曲格列汀杂质汇总

瑞舒伐他汀钙相关杂质列表(现货)：深圳恒丰万达专业提供杂质对照品，标准品，快速优惠热线138****3301序列杂质简称相关杂质结构纯度1A 对接异构体-1RosuvastatinImpurity 23CAS No.N/A C29H40FN3O6S M.W.577.71R-097999.85%2Z-10对接异构体-2RosuvastatinImpurity 24CAS No.1378943-63-5C29H40FN3O6S M.W.577.71R-098099.74%3C 对接异构体-3RosuvastatinImpurity 25CAS No.N/A C29H40FN3O6S M.W.577.71R-098195.39%4E对接异构体（Z 式）-4(Z)-Rosuvastatin Impurity 15CAS No.1821422-50-7C29H40FN3O6S M.W.577.71R-097199.74%5Q对接光降解-1CAS No.N/A C29H40FN3O6S M.W.577.71R-099099.31%6P对接光降解-2CAS No.N/A C29H40FN3O6S M.W.577.71R-099299.69%7I丙酮加合物CAS No.N/A C32H46FN3O7S M.W.635.7998.23%8Z-12对接脱氟CAS No.N/AC29H41N3O6S M.W.559.72R-099399.46%9Z-16双键环氧脱丙酮叉CAS No.N/AC29H40FN3O7S M.W.593.7199.18%10B脱丙酮叉异构体-1ent-Rosuvastatin tert-Butyl Ester CAS No.615263-60-0C26H36FN3O6S M.W.537.65R-091899.90%11Z-11脱丙酮叉异构体-2(3S,5S)-Rosuvastatintert-Butyl Ester CAS No.2185805-16-5C26H36FN3O6S M.W.537.65R-097699.66%12D 脱丙酮叉异构体-3(3R,5R)-tert-ButylRosuvastatin (Rosuvastatin Impurity)CAS No.2162136-65-2C26H36FN3O6S M.W.537.65R-0911100%13F 脱丙酮叉异构体（Z 式）-4CAS No.1821422-51-8C26H36FN3O6S M.W.537.65R-099699.44%14S脱丙酮叉光降解-1CAS No.N/A C26H36FN3O6S M.W.537.65R-098999.61%15R脱丙酮叉光降解-2CAS No.N/A C26H36FN3O6S M.W.537.65R-099199.20%16J丙酮加合物脱丙酮叉Rosuvastatin EP Impurity A CAS No.1714147-49-5C29H42FN3O7S M.W.595.72R-099799.65%17Z-13无氟脱丙酮叉CAS No.N/AC26H37N3O6S M.W.519.65R-099599.17%18Z-255-甲氧基脱叉杂质RosuvastatinImpurity 42CAS No.N/A C27H38FN3O6S M.W.551.67R-0910098.80%19Z-263-甲氧基脱叉杂质RosuvastatinImpurity 47CAS No.N/A C27H38FN3O6S M.W.551.67R-0910598.65%203,5-二甲氧基脱叉杂质Rosuvastatin Impurity 44CAS No.N/A C28H40FN3O6S M.W.565.70R-0910698%21G钙盐异构体-1Rosuvastatin EP Impurity G Calcium Salt CAS No.1242184-42-4(free acid)C22H27FN3O6S.1/2Ca M.W.480.5420.0499.88%22Z-1钙盐异构体-2(3S,5S)Rosuvastatin Calcium Salt CAS No.1584149-34-7(free acid)C22H27FN3O6S.1/2Ca M.W.480.5420.04R-091598.15%23H钙盐异构体-3Rosuvastatin EP Impurity B Calcium Salt(3R,5R)-Rosuvastatin Calcium Salt CAS No.1422515-55-61094100-06-7(free acid)C22H27FN3O6S.1/2Ca M.W.480.5420.04R-091296.13%24V钙盐异构体（Z 式）-4Rosuvastatin Z-Isomer Calcium Salt CAS No.1444772-08-01445208-17-2(free acid)C22H27FN3O6S.1/2Ca M.W.480.5420.0499.51%25Z-245-甲氧基钠盐CAS No.N/AC23H29FN3NaO6S M.W.517.5599.50%26Z-273-甲氧基钠盐CAS No.N/AC23H29FN3NaO6S M.W.517.5596.83%27Z-293,5-二甲氧基钠盐CAS No.N/AC24H31FN3NaO6S M.W.531.5797.78%28U钙盐异构体光降解-5RosuvastatinImpurity 1Calcium Salt CAS No.854898-49-0854898-48-9(free acid)C22H27FN3O6S.1/2Ca M.W.480.5420.0499.75%29T 钙盐异构体光降解-6RosuvastatinImpurity 2Calcium Salt CAS No.854898-50-3854898-53-6(free base)C22H27FN3O6S.1/2Ca M.W.480.5420.0499.83%30Z-18钠盐异构体光降解-7(混合物)RosuvastatinImpurity 1Calcium SaltCAS No.N/A C22H27FN3O6S.1/2Ca M.W.480.5420.04R-093499.16%31Z-20钙盐异构体光降解-8Rosuvastatin Impurity CAS No.N/A C22H26FN3O6S M.W.479.5296.69%32Z-14钙盐无氟DesfluoroRosuvastatin Calcium Salt CAS No.N/A847849-66-5(acid)C22H28N3O6S.1/2Ca M.W.462.5420.04R-099499.78%33K 丙酮加合物钙盐Rosuvastatin EPImpurity A Calcium Salt CAS No.1714147-47-31715120-13-0(free acid)C25H33FN3O7S.1/2Ca M.W.538.6120.04R-092599.46%34M 内酯Rosuvastatin EPImpurity D CAS No.503610-43-3C22H26FN3O5S M.W.463.52R-09199.46%35N 内酯异构体CAS No.N/AC22H26FN3O5S M.W.463.5299.46%36内酯异构体CAS No.N/A C22H26FN3O5S M.W.463.5297%37Z-283-甲氧基内酯CAS No.N/AC23H28FN3O5S M.W.477.5598.97%38L5-氧代Rosuvastatin EP Impurity C freed acid CAS No.1620823-61-1(sodium salt)1422619-13-3(acid)C22H26FN3O6S M.W.479.5297.92%39Z-63-氧代3-Oxo Rosuvastatin Sodium Salt CAS No.1346606-28-71346747-49-6(acid)C22H25FN3O6S.Na M.W.478.5222.99R-091798.61%40O内酯脱水Rosuvastatin2,6-Diene Lactone Impurity CAS No.1246665-85-9C22H24FN3O4S M.W.445.5299.36%R-094141Z-44,6-二烯Rosuvastatin4,6-Diene Impurity CAS No.1422954-13-9C22H26FN3O5S M.W.463.53R-092795.44%42Z-152,6-二烯CAS NO.1422954-12-8(free acid)C22H26FN3O5S R-092695.70%43Z-8脱甲基二钠盐（体内代谢产物）N-Desmethyl Rosuvastatin Disodium Salt CAS No.371775-74-5(free base)C21H24FN3O6S.2Na M.W.465.50222.99R-09598.87%44W光降解内酯CAS No.854898-47-8C22H26FN3O5S M.W.463.5299.80%45X 光降解内酯CAS No.854898-46-7C22H26FN3O5S M.W.463.5297.84%46Z-2Z 式异构体内酯CAS No.N/A C22H26FN3O5S M.W.463.5296.52%47Z-9脱甲基内酯（体内代谢产物）N-Desmethyl Rosuvastatin Lactone CAS:1797419-58-9C21H24FN3O5S M.W.449.5097.42%48Z-7基因毒性杂质（体内代谢产物）Rosuvastatin Impurity 28CAS No.N/A C22H28FN3O7S M.W.497.54R-098498.94%49Z-5母核烯醛（工艺相关杂质）CAS No.890028-66-7C18H20FN3O3S M.W.377.4398.85%50Z-42母核无氟膦盐CAS No.N/A C34H35BrN3O2PS M.W.660.6099.14%51Y 本体脱丙酮叉CAS No.N/A C26H36FN3O6S M.W.537.6599.74%更多其他项目：雷西纳德，阿格列汀，依鲁替尼，唑吡坦，利奈唑胺，西他沙星，沙丁胺醇，罗替戈汀，丙戊酸钠，左乙拉西坦，西格列汀，特地唑胺，帕瑞昔布钠，帕布昔利布，赛乐西帕，伏硫西汀，曲格列汀，米拉贝隆，沙芬酰胺，达泊西汀，吡格列酮，达泊西汀，吉非替尼，去甲肾上素，阿昔洛韦，文拉法辛，普拉洛芬，普拉克索，曲唑酮，茚达特罗，阿扎胞苷，酮替芬，依折麦布，西那卡塞，氨曲南，替诺福韦，厄多司坦，孤法辛，雷贝拉唑，阿法替尼，依达拉奉，帕利哌酮，达比加群酯，鲁拉西酮，尼非卡兰，瑞巴派特，苯达莫司汀，利伐沙班，法舒地尔，普拉格雷，维格列汀，索非布韦，文拉法辛等。

相关杂质整理列表中文名英文名CAS 号规格纯度结构式西格列汀杂质1SitagliptinImpurity 1823817-56-710mg-25mg-50mg-100mg ≥99%西格列汀杂质2SitagliptinImpurity 2486460-32-610mg-25mg-50mg-100mg ≥99%西格列汀杂质3SitagliptinImpurity 3N/A 10mg-25mg-50mg-100mg ≥99%由西格列汀和西格列汀EP 杂质A 组成的混合物A MixtureConsisiting Of Sitagliptin AndSitagliptin EPImpurity A N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质7SitagliptinImpurity 7823817-55-610mg-25mg-50mg-100mg ≥99%西格列汀EP 杂质A Sitagliptin EP Impurity A 823817-55-610mg-25mg-50mg-100mg ≥99%西格列汀杂质9SitagliptinImpurity 91234321-81-310mg-25mg-50mg-100mg ≥99%西格列汀杂质10SitagliptinImpurity 10N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质11SitagliptinImpurity 11922178-94-710mg-25mg-50mg-100mg ≥99%西格列汀EP 杂质A Sitagliptin EP Impurity A 823817-58-910mg-25mg-50mg-100mg ≥99%西格列汀杂质14SitagliptinImpurity 141675201-14-510mg-25mg-50mg-100mg ≥99%西格列汀EP 杂质B Sitagliptin EP Impurity B 486460-31-510mg-25mg-50mg-100mg ≥99%西格列汀EP 杂质C Sitagliptin EP Impurity C 945261-48-3&1345822-86-710mg-25mg-50mg-100mg ≥99%西格列汀杂质17SitagliptinImpurity 171253056-18-610mg-25mg-50mg-100mg ≥99%西格列汀杂质18SitagliptinImpurity 18N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质19SitagliptinImpurity 191351498-25-310mg-25mg-50mg-100mg ≥99%西格列汀杂质20SitagliptinImpurity 202088771-61-110mg-25mg-50mg-100mg ≥99%西格列汀杂质21SitagliptinImpurity 21N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质22SitagliptinImpurity 22N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质23SitagliptinImpurity 23851307-12-510mg-25mg-50mg-100mg ≥99%西格列汀杂质24SitagliptinImpurity 24486459-98-710mg-25mg-50mg-100mg ≥99%西格列汀杂质25SitagliptinImpurity 25936630-57-8&1204818-19-810mg-25mg-50mg-100mg ≥99%西格列汀杂质26SitagliptinImpurity 261256815-03-810mg-25mg-50mg-100mg ≥99%西格列汀杂质27SitagliptinImpurity 271608491-98-010mg-25mg-50mg-100mg ≥99%西格列汀杂质28SitagliptinImpurity 28898543-70-910mg-25mg-50mg-100mg ≥99%西格列汀杂质29SitagliptinImpurity 292072867-07-110mg-25mg-50mg-100mg ≥99%西格列汀杂质30SitagliptinImpurity 301334244-32-410mg-25mg-50mg-100mg ≥99%西格列汀杂质31SitagliptinImpurity 311334244-28-810mg-25mg-50mg-100mg ≥99%西格列汀杂质32SitagliptinImpurity 321334244-24-410mg-25mg-50mg-100mg ≥99%西格列汀杂质33SitagliptinImpurity 33N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质34SitagliptinImpurity 34945261-46-110mg-25mg-50mg-100mg ≥99%西格列汀杂质35SitagliptinImpurity 35945261-47-210mg-25mg-50mg-100mg ≥99%西格列汀杂质36SitagliptinImpurity 36N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质37SitagliptinImpurity 371379666-94-010mg-25mg-50mg-100mg ≥99%西格列汀杂质38SitagliptinImpurity 38N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质39SitagliptinImpurity 39N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质40SitagliptinImpurity 40940002-57-310mg-25mg-50mg-100mg ≥99%西格列汀杂质41SitagliptinImpurity 41847445-81-2&767340-03-410mg-25mg-50mg-100mg ≥99%西格列汀杂质42SitagliptinImpurity 42N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质43SitagliptinImpurity 43N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质44SitagliptinImpurity 44N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质45SitagliptinImpurity 45N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质46SitagliptinImpurity 461253056-01-710mg-25mg-50mg-100mg ≥99%西格列汀杂质47SitagliptinImpurity 47N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质48SitagliptinImpurity 48N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质49SitagliptinImpurity 49N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质50SitagliptinImpurity 50N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质51SitagliptinImpurity 51881995-69-310mg-25mg-50mg-100mg ≥99%西格列汀杂质52SitagliptinImpurity 52N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质53SitagliptinImpurity 53764667-65-410mg-25mg-50mg-100mg ≥99%西格列汀杂质54SitagliptinImpurity 54881995-73-910mg-25mg-50mg-100mg ≥99%西格列汀杂质55SitagliptinImpurity 55769195-26-810mg-25mg-50mg-100mg ≥99%西格列汀杂质56SitagliptinImpurity 56486460-23-510mg-25mg-50mg-100mg ≥99%西格列汀杂质57SitagliptinImpurity 57N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质58SitagliptinImpurity 582088771-60-010mg-25mg-50mg-100mg ≥99%西格列汀杂质59SitagliptinImpurity 59N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质60SitagliptinImpurity 601253055-92-310mg-25mg-50mg-100mg ≥99%西格列汀杂质61SitagliptinImpurity 61N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质62SitagliptinImpurity 62N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质63SitagliptinImpurity 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≥99%西格列汀杂质95SitagliptinImpurity 95881995-70-610mg-25mg-50mg-100mg ≥99%西格列汀杂质96SitagliptinImpurity 96764667-64-310mg-25mg-50mg-100mg ≥99%西格列汀杂质97SitagliptinImpurity 971151240-91-310mg-25mg-50mg-100mg ≥99%西格列汀杂质98SitagliptinImpurity 98N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质99SitagliptinImpurity 99N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质100SitagliptinImpurity 100N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质101SitagliptinImpurity 101N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质102SitagliptinImpurity 102N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质103SitagliptinImpurity 103N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质104SitagliptinImpurity 104N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质105SitagliptinImpurity 105N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质106SitagliptinImpurity 106N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质107SitagliptinImpurity 107N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质108SitagliptinImpurity 1082033-24-110mg-25mg-50mg-100mg ≥99%西格列汀杂质109SitagliptinImpurity 109N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质110SitagliptinImpurity 110N/A 10mg-25mg-50mg-100mg ≥99%西格列汀杂质111SitagliptinImpurity 1111036273-20-710mg-25mg-50mg-100mg ≥99%湖北扬信医药科技有限公司经营上万种杂质对照品（优势供应硫酸羟氯喹杂质、硝苯地平杂质、沙丁胺醇杂质、达格列净杂质、厄贝沙坦杂质、阿莫西林克拉维酸钾杂质、利伐沙班杂质、阿托伐他汀钙杂质、西格列汀杂质、利格列汀杂质等），并代理销售中检所、STD 、LGC 、TLC 、EP 、USP 、TRC 等多个品牌产品，提供上万种标准品对照品，真诚为您服务。

曲格列汀杂质7Impurity 71597T N/A50mg-100mg曲格列汀杂质8Trelagliptin Impurity 81598T N/A10mg-25mg-50mg-100mg曲格列汀杂质9Trelagliptin Impurity 91599T N/A10mg-25mg-50mg-100mg曲格列汀杂质10Trelagliptin Impurity 1015910T N/A10mg-25mg-50mg-100mg曲格列汀杂质11Trelagliptin Impurity 1115911T N/A10mg-25mg-50mg-100mg曲格列汀杂质12Trelagliptin Impurity 1215912T N/A10mg-25mg-50mg-100mg曲格列汀杂质13Trelagliptin Impurity 1315913T N/A10mg-25mg-50mg-100mg曲格列汀杂质14Impurity 1415914T N/A50mg-100mg曲格列汀杂质15Trelagliptin Impurity 1515915T2087874-92-610mg-25mg-50mg-100mg曲格列汀杂质16Trelagliptin Impurity 1615916T2087874-94-810mg-25mg-50mg-100mg曲格列汀杂质17Trelagliptin Impurity 1715917T N/A10mg-25mg-50mg-100mg曲格列汀杂质18Trelagliptin Impurity 1815918T N/A10mg-25mg-50mg-100mg曲格列汀杂质19Trelagliptin Impurity 1915919T N/A10mg-25mg-50mg-100mg曲格列汀杂质20Trelagliptin Impurity 2015920T N/A10mg-25mg-50mg-100mg曲格列汀杂质21Impurity 2115921T N/A50mg-100mg曲格列汀杂质22Trelagliptin Impurity 2215922T N/A10mg-25mg-50mg-100mg曲格列汀杂质23Trelagliptin Impurity 2315923T N/A10mg-25mg-50mg-100mg曲格列汀杂质24Trelagliptin Impurity 2415924T N/A10mg-25mg-50mg-100mg曲格列汀杂质25Trelagliptin Impurity 2515925T N/A10mg-25mg-50mg-100mg曲格列汀杂质26Trelagliptin Impurity 2615926T N/A10mg-25mg-50mg-100mg曲格列汀杂质27Trelagliptin Impurity 2715927T N/A10mg-25mg-50mg-100mg曲格列汀杂质28Impurity 2815928T N/A50mg-100mg曲格列汀杂质30Trelagliptin Impurity 3015930T N/A10mg-25mg-50mg-100mg曲格列汀杂质31Trelagliptin Impurity 3115931T N/A10mg-25mg-50mg-100mg曲格列汀杂质34Trelagliptin Impurity 3415934T N/A10mg-25mg-50mg-100mg曲格列汀杂质35Trelagliptin Impurity 3515935T 31737-09-410mg-25mg-50mg-100mg曲格列汀杂质36Trelagliptin Impurity 3615936T N/A10mg-25mg-50mg-100mg曲格列汀杂质37Trelagliptin Impurity 3715937T N/A10mg-25mg-50mg-100mg曲格列汀杂质38Impurity 3815938T N/A50mg-100mg曲格列汀杂质39Trelagliptin Impurity 3915939T N/A10mg-25mg-50mg-100mg曲格列汀杂质40Trelagliptin Impurity 4015940T N/A10mg-25mg-50mg-100mg曲格列汀杂质41Trelagliptin Impurity 4115941T N/A10mg-25mg-50mg-100mg曲格列汀杂质42Trelagliptin Impurity 4215942T N/A10mg-25mg-50mg-100mg曲格列汀杂质43Trelagliptin Impurity 4315943T N/A10mg-25mg-50mg-100mg曲格列汀杂质44Trelagliptin Impurity 4415944T N/A10mg-25mg-50mg-100mg曲格列汀杂质45Impurity 4515945T N/A50mg-100mg曲格列汀杂质46Trelagliptin Impurity 4615946T N/A10mg-25mg-50mg-100mg曲格列汀杂质47Trelagliptin Impurity 4715947T N/A10mg-25mg-50mg-100mg曲格列汀杂质48Trelagliptin Impurity 4815948T N/A10mg-25mg-50mg-100mg曲格列汀杂质49Trelagliptin Impurity 4915949T N/A10mg-25mg-50mg-100mg曲格列汀杂质50Trelagliptin Impurity 5015950T 4270-27-310mg-25mg-50mg-100mg曲格列汀杂质51Trelagliptin Impurity 5115951T N/A10mg-25mg-50mg-100mg曲格列汀杂质52Impurity 5215952T N/A50mg-100mg曲格列汀杂质53Trelagliptin Impurity 5315953T N/A10mg-25mg-50mg-100mg曲格列汀杂质58Trelagliptin Impurity 5815958T147754-12-910mg-25mg-50mg-100mg曲格列汀杂质59Trelagliptin Impurity 5915959T 452-63-110mg-25mg-50mg-100mg曲格列汀杂质60Trelagliptin Impurity 6015960T112399-50-510mg-25mg-50mg-100mg曲格列汀杂质61Trelagliptin Impurity 6115961T334618-07-410mg-25mg-50mg-100mg曲格列汀杂质70Trelagliptin Impurity 7015970T2087874-91-510mg-25mg-50mg-100mg。

恩格列净杂质整理列表（现）货号名称结构式分子式CAS号备注E013009 恩格列净杂质9 C17H16BrClO2N/A 提供COA 氢谱质谱液相E013010恩格列净杂质10 C17H17ClO2N/A 提供COA 氢谱质谱液相E013011恩格列净杂质11 C17H16BrClO2N/A 提供COA 氢谱质谱液相E013013恩格列净杂质13 C17H14BrClO3N/A 提供COA 氢谱质谱液相E013015恩格列净R异构体C23H27ClO7864070-43-9 提供COA 氢谱质谱液相E013016恩格列净杂质16 C24H29ClO8N/A 提供COA 氢谱质谱液相E013031恩格列净α异构体C23H27ClO71620758-33-9提供COA 氢谱质谱液相E013032 恩格列净五元环杂质C 23H 27ClO 7N/A提供COA 氢谱质谱 液相 E013062恩格列净杂质62C 6H 10O 690-80-2提供COA 氢谱质谱 液相 E013099恩格列净杂质99C 17H 16ClIO 2Q ：2851922763提供COA 氢谱质谱 液相更多恩格列净杂质详情（深圳恒丰万达医药科技）纯度：>95%用途：供新药研究及实验使用 规格：10mg/25mg/50mg/100mg更多优势项目杂质：硼替佐米，卡比多巴，克拉霉素，克林霉素，达非那新，地塞米松，依那普利，恩氟沙星，法莫替丁，依托必利，兰索拉唑，左氧氟沙星，氯雷他定，利多卡因，拉西地平，甲氨蝶呤，莫西沙星，诺氟沙星，尼美舒利，奥美拉唑，奥司他韦，氧氟沙星，泮托拉唑，帕罗西汀，雷贝拉唑，利托那韦，卡巴拉汀，瑞舒伐他汀，雷尼替丁，罗红霉素，沙丁胺醇，西他列汀，舍曲林，索菲那新，舒马曲坦，辛伐他汀，西洛多辛，托莫西汀，氨甲环酸，替卡格雷，替卡西林，替米沙坦，伐地那非等。

HPLC法同时测定琥珀酸曲格列汀中9个杂质的含量李尚徐佳雯张斐心1徐州医科大学新药研究与临床药学重点实验室，徐州221000；"江苏福锌雨医药科技有限公司，南京210033摘要目的：建立高效液相色谱法同时测定琥珀酸曲格列汀中9个杂质的含量。

方法：采用Welch Utimate AQ C18（4.6mm!250mm,5|!m）色谱柱，以0.1%磷酸溶液一乙腈为流动相，梯度洗脱，流速1.0mL-min：1,柱温35"，检测波长230nm o结果：该药与已知杂质I〜#色谱峰之间的分离度良好；该药和已知杂质I〜：$分别在各自的线性范围内线性关系均良好（r>!0.9999）,杂质I〜$的校正因子分别为1.3、0.9、0.5、1.2、1.2、1.0、2.1、2.3、1.0,且该药和已知杂质I〜$的平均回收率均在99.0%〜101.0%。

结论：该方法专属性强，重复性好，可用于测定该药中的有关物质。

关键词琥珀酸曲格列汀；高效液相色谱；校正因子；有关物质中图分类号R927.2 文献标志码A文章编号1673-7806（2021）02-092-05琥珀酸曲格列汀是一种二肽基肽酶&（DPP-4）抑制剂叫通过选择性、持续性抑制DPP-4,进而抑制胰高血糖素样肽-l（GLP-l）和葡萄糖依赖性促胰岛素分泌多肽（GIP"的灭活，提高内源性GLP-1和GIP的水平，促进胰岛!细胞释放胰岛素，同时抑制胰岛"细胞分泌胰高血糖素，从而提高胰岛素水平，降低血糖倒。

该药是由日本武田公司和Furiex公司联合研发的全球首个1周1次的长效口服降糖药（商品Zafatek）叫与目前市场上1日1次的短效产品相比，有望大幅度改善患者的便利性和依从性，并可潜在提高血糖控制，减少糖尿病并发症。

本研究根据琥珀酸曲格列汀的合成工艺（见图1）、降解途径并结合强制降解试验的结果生确定了本品可能存在的杂质有9个（结构见图2），即杂质1~$。

奥格列汀杂质(Omarigliptin)中文名称: MK-3102中文同义词: (2R,3S,5R)-2-(2,5-二氟苯基)-5-(2-(甲基磺酰基)吡咯并[3,4-C]吡唑-5(2H,4H,6H)-基)四氢-2H-吡喃-3-胺;(2R,3S,5R)-2-(2,5-二氟苯基)-5-[2-(甲基磺酰基)-2,6-二氢吡咯并[3,4-C]吡唑-5(4H)-基]四氢-2H-吡喃-3-胺;奥格列汀;奥马格列汀英文名称: MK-3102;MK-3102;(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(Methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6 H)-yl)tetrahydro-2H-pyran-3-aMine;MK-3012;(2S,3R,5S)-2-(2,5-Difluorophenyl)-5-[2-(Methylsulfo nyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-aMine (MK-3102 enantioMer);(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyr azol-5(4H)-yl]tetrahydro-2H-pyran-3-amine;OMarigliptin;OMarigliptin .CAS号: 1226781-44-7分子式: C17H20F2N4O3S分子量: 398.43恒丰万达医药科技程先生0755-******** Q：2665774795达泊西汀,尼达尼布杂质,Palbociclib杂质、帕布昔利布杂质,氨氯地平杂质,泊沙康唑杂质福沙匹坦杂质,托匹司他杂质,奥贝胆酸杂质,曲格列汀杂质,阿格列汀杂质,他达那非杂质默沙东超长效二肽基肽酶-4抑制剂2型糖尿病药物奥格列汀(Omarigliptin)默沙东抗癌免疫疗法PD-1抑制剂Keytruda（pembrolizumab）和丙肝（HCV）鸡尾酒MK-5172/MK-8742(Elbasvir)备受业界关注。

高效液相色谱法测定琥珀酸曲格列汀片的含量李广禄【期刊名称】《海峡药学》【年(卷),期】2015(027)012【摘要】OBJECTIVE To establish a HPLC method for the determination of Trelagliptin Succinate tab-lets.METHODS Agilent C18 column(250mm×4.6mm,5μm)was selected,with a mobile phase consists of metha-nol-0.05mol· L-1 potassium dihydrogen phosphate buffer solution ( potassium dihydrogen phosphate 6.8g,add water dissolved and diluted to 1000mL, add 2mL of triethylamine, using phosphoric acid to adjust the pH to 5.5 ) (30:70),The flow rate was 1.0mL· min-1 and the detection wavelength was 277nm.RESULTS The calibration curve was proved to be linear in the range of 20~2000μg· mL-1(r=1.0000).The average recovery was 99.5%,RSD=0.58%(n=9).CONCLUSION The method is accurate and reliable,and can be used for quality control of Trelagliptin succinate tablets.%目的建立琥珀酸曲格列汀片含量测定的高效液相色谱方法. 方法采用安捷伦C18 (250mm ×4.6mm,5μm)色谱柱;以甲醇-0.05mol · L -1磷酸二氢钾缓冲液(取磷酸二氢钾6.8g,加水溶解并稀释至1000mL,加三乙胺2mL,用磷酸调节 pH 值至5.5)(30:70)为流动相,流速:1.0mL· min -1,检测波长277nm. 结果琥珀酸曲格列汀的线性范围为20~200μg· mL -1,r=1.0000,平均回收率为99.5%,RSD为0.58%(n=9). 结论该方法简便灵敏、结果准确,适用于琥珀酸曲格列汀片的质量控制.【总页数】3页(P48-50)【作者】李广禄【作者单位】国药集团容生制药有限公司武陟 454950【正文语种】中文【中图分类】R927.2【相关文献】1.HPLC法测定新型降糖药安奈格列汀片含量 [J], 姜业朝;龚爱琴;张宇航2.高效液相色谱法测定维格列汀R型异构体的含量 [J], 刘宏果;张之奎3.气相色谱法测定琥珀酸曲格列汀原料药中6种残留溶剂 [J], 龚爱琴;扈宁;钱琛;金党琴4.HPLC法同时测定琥珀酸曲格列汀中9个杂质的含量 [J], 李尚;徐佳雯;张斐5.琥珀酸曲格列汀对2型糖尿病小鼠肠道菌群的改变 [J], 陈倩;王亚峰;朵德龙;常亚娥;严英俊;段坤坤因版权原因，仅展示原文概要，查看原文内容请购买。