The primary outcome measure was the rate of poor outcome (ie, GOS showing severe disability, vegetative state, or death).
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6
This trial was terminated prematurely due to futility. There was no difference in the rate of poor outcome (60% vs. 45% for hypothermia and normothermia, respectively; P=0.67) or death (23% vs. 14%, P=0.52).
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9
Sui reported data from 43,933 men who underwent a comprehensive preventative medical between 1971 and 2002 (were free of myocardial infarction, stroke, cancer, or known diabetes mellitus)
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5
The National Acute Brain Injury Study: Hypothermia II was a randomized multicenter trial in which 97 patients with moderate-tosevere TBI received either normothermia or totalbody hypothermia to 33°C for 48 hours.