E2FBP1 antagonizes the p16INK4A-Rb tumor suppressor machinery for growth suppression and cellula

When it comes to recommending science fiction novels,there are several classics and modern gems that are worth exploring.Here are some of the best science fiction novels that you might consider adding to your reading list:1.Dune by Frank Herbert:This epic novel is a mustread for any science fiction enthusiast. It tells the story of Paul Atreides,who navigates the treacherous world of politics and religion on the desert planet of Arrakis.2.Neuromancer by William Gibson:Often credited with popularizing the cyberpunk genre,this novel introduces readers to a world where artificial intelligence and virtual reality are integral parts of society.3.The Left Hand of Darkness by Ursula K.Le Guin:A thoughtprovoking exploration of gender and society,this novel follows an emissary on a mission to a planet where the inhabitants can change their gender at will.4.Snow Crash by Neal Stephenson:This novel combines elements of cyberpunk with a fastpaced narrative about a computer virus that affects both the virtual and real worlds.5.The Hitchhikers Guide to the Galaxy by Douglas Adams:A comedic take on the science fiction genre,this series follows the misadventures of an unwitting human and his alien friend as they travel through space.6.Enders Game by Orson Scott Card:A compelling story about a young boy who is trained to become a military leader in a future where Earth is at war with an alien race.7.1984by George Orwell:While not strictly science fiction,this dystopian novel is a seminal work that explores themes of totalitarianism,surveillance,and individual freedom.8.The Martian by Andy Weir:A more recent addition to the genre,this novel tells the story of an astronaut stranded on Mars,who must use his wits to survive.9.Brave New World by Aldous Huxley:Another dystopian classic,this novel presents a future society where happiness is valued above all else,often at the expense of truth and freedom.10.The ThreeBody Problem by Liu Cixin:A Chinese science fiction novel that explores the impact of contact with an alien civilization and the subsequent conflict it causes.11.Kindred by Octavia Butler:A unique blend of science fiction and historical fiction, this novel follows a black woman who is repeatedly pulled back in time to the antebellum South.12.Do Androids Dream of Electric Sheep?by Philip K.Dick:The novel that inspired the film Blade Runner,it delves into the nature of humanity and what it means to be alive in a world populated by androids.When recommending these novels,consider the readers preferences and interests.Each of these books offers a unique perspective on the future,technology,and humanitys place in the universe.Whether they prefer space operas,dystopian societies,or thoughtprovoking philosophical questions,theres a science fiction novel out there for everyone.。

Page 1/11Data Sheet 702040Blocks tructureFeature sk S tructured operating and programming layout k S elf-optimi s ation k Ramp functionk Timer functionk Digital input filter withprogrammable filter time con s tant k 1 limit comparator k limit s witchJUMO iTRON 04/08/16/32Compact microproce ss or controller sHou s ing for flu s h-panel mounting to DIN IEC 61554Brief de s criptionThe JUMO iTRON controller s erie s compri s e s univer s al and freely programmable com-pact in s trument s for a variety of control ta sks . It con s i s t s of five model s , with the bezel s ize s 96mm x 96mm, 96mm x 48mm in portrait and land s cape format, 48mm x 48mm and 48mm x 24mm.The controller s feature a clearly readable 7-s egment di s play which, depending on the ver-s ion, i s 10 or 20 mm high, for proce ss value and s etpoint indication or for dialog s . Only three k ey s are needed for configuration. Parameter s etting i s arranged dynamically, and after two operation-free s econd s the value i s accepted automatically. S elf-optimi s ation,which i s provided a s s tandard, e s tabli s he s the optimum controller parameter s by a k ey s tro k e. The ba s ic ver s ion al s o include s a ramp function with adju s table gradient s . A timer function ha s been integrated a s an extra.All controller s can be employed a s s ingle-s etpoint controller s with a limit comparator, or as double-s etpoint controller s . The lineari s ation s of the u s ual tran s ducer s are stored. Pro-tection i s IP66 at the front and IP20 at the bac k . The electrical connection i s by a plug-in connector with s crew terminal s .The input s and output s are s hown in the bloc k s tructure below.JUMO iTRON 08Type 702042JUMO iTRON 04Type 702044JUMO iTRON 08Type 702043JUMO iTRON 32Type 702040JUMO iTRON 16Type 702041Approval s /approval mark s (s ee "Technical data")Data Sheet 702040Page 2/11Technical dataThermocouple inputRe s i s tance thermometer inputStandard s ignal inputMea s urement circuit monitoring 1De s ignation Range 1Mea s urement accuracy Ambienttemperature error Fe-Con L Fe-Con J EN 60584Cu-Con U Cu-Con T EN 60584NiCr-Ni K EN 60584NiCr S i-Ni S i N EN 60584Pt10Rh-Pt S EN 60584Pt13Rh-Pt R EN 60584Pt30Rh-Pt6Rh BEN 60584-200to +900°C -200to +1200°C -200to +600°C -200to +400°C -200to +1372°C -100to +1300°C0— 1768°C 0—1768°C +300— 1820°C≤0.4%≤0.4%≤0.4%≤0.4%≤0.4%≤0.4%≤0.4%≤0.4%≤0.4%100 ppm/°C 100 ppm/°C 100 ppm/°C 100 ppm/°C 100 ppm/°C 100 ppm/°C 100 ppm/°C 100 ppm/°C 100 ppm/°CCold junctionPt 100 internal1. The s e range s refer to the ambient temperature of 20°CDe s ignation Connection type RangeMea s urement accuracy Ambienttemperature error Pt 100 EN 607512-/3-wire -200to +850°C ≤0.1%50 ppm/°C Pt 1000 EN 607512-/3-wire -200to +850°C ≤0.1%50 ppm/°C K TY11-62-wire-50to +150°C≤1.0%50 ppm/°CS en s or lead re s i s tance 20Ω max. per lead for 2- and 3-wire circuitMea s urement current 250µALead compen s ationNot required for 3-wire circuit. For 2-wire circuit, lead compen s ation can be implemented in s oftware through proce ss value correction.De s ignation RangeMea s urement accuracy Ambienttemperature error Voltage0—10V , input re s i s tance R E > 100k Ω2—10V , input re s i s tance R E > 100k Ω0—1V , input re s i s tance R E > 10M Ω10,2—1V , input re s i s tance R E > 10M Ω1≤0.1%≤0.1%≤0.1%≤0.1%100 ppm/°C 100 ppm/°C 100 ppm/°C 100 ppm/°C Current4—20mA, voltage drop 3V max.0—20mA, voltage drop 3V max.≤0.1%≤0.1%100 ppm/°C 100 ppm/°C1. for Type 702040/41 with 2 relay output s (option)Tran s ducer Overrange/underrangeProbe /lead s hort-circuit 1Probe/lead breakThermocouple•-•Re s i s tance thermometer •••Voltage 2—10V / 0.2—1V0—10V/ 0—1V •••-•-Current4—20mA 0—20mA•••-•-1. In the event of a fault, the output s move to a defined s tatu s (configurable).= factory s etting •recogni s ed-not recogni s edData Sheet 702040Page 3/11Output sControllerTimerElectrical dataHou s ingA ss ignment Type 702040/41Type 702042/43/44Output 1relayrelay Output 2logic 0/5V or logic input logic 0/5V Output 2 (option)logic 0/12V or logic input logic 0/12V Output 2 (option)relay not po ss ible Output 3not availablerelayTechnical data Relay ratingcontact life n.o. (ma k e) contact 3A at 250VAC re s i s tive load 150 000 operation s at rated loadLogiccurrent limiting load re s i s tance 0/5V 20mAR load 250Ω min .Logiccurrent limiting load re s i s tance 0/12V 20mAR load 600Ω min.= factory s ettingController types ingle-s etpoint controller with limit comparator, double-s etpoint controllerController s tructure s P/PD/PI/PIDA/D converter re s olution better than 15 bitS ampling time210m s ec/250m s ec with activated timer functionAccuracy0.7% ± 10ppm/°CS upply (s witch-mode power s upply)110—240V -15/+10%AC 48—63Hz, or 20—30V AC/DC 48—63Hz, or10—18V DC (Connection to S ELV or PELV)Te s t voltage s (type te s t)to EN 61010, Part 1, March 1994,overvoltage category II, pollution degree 2, for Type 702040/41overvoltage category III, pollution degree 2, for Type 702042/43/44Power con s umption max. 7VA Data bac k upEEPROMElectrical connectionat the rear, via plug-in s crew terminal s ,conductor cro ss -s ection up to 1.5mm 2 (1.0mm 2 for Type 702040/41) or2x 1.5mm 2 (1.0mm 2 for Type 702040/41) with ferrule sElectromagnetic compatibility interference emi ss ion interference immunity EN 61 326Cla ss Bto indu s trial requirement sS afety regulationto EN 61010-1In s tallation height maximum 2000 m above s ea levelCa s e typePla s tic ca s e for panel mounting acc to. IEC 61554 (indoor u s e)Dimen s ion s in mm (for Type)702040702041702042702043702044Bezel s ize48x 2448x 4848x 96(portrait)96x 48(land s cape)96x 96Depth behind panel100100707070Panel cut-out45+0.6x 22.2+0.345+0.6x 45+0.645+0.6x 92+0.892+0.8x 45+0.692+0.8x 92+0.8Ambient/s torage temperature range 0—55°C /-40 to +70°CData Sheet 702040Page 4/11Approval s /approval mark sDi s play and control sSelf-optimi s ation (SO)The s tandard s elf-optimi s ation facility produce s an automatic adju s tment of the controller to the proce ss .S elf-optimi s ation determine s the controller parameter s for PI and PID controller s (proportional band, re s et time, derivative time), a s well a s the cycle time and the filter time con s tant of the digital input filter.Ramp functionClimatic condition s not exceeding 75% rel. humidity, no conden s ationOperating po s ition unre s tricted Protection to EN 60529,IP66 at the front, IP20 at the bac kWeight75g approx.95g approx.145g approx.160g approx.200g approx.Approval mark Te s ting agencyCertificate/certification numberIn s pection ba s i sValid forUL Underwriter Laboratorie s E201387UL 61010-1all device s C S A C S A-Approval232831CAN/C S A-C22.2No. 61010.1-04all device sData Sheet 702040Page 5/11Limit comparatorLimit s witch (extra code)If the limit comparator function i s active, then the s witched s tate will have to be re s et by hand.Precondition: the condition that cau s ed the alarm i s no longer pre s ent (for l k 8: proce ss value < AL). The di s play s how s the alarm s tatu s .The alarm s tatu s will be retained after a power failure.Timer function (extra code)U s ing the timer function, the control action can be influenced by mean s of the adju s table time t i 0. After the timer ha s been s tarted by power ON, by pre ss ing the k ey or via the logic input, the timer s tart value t i 0 i s counted down to 0, either in s tantly or after the proce ss value ha s gone above or below a programmable tolerance limit. When the timer ha s run down, s everal event s are triggered, s uch a s control s witch-off (output 0%) and s etpoint s witching. Furthermore, it i s po ss ible to implement timer s ignalling during or after the timer count, via an output.The timer function can be u s ed in conjunction with the ramp function and s etpoint s witching.Table: Timer function s (u s ing the example of a rever s ed s ingle-s etpoint controller)Data Sheet 702040Page 6/11Tolerance limitThe po s ition of the tolerance limit depend s on the controller type:- S ingle-s etpoint controller (rever s ed, heating): Tolerance limit i s below the s etpoint - S ingle-s etpoint controller (direct, cooling): Tolerance limit i s above the s etpoint - Double-s etpoint controller: Tolerance limit i s below the s etpointIf, during the control proce ss , the proce ss value goe s above/below the tolerance limit, then the timer will be s topped for the duration of the infringement.Di s play and operationThe timer value i s di s played at the operating level and remain s s o permanently (no time-out).Operation i s from the k eypad, when the timer value i s vi s ible in the di s play, or via the logic input. The operating option s compri s e s tart,s top, continue and cancel timer function, and are s hown differently in the di s play.The current timer value and the timer s tart value are acce ss ible and adju s table at any time at a s eparate timer level.Data Sheet 702040Page 7/11Parameter and configurationOperating levelParameter levelConfiguration levelDe s ignation Di s play Factory s ettingValue range S etpointSP /SP1/SP20S PL—S PH Ramp s etpointSPr 0S PL—S PH Timer value/timer s tart valuet i /t i 00 —999.9hDe s ignation Di s play Factory s ettingValue range S etpoint 1SP 10S PL—S PH S etpoint 2SP 20S PL—S PH Limit value for limit comparator AL 0-1999to +9999digit Proportional band 1Pb:100—9999digit Proportional band 2Pb:200—9999digit Derivative time dt 80s ec 0—9999s ec Re s et time rt 350s ec 0—9999s ec Cycle time 1CY 120.0s ec 1.0—999.9s ec Cycle time 2CY 220.0s ec1.0—999.9s ec Contact s pacingdb 00—1000digit Differential (hy s tere s i s ) 1HYS.110—9999digit Differential (hy s tere s i s ) 2HYS.210—9999digit Wor k ing point Y:00%-100to +100%Maximum output Y:1100%0to 100%Minimum output Y:2-100%-100to +100%Filter time con s tant dF 0.6s ec 0.0—100.0s ec Ramp s loperASd—999digitDe s ignation Di s play Factory s etting Value range/s electionTran s ducerC111Pt100Pt100, Pt1000, K TY11-6, T, J, U, L, K , S ,R, B, N, 0 (4)—20mA, 0 (2)—10VDecimal place/unitC112none/°C none, one, two/°C, FController type/output s C113s ee table on next pageLimit comparator function C114no function no function, l k 1—8Ramp functionC115no function no function, °C/min, °C/h Output s ignal on overrange/ underrange C1160% output limit comparator off 0%, 100%, -100% limit comparator on/offLogic inputC117no function k ey / level inhibit,ramp s top, s etpoint s witchingOutput s 1, 2 and 3(only Type 702042/43/44)C118function s a s defined under C113freely configurable(s ee table on next page)Timer functionC120no function s ee de s cription “Timer function”S tart condition for timerC121from k eypad/logic input - power ON - k eypad/logic input- tolerance limitTimer s ignalling C122no function - timer s tart to timer run-down- after run-down for 10s ec - after run-down for 1 min.- after run-down until ac k nowledgementUnit of time (timer)C123mm.ss - mm.ss- hh.mm - hhh.hS tart value of value range SCL0-1999 to +9999 digitData Sheet 702040Page 8/11Controller type/output s (C 113)Expanded configuration option s for the output s on Type 702043/44 (C118)End value of value range SCH 100-1999 to +9999 digit Lower s etpoint limit SPL -200-1999 to +9999 digit Upper s epoint limitSPH 850-1999 to +9999 digit Proce ss value correction OFFS 0-1999 to +9999 digit Differential (hy s tere s i s )HySt 1 0—9999 digitController typeOutput 1Output 2 + 3S ingle s etpoint rever s ed controller limit comparator/timer s ignalling S ingle s etpoint direct controllerlimit comparator/timer s ignallingDouble s etpointcontroller rever s edcontroller direct S ingle s etpoint rever s ed limit comparator/timer s ignalling controller S ingle s etpoint direct limit comparator/timer s ignallingcontrollerDouble s etpoint controller directcontroller rever s ed= factory s ettingOutput 1: Relay (K1)Output 2: Logic (K2)Output 3: Relay 1-s e t p o i n t c o n t r o l l e rFunction s of the output s a s defined under C 113controller output limit comparator timer s ignalling controller output timer s ignalling limit comparator limit comparator controller output timer s ignalling limit comparator timer s ignalling controller output timer s ignalling controller output limit comparator timer s ignalling limit comparator controller output 2-s e t p t .c o n t r o l l e rcontroller output 1controller output 2limit comparator/timer controller output 1limit comparator/timer controller output 2controller output 2controller output 1limit comparator/timer controller output 2limit comparator/timer controller output 1limit comparator/timer controller output 1controller output 2limit comparator/timercontroller output 2controller output 1Data Sheet 702040Page 9/11Dimen s ion sType 702040 / …Type 702043/...Type 702041 / …Type 702044/...Type 702042 / …Typehorizontal vertical 70.2040/418mm min.8mm min.70.2042/43/4410mm min.10mm min.Edge-to-edge mounting(minimum s pacing s of the panel cut-out s)Data Sheet 702040Page 10/11Connection diagram sJUMO iTRON 32, Type 702040, 48mm x 24mm format JUMO iTRON 16, Type 702041, 48mm x 48mm formatJUMO iTRON 08, Type 702042, 48mm x 96mm format (portrait)JUMO iTRON 08, Type 702043. 96mm x 48mm format (land s cape)JUMO iTRON 04, Type 702044, 96mm x 96mm formatStandard ver s ion / Ver s ion with 12V logic outputVer s ion with 2 relay outputs2014-09-01/00357838Data Sheet 702040Page 11/11Order detail sExtra order code s for cu s tomized configuration(2)Ba s ic type exten s ion(3)Input s(1)(2)(3)(4)(5)(6)Type de s ignation 7020../..-...-...-../...,...** Li s t extra code s in s equence, s eparated by comma s(1)Ba s ic type(bezel s ize in mm)40=48x 24, 41 = 48x 48, 42 = 48x 96 (portrait), 43 = 96x 48 (land s cape), 44 = 96x 96(2)Ba s ic typeexten s ion 8899==controller type configurable 1controller type configured to cu s tomer s pecification 2(3)Input s 888999==input s configurable 1input s configured to cu s tomer s pecification 2(4)Output s000=S tandardType 702040/41Type 702042/43/44Output 1relay (n.o. ma k e)relay (n.o. ma k e)Output 2logic 0/5V , optionally configurable a s logic input logic 0/5V Output 3not available relay (n.o. ma k e)Option sType 702040/41Type 702042/43/44113=Output 2(output s 1+3 a s for S tandard)logic 0/12V , optionally configurable a s logic input logic 0/12V 101=Output 2(output 1 a s for S tandard)relay (n.o. ma k e)(logic input i s alway s available)not po ss ible(5)Supply162523===10—18V DC20—30V AC/DC 48—63Hz110—240V AC -15/+10% 48—63Hz (6)Extra code069=UL and C S A approval 210=Timer function220=Timer function + limit s witch 3Delivery package ex-factory for Type 702040/41Type 702042/43/441 mounting frame2 mounting brac k et s1 s eal, 1 Operating In s truction s 70.20401. s ingle-s etpoint with limit comparator, s ee factory s etting s under configuration and parameter level2. s ee extra order code s (below) or factory s etting s under configuration and parameter level3. The linearization s for K TY11-6 and thermocouple B have been deletedController typeOutput 1Output 2 and 310=s ingle s etpoint rever s ed 1controller limit comparator/timer s ignalling 11=s ingle s etpoint direct 2controllerlimit comparator/timer s ignalling 30=double s etpoint controller rever s edcontroller direct 20=s ingle s etpoint rever s ed 1limit comparator/timer s ignalling controller 21=s ingle s etpoint direct 2limit comparator/timer s ignalling controller33=double s etpointcontroller directcontroller rever s ed1. controller output i s active when proce ss value i s below s etpoint, e. g. heating2. controller output i s active when proce ss value i s above s etpoint, e. g. cooling001=Pt1003-wire 040=Fe-Con J 045=Pt13 Rh-Pt R 063=0—10V 003=Pt1002-wire041=Cu-Con U 046=Pt30 Rh-PtRh B 071=2—10V 005=Pt1000 2-wire 042=Fe-Con L 048=NiCr S i-Ni S i N601=K TY11-6 (PTC)006=Pt1000 3-wire 043=NiCr-Ni K 052=0—20mA 039=Cu-Con T044=Pt10Rh-PtS053=4—20mA= factory-s et。

‎‎‎‎保修说明书‎英文‎ Th‎e fol‎l owin‎g exc‎e rpt ‎f rom ‎t he o‎r igin‎a l ra‎n dom,‎and ‎c onve‎r ted ‎t o pl‎a in t‎e xt, ‎d o no‎trep‎r esen‎t the‎full‎cont‎e nt, ‎f or r‎e fere‎n ce o‎n ly. ‎售后服务承‎诺书 Af‎t er s‎a le s‎e rvic‎eund‎e rtak‎i ng 浙‎江新天地家‎私秉持“全‎方位、高品‎质、快速度‎”的服务标‎准，以客户‎满意为目标‎，谨此公开‎承诺。

‎ Zh‎e jian‎g new‎worl‎d fur‎n itur‎e uph‎o ld t‎h e pr‎i ncip‎l e of‎a fu‎l l ra‎n ge, ‎h igh ‎q uali‎t y, f‎a sts‎e rvic‎e sta‎n dard‎s, cu‎s tome‎r sat‎i sfac‎t ion ‎a s th‎e goa‎l, to‎the ‎p ubli‎c mit‎m ent.‎‎一、服‎务承诺 O‎n e, s‎e rvic‎e mit‎m ent ‎1．我公司‎组建了一批‎强硬的应急‎维修服务队‎，有经验丰‎富的现场工‎程师和高级‎技师，对出‎现的任何问‎题都能在最‎快的时间内‎赶到现场，‎进行维修和‎更换。

‎ 1,‎our ‎p any ‎h as s‎e t up‎a nu‎m ber ‎o f to‎u gh e‎m erge‎n cy s‎e rvic‎e tea‎m, on‎-site‎expe‎r ienc‎e d en‎g inee‎r s an‎d sen‎i or t‎e chni‎c ians‎, arr‎i ved ‎o n th‎e sce‎n e in‎the ‎f aste‎s t ti‎m e fo‎r any‎prob‎l ems,‎main‎t enan‎c e an‎d rep‎l acem‎e nt. ‎2．产品交‎付一周内，‎我公司售后‎服务部的工‎作人员会根‎据客户的联‎系方式，进‎行电话跟踪‎咨询，直到‎客户满意为‎止。

Modelo E-237PANDOOPTIMIZA SUS PROCESOS GRACIAS A SU APUESTA POR LAFABRICACIÓN INTELIGENTE CON SOLIDWORKSSituada en Argentona (Barcelona) con casi 40 años de experiencia, INOXPAN es reconocida en el mercado bajo la marca PANDO por su extensa experiencia en el diseño, fabricación y comercialización de campanas extractoras de cocina , hornos, placas de gas e inducción y vinotecas, para uso doméstico.niciaron su andadura en España en el año 1979, siempre como artesanos especialistas en la transformación del acero inoxidable. Al poco tiempo, se implantaron en mercados exteriores, como Francia y Portugal, donde su presencia está consolidada desde hace ya muchos años como el referente en productos de marca premium del sector y también en otros países de Europa como I nglaterra, Alemania, Bélgica y Holanda. Recientemente han conseguido posicionarse en el mercado latinoamericano y ahora se encuentran en la conquista de Estados Unidos.INNOVACIÓN CONSTANTEEl trabajo continuo, con fabricación propia y con un amplio departamento de I+D+i, llevaron a PANDO a convertirse en líder absoluto en el mercado español en el canal “Tienda estudio de cocina”; siendo éste su cliente principal, junto con arquitectos, decoradores-interioristas y diseñadores, que ven en PANDO como el único fabricante capaz de dar solución a todas sus necesidades.Una marca con un fuerte compromiso con sus orígenes y con la necesidad de aumentar el prestigio que ha conseguido gracias al trabajo de todo el equipo que la impulsa.Se esfuerzan cada día para ser mejores y para que sus campanas de cocina sean las más eficientes a nivel de extracción, ruido, tratamiento de los humos y consumo energético. Integran los mejores motores ECO del mercado y los sistemas de iluminación LED en prácticamente la totalidad de las campanas que fabrican para seguir siendo líderes en calidad frente a las empresas de su competencia en el sector. “Nuestro amplio portfolio y la posibilidad de ofrecer soluciones a medida a nuestros clientes, sumado a la calidad de todos los componentes, son nuestros principales puntos fuertes y han hecho que nos convirtamos en el N.º 1 en proveedores de campanas extractoras” comenta Sergio Seña, Director de compras de PANDO.SOLIDWORKS COMO SOLUCIÓN DEFINITIVAEn su búsqueda permanente de eficiencia e i nnovación, PANDO necesitó reestructurar sus procesos y ser competitivo en el sector, por ello en 2008 decidió incorporar las soluciones de diseño de SOLI DWORKS. Tras unos años trabajando en un entorno 3D más productivo, resolvieron en 2015 ampliar su eficacia e i mplantaron S OL DWORKS P DM P rofessional y SOL I DWORKS Composer con el objetivo de agilizar el desarrollo de sus productos, enriquecer la comunicación con sus proveedores, quienes disponían de la tecnología SOLIDWORKS para sus desarrollos, y mejorar la presentación de sus productos previos a la fabricación.Durante este proceso, CIMWORKS cómo su distribuidor oficial, apoyó la evaluación de las soluciones y brindó la formación y asesoramiento necesario, que hicieron determinante la toma de decisión y llevar a cabo la ampliación de la tecnología SOLI DWORKS en PANDO. Además, tras la implantación de las herramientas, contaron con una formación especializada que ha permitido una mejora constante de los procesos productivos dentro de la organización.LA IMPORTANCIA DEL CONTROL DE DATOSCon SOLI DWORKS PDM Professional, han logrado tener un mayor control de la información de los proyectos, permitiendo reutilizar los diseños gestionar todo el proceso de desarrollo de sus productos en un menor tiempo, optimizando los flujos de trabajo y mejorando notablemente la gestión de la documentación técnica. Ahora en PANDO el control de la información de cada documento agiliza la creación de nuevos proyectos, permitiendo la estandarización de productos de serie nuevos. También han conseguido ahorrar tiempo, ya queReto:Desarrollar productos de forma ágil y condatos precisos, gestionar y controlar los datosde los proyectos y mejorar su presencia en la presentación de productosSolución:Implantar el software de diseño SOLIDWORKS, de gestión de datos de producto SOLIDWORKS PDM Professional y de desarrollo de documentación gráfica SOLIDWORKS Composer.Beneficios:•Se ganó control en los datos, mejorando la optimización de los recursos y aumentando la agilidad para realizar cambios y personalizar productos.•Se agilizó la búsqueda de datos y archivos relacionados con otros proyectos•Se agilizó en un 30% la producción de documentación técnica, reduciendo el tiempo de salida al mercado de sus productos•Se mejoró estéticamente la presentación desus productos ganando presencia frente a susclientes potenciales“D esd e qu e h e mose ntrado e n e l mundoSOLIDWORKS si e mpr eque re mos ir ampliandolas herramientas de la suite. El mercadote re quie re cada ve z más datos, máspre se ncia y con e stas solucione s lohe mos conse guido.”antes la gestión de las referencias y de todas las versiones se realizaba de forma manual.El fácil acceso a archivos ordenados les proporciona una idea fiable y sólida para trabajar en cualquier proyecto. La trazabilidad de los datos y la adecuada estructura de éstos, les han ayudado a reducir al mínimo el número de errores y a agilizar el proceso de fabricación de sus productos. Así mismo, la comunicación fluye entre departamentos y se potencia la visibilidad de los datos, lo que repercute directamente en el aumento de agilidad para responder a las demandas de los clientes.DOCUMENTACIÓN TÉCNICA DE CALIDADLa creación de la documentación solía ser un paso por separado que tenía lugar después del diseño de productos, provocando retrasos y trabajo extra, mientras que ahora gracias a SOL DWORKS Composer, es un proceso que se realiza simultáneamente, lo que ha permitido que PANDO reduzca hasta en un 30% el tiempo de salida al mercado de sus productos y ha mejorado la estética de sus documentos técnicos, consiguiendo la presencia que requerían.“Ahora tenemos la documentación más rápido y bien organizada, pudiendo implicar no solo a la oficina técnica sino a otros departamentos. Hoy en día presentar a un cliente un plano en 2D se considera obsoleto”remarca Sergio Señ seguridad que proporcionan las herramientas de SOL I DWORKS ha hecho que se agilicen los procesos permitiendo a PANDO tener la oportunidad de innovar en sus productos y desarrollar nuevas líneas de negocio con el propósito de alcanzar sus objetivos de mercado. Actualmente, utilizan las herramientas SOLIDWORKS un total de 5 personas: 2 en el área de diseño, 1 persona para la gestión de datos en el área de calidad, el responsable técnico y el director de producción.El siguiente paso es potenciar la oficina técnica, tanto para desarrollo de producto nuevo, como producto especial, utilizando el potencial de SOL DWORKS para el desarrollo de los proyectos. También impulsar en más departamentos, el uso de la documentación gráfica como vídeos o manuales interactivos, utilizando los diseños 3D para la presentación de producto y además tener la posibilidad de validar los diseños y poder disponer de los datos de simulación del comportamiento de las campanas a nivel de fluodinámica, aspiración, etc.La documentación técnica de calidad generada con SOLIDWORKS Composer ha cobrado un importante papel en el posicionamiento de PANDO como líder indiscutible del sectorCampanas extractoras de cocina , hornos, placas de 50Argentona (Bancelona) - España www.pando.es CIMWORKSLa plataforma 3DEXPERIENCE impulsa nue stras aplicacione s y ofre ce un e xte nso portfolio de experiencias que dan solución a 12 industrias diferentes.Dassault Systèmes, la compañía de 3DEXPERIENCE®, suministra a empresas y usuarios universos virtuales en los que pueden dar rienda suelta a su imaginación para crear diseños innovadores y sostenibles. Sus soluciones, líderes mundiales, transforman las fases de diseño, producción y asistencia de todo tipo de productos. Las soluciones de colaboración de Dassault Systèmes fomentan la innovación social, lo que amplía las posibilidades de que el mundo virtual mejore el mundo real. El grupo aporta un gran valor a más de 220 000 clientes de todos los tamaños y sectores en más de 140 países. Si desea obtener más información, visite /es.Europe/Middle East/Africa Dassault Systèmes10, rue Marcel Dassault CS 4050178946 Vélizy-Villacoublay Cedex France AmericasDassault Systèmes 175 Wyman StreetWaltham, Massachusetts 02451-1223USA Asia-PacificDassault Systèmes K.K.ThinkPark Tower2-1-1 Osaki, Shinagawa-ku,Tokyo 141-6020Japan。

Screening for vector-borne disease IDEXX 4Dx® Plus Test clinical reference guideWith the IDEXX 4Dx ® Plus T est, a positive result can also be an indication of ticks and and the pathogens they carry. Know more with every resultdetect antibodies to these pathogens When you use the IDEXX 4Dx Plus T est as a screening tool, you maycarried by these ticks Anaplasmaphagocytophilum Borrelia burgdorferi (Lyme disease)Ehrlichia ewingiiEhrlichia canis Anaplasma platysBabesia spp.Rocky Mountain spotted feverEhrlichia chaffeensis TularemiaRocky Mountain spotted fever STARIBartonella spp.Babesia spp.Ehrlichia canis Brown dog tickRhipicephalus sanguineusAmerican dog tickDermacentor variabilisBlack-legged tick (deer tick)Ixodes scapularis Ixodes pacificusLone star tickAmblyomma americanumRocky Mountain spotted fever TularemiaGeographic tickdistribution as of 20213that may also transmit other pathogens and infections to dogs and peopleLyme diseasebacterium Borrelia burgdorferi cases that have mild to severe disease.* S erology is typically used to diagnose Lyme disease. B. burgdorferi Did you know?•D ogs testing positive for antibodies to the C 6 peptide had 43% increased risk of having chronic kidney disease (CKD) compared to seronegative dogs.4• T he C 6 peptide used in the IDEXX 4Dx ® Plus Test and Lyme Quant C 6® Antibody Test does not cross-react with the antibody response to commercially available Lyme vaccines.5 • D ogs with seroreactivity to both B. burgdorferi and Anaplasma phagocytophilum may have two times the risk of developing clinical illness than singularly infected dogs.2Borrelia burgdorferiPrimary vectorsIxodes scapularis or Ixodes pacificus Black-legged tick (deer tick)Pathology• Localizes in tissues of infected dogs • Synovitis (may be subclinical) • Lyme nephritisClinical presentationChronic infection with clinical signs that may present acutely:• Fever, anorexia• Polyarthritis, lameness• Rapidly progressive renal failure • Neurologic syndromesLaboratory abnormalities• Elevated C 6 antibody level ≥ 30 U/mL • May have proteinuria• M ay have IDEXX SDMA ® T est result > 14 µg/dLCKD monitoring• Chemistry panel with SDMA – R ecommended to evaluate forthe development of protein-losing kidney disease• Urinalysis with Reflex UPC – R ecommended to evaluate forproteinuria • CBC with blood film evaluation – R ecommended as part of aminimum databaseHeartworm diseaseDirofilaria immitis, the causative agent of heartworm disease, is transmitted when mosquitoes infected with D. immitis larvae feed on (or bite) a healthy dog. Heartworm disease has subtle or mild clinical signs in the early stages, making preventive measures so much more important—especially as advanced infection may result in death.Did you know?•D espite availability of monthly preventives, prevalence rates of canine heartworm have remained consistent nationwide.7•T he American Heartworm Society (AHS) and the Companion Animal Parasite Council (CAPC) recommend testing all dogs for both antigen and microfilariae annually.7,8•F or more information and current recommendations on treating canine heartworm disease, goto or . Dirofilaria immitisPrimary vectorMosquitoPathologyInfective larvae (L3) mature to adult worms in the heart and pulmonary arteriesClinical presentation Asymptomatic at first, later developing:• Mild, persistent cough• Lethargy• Exercise intolerance• Reduced appetite• Weight lossLaboratory abnormalities that may be seen • Eosinophilia• Azotemia• Increased liver enzymes• ProteinuriaAnaplasmaphagocytophilumAnaplasma platysPrimary vectorsIxodes scapularis Ixodes pacificusBlack-legged tick (deer tick)Rhipicephalus sanguineus (brown dog tick)PathologyInfects neutrophilsInfects plateletsClinical presentationCan present acutely:• F ever • Anorexia • Lethargy• Polyarthritis, lameness • Neurologic signsUsually minimal clinical signs, but some dogs may have:• F ever • Uveitis• Petechiae and ecchymoses • EpistaxisLaboratory abnormalities• Thrombocytopenia• Anemia• Lymphopenia• Increased liver enzymesOther findings may be seen:• Decreased albumin • Increased globulin• Increased ALP and ALT • Proteinuria• Decreased Urine SG • Increased UPC NotePrevious infection may not prevent reinfection and persistent infections are possible.9,10Canine anaplasmosisCanine granulocytic anaplasmosis is caused by the bacterium Anaplasma phagocytophilum (transmitted by the black-legged tick [deer tick]). Anaplasma platys (transmitted by the brown dog tick) is the cause of infectious cyclic thrombocytopenia.Did you know?•M any mammalian species, including humans, are susceptible to A. phagocytophilum infection. •D ogs coinfected with Anaplasma and other bacterial pathogens may have more complex disease presentations and respond more slowly to therapy.• A .platys infects canine platelets and is frequently seen as a coinfection with Ehrlichia canis .Canine ehrlichiosisCanine ehrlichiosis is caused by the bacteria Ehrlichia canis (transmitted by the brown dog tick) and Ehrlichia ewingii (transmitted by the lone star tick). Canine Ehrlichia infections may progress to the subclinical phase or may become chronic infections.Ehrlichia canisEhrlichia ewingiiPrimary vectorRhipicephalus sanguineus (Brown dog tick)Amblyomma americanum (Lone star tick)PathologyInfects monocytes Infects granulocytesClinical presentation• Fever, anorexia, lethargy • Bleeding disorders • Polyarthritis, lameness • Lymphadenomegaly • Neurologic signs• Fever, anorexia, lethargy • Polyarthritis, lameness • Neurologic signsLaboratory abnormalitiesNotePrevious infection may not prevent reinfection, and persistent infections are possible.12,14Did you know?• D ogs coinfected with E. canis and A. platys were found to have more severe anemia and thrombocytopenia than dogs with either single infection.11• I n a study of healthy dogs with antibodies to E. canis , 39% were thrombocytopenic.12• C hronic E. canis infections, if left untreated, can lead to bone marrow dysfunction or kidney disease.• D ogs with Ehrlichia antibodies in E. canis endemic areas had a 112% increased risk of developing chronic kidney disease (CKD).13CKD monitoring• Chemistry panel with SDMA - R ecommended to evaluate forsecondary kidney disease.• Urinalysis with UPC - R ecommended to evaluatefor proteinuria • CBC with blood film - R ecommended as part of aminimum database• Anemia• Thrombocytopenia • Hyperglobulinemia • ProteinuriaOther clinical findings may include:• Decreased albumin • Increased globulin• Mild increased ALT and ALP • Increased SDMA • Creatinine• Decreased urine specific gravity, proteinuria • Increased urine protein:creatinine (UPC) ratio.Serology and PCR for sick patients For dogs presenting with clinical signs consistent with a vector-borne disease, usingserology and PCR together improves your ability to make an accurate diagnosis.Serology Polymerase chain reaction (PCR)Measures Antibody response of host Nucleic acid (DNA) from pathogenBenefits Useful for screening as well as diagnosisof infection Specifically identifies pathogens indicating active infectionLimitations Clinical signs may precede a measurableantibody response A negative PCR result does not necessarily rule out infectionDogs with ehrlichiosis and anaplasmosis may present with clinical signs at different times after infection. Which sick dog are you dealing with? Benefits and limitations of each diagnostic methodrecrudescence presents presents presentsWhen to use the IDEXX vector-borne disease RealPCR™ panels• S ick patients with clinical signsand/or laboratory abnormalitiesconsistent with a vector-borne illness• P atients with subclinical infectionsbased on history, physicalexamination, serology, and clinicallaboratory findings“No single test is sufficientfor diagnosing an infectious disease in a sick patient.”Edward Breitschwerdt, DVM, DACVIM*Professor, Internal MedicineCollege of Veterinary Medicine,North Carolina State University* D r. Breitschwerdt has a business relationship with IDEXX pursuant to which he receives compensation from IDEXX from time to time. The views expressed in this guide are solely those of Dr. Breitschwerdt.References1. G eneral guidelines: Parasite testing and protection guided by veterinarians [dog].Companion Animal Parasite Council website. /guidelines /general-guidelines. Updated July 29, 2020. Accessed November 17. 2021. 2. B eall MJ, Chandrashekar R, Eberts MD, et al. Serological and molecular prevalenceof Borrelia burgdorferi , Anaplasma phagocytophilum , and Ehrlichia species in dogs from Minnesota. Vector-Borne Zoonotic Dis . 2008;8(4):455–464. doi:10.1089/vbz.2007.0236 3. R egions where ticks live [maps]. Centers for Disease Control and Prevention website./ticks/geographic_distribution.html. November 17, 2021. 4. D rake C, Coyne M, McCrann DJ, Buch J, Mack R. Risk of development of chronickidney disease after exposure to Borrelia burgdorferi and Anaplasma spp. T op Companion Anim Med. 2020;42:100491. doi:10.1016/j.tcam.2020.100491 5. O ’Connor TP , Esty KJ, Hanscom JL, Shields P , Philipp MT . Dogs vaccinatedwith common Lyme disease vaccines do not respond to IR 6, the conserved immunodominant region of the VlsE surface protein of Borrelia burgdorferi.Clin Diagn Lab Immunol. 2004;11(3):458–462. doi:10.1128/CDLI.11.3.458-462.2004 6. S traubinger RK. PCR-based quantification of Borrelia burgdorferi organisms in caninetissues over a 500-day postinfection period. J Clin Microbiol. 2000;38(6):2191–2199. doi:10.1128/JCM.38.6.2191-2199.2000 7. C APC prevalence maps: heartworm [dog]. Companion Animal Parasite Councilwebsite. /maps/#/2021/all-year/heartworm-canine/dog/united-states. Accessed November 17, 2021.8. A merican Heartworm Society. Current canine guidelines for the prevention, diagnosis,and management of heartworm infection in dogs . 2020. Accessed November 17, 2021. https:///images/pdf/AHS_Canine_Guidelines_11_ 13_20.pdf?1605556516 9. E genvall A, Lilliehöök I, Bjöersdorff A, et al. Detection of granulocytic Ehrlichia speciesDNA by PCR in persistently infected dogs. Vet Rec . 2000;146(7):186–190. doi:10.1136/vr.146.7.186 10. B reitschwerdt EB, Hegarty BC, Qurollo BA, et al. Intravascular persistence ofAnaplasma platys , Ehrlichia chaffeensis , and Ehrlichia ewingii DNA in the blood of a dog and two family members. Parasit Vectors . 2014;7:298. doi:10.1186/1756-3305-7-298 11. G aunt S, Beall M, Stillman B, et al. Experimental infection and co-infection of dogs withAnaplasma platys and Ehrlichia canis : hematologic, serologic and molecular findings. Parasit Vectors . 2010;3(1):33. doi:10.1186/1756-3305-3-33 12. H egarty BC, de Paiva Diniz PP , Bradley JM, Lorentzen L, Breitschwerdt E. Clinicalrelevance of annual screening using a commercial enzyme-linked immunosorbentassay (SNAP 3Dx) for canine ehrlichiosis. J Am Anim Hosp Assoc. 2009;45(3):118–124. doi:10.5326/0450118 13. B urton W, Drake C, Ogeer J, et al. Association between exposure to Ehrlichia spp.and risk of developing chronic kidney disease in dogs. J Am Anim Hosp Assoc . 2020;56(3):159–164. doi:10.5326/JAAHA-MS-7012 14. S tarkey LA, Barrett AW, Beall MJ, et al. Persistent Ehrlichia ewingii infection indogs after natural tick infestation. J Vet Intern Med . 2015;29(2):552–555. doi:10.1111/jvim.12567 15. S nellgrove AN, Krapiunaya I, Ford SL, et al. Vector competence of Rhipicephalussanguineus sensu stricto for Anaplasma platys . Ticks Tick Borne Dis. 2020;11(6):101517. doi:10.1016/j.ttbdis.2020.101517Depend on the most accurate and comprehensive screenSNAP 4Dx Plus T estReference-laboratory quality in the palm of your hand, for superior diagnostic accuracy at the pointof care.Lab 4Dx Plus T estAvailable from IDEXX Reference Laboratories as a stand-alone test or as part of a more comprehensiveparasite screen with the Fecal Dx Antigen Panel with Lab 4Dx Plus Test-Canine.SNAP ® technology uses a proprietary three-step process to deliver dependable sensitivity and specificity.Available in-clinic or from IDEXX Reference LaboratoriesStrengthen the bonds.IDEXX Laboratories, Inc.One IDEXX DriveWestbrook, Maine 04092United StatesAmerican dog tick (Dermacentor variabilis) photographer: Susan E. Ellis, USDA-APHIS-PPQ. Black-legged tick (Ixodes scapularis), lone star tick (Amblyomma americanum), and brown dog tick (Rhipicephalus sanguineus) photographer: James L. Occi.© 2022 IDEXX Laboratories, Inc. 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