槲皮素可通过自噬途径减轻高糖对许旺细胞的损害高糖导致许旺细胞醛糖还原酶活力和多元醇代谢能力升高，从而导致细胞器损害。
自噬可以清除损害的细胞器，提供细胞存活的物质基础。
最近研究表明，槲皮素可拮抗高糖抑制的神经细胞增殖。
但其是否对许旺细胞有保护作用？该神经保护作用又是否通过自噬途径实现？来自中国医学科学院北京协和医院的屈岭博士所在课题组研究结果显示，高糖环境下可见，2种大鼠许旺细胞永生化大鼠RSC96细胞和原代培养大鼠许旺细胞自噬小体明显减少，增殖活力和自噬分子标志物Beclin1和 LC3表达明显下降。
而经槲皮素干预后，2种大鼠许旺细胞自噬能力和增殖活力提高，研究结果说明槲皮素能通过自噬途径减轻高糖对许旺细胞的损害。
显示结果的文章发表在《中国神经再生研究（英文版）》杂志2014年6月第12期。
Article: "Quercetin alleviates high glucose-induced Schwann cell damage by autophagy" by Ling Qu1, Xiaochun Liang1, Bei Gu2, Wei Liu1 (1 Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College, China Academy of Medical Sciences, Beijing, China; 2 Cell Center, Institute of Basic Medical Science, Peking Union Medical College, China Academy of Medical Sciences, Beijing, China)Qu L, Liang XC, Gu B, Liu W. Quercetin alleviates high glucose-induced Schwann cell damage by autophagy. Neural Regen Res. 2014;9(12):1195-1203.欲获更多资讯：Neural Regen ResQuercetin alleviates high glucose-induced Schwann cell damage by autophagyIt is believed that hyperglycemia leads to increased aldose reductase activity and polyol metabolism in Schwann cells, and the resultant abnormal metabolite s cause the organelle’s damage and morphological changes such as swelling and vacuolation. Autophagy can remove the damaged organelles, but also provide the materials for cell survival under stressful conditions. Quercetin can reverse high glucose-induced inhibition of neural cell proliferation. Quercetin is also implicated in the mechanism underlying the reduction of apoptosis through autophagy induction. Whether or not quercetin protects Schwann cells through autophagy pathways remains unclear. Dr. Ling Qu and co-workers from Peking Union Medical College Hospital, Peking Union Medical College, China Academy of Medical Sciences, China show that under high glucose conditions, there are fewer autophagosomes in immortalized rat RSC96 cells and primary rat Schwann cells than undercontrol conditions, the proliferative activity of both cell types is signifcantly impaired, and the expression of Beclin-1 and LC3, the molecular markers for autophagy, is significantly lower. After intervention with quercetin, the autophagic and proliferative activity of both cell types is rescued. These results, published in the Neural Regeneration Research (Vol. 9, No. 12, 2014), suggest that quercetin can alleviate high glucose-induced damage to Schwann cells by autophagy.Article: "Quercetin alleviates high glucose-induced Schwann cell damage by autophagy" by Ling Qu1, Xiaochun Liang1, Bei Gu2, Wei Liu1 (1 Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College, China Academy of Medical Sciences, Beijing, China; 2 Cell Center, Institute of Basic Medical Science, Peking Union Medical College, China Academy of Medical Sciences, Beijing, China)Qu L, Liang XC, Gu B, Liu W. Quercetin alleviates high glucose-induced Schwann cell damage by autophagy. Neural Regen Res. 2014;9(12):1195-1203.。
