴铵联合布地奈德雾化吸入治疗和单纯布地奈德治疗,比较临床症状体征消失时间,住院时间和总有效率,观察不良反应.结果治疗1周后,观察组咳嗽、喘息、哮鸣音消失时间及住院时间均短于对照组(P<0.05).观察组总有效率(95.8%)优于对照组(79.2%)(P<0.05).结论特布他林、异丙托溴铵联合布地奈德雾化吸入治疗儿童支气管哮喘急性发作,临床症状体征消失时间和住院时间短,总有效率较高,不良反应少,值得在临床上推广应用.【期刊名称】《中国卫生标准管理》【年(卷),期】2015(006)018【总页数】2页(P130-131)【关键词】特布他林;异丙托溴铵;布地奈德;儿童支气管哮喘【作者】蓝颖艳【作者单位】530600 广西南宁马山县妇幼保健院儿科【正文语种】中文【中图分类】R725.6特布他林、异丙托溴铵联合布地奈德雾化吸入治疗儿童支气管哮喘急性发作的疗效分析蓝颖艳【摘要】目的观察特布他林、异丙托溴铵联合布地奈德雾化吸入治疗儿童支气管哮喘急性发作的疗效。

布地奈德、异丙托溴胺与特布他林联合氧气雾化治疗小儿喘息性肺炎疗效观察目的讨论布地奈德、异丙托溴胺与特布他林联合氧气雾化治疗小儿喘息性肺炎的效果。

方法现随机选取2015年7月～2016年8月我院儿科收治的小儿喘息性肺炎78例，分成对照组39例，实验组39例，对照组给予单纯布地奈德雾化吸入治疗，实验组患者给予布地奈德、异丙托溴胺与特布他林联合氧气雾化治疗，对两组患者的治疗效果、临床症状消失时间和住院时间进行对比和分析。

结果实验组的治疗有效率为96.67%，明显高于对照组的84.61%，组间差异明显具有统计学意义（P＜0.05）；实验组患者住院时间和症状消失时间明显低于对照组，组间差异有统计学意义（P＜0.05）。

结论在小儿喘息性肺炎的治疗中，采用布地奈德、異丙托溴胺与特布他林联合氧气雾化治疗方案明显提高了治疗的有效率，临床症状改善较快，住院时间较短，值得临床推广和应用。

标签：布地奈德；异丙托溴胺；特布他林；氧气雾化；喘息性肺炎小儿喘息性肺炎是儿科临床上较为常见的一种疾病，疾病发作时会出现咳嗽、气促、憋喘等症状，在本次治疗中采用的是布地奈德、异丙托溴胺与特布他林联合氧气雾化治疗方案[1]，结果发现效果良好，详情如下。

1 资料与方法1.1 一般资料现随机选取2015年7月～2016年8月我院儿科收治的小儿喘息性肺炎78例，分成对照组39例，实验组39例，实验组男23例，女16例，年龄2～6岁，平均年龄（4.2±0.3）岁，对照组男30例，女9例，年龄3～7岁，平均年龄（5.5±0.8）岁，两组患儿的一般资料差异无统计学意义（P>0.05）。

1.2 方法两组患儿入院后均进行抗炎和抗感染治疗，在此基础上对照组给予布地奈德（生产企业：AstraZeneca Pty Ltd，国药准字H20140475）雾化吸入，每次0.5 mg，每天两次，氧气流量保持在4 L/min，连续治疗7天。

实验组给予0.5 mg布地奈德、0.15 mg异丙托溴铵和2.0 mg的沙丁安醇配置成混合液，同时给予氧气雾化吸入治疗，氧气流量保持在6 L/min，每次吸氧20 min，每天两次，连续治疗7天。

布地奈德、硫酸特布他林联合异丙托溴铵治疗小儿喘息性支气管炎的效果观察郑连花（阳春市妇幼保健院，广东　阳春　529600）[摘要]目的：探讨用布地奈德、硫酸特布他林联合异丙托溴铵对喘息性支气管炎患儿进行雾化吸入治疗（aerosol inhalation therapy，AIT）的临床效果。

方法：将近年来某医院收治的35例喘息性支气管炎患儿随机分为观察组（OBG 组，n=20）与对照组（REG 组，n=15）。

对两组患儿均进行常规治疗，在此基础上用布地奈德、硫酸特布他林联合异丙托溴铵对OBG 组患儿进行雾化吸入治疗，用地塞米松对REG 组患儿进行雾化吸入治疗。

比较两组患儿临床症状和体征改善的时间、治疗的总有效率及用药后其发生不良反应的情况。

结果：治疗后，OBG 组患儿痰鸣音、喘息和咳嗽改善的时间均短于REG 组患儿，其治疗的总有效率高于REG 组患儿，P ＜0.05。

用药后，两组患儿均未出现不良反应。

结论：用布地奈德、硫酸特布他林联合异丙托溴铵对喘息性支气管炎患儿进行雾化吸入治疗能显著改善其临床症状，缓解其病情，且用药的安全性较高。

[关键词]布地奈德；硫酸特布他林；异丙托溴铵；小儿喘息性支气管炎；雾化吸入[中图分类号]R725.6 [文献标识码]B [文章编号]2095-7629-（2020）12-0114-02Effect of budesonide and terbutaline sulfate combined with ipratropium bromide in the treatment of asthmaticbronchitis in childrenZheng Lianhua(Yangchun Maternal and Child Health Hospital, Yangchun Guangdong 529600)[abstract] objective: to study the cloth to Ned, terbutaline sulfate in combination with isopropyl bromide on atomization inhalation therapy in children with asthmatic bronchitis (aerosol inhalation therapy, AIT) clinical effect. Methods: 35 children with asthmatic bronchitis admitted to a hospital in recent years were randomly divided into observation group (OBG group, n=20) and control group (REG group, n=15). Both groups of children were routinely treated. On this basis, budesonide and terbutaline sulfate combined with ipratropium bromide were used for atomization inhalation treatment in the OBG group, and dexamethasone was used for atomization inhalation treatment in the REG group. The time of improvement of clinical symptoms and signs, the total effective rate of treatment and the incidence of adverse reactions were compared between the two groups. Results: After treatment, the improvement time of sputum, wheeze and cough in OBG group was shorter than that in REG group, and the total effective rate was higher than that in REG group (P < 0.05). After taking the drug, no adverse reactions occurred in the two groups. Conclusion: Nebulized inhalation therapy with budesonide, terbutaline sulfate and ipratropium bromide in children with asthmatic bronchitis can significantly improve their clinical symptoms, alleviate their condition, and the safety of the drug is higher.[Key words] Budesonide; Terbutaline sulfate; Ipratropium bromide; Asthmatic bronchitis in children; Atomization inhalation表1 两组患者临床疗效的对比组别例数疗效分级[n（％）]总有效率（%）显著好转好转无效Research 组Matched 组χ²值P 值555534（61.82）30（54.55）1.0860.29716（29.09）14（25.45）0.3340.5635（9.09）11（20）4.7880.02990.91804.7880.029注：总有效率=（总例数-无效例数）/总例数×100%。