CpG岛甲基化(CIMP)相关基因: hMLH1、hMSH2、p16、p14、MYF、 MDR1、E-cadherin
2、干细胞在大肠癌发生中的作用
• 干细胞表面标志物: RNA结合蛋白Musashi-1(Msi-1) CD29
Nishimura S,Wakabayashi N,Toyoda K,et al.Expression of Musashil in human normal colon crypt cells:a possible stem marker of human colon epithetlium [J].Dig Dis Sci,2003,48(8):1523-1529. Fujimoto K,Beauchamp RD,Whitehead RH,el al.Identification and isolation of candidate human colonic clonogenic cells based on cell surface integrin expression [J].Gastroenterology,2002,123(6):1941-1948. Barker N,van Es JH,Kuipers J,et al.Identification of stem cells in small intestine and colon by marker gene Lgr5 [J].Nature,2007,449(7165):1003-1007. Arena V, Caredda E, Cufino V, et al. Differential CD133 expression pattern during mouse colon tumorigenesis.[J]. Anticancer Res. 2011,31(12):4273-5. Takaishi S,Okumura T,Tu S,et al.Identification of gastric cancer stem cells using the cell surface marker CD44 [J].Stem Cells,2009,27(5):1006-1020. Li C,Heidt DG,Dalerba P,et al.Identification of pancrestic cancer stem cells [J].Cancer Res,2007,67(3):1030-1037.