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神经妥乐平治疗老年带状疱疹后神经痛的疗效观察
梁临平;李美晔;张宪军
【期刊名称】《临床神经病学杂志》
【年(卷),期】2006(19)3
【摘要】目的观察神经妥乐平治疗老年带状疱疹后神经痛(PHN)的疗效.方法将58例老年PHN患者随机分为神经妥乐平组和卡马西平组,应用视觉模糊评分法(VAS)评价两组治疗后疼痛的改善情况并观察药物不良反应.结果治疗第2周、4周、6周后神经妥乐平组VAS较治疗前明显下降(均P<0.01),总有效率为80%,明显优于卡马西平组(46.4%)(P<0.05),两组患者均未出现明显不良反应.结论神经妥乐平治疗老年PHN的疗效优于卡马西平.
【总页数】2页(P224-225)
【作者】梁临平;李美晔;张宪军
【作者单位】250012,山东大学齐鲁医院皮肤科;250012,山东大学齐鲁医院神经内科;250012,山东大学齐鲁医院皮肤科
【正文语种】中文
【中图分类】R745
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1.神经妥乐平联合窄波UVB治疗老年带状疱疹后遗神经痛 [J], 孙立;张瑞
2.氟哌噻吨美利曲新联合加巴喷丁和甲钴胺治疗老年带状疱疹后神经痛的临床疗效观察 [J], 袁俊
3.神经妥乐平联合椎旁神经阻滞术治疗带状疱疹后神经痛近期疗效观察 [J], 孙凌梅;程俏;吕客;童迅
4.揿针治疗老年带状疱疹后神经痛疗效观察 [J], 周洁;张华
5.神经妥乐平联合体外冲击波疗法治疗带状疱疹后神经痛的疗效观察 [J], 杨杰;胡红专;黄忠义
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应用神经妥乐平进行神经阻滞治疗痛症97例临床观察
宫士凯;扬金利;李仲廉
【期刊名称】《中国疼痛医学杂志》
【年(卷),期】2004(010)003
【摘要】神经妥乐平(Neurotropin)是将牛痘病毒疫苗接种到家兔的皮肤组织，从炎症反应的组织中提纯精制而成的一种非蛋白小分子生物活性物质。
神经妥乐平药理作用广泛，具有镇痛、神经修复、免疫调节、改善组织缺血、提高局部皮肤温度及消除神经根水肿等作用。
我院在应用神经妥乐平配置混合液进行神经阻滞治疗痛症方面进行临床观察，现将观察结果报告如下。
【总页数】2页(P188-189)
【作者】宫士凯;扬金利;李仲廉
【作者单位】天津市中医学院第一附属医院除痛中心,天津,300193;天津市中医学院第一附属医院除痛中心,天津,300193;天津市中医学院第一附属医院除痛中心,天津,300193
【正文语种】中文
【中图分类】R4
【相关文献】
1.前列地尔和神经妥乐平联合连续硬膜外阻滞治疗红斑性肢痛症 [J], 冉菊红;王艳萍;马民玉
2.神经妥乐平治疗腰痛症的临床观察 [J], 施桂英;董怡
3.小趾展肌神经阻滞治疗顽固性跟痛症临床观察 [J], 王德强;舒春华;王建波
4.神经妥乐平联合曲安奈德椎旁阻滞治疗伴有冷感的腰椎间盘突出症的临床观察[J], 吴明明; 郑世江; 肖晶
5.超声引导下选择性颈神经根阻滞治疗颈神经根痛:局部麻醉药联合神经妥乐平或糖皮质激素的随机对照研究 [J], 石潇;杨雨;方洪伟;王祥瑞
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紫杉醇类药物治疗胃癌致周围神经病变机制及黄芪多糖防治研究进展王晓寅;陈如笛;张晓丽【期刊名称】《河北北方学院学报（自然科学版）》【年(卷),期】2024(40)6【摘要】胃癌发病率、死亡率、复发率均较高,紫杉醇是临床常用治疗进展期胃癌的化疗药物,化疗致周围神经病变(chemotherapy-induced peripheral neuropathy,CIPN)是临床常见紫杉醇类化疗制剂不良反应,为应用紫杉醇化疗时最主要的剂量限制性因素。
黄芪多糖(astragalus polysaccharide,APS)具有介导信号通路发挥抗肿瘤、增强免疫力、降低胃癌细胞耐药性、减少药物毒性等多种功效,黄芪桂枝五物汤对CIPN有防治作用,可减轻紫杉醇化疗所引起的神经毒性症状。
综述了紫杉醇致周围神经病变(paclitaxel-induced peripheral neuropathy,PIPN)的可能机制及黄芪降低PIPN发生率的可能机制,以期为临床PIPN治疗提供新思路,亦为含黄芪多糖类中药制剂的传承创新与开发提供参考。
【总页数】3页(P57-59)【作者】王晓寅;陈如笛;张晓丽【作者单位】河北北方学院附属第二医院;河北北方学院药学院;河北北方学院生命科学研究中心【正文语种】中文【中图分类】R969.3;R735.2【相关文献】1.紫杉醇诱导周围神经病变的作用机制研究进展及中医辨治探讨2.紫杉醇所致周围神经病变的机制研究进展3.紫杉类药物所致周围神经病变免疫炎症机制研究进展4.冷冻疗法对胃癌患者紫杉醇致周围神经病变和心理痛苦的影响5.基于细胞因子芯片分析白蛋白结合型紫杉醇致周围神经病变的分子机制因版权原因，仅展示原文概要，查看原文内容请购买。
神经妥乐平联合医用臭氧治疗周围神经病变的效果观察李泓锡;姚鹏【期刊名称】《医学综述》【年(卷),期】2017(023)015【摘要】目的观察神经妥乐平联合医用臭氧治疗周围神经病变的效果.方法收集2014年6月至2017年3月于中国医科大学附属盛京医院诊断为糖尿病周围神经病变的68例患者临床资料,根据治疗方法分为常规组和联合组,每组34例.常规组给予常规改善循环、营养神经药物、神经妥乐平及镇痛药物治疗;联合组在此基础上给予医用臭氧治疗,且所有患者住院治疗时间在10～15 d.观察两组治疗前、出院时、出院后1个月的视觉模拟评分(VAS)、生命质量评分、镇痛药用量、治疗总有效率和不良反应发生情况.结果两组间VAS及生命质量评分[生理总分(PCS)和心理总分(MCS)]比较,差异均有统计学意义(均P＜0.05);治疗前、出院时和出院1个月3个时点间VAS评分、PCS评分、MCS评分差异有统计学意义(P＜0.01),但组间·时点间的交互作用差异均无统计学意义(P＞0.05).两组间镇痛药用量比较,差异有统计学意义(P＜0.01);治疗前、出院时和出院1个月3个时点间盐酸羟考酮缓释片用量差异有统计学意义(P＜0.01),且组间·时点间交互作用差异亦有统计学意义(P =0.004).出院时联合组治疗总有效率为88.24％ (30/34),高于常规组的67.65％(23/34)(x2=4.191,P=0.041);出院1个月联合组治疗总有效率为94.12％ (32/34),高于常规组的76.47％ (26/34)(x2 =4.221,P=0.040).两组患者治疗期间均未出现严重不良反应,联合组患者恶心呕吐、便秘及头晕发生率明显低于常规组(均P ＜0.05).结论神经妥乐平联合医用臭氧治疗周围神经病变,能够有效缓解疼痛症状、改善患者的生命质量,减少镇痛药用量,提高治疗有效率.%Objective To observethe effect of neurotropin combined with medical ozone in the treatment of peripheral neuropathy.Methods The clinical data of 68 patients diagnosed with diabetic peripheral neuropathy was collected in Shengjing Hospital of China Medical University from June 2014 to March 2017,which were divided into a routine group and a combined group according to the treatment method,34 cases each group.The routine group was given routine improvement of circulation,nutrition nerve drugs,neurotropin and analgesic drug treatment;the combined group was given medical ozone treatment on the basis of the routine group,and all of the patients were hospitalized for about 10 to 15 days.The visual analogue scale(VAS),quality of life score,analgesic dosage,the total effective rate of treatment and the incidence of adverse reactions of the two groups were observed at the time point of pro-treatment,discharge and 1 month after discharge.Results There was significant differences between VAS and quality of lifescores[physical component summary(PCS) and mental component summary(MCS)] of the two groups(all P ＜ 0.05);there were significant differences in VAS score,PCS score and MCS score between the two groups before treatment,at discharge and one month after discharge(P ＜0.01),but there was no statistically significant difference between the group · time point interaction(P ＞ 0.05).The difference of analgesic dosage between the two groups was statistically significant (P ＜ 0.01);there was significant difference in the dosage of oxycodone hydrochloride sustained-release tablets between the time points of before treatment,at discharge and one month after discharge(P ＜0.01),and the difference between group · timepoint interaction was also statistically significant (P =0.004).The total effective rate in the combined group at discharge was 88.24％(30/34),which was higher than that of the routine group's 67.65％ (23/34) (x2 =4.191,P =0.041);at one month after discharge,the total effective rate in the combined group was 94.12％ (32/34),which was higher than that of the routine group's 76.47％ (26/34)(x2 =4.221,P =0.040).There were no serious adverse reactions in the two groups during the treatment.The incidences of nausea,vomiting,constipation and dizziness in the combined group were significantly lower than those in the routine group (all P ＜0.05).Conclusion Neurotropin combined with medical ozone used for peripheral neuropathy can significantly relieve pain symptoms,improve patients'quality of life,reduce the dosage of analgesic,and improve the efficiency of treatment.【总页数】5页(P3102-3106)【作者】李泓锡;姚鹏【作者单位】中国医科大学附属盛京医院疼痛科,沈阳110001;中国医科大学附属盛京医院疼痛科,沈阳110001【正文语种】中文【中图分类】R453.9;R587.2【相关文献】1.医用臭氧治疗仪联合局部用药治疗妇科阴道炎效果观察 [J], 杨美英2.加强心理护理联合医用臭氧治疗慢性乙型病毒性肝炎的效果观察 [J], 刘婷婷;褚运松3.莫匹罗星联合医用臭氧治疗溃疡期压疮的效果观察 [J], 陈阳新;梁红丽;郭亚金;朱新海4.神经妥乐平对糖尿病周围神经病变患者止痛效果观察 [J], 李建军5.神经妥乐平对糖尿病周围神经病变患者止痛效果观察 [J], 李建军因版权原因，仅展示原文概要，查看原文内容请购买。
神经妥乐平治疗带状疱疹神经痛疗效观察
潘毅
【期刊名称】《华夏医学》
【年(卷),期】2003(016)002
【摘 要】@@ 带状疱疹并发的神经痛一直是皮肤科临床治疗中比较棘手的问题.现
将我科自2001年1月至2002年3月利用神经妥乐平3CC针剂肌注的方法治疗
带状疱疹神经痛,取得较好的疗效.现报告如下.
【总页数】1页(P163-163)
【作 者】潘毅
【作者单位】温州市第三人民医院皮肤科,浙江,温州,325000
【正文语种】中 文
【中图分类】R758.3
【相关文献】
1.神经妥乐平椎旁神经阻滞治疗带状疱疹后遗神经痛的疗效观察 [J], 伍小敏;陈天
葆
2.神经妥乐平联合椎旁神经阻滞术治疗带状疱疹后神经痛近期疗效观察 [J], 孙凌
梅;程俏;吕客;童迅
3.神经妥乐平联合体外冲击波疗法治疗带状疱疹后神经痛的疗效观察 [J], 杨杰;胡
红专;黄忠义
4.神经妥乐平配合扫荡针法治疗带状疱疹神经痛的疗效观察 [J], 郑世江;吴明明
5.钩活术加神经妥乐平椎旁阻滞治疗带状疱疹后遗神经痛疗效观察 [J], 魏玉锁
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神经妥乐平复合液皮内注射联合神经阻滞治疗带状疱疹后遗神
经痛效果观察
王海洪;王妍清
【期刊名称】《临床合理用药杂志》
【年(卷),期】2018(11)13
【摘要】目的观察神经妥乐平复合液皮内注射联合神经阻滞治疗带状疱疹后遗神经痛(PHN)患者的临床效果。
方法采用随机数字表法将50例PHN患者随机分为治疗组和对照组,各25例。
对照组予维生素B复合液治疗。
治疗组在对照组基础上加用神经妥乐平复合液皮内注射联合神经阻滞治疗。
对比2组患者临床疗效和治疗前后VAS疼痛评分。
结果治疗组总有效率为96.00%高于对照组的76.00%,差异有统计学意义(χ~2=16.611,P<0.05)。
治疗前,2组患者的VAS评分比较差异无统计学意义(P>0.05);治疗后,2组VAS评分均低于治疗前,且治疗组低于对照组,差异有统计学意义(P<0.05)。
结论神经妥乐平复合液皮内注射联合神经阻滞能显著降低PHN患者的疼痛,整体治疗效果明显,值得在各大医院推广应用。
【总页数】2页(P97-98)
【作者】王海洪;王妍清
【作者单位】贵阳市第一人民医院
【正文语种】中文
【中图分类】R275.921.2
【相关文献】
1.神经阻滞联合神经妥乐平治疗带状疱疹后遗神经痛临床观察
2.神经妥乐平椎旁神经阻滞治疗带状疱疹后遗神经痛的疗效观察
3.神经阻滞联合神经妥乐平治疗带状疱疹神经痛的临床观察
4.神经妥乐平联合椎旁神经阻滞术治疗带状疱疹后神经痛近期疗效观察
5.神经妥乐平罗哌卡因复合液神经阻滞治疗带状疱疹性神经痛
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神经妥乐平联合医用臭氧治疗周围神经病变的效果观察李泓锡;姚鹏【摘要】目的观察神经妥乐平联合医用臭氧治疗周围神经病变的效果.方法收集2014年6月至2017年3月于中国医科大学附属盛京医院诊断为糖尿病周围神经病变的68例患者临床资料,根据治疗方法分为常规组和联合组,每组34例.常规组给予常规改善循环、营养神经药物、神经妥乐平及镇痛药物治疗;联合组在此基础上给予医用臭氧治疗,且所有患者住院治疗时间在10～15 d.观察两组治疗前、出院时、出院后1个月的视觉模拟评分(VAS)、生命质量评分、镇痛药用量、治疗总有效率和不良反应发生情况.结果两组间VAS及生命质量评分[生理总分(PCS)和心理总分(MCS)]比较,差异均有统计学意义(均P＜0.05);治疗前、出院时和出院1个月3个时点间VAS评分、PCS评分、MCS评分差异有统计学意义(P＜0.01),但组间·时点间的交互作用差异均无统计学意义(P＞0.05).两组间镇痛药用量比较,差异有统计学意义(P＜0.01);治疗前、出院时和出院1个月3个时点间盐酸羟考酮缓释片用量差异有统计学意义(P＜0.01),且组间·时点间交互作用差异亦有统计学意义(P =0.004).出院时联合组治疗总有效率为88.24％ (30/34),高于常规组的67.65％(23/34)(x2=4.191,P=0.041);出院1个月联合组治疗总有效率为94.12％ (32/34),高于常规组的76.47％ (26/34)(x2 =4.221,P=0.040).两组患者治疗期间均未出现严重不良反应,联合组患者恶心呕吐、便秘及头晕发生率明显低于常规组(均P ＜0.05).结论神经妥乐平联合医用臭氧治疗周围神经病变,能够有效缓解疼痛症状、改善患者的生命质量,减少镇痛药用量,提高治疗有效率.%Objective To observe the effect of neurotropin combined with medical ozone in the treatment of peripheral neuropathy.Methods The clinical data of 68 patients diagnosed with diabetic peripheral neuropathy was collected in Shengjing Hospital ofChina Medical University from June 2014 to March 2017,which were divided into a routine group and a combined group according to the treatment method,34 cases each group.The routine group was given routine improvement of circulation,nutrition nerve drugs,neurotropin and analgesic drug treatment;the combined group was given medical ozone treatment on the basis of the routine group,and all of the patients were hospitalized for about 10 to 15 days.The visual analogue scale(VAS),quality of life score,analgesic dosage,the total effective rate of treatment and the incidence of adverse reactions of the two groups were observed at the time point of pro-treatment,discharge and 1 month after discharge.Results There was significant differences between VAS and quality of lifescores[physical component summary(PCS) and mental component summary(MCS)] of the two groups(all P ＜ 0.05);there were significant differences in VAS score,PCS score and MCS score between the two groups before treatment,at discharge and one month after discharge(P ＜0.01),but there was no statistically significant difference between the group · time point interaction(P ＞ 0.05).The difference of analgesic dosage between the two groups was statistically significant (P ＜ 0.01);there was significant difference in the dosage of oxycodone hydrochloride sustained-release tablets between the time points of before treatment,at discharge and one month after discharge(P ＜0.01),and the difference between group · time point interaction was also statistically significant (P =0.004).The total effective rate in the combined group at discharge was 88.24％(30/34),which was higher than that of the routine group's 67.65％ (23/34)(x2 =4.191,P =0.041);at one month after discharge,the total effective rate in the combined group was 94.12％ (32/34),which was higher than that of the routine group's 76.47％ (26/34)(x2 =4.221,P =0.040).There were no serious adverse reactions in the two groups during the treatment.The incidences of nausea,vomiting,constipation and dizziness in the combined group were significantly lower than those in the routine group (all P ＜0.05).Conclusion Neurotropin combined with medical ozone used for peripheral neuropathy can significantly relieve pain symptoms,improve patients'quality of life,reduce the dosage of analgesic,and improve the efficiency of treatment.【期刊名称】《医学综述》【年(卷),期】2017(023)015【总页数】5页(P3102-3106)【关键词】糖尿病周围神经病变;臭氧;神经妥乐平;加巴喷丁【作者】李泓锡;姚鹏【作者单位】中国医科大学附属盛京医院疼痛科,沈阳110001;中国医科大学附属盛京医院疼痛科,沈阳110001【正文语种】中文【中图分类】R453.9;R587.2糖尿病周围神经病变(diabetic peripheral neuropathy，DPN)为糖尿病最常见的慢性并发症之一，国外报道其发病率高达60%～90%[1]，国内报道患病率为63.3%[2]。
