Banking Biological Samples for Pediatric Research Botkin儿科的研究生物样品组成的银行

“生物银行”的中国之路来源：生物谷| 孔静2014-11-21 14:08生物样本库又称为"生物银行"，它的存储品不是钱，是组织、血液、细胞、DNA等生物样本以及与其相关的临床资料及其质量控制信息管理与应用系统。

但生物样本库不仅具备存储功能，更主要的含义是资源的应用和共享，利用其庞大和详细的样本数据，为人类健康服务。

它不仅是各类基础科学研究和临床实验的基础，更是将科研成果快速产业化病投入临床应用，开展转化医学的物质基础。

"生物银行"受到全世界各国的高度重视，每个国家都在积极打造更有影响力的"生物银行"。

2012年3月，"英国生物样本库管理系统"在英国正式开业，存储样本总数超过5000万份。

存储量为600万份的生物样本库也在哥本哈根落成。

美国RAND公司的研究报告指出，本世纪初美国生物银行存贮的人体组织样本数量超过3亿份，并以每年2000万份的速度增加。

2015年之前，生物样本库市场每年以30%的速度增长。

2015年，将达到1830亿美元市场规模。

我国由于基本种类和资源丰富等特点及优势，极大的促进了生物样本库的建设与发展。

1994年中国科学院建立了中华民族永生细胞库，1996年建立了北京大学肿瘤医院肿瘤组织库，还有山东脐带血造血干细胞库、北京脐带血造血干细胞库等。

北京重大疾病临床数据和样本资源库二期工程也正在顺利推进，纳入临床资源样本库的疾病种类已从一期工程的6类扩展至15类，2016年达到病例10万份、样本100万份。

目前我国建成了全球最大的基因测序服务中心和基因组学研究中心；国家基因库更是拥有3000万份人、动植物和微生物样本的世界级生物样本库和组学数据库，新一代测序能力与超大规模生物信息计算分析能力世界第一。

面对着生物样本库的大量建设和庞大的样本数据，新的问题又摆在我们眼前。

目前国内各方面都在积极推进样本库的建设工作，但由于缺乏足够的交流与沟通，不同的样本库在建设过程中没有统一的标准，在管理和质量水平上存在较大的差别，同国外的样本库之间也存在着一定的差距。

生物识别技术外文翻译文献生物识别技术外文翻译文献(文档含中英文对照即英文原文和中文翻译)外文：The first chapter1.1 The research background of iris recognitionBiometrics is a technology for personal identification using physiological characteristics and behavior characteristics inherent in the human body. Can be used for the biological characteristics of biological recognition, fingerprint, hand type face, iris, retina, pulse, ear etc.. Behavior has the following characteristics: signature, voice, gait, etc.. Based on these characteristics, it has been the development of hand shape recognition, fingerprint recognition, facial recognition, iris recognition, signature recognition and other biometric technology, many techniques have been formed and mature to application of.Biological recognition technology in a , has a long history, the ancient Egyptians through identification of each part of the body size measure to carry out identity may be the earliest human based on the earliest history of biometrics. But the modern biological recognition technology began in twentieth Century 70 time metaphase, as biometric devices early is relatively expensive, so only a higher security level atomic test, production base.due to declining cost of microprocessor and various electronic components, precision gradually improve, control device of a biological recognition technology has been gradually applied to commerce authorized, such as access control, attendance management, management system, safety certification field etc..All biometric technology, iris recognition is currently used as a convenient and accurate.Making twenty-first Century is information technology, network technology of the century, is also the human get rid of traditional technology, more and more freedom of the century. In the information, free for the characteristics of the century, biometric authentication technology, high-tech as the end of the twentieth Century began to flourish, will play a more and more important role in social life, fundamentally change the human way of life . Characteristics of the iris, fingerprint, DNA the body itself, will gradually existing password, key, become people lifestyle, instead of at the same time, personal data to ensure maximum safety, maximize the prevention of various types of crime, economic crime.Iris recognition technology, because of its unique in terms of acquisition, accuracy and other advantages, will become the mainstream of biometric authentication technology in the future society. Application of safety control, the customs import and export inspection, e-commerce and other fields in the future, is also inevitable in iris recognition technology as the focus. This trend, now in various applications around the world began to appear in the.1.2 Objective and significance of iris recognitionIris recognition technology rising in recent years, because of its strong advantages and potential commercial value, driven by some international companies and institutions have invested a lot of manpower, financial resources and energy research. The concept of automatic iris identification is first proposed by Frown, then Daugman for the first time in the algorithm becomes feasible.The iris is a colored ring in the pupil in the eye of fabric shape, each iris contains a structure like the one and only based on the crown, crystalline, filaments, spots, structure, concave point, ray, wrinkles and fringe characteristic. The iris is different from the retina, retinal is located in the fundus, difficult to image, iris can be seen directly, biometric identification technology can obtain the image of iris fine with camera equipment based on the following basis: Iris fibrous tissue details is rich and complicated, and the formation and embryonic tissue of iris details the occurrence stage of the environment, have great random the. The inherent characteristics of iris tissue is differ from man to man, even identical twins, there is no real possibility of characteristics of the same.When the iris are fully developed, he changes in people's life and tiny. In the iris outer, with a layer of transparent corneal it is separated from the outside world. So mature iris less susceptible to external damage and change.These characteristics of the iris has the advantages, the iris image acquisition, the human eye is not in direct contact with CCD, CMOS and other light sensor, uses a non technology acquisition invasion. So, as an important biometric identity verification system, iris recognition by virtue of the iris texture information, stability, uniqueness and non aggressive, more and more attention from both academic and industrial circles.1.3 Status and application of domestic and foreign research on iris recognitionIDC (International Data Group) statistics show that: by the end of 2003, the global iris recognition technology and related products market capacity will reach the level of $2000000000. Predicted conserved survey China biometric authentication center: in the next 5 years, only in the Chinese, iris recognition in the market amounted to 4000000000 rmb. With the expansion of application of the iris recognition technology, and the application in the electronic commerce domain, this number will expand to hundreds of billions.The development of iris recognition can be traced back to nineteenth Century 80's.. In 1885, ALPHONSE BERTILLON will use the criminal prison thoughts of the application of biometrics individual in Paris, including biological characteristics for use at the time: the size of the ears, feet in length, iris.In 1987, ARAN SAFIR and LEONARD FLOM Department of Ophthalmology experts first proposed the concept, the use of automatic iris recognition iris image in 1991, USA Los ala Moss National Laboratory JOHNSON realized an automatic iris recognition system.In 1993, JOHN DAUGMAN to achieve a high performance automatic iris recognition system.In 1997, the first patent Chinese iris recognition is approved, the applicant, Wang Jiesheng.In 2005, the Chinese Academy of Sciences Institute of automation, National Laboratory of pattern recognition, because of outstanding achievement "in recognition of" iris image acquisition and aspects, won the two "National Technology Invention Prize", the highest level represents the development of iris recognition technology in china.In 2007 November, "requirements for information security technology in iris recognition system" (GB/T20979-2007) national standards promulgated and implemented, the drafting unit: Beijing arithen Information Technology Co., ltd..Application of safety control, the customs import and export inspection, e-commerce and other fields in the future, is also inevitable in iris recognition technology as the focus. This trend, now in various applications around the world began to appear in the. In foreign countries, iris recognition products have been applied in a wide range.In February 8, 2002, the British Heathrow Airport began to test an advanced security system, the new system can scan the passenger's eyes, instead of to check passports. It is reported, the pilot scheme for a period of five months, a British Airways and virgin Airlines passengers can participate in this test. The International Air Transport Association interested in the results of this study are, they encourage the Heathrow Airport to test, through the iris boarding passengers to determine its identity as a boarding pass.Iris recognition system America "Iriscan" developed has been applied in the three business department of Union Bank of American Texas within. Depositors to be left with nothing whatsoever to banking, no bank card password, no more memories trouble. They get money from the A TM, a camera first eye of the user to scan, and then scan the image into digital information and data check, check the user's identity.America Plumsted school in New Jersey has been in the campus installed device of iris recognition for security control of any school, students and staff are no longer use cards and certificates of any kind, as long as they passed in the iris camera before, their location, identity is system identification, all foreign workers must be iris data logging to enter the campus. At thesame time, through the central login and access control system to carry on the control to enter the scope of activities. After the installation of the system, various campus in violation of rules and infringement, criminal activity is greatly reduced, greatly reducing the campus management difficulty.In Afghanistan, the United Nations (UN) and the United Nations USA federal agency refugee agency (UNHCR) using iris recognition system identification of refugees, to prevent the same refugee multiple receive relief goods. Use the same system in refugee camps in Pakistan and Afghanistan. A total of more than 2000000 refugees use iris recognition system, this system to a key role for the United Nations for distribution of humanitarian aid from.In March 18, 2003, Abu Zabi (one of the Arabia and the United Arab Emirates) announced the iris recognition technology for expelled foreigners iris tracking and control system based on the borders opened the world's first set of national level, this system began construction from 2001, its purpose is to prevent all expelled by Abu Zabi tourists and other personnel to enter the Abu Zabi. Without this system in the past, due to the unique characteristics of the surface of the Arabs (Hu Xuduo), and the number of the expulsion of the numerous, customs inspection staff is very difficult to distinguish between what is a deported person. By using this system, illegal immigration, all be avoided, the maximum guarantee of national security.Kennedy International Airport in New Jersey state (John F. Kennedy International Airport) of the iris recognition system installed on its international flights fourth boarding port, 300 of all 1300 employees have already started to use the system login control. By using this system, all can enter to the apron personnel must be after the system safety certification of personnel. Unauthorized want to break through, the system will automatically take emergency measures to try to force through personnel closed in the guard space. Using this system, the safety grade Kennedy International Airport rose from B+ to A+ grade. The Kennedy International Airport to travel to other parts of the passengers has increased by 18.7%.Generally speaking, the iris recognition technology has already begun in all walks of life in various forms of application in the world. At the same time, to the application of their units of all had seen and what sorts of social benefits and economic benefits are not see. This trend is to enhance the high speed, the next 10 years will be gradually achieve the comprehensive application of iris recognition in each industry.In China, due to the Chinese embargo and iris technology itself and the difficulty in domestic cannot develop products. So far, there has not been a real application of iris recognition system. However, many domestic units are expressed using strong intention, especially the "9 · 11" later, security anti terrorism consciousness has become the most concerned problems in the field of aviation, finance. Iris recognition system is a major airline companies, major financial institutions and other security mechanisms (such as aerospace bureau) become the focus of attention of object and other key national security agency. As with the trend of development in the world, iris recognition technology will in the near future in application China set off climax.The second chapter of introduction of iris recognition technology2.1 Technology of biological feature recognition based on2.1.1 Present status and development of biological feature recognition“9.11" event is an important turning point in the development of biometric ident ification technology in the world, the importance of it makes governments more clearly aware of the biological recognition technology. Traditional identity recognition technologies in the face ofdefect anti terrorism has shown, the government began a large-scale investment in the research and application of biometric technology. At the same time, the public understanding of biological recognition technology with "9.11" exposure rate and greatly improve the.The traditional method of individual identification is the identity of the people with knowledge, identity objects recognition. The so-called identity: knowledge refers to the knowledge and memory system of personal identification, cannot be stolen, and the system is easy to install, but once the identification knowledge stolen or forgotten, the identity of easily being fake or replaced, this method at present in a wide range of applications. For example: the user name and password. The so-called identity items: refers to the person, master items. Although it is stable and reliable, but mainly depend on the outer body, lost or stolen identification items once proof of identity, the identity of easily being fake or replaced, for example: keys, certificates, magnetic card, IC card etc..Biometric identification technology is related to physical characteristics, someone using prior record of behavior, to confirm whether the facts. Biometric identification technology can be widely used in all fields of society. For example: a customer came into the bank, he did not take bank card, also did not remember the password directly drawing, when he was drawing in the drawing machine, a camera to scan on his eyes, and then quickly and accurately complete the user identification and deal with business. This is the application of the iris recognition system of modern biological identification technology. "".America "9.11" after the incident, the anti terrorist activity has become the consensus of governments, it is very important to strengthen the security and defense security at the airport, some airports USA can in the crowd out a face, whether he Is it right? Wanted. This is the application of modern technology in biological feature recognition "facial recognition technology".Compared with the traditional means of identity recognition, biometric identity recognition technology in general has the following advantages:(1) the security performance is good, not easy to counterfeit or stolen.(2) carry, whenever and wherever possible, therefore more safety and security and other identification method.For the biological information of biometric recognition, its basic nature must meet the following three conditions: universality, uniqueness and permanency.The so-called universality, refers to any individual has the. Uniqueness, is in addition to other than himself, other people did not have any, namely different. The so-called permanent, refers to the character does not change over time, namely, life-long.Feature selection of organisms with more than three properties, is the first step of biological recognition.In addition, there are two important indexes in biological recognition technology. The rejection rate and recognition rate. Adjusting the relation of these two values is very important. The reject rate, the so-called false rejection, this value is high, use frequency is low, the error recognition, its value is high, safety is relatively reduced. So in the biological identification of any adjustment, the two index is a can not abandon the process. The choice of range size, related to the biological identification is feasible and available .And technology of identity recognition based on iris feature now appears, it is the development of biometric identification technology quickly, due to its uniqueness, stability,convenience and reliability, so the formation of biometric identification technology has the prospects for development.Generally speaking, the biological recognition system consists of 4 steps. The first step, the image acquisition system of collecting biometric image; the second step, the biological characteristics of image preprocessing (location, normalization, image enhancement and so on); the third step, feature information extraction, converted into digital code; the fourth step, the generation of test code and database template code to compare, make identification。

PART 210 CURRENT GOOD MANUFACTURING PRACTICE IN MANUFACTURING，PROCESSING，PACKING, OR HOLDING OF DRUGS；GENERAL210部分有关于生产、加工、包装和药品的储存的现行GMP;一般准则Sec. 210.1 Status of current goodmanufacturing practice regulations。

210.1 cGMP的法规地位。

(a）The regulations set forth in this part and in parts 211 through 226 of this chapter contain the minimum current good manufacturing practice for methods to be used in, and the facilities or controls to be used for, the manufacture，processing, packing, or holding of a drug to assure that such drug meets the requirements of the act as to safety, and has the identity and strength and meets the quality and purity characteristics that it purports or is represented to possess. （a）在本部分及本章第211－226部分中所陈述的法规,为现行GMP最低要求，适用于药品制造、加工、包装或贮存中所采用的方法及所使用的设施或控制手段,以保证该药品符合《联邦食品、药品及化妆品法案》（以下简称法案）对安全性的要求，具有均一性和效价（或含量)并符合或代表其生产过程的质量及纯度等特征。

动物医学实验报告英文AbstractThe purpose of this experiment was to investigate the effectiveness of a new medication in treating a specific disease in animals. The experiment involved the use of a control group and a treatment group, with each group consisting of ten animals. The animals were closely monitored for a period of four weeks, and their health conditions were assessed regularly. It was found that the animals in the treatment group showed significant improvement in their symptoms compared to those in the control group. This suggests that the new medication may be an effective treatment option for the disease in animals.IntroductionAnimal veterinary medicine plays a crucial role in ensuring the health and well-being of animals. Experimental research in this field allows for the development of new treatments and therapies to combat various diseases that affect animals. Animal models are commonly used in such experiments as they mimic human physiology closely and provide valuable insights into the effectiveness and safety of new medications. This report presents the findings of an experiment conducted to evaluate the effectiveness of a new medication in treating a specific disease in animals.MethodsFor this experiment, twenty animals were divided into two groups: a control group and a treatment group. Each group consisted of ten animals. All animals were infected with the same disease and were chosen randomly to ensure a fair distribution. The control group received a placebo treatment, while the treatment group received the new medication.The animals' health conditions were assessed at the beginning of the experiment, and regular assessments were conducted every week for a period of four weeks. The assessments included measuring various health parameters like body temperature, heart rate, respiratory rate, and blood samples for laboratory analysis. The animals were also observed for any changes in behavior, appetite, and overall well-being. ResultsAnalysis of the data collected showed that the animals in the treatment group exhibited significant improvement in their symptoms compared to those in the control group. The animals in the treatment group had lower body temperatures, heart rates, and respiratory rates, indicating a reduction in discomfort and inflammation associated with the disease. The blood samples showed a decrease in infection markers and an increase in immune response indicators in the treatment group, suggesting that the new medication boosted the animals' immune systems. Additionally, the animals in the treatment group displayedincreased appetite and energy levels, indicating an overall improvement in their well-being.DiscussionThe results of this experiment suggest that the new medication is effective in treating the specific disease in animals. The lower body temperatures, heart rates, and respiratory rates observed in the treatment group indicate a reduction in inflammation, which is a common symptom of the disease. The decrease in infection markers and increase in immune response indicators suggest that the new medication improved the animals' immune systems, helping them fight off the disease. The increase in appetite and energy levels further support the positive outcomes of the treatment.However, further research is required to validate these findings and determine the long-term effects of the new medication. Additionally, it would be beneficial to conduct similar experiments on a larger number of animals to strengthen the conclusions and ensure the generalizability of the results.ConclusionIn conclusion, this experiment demonstrated the effectiveness of a new medication in treating a specific disease in animals. The animals in the treatment group exhibited significant improvement in their symptomscompared to those in the control group. These findings suggest that the new medication may serve as a valuable treatment option for the disease in animals. Further research and experiments are necessary to confirm these results and assess the long-term effects of the medication.。

锚定生物与医药硕士学位条件锚定生物与医药硕士学位的条件包括以下几个方面：
1. 学术背景：申请者需要拥有本科阶段的生物学、医学、药学等相关专业学历背景。

2. 学术成绩：申请者的本科阶段学习成绩需要达到一定的水平，通常要求平均成绩在班级前50%。

3. 研究经验：申请者需要在本科阶段或之前有过相关的研究经验，能够展示出对生物与医药领域的兴趣和研究能力。

4. 推荐信：申请者需要提供两封推荐信，推荐人需要是在学术领域有较高声望的专业人士。

5. 个人陈述：申请者需要在个人陈述中充分展示自己对生物与医药领域的兴趣、动机和职业规划。

6. 英语水平：锚定生物与医药硕士学位通常要求申请者的英语水平达到一定的标准，如托福、雅思等。

7. 其他材料：申请者可能需要提交一些其他材料，如研究成果、奖项等，以支持自己的申请。

总之，锚定生物与医药硕士学位的条件比较严格，申请者需要认真准备，全面展示自己的学术背景、研究能力和职业规划。

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专利名称：用于诊断胰腺癌的包括用于特异性结合至补体因子B蛋白的抗体和用于特异性结合至糖类抗原19‑9蛋
白的抗体的试剂盒
专利类型：发明专利
发明人：白融基,李旼珽
申请号：CN201480078913.3
申请日：20140903
公开号：CN106461665A8
公开日：
20170630
专利内容由知识产权出版社提供
摘要：本申请涉及包括用于特异性结合至补体因子B蛋白的抗体和用于特异性结合至糖类抗原19-9蛋白的抗体的胰腺癌诊断试剂盒、利用该胰腺癌诊断试剂盒提供用于诊断胰腺癌的信息的方法以及利用该胰腺癌诊断试剂盒的胰腺癌诊断方法。

根据本申请，能够提供具有提高的敏感性和特异性的用于胰腺癌诊断的标志物。

申请人：延世大学校产学协力团
地址：韩国首尔市
国籍：KR
代理机构：北京度衡知识产权代理有限公司
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•综述•2人体表征分子鉴识专题*人面部形态刻画的法医遗传学研究进展杜情情，卢朝龙，丛斌，李淑瑾(河北医科大学法医学院河北省法医学重点实验室，河北石家庄050019)摘要：法医DNA表型(forensic DNA phenotyping,FDP)分析利用现场遗留生物样本DNA预测个体表型特征，如族群地域来源、身高、体质量、肤色、毛发颜色与形态、虹膜颜色、男性秃发、面部形态和年龄等，为案件的侦查提供线索，其中面部形态特征较为复杂。

本文从面部形态的测量采集、面部形态相关基因的研究、面部形态刻@的模型建立及法医学应用和伦理问题等方面进行全面分析，对其最新研究进展进行综述。

关键词：法医遗传学；表型；面部；综述中图分类号：DF795.2文献标志码：A doi：10.12119/j.issn.1004-5519.2019.05.005文章编号：1004-5619(2019)05-0531-06Research Progress on Forensic Genetics of Facial Morphological DepictionDU Qing-qing)LU Chao-long,CONG Bin,LI Shu-jin(Hebei Key LaOoratory of Forensic Medicirie)College of Forensic Medicine.,Hebei Medicol University)SShin-zhuong050017)Chine)Abstrcct:Forensic DNA phenotyping(FDP)analysis uses DNA from biological samples left in crime scenes to podiat indiviOunl phenotypic.aits,sucC ne geogophicnl oogin of ethnic goup,height, weight,sUin caloe,hait caloe a nd sUape,iris caloe,male baldoese,fPcinl mo#hologp,age,etc=theredp providing clue a Pe case invesUnatiooe.Amoog these traite,featuree oP Pcill moohologp are relativety more campocaud.T his papee makes al overall analpsis oP the measu■emenS ald callectioo oP focid moehologp,researca oo moePologp relates geoes,foredsic appocatioo ald estanlisUmedS oP P-moePologp depictiov model,ethical issuee,etc.,thed summarizee00lateeS researca progrese ov PaUues oP Pcid morppologp.Keywords:Predsic hededcs;phedotypinh；P cc;mview近35年来，法医检案多采用短串联重复(short tangem repeats,STR)序列复合扩增联合毛细管电泳分析技术，解决了大量法医物证案件，是法医物证学检验的主要手段。

妇产科专科生物样本库的建设和管理于焕镝（复旦大学附属妇产科医院，上海 200090）【摘要】妇产科专科生物样本库的建设对于妇产科疾病分析与研究有重要的意义，对具体的样本库建设要点和管理中需要克服的难点等进行分析，这会使具体的样本库应用效果有更显著提升。

【关键词】妇产科；生物样本；建设；管理【中图分类号】R194 【文献标识码】A 【文章编号】ISSN.2095-8242.2020.23.4.02Construction and Management of Biological Sample Bank forObstetrics and Gynecology SpecialityYU Huan-di(Obstetrics and Gynecology Hospital Affiliated to Fudan University,Shanghai 200090,China)【Abstract】The construction of biological sample bank for obstetrics and gynecology specialty is of great significance for the analysis and research of obstetrics and gynecology diseases.This paper analyzes the key points of the construction of specific sample bank and the difficulties to be overcome in management,which will significantly improve the application effect of specific sample bank.【Key words】Obstetrics and gynecology; Biological samples;Construction;Management妇产科专科生物样本库的建设对于妇产科疾病分析与研究有重要的意义，所以积极的进行样本库的建设有非常重要的意义。