西酞普兰与氟西汀治疗抑郁症对照研究.

艾司西酞普兰与氟西汀治疗抑郁症对照观察摘要】目的：探讨艾司西酞普兰治疗抑郁症的疗效与安全。

方法：对90例抑郁症患者随机分为两组，艾司西酞普兰组46例，氟西汀组44例，疗程8周，用汉密尔顿抑郁量表(HAMD)、副反应量表(TESS)评定疗效和不良反应。

结果：艾司西酞普兰与氟西汀总的疗效差异无显著性；艾司西酞普兰主要不良副反应明显低于氟西汀。

结论：艾司西酞普兰是一种安全、有效的抗抑郁药。

【关键词】抑郁症；艾司西酞普兰；氟西汀；疗效；安全性【中图分类号】R749.3 【文献标识码】A 【文章编号】1007-8231（2015）17-0044-02Effectiveness of escitalopram and fluoxetine in treatment depressionZhang Yonghui .Yunnan Mental Health Hospital Kunming 650224, China【Abstract】Objective To explore the efficacy and safety of escitalopram in the treatment of depression.Method 90 cases with diagnosis of depression were randomly assigned into escitalopram group (n=46) andfluoxetine group（n=44）for 8weeks .The effects and side reactions were evaluated with Hamilton depression scale (HAMD) and treatment emergent symptom scale (TESS) before and after the treatment.Results There were no significant differences in effectiveness between two groups. Howere, escitalopram had fewer side effects than fluoxetine .Conclusion The study suggests that escitalopram is a safe and effective antidepressant.【Key words】Depression; Escitalopram;Fluoxetine;Efficacy; Safety为进一步探讨艾司西酞普兰（来士普）治疗抑郁症的疗效和安全性，我们以氟西汀为对照进行研究。

探讨艾司西酞普兰和氟西汀治疗抑郁症的临床效果及对抑郁症患者认知功能障碍的影响张金铭【期刊名称】《中国继续医学教育》【年(卷),期】2016(8)28【摘要】Objective To study the clinical effect of escitalopram and fluoxetine in the treatment of depression and to explore the effect of the treatment on cognitive dysfunction in patients with depression. Methods 80 cases of depression patients in our hospital from January 2010 to January 2011 in were selected and divided into control group and experimental group. The test group of 40 patients, using escitalopram treatment, the control group of 40 patients received fluoxetine treatment, compared the clinical therapeutic effect of two groups, observed in patients with cognitive dysfunction to improve the situation.Results In the ifrst and eighth weeks, the effective rates of control group were 2.5% and 70%, the control group was 17.5% and 80%, and the results of two groups were statistically signiifcant (P<0.05).ConclusionThe clinical effect of escitalopram in the treatment of depression patients is prominent, quick effect, high effective rate.%目的：研究分析艾司西酞普兰和氟西汀治疗抑郁症的临床效果，探讨其对患者认知功能障碍的影响。

艾司西酞普兰与氟西汀治疗抑郁症对症研究摘要】目的比较艾司西酞普兰与氟西汀治疗抑郁症的临床疗效和安全性。

方法将68例符合中国精神障碍分类与诊断标准第三版抑郁发作诊断标准的患者，随机分为艾司西酞普兰组与氟西汀组，疗程6周。

用汉密尔顿抑郁量表（HAMD）评定疗效，用副反应量表（TESS）评定不良反应。

结果艾司西酞普兰组与氟西汀组的有效率分别为85.3%和82.4%，两组相仿。

但治疗1周和2周后，艾司西酞普兰组的有效率高于氟西汀组，两组间不良反应比较差异无显著性。

结论艾司西酞普兰是一种起效较快，且安全、有效的新型抗抑郁药。

【关键词】艾司西酞普兰氟西汀抑郁症艾司西酞普兰（商品名：百适可）抗抑郁的疗效及安全性方面如何？我们对此进行了研究。

1 对象和方法1.1 对象选择2009年6月至2010年12月的门诊及住院患者，符合中国精神障碍分类与诊断标准第3版单次或复发性抑郁发作的诊断标准；入组前2周未服用任何抗精神病药与抗抑郁药；无严重躯体疾病，无物质滥用；排除双相情感性精神障碍快速循环性或伴有精神病症状者，以及妊娠及哺乳期妇女。

共68例，随机平分为两组。

艾司西酞普兰组34例，男18例，女16例：年龄18～59岁，平均（27.3±8.8）岁；病程1个月～2年，平均（6.7±5.8）个月。

氟西汀组34例，男19例，女15例：年龄17～59岁，平均（27.8±8.5）岁；病程1个月～2年，平均（6.2±4.9）个月。

两组以上各项差异均无显著性（P均＞0.05）。

1.2 方法艾司西酞普兰剂量为10～20mg/d，氟西汀剂量为20～60mg/d，疗程6周，均不使用其他精神药物。

在治疗前及治疗1、2、4及6周末用汉密尔顿抑郁量表（HAMD，17项）评定疗效，以副反应量表（TESS）评定不良反应。

评定者一致性kappa=0.88。

治疗前后监测血常规，肝功能及心电图。

按HAMD总分评定疗效，≤7分为痊愈，减分率≥50%为有效，＜50%为无效。

艾司西酞普兰与氟西汀治疗抑郁症对照研究作者：徐伏莲许律琴来源：《中国实用医药》2009年第01期[摘要] 目的比较艾司西酞普兰与氟西汀治疗抑郁症的疗效和安全性。

方法随机将77例符合CCMD—3抑郁发作的住院患者分为艾司西酞普兰组和氟西汀组，艾司西酞普兰组剂量10～20 mg/d，氟西汀组20～40 mg/d，疗程6周。

疗效采取汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA）评定，不良反应和安全性用TESS和实验室检查评定。

结果两组总体疗效相当，艾司西酞普兰组有效率为87.2%，治愈率为48.7%，氟西汀组有效率86.8%，治愈率47.4%，两组疗效比较差异无显著性。

但1周末时HAMD评分及减分率两组间差异有显著性，说明艾司西酞普兰起效快；艾司西酞普兰组不良反应发生率明显少于氟西汀组，差异有统计学意义。

结论艾司西酞普兰是安全、有效的抗抑郁药。

A controlled study on the treatment of depression with escitalopram and FluoxetineXU Fu-lian.The T hird Peopl’s Hospital of Jiangmen City of Guangdong Province, Jiangmen 52900,China【Abstract】Objective To study the efficacy and safety of escitalopram in the treatment of depression.Methods 77 patients who met CCMD-3 criterion for depression episode were randomly assigned to escitalopram group(n=39) with 10-20 mg per day and Fluoxetine group(n=38) with 20-40 mg per day for the treatment of6 weeks. Clinical effectiveness was evaluated using HAMD and HAMA,and adverse reactions and safety were assessed with TESS and laboratory examination.Results There was no significant difference of the efficacy between two groups (P>0.05). The response rate and rem ission rate were 87.2% and 48.7% for escitalopram group and were 86.8% and 47.42% for Fluoxetine group respectively. Escitalopram showed rapider efficacy and less side effects than Fluoxetine(P【Key words】Escitalopram; Fluoxetine;Depression艾司西酞普兰是消旋体西酞普兰的S-异构体。