PREPARATION A LORAL

Amphotericin B solution Catalog Number A2942Storage Temperature –20 °C CAS RN 1397-89-3Product DescriptionMolecular Formula: C 47H 73NO 17Molecular Weight: 924.08Melting Point: >170 °C with decompositionλmax :1406 nm, 382 nm, 363 nm, 345 nm (MeOH)Amphotericin B, many times referred to as Fungizone ™, is an antimycotic. Normal usage is 2.5 mg/L along with the addition of penicillin and streptomycin to themedium. This product is used at 10 mL/L of medium. Amphotericin B is stable in culture at 37 °C up to 3days. To kill yeast and fungi, it is recommended to use this product at 2–4 times the normal level (20–40 mL/L) in medium without penicillin andstreptomycin, for 2–3 subcultures. Then, return the cells to normal medium conditions. In the meantime, clean the incubator with SigmaClean water bath cleaner (Catalog Number S5525) and in addition, add this cleaner to the water reservoir to prevent recontamination.This product is supplied as 250 µg/mL Amphotericin B in deionized water. This product is a solution containing Amphotericin B with the following components added to improve its solubility:sodium deoxycholate, sodium chloride, and sodium phosphate.Precautions and DisclaimerThis product is for R&D use only, not for drug,household, or other uses. Please consult the Safety Data Sheet for information regarding hazards and safe handling practices.Preparation InstructionsAlthough the specification for this item is a clear, yellow solution, it is not unusual for this material to form a precipitate in aqueous solutions. Many times,thoroughly mixing the solution will redissolve most of the precipitate. However, this precipitate will probably not fully resolubilize, but the amphotericin B should still be suitable for use.Storage/StabilityStable for 3 days in culture at 37 °C. Stable at 2–8 °C for 2–3 weeks. For long term stability, solutions should be kept frozen at –20 °C.Reference1.The Merck Index, 10th ed., Entry# 611.Fungizone is a trademark of E. R. Squibb and Sons, L.L.C.DS,CMH,SAG,MAM 11/15-1©2015 Sigma-Aldrich Co. LLC. All rights reserved. SIGMA-ALDRICH is a trademark of Sigma-Aldrich Co. LLC, registered in the US and other countries. Sigma brand products are sold through Sigma-Aldrich, Inc. Purchaser must determine the suitability of the product(s) for theirparticular use. Additional terms and conditions may apply. Please see product information on the Sigma-Aldrich website at and/or on the reverse side of the invoice or packing slip.。

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文档下载后可定制随意修改，请根据实际需要进行相应的调整和使用，谢谢!并且，本店铺为大家提供各种各样类型的实用资料，如教育随笔、日记赏析、句子摘抄、古诗大全、经典美文、话题作文、工作总结、词语解析、文案摘录、其他资料等等，如想了解不同资料格式和写法，敬请关注!Download tips: This document is carefully compiled by theeditor. I hope that after you download them,they can help yousolve practical problems. The document can be customized andmodified after downloading,please adjust and use it according toactual needs, thank you!In addition, our shop provides you with various types ofpractical materials,such as educational essays, diaryappreciation,sentence excerpts,ancient poems,classic articles,topic composition,work summary,word parsing,copyexcerpts,other materials and so on,want to know different data formats andwriting methods,please pay attention!Preparation is key to success. Whether it's for a job interview, a presentation, or a big event, being prepared can make all the difference. So, how do we prepare? Well, there are many ways to go about it.Firstly, it's important to do your research. Whether you're preparing for a test or a meeting, knowing the subject matter is crucial. You can read books, search the internet, or talk to experts in the field. The more knowledge you have, the better prepared you'll be.Next, practice makes perfect. If you have a presentation coming up, rehearse it multiple times. Practice in front of a mirror or with a friend. This will help you become more comfortable with the material and improve your delivery. Similarly, if you have an interview, practice answering common questions. This will help youfeel more confident and prepared on the day.Another aspect of preparation is organization. Make a to-do list or create a schedule to keep track of what needs to be done. This will help you stay focused and ensure that you don't forget anything important. Additionally, gather all the necessary materials or resources you'll need in advance. Being organized will save you time and stress in the long run.In addition to research and practice, it's important to take care of yourself before any big event. Get enough sleep, eat a healthy meal, and take some time to relax. When you're well-rested and nourished, you'll be able to perform at your best. Don't forget to also take care of your mental well-being. Find ways to manage stress, such as meditation or exercise. Taking care of yourself will help you stay focused and calm during any high-pressure situation.Lastly, be adaptable. No matter how well you prepare, things may not always go according to plan. It's important to be flexible and ready to adjust if needed. Have a backup plan or alternative solutions in mind. Being able to adaptto unexpected situations will show your resilience and ability to think on your feet.In conclusion, preparation is essential for success. By doing research, practicing, staying organized, taking care of yourself, and being adaptable, you'll be well-prepared for any situation that comes your way. So, start preparing now and watch as your confidence and success soar.。

专利名称：PREPARATION OF ROAST ADLAY 发明人：AIBA TOMIO申请号：JP3520081申请日：19810313公开号：JPS57150354A公开日：19820917专利内容由知识产权出版社提供摘要：PURPOSE:To prepare roast adlay having excellent flavor, preventing the degradation of the active components, by roasting polished adlay in hot air stream under fluidized state, and pulverizing the adlay after cooling. CONSTITUTION:Polished adlay seeds are sprinkled with water, and the adlay uniformly moistened to a water content of 5-15% is supplied to the fluidizing bed having straightening vanes at the bottom and roasted at 250-500 deg.C with hot air stream under fluidized state. The temperature of the hot air is preferably 280-350 deg.C, and its flow velocity is 4-9m/sec. The roast adlay is quenched with a ventilation cooler, and pulverized to a desired particle size. If necessary, the powder is seasoned with sugar, salt, or other seasonings. The fine powder can be used as a paste or a drink, and the coarse powder can be used as a raw material of a granular cake, rice-flour cake, millet-and-rice cake, etc. by seasoning, or as a raw material of adlay miso or adlay soy.申请人：HIGETA SHIYOUYU KK更多信息请下载全文后查看。

专利名称：PERORALLY APPLICABLE PREPARATIONCONTAINING HISTAMINASE OF VEGETABLEORIGIN, RESISTANT TO PEPSIN ANDTRYPSIN AND A PROCESS FOR PRODUCINGIT发明人：SIPKA, Sándor,GYÖRY, Zoltán,BORBÉLY,Jánosné,KERESZTES, Tamás,VÁRNAI,Péter,BÍRÓ, Tamás申请号：EP10763851.2申请日：20100902公开号：EP2611454A1公开日：20130710专利内容由知识产权出版社提供摘要：The subject of the invention is a perorally applicable preparation of vegetable origin, resistant to pepsin and trypsin, based on histaminase, optionally for the use as an agent for improving digestion, reducing appetite or reducing body weight. The preparation of the invention is a pressed juice - which is optionally in lyophilized form -obtained from seedlings of pea (Pisum sativum L.), lentil (Lens culinaris), chick pea (Cicer arietinum), grass pea (Latirus sativus), bean (Phaseolus vulgaris) or field bean (Vicia faba) or - from a mixture of seedlings of the above mentioned plants - which contains histaminase, catalase and protease inhibitor. The subject as well of the invention is the production of the above preparation. ˙申请人：Debreceni Egyetem地址：Egyetem tér 1 4032 Debrecen HU国籍：HU代理机构：Varnai, Aniko 更多信息请下载全文后查看。

有关preparation英语作文Preparation is the key to success in various aspects of life. Whether it's preparing for a job interview, an important presentation, or even a marathon, the effort and thought put into preparing can make a significant difference in the outcome. The process of preparation involves several steps, each of which contributes to the overall readiness for any challenge or opportunity that comes one's way.The initial phase of preparation is often about gathering information. This could involve researching the company one is interviewing with, understanding the audience for a presentation, or learning about the course for a race. Having comprehensive knowledge allows for a more tailored and effective strategy. It's not just about having the information but understanding it well enough to apply it practically.After gathering information, the next step is planning. This is where one takes the information and crafts a strategy. For an interview, this might mean preparing answers to common questions or highlighting certain aspects of one's experience. For a presentation, it involves structuring the talk to engage the audience and convey the message clearly. In the context of a marathon, it's about creating a training schedule that gradually builds endurance.Practice is an integral part of preparation. It's one thing to have a plan, but another to execute it effectively. Rehearsing for an interview by conducting mock sessions, practicing a presentation multiple times to ensure smooth delivery, or following through with the training plan for a marathon are all forms of practice that refine one's approach and increase confidence.Adaptability is also a crucial element of preparation. Despite the best-laid plans, unexpected situations can arise. Being prepared means having the flexibility to adjust one's strategy when necessary. This could mean changing the focus of an interview answer on the spot, modifying a presentation to better suit the audience's reaction, or altering a training plan due to injury or weather conditions.Finally, mental preparation cannot be overlooked. It's essential to enter any situation with the right mindset. This involves visualizing success, managing stress, and maintaining a positive attitude. Mental preparation helps in staying focused and calm, allowing for better performance.In conclusion, preparation is a multifaceted process that requires diligent information gathering, strategic planning, dedicated practice, adaptability, and mental fortitude. By embracing these components, one can enhance their readiness for any endeavor and increase the likelihood of achieving their goals. The art of preparation is not just about the actions taken but the mindset cultivated, and it is this combination that paves the way for success. 。

专利名称：A process for the preparation of alubricating oil additive concentrate发明人：Crawford, John,Cane, Charles,O'Connor, Sean Patrick申请号：EP90307916.8申请日：19900719公开号：EP0410648A3公开日：19910320专利内容由知识产权出版社提供摘要：A process for the production of a lubricating oil additive concentrate comprises reacting at elevated temperature the following components:- component (A) a defined acid component (B) - a calcium base added either in a single addition or in a plurality of additions at intermediate points during the reaction, component (C) - at least one compound which is (i) water, (ii) a polyhydric alcohol having 2 to 4 carbon atoms, (iii) a di-‐(C₃ or C₄) glycol, (iv) a tri-(C₂-C₄) glycol, (v) a mono- or poly-alkylene glycol alkyl ether of the formula (I) R(OR¹)OR² (I) wherein R is a C₁ to C₆ alkyl group, R¹ is an alkylene group, R² is hydrogen or a C₁ to C₆ alkyl group and x is an integer from 1 to 6, (vi) a C₁ to C₂₀ monohydric alcohol, (vii) a C₁ to C₂₀ ketone, (viii) a C₁ to C₁₀ carboxylic acid ester, or (ix) a C₁ to C₂₀ ether, optionally, component (D) - a lubricating oil, component (E) - carbon dioxide added subsequent to the, or each, addition of component (B), and component (F) - a compound of formula II R³X (II) wherein X is a halogen and R³ is an alkyl, alkenyl or alkaryl group or halo derivative thereof.申请人：BP CHEMICALS (ADDITIVES) LIMITED地址：Britannic House 1 Finsbury Circus London EC2M 7BA GB国籍：GB代理机构：Fawcett, Richard Fennelly 更多信息请下载全文后查看。

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bomber 中型轰炸机medium brim fur felt hat 中阔度帽边毛毡帽medium brown cloth 中褐色布medium bunch rice vermicelli 中扎米粉条medium capacity exchange 中容量交换机medium carbon steel 中碳钢medium chrome yellow 中铬黄medium cloth 中厚毛织物medium coaxial cable 中同轴电缆medium coloured kidney bean 中花芸豆medium cross-bred wool 中支交配种羊毛medium density fibreboard 中密度纤维板medium density polyethylene 中密度聚乙烯medium dozer 中型推土机medium duty engine 中型发动机medium duty truck 中型运输卡车medium flat file 中扁锉medium frequency ammeter 中频电流表medium frequency coreless induction melting furnace 中频无心感应熔炼炉medium frequency direction finder 中频测向器medium frequency furnace 中频电炉medium frequency induction melting furnace 中频感应熔炼炉medium frequency motor for woodworking 中频木工电动机medium frequency transformer 中频变压器medium frequency voltmeter 中频电压表medium green cloth 中绿色布medium heavy steel plate 中厚钢板medium horse-power crawler tractor 中马力履带拖拉机medium leaded brass 中铅黄铜medium length fibre 中长纤维medium mounted harrow 悬挂中耙medium observation aircraft 中型观察机medium oriented yarn 中取向丝medium overcoat 中大衣medium plate 中厚钢板medium power vacuum-tube 中功率真空管medium pressure stainless steel hose 中压金不锈钢软管medium range interceptor 中程截击机medium range surveillance aircraft 中程侦察机medium range transporter 中程运输机medium rare earth richment 中稀土富集物medium roll 中间轧机medium round file 中圆锉medium section mill 中型型钢轧机medium selecting machine 中选机medium size crude carrier 中型原油船medium size turbine generator 中型汽轮发电机medium sized sinterer 中型烧结机medium sized tractor 中型拖拉机medium solvent refined oil 中溶剂精制油medium speed 3-thread overlock sewing machine 中速三线包缝机medium speed 4-thread overlock sewing machine 中速四线包缝机medium speed computer 中速计算机medium speed diesel engine 中速柴油机medium speed disk coal mill 平盘中速磨煤机medium speed engine 中速发动机medium speed flat bed sewing machine 中速平缝机medium speed storage 中速存储器medium speed tape rerecorder 中速磁带复录机medium square file 中方锉medium staple fibre 中长纤维medium steel 中硬钢medium stone bit 中粒金刚石钻头medium stripes 提花缎纹条子布medium tactical transport 中型战术运输机medium temperature binding agent 中温粘合剂medium temperature sensor in pipeline 管道内介质温度传感器medium transport helicopter 中型运输直升机medium type earth mover 中型运土机medium type tractor 中型拖拉机medium wave antenna core 中波天线磁棒medium wave broadcast-transmitter 中波广播发射机medium wave receiver 中波接收机medium weft 中捻度纬纱medium weight fabric 中厚织物medium weight fancy suiting 中厚花呢medium weight rubber sheathed cable 中型橡胶套电缆medium weight waffle cushion 方格饼式中级载重衬垫medium wide-strip mill 中型宽带材轧机medium wool 中等长度羊毛medium yarn in hanks 中支绞纱medium yellow cloth 中黄色布medium yellow filter 中黄滤光镜medium-bus 中型公共汽车medium-carbon graphite 中碳石墨medium-hard steel 中等硬度钢medium-heavy lathe 中型车床medium-infrared fiber 中红外光纤medium-plate mill 中板轧机medium-pressure acetylene generator 中压乙炔发生器medium-pressure boiler 中压锅炉medium-pressure cylinder 中压汽缸medium-pressure generator 中压式发生器medium-pressure steam turbine 中压汽轮机medium-pressure tyre 中压轮胎medium-range air-to-air missile 中程空对空导弹medium-resolution detector 中分辨率探测器medium-type truck 中型载货汽车medium-waled corduroy 中条灯芯绒medium-wave tower 中波塔mediums 上浆中档坯布medlar 枸杞medlure 诱杀酯medoc 麦道克葡萄酒medrogestone 美罗孕酮medroxalol 美沙洛尔medroxyprogesterone acetate 醋酸甲羟孕酮medroxyprogesterone 甲羟孕酮medrylamine 甲氧海明medrysone 甲羟松medulla junci 灯心草medulla of stachyurus 小通草medullated fibre 髓质纤维medullo-puncture needle 骨穿针medwurst 熏制软香肠meerschaum 海泡石mefeclorazine 美非氯嗪mefenamic acid 甲灭酸mefenorex 美芬雷司mefexamide 美非沙胺meflophenhydramine 甲氟海明mefoxin vial 注射用美福仙mefruside 美夫西特mega 米加牌手表megafog 雾信号器megaperm 梅格珀姆铁镍锰高导磁率合金megaphone 传声筒megapulse laser 兆瓦脉冲激光器megapyr 梅格派尔铁铬铝电阻丝合金megascope 扩大照相机megasweep 摇频振荡器megatanker 百万吨级油轮megestrol acetate 甲地孕酮megestrol 甲地孕酮megger 兆欧表meglumine 葡甲胺meglumini diatrozoas 泛影葡胺meglumini iodipamidum 胆影葡胺meglutol 美格鲁托megna 梅根牌手表megohmmeter 兆欧计mehari 梅阿丽牌汽车meisag 迈萨格牌手表meisen 铭仙绸mekometer 测距器mekydro 液压齿轮meladinin 敏白灵meladrazine 美拉肼melamin alkyl varnish coated glass cloth 三聚氰胺烷基漆玻璃布melamine cyanurate 氰尿酸三聚氰胺melamine faced chipboard 三聚氰胺贴面板melamine plastics 密胺塑料melamine resin varnish 密胺树脂清漆melamine resin 密胺树脂melamine tableware 三聚氰氨餐具melamine 三聚氰胺melamine-formaldehyde resin 三聚氰胺甲醛树酯melamino-formaldehyde resin fibre 三聚氰胺甲醛树脂纤维melaminoplast 三聚氰胺塑料melana 梅拉纳聚丙烯腈系纤维melange cloth 混色织物melange lustre 混色有光织物melange serge 混色哔叽melange suitings 混色薄开司米毛织物melange yarn 混色纱melange 混色毛纱melanger machine 混条针梳机melanoscope 红外线镜melarsonyl potassium 美拉胂钾melarsoprol 美拉胂醇melaye 梅拉伊绸meldable fibre 热熔纤维meldane 蝇毒磷meldometer 熔点测定计mele silk 混色丝线melene 蜂花烯melengestrol 美仑孕酮melia 苦楝根皮melissane 三十烷melissic acid 三十烷酸melitoxin 双杀鼠灵melitracen 美利蒽melleril tablet 美立廉片mellitic acid 苯六甲酸mellophone 圆号mellotte's alloy 梅洛特铋锡铅易熔合金melni alloy 梅尔尼镍基耐热合金melodica 笛琴melodion 簧风琴melody chenille spread 曲谱图案床单melofil 梅洛菲尔melon jam 甜瓜酱melon seed chocolate 瓜仁朱古力melon seed 甜瓜子melon 甜瓜melperone 美哌隆melphalan 美法仑melprex 多果定melt spun fibre 熔纺纤维melt-blown fabric 熔喷法非织造布melt-blown micro fibre 熔喷超细纤维melting holding furnace 熔炼保温炉melting copper furnace 熔铜炉melting furnace 熔化炉melting ladle 熔勺melting point determination apparatus 熔点测定仪melting point thermometer 溶点温度计melting point tube 溶点测定管melting pot 熔炉melting steel furnace 熔钢炉melting-refining furnace 熔炼炉melton fabrics 麦尔登melton 麦尔登呢meltonette 麦尔登薄呢mema 醋酸甲氧乙汞memantine hydrochloride 盐酸美金刚胺membrane compressor 隔膜式压缩机membrane filter 膜式过滤器membrane manometer 膜式压力计membrane of chicken gizzard 鸡内金membrane of hen egg 凤凰衣membrane pressure gauge 薄膜压力计membrane pump 隔膜泵membrane salinometer 薄膜盐度计membrane screen printing machine 薄膜丝网印花机membrane valve 薄膜阀membrane 薄膜membrane-case manometer 膜盒压力计membrane-type hydrophone 薄膜式水听器membrane-type manometer 膜式压力计membranometer 薄膜压力计membranous pump 隔膜泵meme 咪咪牌手表memhaden meal 油鲱鱼粉memhaden oil 油鲱油memistor 电解存储器memmi 亚胺甲汞memnescope 瞬变示波器memo-telephone 记录电话memorial crown 纪念硬币memorizer 记忆器memorizing meter 记录仪memory buffer 存储缓冲器memory capacitor 存储电容器memory card 存储器卡memory condenser 存储电容器memory core tester 存储磁芯试验器memory data register 存储数据寄存器memory decoder 存储器解码器memory drum 记忆装置鼓memory expansion kit 存储器扩展组件memory filter 记忆滤波器memory information register 存储信息寄存器memory machine 存储机memory oscilloscope 存储器示波器memory register 存储寄存器memory relay 存储式继电器memory scope 存储式示波器memory stitcher 电子缝纫机memory synchroscope 存储式同步示波器memory totalizer 总和存储器memory 存储器memotine 美莫丁memphis cotton 孟菲斯棉men's ladies' pure silk wadding padded jackets 真丝绸丝棉男女棉衣men's and ladies' shirts 男女衬衫men's and ladies' shorty 男女特短服men's and women's boxer shorts 男女平脚裤men's and women's long sleeve shirts 男女长袖衫men's and women's pants 男女长裤men's and women's short sleeve shirts 男女短袖衫men's and women's shorty 男女特短服men's and women's sport shorts 男女运动短裤men's and women's sports wear 男女运动服men's and women's tank top 男女大圆领背心men's and women's turtle neck long sleeve shirts 男女高领长袖衫men's and women's western-style clothes and kimono 西装和服men's athletic supporter 男运动缚带men's boilersuit 男工装连衣裤men's clothing 男服men's embroidered shirt 男绣花衬衫men's garment 男装men's jacket 男茄克衫men's jean garment 男牛仔布服装men's long sleeve shirt 男长袖衬衫men's morning gown 男晨衣men's printed handkerchief 男式印花手帕men's pure silk ensemble 真丝绸男套装men's pyjamas 男睡衣men's quited jacket vest 男棉袄和背心men's shirt 男衬衫men's shorts 男短裤men's sport shorts 男运动短裤men's terylene cotton gingham shirt 棉涤纶方格男衬衫men's trousers 男长裤men's woollen overcoat 毛制男大衣men's woollen suit 毛制男西服套装men's woollen western-style coat 毛制男西服上衣men's working bib pants 男工作背带裤men's working coat 男工作上衣men's working set 男工作服装men's woven striped hand kerchief 男式织条手帕men's-ladies' doctor wears 男-女医生服men's-ladies' gowns 男女晨衣menacor capsule 心力加胶囊menadiol diacetate 维生素k醋酸酯menadiol sodium sulfate 维生素k硫酸钠menadiol 维生素k4menadione sodium bisulfite 维生素k亚硫氢钠menadione 维生素kmenadoxime 甲萘多昔menaphtame 赛信menatetrenone 维生素kmenazon 灭蚜松menbutone 孟布酮mende 光滑细里子哔叽mendel 门代尔mendelevium analyzer 钔含量分析仪mending cotton 缝补棉线mending wool 缝补绒线mendok 节生钠menglytate 孟格立酯meningococcal polysaccharide vaccine 流行性脑膜炎多糖疫苗meniscectomy knife 半月板切除刀meniscus astrograph 弯月形透镜天体摄影仪meniscus lens 凹凸透镜meniscus photoheliograph 弯月形透镜太阳摄影仪meniscus transit 弯月形透镜中星仪menite 速灭磷menkwa cotton 原棉menoctone 美诺酮menouffieh cotton 梅努弗棉menstruation bandage 月经带menstruation knicker 月经短内裤menstruation pad 月经垫menstruation-regulating capsule 女宝menswear 男服mentel 斗篷mentha haplocalyx 薄荷mentha piperita leaf 椒样卜荷叶menthane hydroperoxide 盖萜烷过氧化氢menthocamphorate 清凉油menthol cigarette 薄荷香烟menthol crystal 薄荷脑menthol tobacco flavour 薄荷烟草香精menthol 薄荷脑menthol-dl 合成薄荷脑menu card holder 菜单卡片夹menzies tartan 门齐斯格子呢meobal 灭杀威mepa 美帕牌手表mepacrine 米帕林mepacrini hydrochloridum 阿的平mepartricin 美帕曲星mepenzolate bromide 溴美喷酯mephanac 2甲4氯mephenesin 美芬辛mephenoxalone 美芬恶酮mephentermine 美芬丁胺mephentermini sulfas 恢压敏mephenytoin 美芬妥英mephosfolan 二噻磷mepiprazole 美吡哌唑mepiquat chloride 助壮素水剂mepivacaine 甲哌卡因mepramidil 美普地尔meprednisone 甲泼尼松mepro 2甲4氯丙酸meprobamate 甲丙氨酯meprochol 美普溴铵mepronil 担菌宁meprophendiol 美普芬醇meproscillarine 甲海葱次甙meprotixol 美普替索meprylcaine 美普卡因meptazinol hydrochloride 盐酸美他齐诺meptin tablet 美咳清片mepyramine 美吡拉敏mequidox 美喹多司mequinol 甲氧苯酚mequitazine 美喹他嗪merak 梅拉克牌汽车meraklon 梅拉克纶聚丙烯纤维merakrin 梅拉克林聚丙烯单丝meralein sodium 美拉林钠meraline raye 梅拉林赖条子薄呢meralluride 美拉鲁利meratia praecox 腊梅merbam 10 胺硫苯汞merbromine 汞溴红mercan 醋酸氨苯汞mercaptamine 巯乙胺mercaptan sulfer 硫醇硫mercaptan 硫醇mercapto benzothiazole 巯基苯并噻唑mercaptobenzothiazole 2-硫醇基苯并噻唑mercaptol 缩硫醇mercaptomerin 硫汞林mercaptophos 倍硫磷mercaptopurine 巯嘌呤mercedes-benz 梅塞德斯-奔驰牌汽车mercerization style 丝光织物mercerized bed sheet 丝光床单mercerized cotton socks 麻纱短袜mercerized cotton stockings 麻纱长袜mercerized cotton thread 丝光棉线mercerized cotton yarn 丝光棉纱mercerized cotton 丝光棉布mercerized hose 麻纱长袜mercerized sewing thread 丝光缝纫线mercerized stripe 丝光纱条子棉布mercerized towel 丝光毛巾mercerized wool 丝光羊毛mercerized yarn 丝光纱线mercerizer 丝光机mercerizing machine 丝光机mercery 丝织品merchant bar iron 普通条钢merchant bar mill 条钢轧机merchant vessel 商船merciline 梅雪林绸merckdelan 二噻农merco bronze 默柯铅青铜mercoid 水银转换开关mercolized wax 面蜡mercoloy 梅科洛依铜镍锌合金mercruy tele-psychrometer 水银遥测湿度计mercruy telluride-cadmium telluride detector 碲化汞-碲化镉探测器mercruy-cadmium-telluride infrared detector 碲汞镉红外探测器mercuderamide 汞拉米特merculine 水杨酸苯汞mercumatiline sodium 汞香豆林钠mercuram 福美双mercuran 醋酸甲氧乙汞mercurey 麦尔格瑞红葡萄酒mercurial barometer 水银气压计mercurial gauge 水银压力计mercurial lamp metal-film resistor 汞灯金属膜电阻器mercurial ointment 汞软膏mercurial pressure gauge 水银压力表mercurial sphygmomanometer 血压计mercurial thermometer 水银温度计mercurial vacuum gauge 水银真空表mercuric acetate 乙酸汞mercuric ballast 高汞镇流器mercuric bromide 溴化汞mercuric bulb 高汞灯泡mercuric chloride 升汞mercuric cyanide 氰化汞mercuric fluoride 氟化汞mercuric fulminate 雷酸汞mercuric iodide x-ray detector 碘化汞x射线探测器mercuric iodide 碘化汞mercuric nitrate 硝酸汞mercuric oxide 氧化汞mercuric p-chlorbenzoate 对氯苯甲酸汞mercuric pressure gauge 水银压力计mercuric sulfate 硫酸汞mercuric sulfide 硫化汞mercuric thiocyanate 硫氰酸汞mercuric vacuum gauge 水银真空表mercurical barometer 水银气压计mercurobutol 汞氯丁酚mercurochrome 红汞mercurophylline 汞非林mercurous acetate 醋酸亚汞mercurous bromide 溴化亚汞mercurous chloride electrode 甘汞电极mercurous chloride 甘汞mercurous iodide 碘化亚汞mercurous nitrate 硝酸亚汞mercurous sulfate 硫酸亚汞mercury air pump 水银气泵mercury amidochloride 氯化氨基汞mercury arc lamp 水银弧光灯mercury arc power converter 汞弧功率变换器mercury arc rectifier 汞弧整流器mercury barometer 水银气压计mercury bichloride 氯化汞mercury boiler 水银蒸煮器mercury bulb 水银灯mercury cell 汞干电池mercury circuit breaker 水银断路器mercury cleaner 水银清洗装置mercury coherer 汞检波器mercury condenser 水银冷凝器mercury contact relay 汞接点继电器mercury contact thermometer 水银接点温度计mercury converter 水银整流器mercury dc.transformer 水银直流变压器mercury detector 水银检波器mercury difference-pressure meter 水银差压计mercury diffusion pump 水银扩散泵mercury distant-reading thermometer 远距离读数水银温度计mercury electrode 汞电极mercury frequency changer 水银变频器mercury gasometer 水银气量器mercury gauge manometer 水银压力计mercury gauge 水银压力计mercury halide lamp 水银卤素灯mercury indicator 水银指示器mercury injection apparatus 压汞仪mercury injection capillary pressure apparatus 压汞毛细管压力仪mercury interrupter 水银断续器mercury intrusion porosimeter 汞注入孔隙计mercury inverter 水银换流器mercury iodine lamp 水银碘灯mercury lamp 水银灯mercury laser 汞激光器mercury level 水银水平仪mercury manometer 水银测压计mercury memory 水银存储器mercury oxide cell 氧化汞电池mercury oxide 氧化汞mercury permeameter 水银渗透率仪mercury plethysmograph 水银体积描记器mercury porosimetry 水银孔隙度计mercury power rectifier 大功率水银整流器mercury pump 水银泵mercury purifying apparatus 水银净化器mercury rectifier 水银整流器mercury relay pulse generator 水银继电器脉冲发生器mercury relay 水银继电器mercury reservoir 水银容器mercury salt 汞盐mercury search light 水银探照灯mercury spectrum lamp 汞灯mercury spring thermometer 水银压力式温度计mercury storage 汞存储器mercury subchloride 一氯化汞mercury switch interlock 水银开关联锁装置mercury switch 水银开关mercury tank rectifier 汞槽整流器mercury tank 水银槽mercury thermometer 水银温度计mercury thermostat 汞控恒温器mercury trap 捕汞器mercury turbine 汞汽轮机mercury type temperature relay 水银温度继电器mercury type watthour meter 水银瓦特小时计mercury vacuum gauge 水银真空表mercury vacuum pump 水银真空泵mercury valve 水银阀mercury vaper diffusion pump 汞汽扩散泵mercury vapor analyzer 汞蒸气分析仪mercury vapor arc lamp 汞汽灯mercury vapor detector 汞蒸气检波器mercury vapor jet pump 水银蒸气喷射泵mercury vapor lamp 水银灯mercury vapormeter 汞蒸气仪mercury vapour pump 汞汽泵mercury vapour rectifier tube 汞汽整流管mercury vapour rectifier 汞弧整流器mercury vapour tube 汞汽管mercury xenon lamp 汞氙灯mercury 水星牌汽车mercury 水银mercury-203 bmhp 放射性汞-溴羟基丙烷mercury-203 propylurea 放射性汞-丙脲mercury-arc converter 汞弧变换器mercury-in-glass thermometer 玻璃管水银温度计mercury-motor meter 水银电动式电度表mercury-rare gas laser 水银-稀有气体激光器mercusol 水杨酸苯汞merfenel 51 胺硫苯汞mergamma 丹汞合剂meridian finder 子午线探寻仪meridian instrument 子午仪meridian photometer 子午光度计meridian ring globe 子午环地球仪meridian telescope 子午望远镜meridian transit 中星仪merino combing 美利奴精梳毛merino crepe 美利奴闪光丝毛绉merino fibre 美利奴再生毛merino tulle 美利奴网眼纱merino wool 美利奴羊毛merino yarn 美利奴精纺毛纱merino 美利奴羊毛merinova 梅里诺瓦酪素短纤维merinyl 羊毛耐纶混纺纱merisoprol 放射性汞丙醇merit fish 银汉鱼merkur 默克牌汽车meroquinolamide 汞喹米特merpan 克菌丹merpelan 噻环混剂merphos 脱叶亚磷merry cake 嘻嘻酥merry peanut muffin 乐口酥merry 甜樱桃mersalyl 汞撒利mersolite 赛力散mertect 涕必灵merthiolate 硫柳汞merthiolate 水杨乙汞mesa stripe laser 台面条状激光器mesa surface laser 台面式激光器mescal maguey 梅斯考尔马奎叶纤维mesched rug 梅什德地毯meseclazone 美西拉宗mesh bag 网袋mesh belt conveyor bright quenching furnace 网带输送式光亮淬火炉mesh copper powder conducting resin 网格铜粉导电树脂mesh eyeshield 网眼式眼罩mesh gear 啮合齿轮mesh multiplier 网络倍增器mesh reinforcement 网形钢筋mesh screen 筛子mesh sinker 钢筋网沉放器mesh socks 网眼袜mesh winding 网形绕组meshing bevel gear 啮合伞齿轮meshing gear 啮合齿轮mesitoyl ■酰mesityl oxide 异丙叉丙酮mesna 巯乙磺酸钠meson measuring set 介子测检器mesoran 叠氮津mesoranil 叠氮津mesoridazine 美索达嗪message handling system 报文处理系统message memory 信息存储器message meter 通话计数器message register 通话计次器messaline 梅萨林丝缎messenger wire clamp 吊线夹messmotor 积分马达messtin 饭盒mestanolone 美他诺龙mesterolone 美睾酮mestizo wool 交配种羊毛mestranol 绝鼠mestranol 美雌醇mesulfamide 美磺胺mesulfen 二甲噻蒽mesuprine 美舒普林mesurol 灭虫威mesuximide 甲琥胺mesyston 异砜磷meta nitro aniline 间硝基苯胺meta 蜗牛敌meta-acid 偏酸meta-cresol 间甲酚meta-phenyldimethylamine and paraphenyldimethylamine 间苯二甲胺与对苯二甲胺meta-xylene 间二甲苯metabituminous coal 肥煤metabolimeter 新陈代谢器metabolism analyzer 新陈代谢分析仪metabromsalan 美溴沙仑metabutethamine 间布他明metabutoxycaine 美布卡因metacarbonic acid 碳酸metacetaldehyde 蜗牛敌metacetonic acid 丙酸metachlor 草不绿metachromatic filter 变色滤光器metachrome dye 同浴铬媒染料metacide 甲基一六０五metacinnabarite 黑珠metacrate 速灭威metacrolein 三聚丙烯醛metacycline 甲烯土霉素metadelphene 避蚊胺metadoxine 美他多辛metadurain 变质暗煤metadyne generator 微场扩流发电机metadyne 微场扩流发电机metafilm strain gauge 金属膜应变计metafilter 层滤机metaglycodol 美他二醇metahexamide 美他己脲metaisosystoxsulfon 磺吸磷metal argentine 银色锡基餐具合金metal ash tray 金属烟缸metal band 金属带metal bar 金属棒metal bellow coupling 金属波纹管联轴器metal bladed drag 金属刃刮路机metal block 金属块metal bolometer 金属热辐射计metal brush 金属刷metal button-sewing machine 缝金属扣机metal can 金属罐metal cap 金属瓶盖metal capsule 金属盒metal card clothing welding machine 金属针布焊接器metal card clothing wrapping machine 金属针布包卷机metal card clothing 金属针布metal card memory 金属卡片存储器metal carving 金属雕刻品metal cased magnesite brick 铁壳镁砖metal casting and forging 金属铸锻件metal casting 金属铸件metal catcher 金属杂质分离器metal chelating dye 金属螯合染料metal chopstick 金属筷metal cleaner 金属清洗剂metal cloth 金属线织物metal coating apparatus 金属镀层厚度计metal cold extrusion press 金属冷挤压机metal comb 铁梳metal comparator 金属比测仪metal complex dye 金属络合染料metal conditioner 金属清洗剂metal cone picture tube 锥形金属壳显像管metal connecting fitting of high grade furniture 高档家具五金连接件metal crystal 金属晶体metal cut saw 金属锯metal cutter 金属切割器metal cutting machine tool 金属切削机床metal cutting machine 金属切削机metal cutting oil 金属切削油metal decorating machine 铁皮印刷机metal decorating press 金属薄板彩印机metal desk lamp 金属台灯metal detector 金属探测器metal disc fuel filter 金属盘式燃料过滤器metal disc 金属盘metal drawing die 金属拉丝模metal drum 金属桶metal electric hair dryer 金属电干发器metal electrode 金属焊条metal extrusion press 金属挤压机metal fibre paper 金属纤维纸metal fibre 金属纤维metal filled glass filament 金属芯玻璃丝metal film resistor 金属膜电阻器metal filter 金属过滤器metal finishing machine 金属修整机metal flashlight 金属电筒metal foil resistor 薄式平面电阻器metal foil paper 金属箔纸metal foil printing machine 金属箔印刷机metal foil 金属箔metal forming equipment 锻压设备metal forming machine tool 金属成形机床metal forming machine 金属成形机metal forming machinery 锻压机械metal fragment detector 金属碎片探测器metal framed mirror 金属架镜子metal free optical fiber cable 无金属光缆metal furniture castor 金属家具脚轮metal gasket 金属垫片metal gate metal window frame 金属门窗框metal graphite brush 金属石墨电刷metal hacksaw 金属弓锯metal health ball 金属健身球metal hose 金属软管metal insulator semiconductor 金属绝缘体半导体metal interface amplifier 金属界面放大器metal kinescope 金属壳显像管metal lace 金银线花边metal lamp holder 金属灯座metal lamp shade 金属灯罩metal lath 金属网metal lathe 金属车床metal lens 金属透镜metal lifting handle 金属提手metal locator 金属探测器metal loom reed 织机金属筘metal marking gauge 金属划线规metal material testing machine 金属材料试验机metal mesh spinning band still 金属网麻花带蒸馏器metal mould milling machine 金属模铣床metal mould 金属铸模metal oil diffusion pump 金属油扩散泵metal oil filter 烧结式滤油器metal ore 矿砂metal oxide film resistor 金属氧化膜电阻器metal oxide resistor 金属氧化物电阻器metal oxide semiconductor integrated circuit 金属氧化物半导体集成电路metal oxide semiconductor 金属氧化物半导体metal pencil case 铁质文具盒metal pin tooth 金属钉牙metal plate 金属板metal polish 金属抛光剂metal powder folw meter 金属粉末流动性测定仪metal powder press 金属粉末压机。

Panther Fusion® Extraction Reagents-XFor in vitro diagnostic use.Intended Use . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2 Principles of the Procedure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2 Materials Provided . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2 Materials Required and Available Separately . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2 Warnings and Precautions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3 Storage and Handling Requirements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4 Sample Preparation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5 Definitions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5 Notes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5 Preparation of Working Diluents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .6 Nasopharyngeal (NP) Swab in VTM and Nasal Swab in Liquid Amies Specimen Processing . . . . . .6 Lower Respiratory Tract (LRT) Specimen Processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .6 EDTA Plasma and Serum Specimen Processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .6 EDTA Whole Blood Specimen Processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7 Stool Specimen Processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7 Urine Specimen Processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7 Cerebrospinal Fluid (CSF) Specimen Processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7 ThinPrep Specimen Processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7 Vaginal, Endocervical, Rectal, Throat, and Lesion Swab Specimen Processing . . . . . . . . . . . . . . . .8 Lim or Carrot Broth Culture Specimen Processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8 Panther Fusion System Test Procedure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8 Work Area Preparation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8 Reagent Preparation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8 Specimen Handling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8 System Preparation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9 Limitations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9Intended UseIntended UseThe Panther Fusion ® Extraction Reagents-X are intended for extraction of DNA fromnasopharyngeal, lower respiratory tract (bronchial wash and bronchoaveolar lavage), EDTA plasma, serum, EDTA whole blood, stool, urine, cerebral spinal fluid (CSF), ThinPrepsamples, vaginal swabs, endocervical swabs, rectal swabs, throat swabs, skin lesions, Lim broth cultures, and Carrot broth cultures using upstream sample extraction capabilities of the Panther Fusion System ®.Principles of the ProcedurePrior to processing and testing on the Panther Fusion system, prepare specimens as described in this document. The internal control target present in the Internal Control-X (IC-X) reagent is added to each test specimen via the working Panther Fusion CaptureReagent-X (wFCR-X). The IC-X in the reagent may be used to monitor specimen processing, amplification and detection. Capture oligonucleotides hybridize to nucleic acid in the test specimen. Hybridized nucleic acid is then separated from the specimen in a magnetic field. Wash steps remove extraneous components from the reaction tube. The elution step elutes purified nucleic acid. During the nucleic acid capture and elution step, DNA is isolated from specimens.Refer to the Panther Fusion assay package inserts for specific information on sample preparation for approved assays. Refer to the Panther Fusion Operator's Manual forinformation on the operation of the Panther Fusion System.Materials ProvidedPanther Fusion Extraction Reagents-X (Cat No. PRD-04477)Materials Required and Available SeparatelyNote: Materials available from Hologic have catalog numbers listed, unless otherwise specified.Cat. No.Panther System303095Panther Fusion ModulePRD-04173Panther Fusion SystemPRD-04172Panther Fusion Internal Control-X 960 TestsPRD-04476Panther Fusion Internal Control-X tube, 4 per box Panther Fusion Specimen Lysis Tubes (SLT), 100 per bag PRD-04339Aptima Penetrable Caps 105668Transport Tube, Polypropylene, 50 per bag 401457Specimen Aliquot Tubes (SAT), 100 pack503762ComponentQuantity Volume Description Panther Fusion CaptureReagent-X 4 x 240 test bottles 173 mL/bottleA buffered salt solution containing solid phase (magnetic particles) and non-infectious nucleic acids Panther Fusion Enhancer Reagent-X4 x 240 test bottles 70 mL/bottle An alkaline solution of lithium hydroxideWarnings and PrecautionsAptima Multitest Swab Specimen Collection Kit PRD-03546Aptima Specimen Transfer Kit301154CSpecimen Transport Medium (STM)PRD-04423Urine Transport Medium (UTM)PRD-04943Viral Transport Medium (VTM)VTM verified for use:Remel MicroTest M4, M4RT, M5 or M6 formulationCopan Universal Transport MediumBD Universal Viral Transport MediumBlood Transport Medium (BTM)PRD-04944Open Access Diluent Additive PRD-04945Proteinase K—Phosphate Buffered Saline (PBS)—Warnings and Precautionse routine laboratory precautions. Wear disposable, powderless gloves, protective eyewear, and laboratory coats when handling specimens and kit reagents. Wash handsthoroughly after handling reagents.B.Avoid microbial and ribonuclease contamination of reagents.C.Dispose of all material that has come into contact with specimens and reagents inaccordance with applicable national, international, and regional regulations.D.Store reagents at the recommended storage condition. See Storage and HandlingRequirements.E.The Panther Fusion Enhancer Reagent-X (FER-X) is corrosive, harmful if swallowed andcauses severe skin burns and eye damage.F.Specimens may be infectious. Use Universal Precautions when performing this assay.Proper handling and disposal methods should be established by the laboratory director.Only personnel adequately trained in handling infectious materials should be permitted to perform this diagnostic procedure.G.Do not use the reagents after the expiration date.H.Do not combine any assay reagents or fluids. Do not top off reagents or fluids; thePanther Fusion system verifies reagent levels.I.Quality control requirements must be performed in conformance with local, state, and/orfederal regulations or accreditation requirements and your laboratory’s standard qualitycontrol procedures.J.Some reagents of this kit may be labeled with risk and safety symbols.Note: Hazard Communication information for labeling of globally marketed productsreflects the US and EU Safety Data Sheets (SDS) classifications. For hazardcommunication information specific to your region, refer to the region specific SDS on the Safety Data Sheet Library at .Storage and Handling RequirementsStorage and Handling RequirementsA.The following table provides storage and handling requirements for the Panther FusionExtraction Reagents-X.*On board stability starts at the time the reagent is placed on the Panther Fusion system for the Panther Fusion FCR-X and FER-X.**Working Panther Fusion Capture Reagent-X (Panther Fusion Capture Reagent-X that has been mixed with Internal Control-X on the Panther Fusion system) and Panther Fusion Enhancer Reagent-X are stable for 60 days when capped and stored at 15ºC to 30ºC. Do not refrigerate.B.Discard any unused reagents that have surpassed their on board stability.C.Avoid cross-contamination during reagent handling and storage.D.Do not freeze reagents.US Hazard InformationPanther Fusion Enhancer Rgt (FER-X)LITHIUM HYDROXIDE, MONOHYDRATE 5 – 10%DANGERH302 - Harmful if swallowedH314 - Causes severe skin burns and eye damageP264 - Wash face, hands and any exposed skin thoroughly after handlingP270 - Do not eat, drink or smoke when using this productP260 - Do not breathe dust/fume/gas/mist/vapors/sprayP280 - Wear protective gloves/protective clothing/eye protection/face protectionP305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Removecontact lenses, if present and easy to do. Continue rinsingP310 - Immediately call a POISON CENTER or doctor/physicianP303 + P361 + P353 - IF ON SKIN (or hair): Remove/Take off immediately all contaminatedclothing. Rinse skin with water/showerP363 - Wash contaminated clothing before reuseP304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a positioncomfortable for breathingP310 - Immediately call a POISON CENTER or doctor/physicianP301 + P312 - IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwellP330 - Rinse mouthP301 + P330 + P331 - IF SWALLOWED: rinse mouth. Do NOT induce vomitingP405 - Store locked upEU Hazard InformationPanther Fusion Enhancer Rgt (FER-X)LITHIUM HYDROXIDE, MONOHYDRATE 5 – 10%DANGERH302 - Harmful if swallowedH314 - Causes severe skin burns and eye damageP260 - Do not breathe dust/fume/gas/mist/vapours/sprayP280 - Wear protective gloves/protective clothing/eye protection/face protectionP303 + P361 + P353 - IF ON SKIN (or hair): Remove/Take off immediately all contaminatedclothing. Rinse skin with water/showerP305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Removecontact lenses, if present and easy to do. Continue rinsingP310 - Immediately call a POISON CENTER or doctor/physicianP280 - Wear eye protection/ face protectionReagentUnopened Storage On-board/Open Stability*Opened Storage**Panther Fusion CaptureReagent-X15 °C to 30 °C 30 days 15 °C to 30 °C Panther Fusion EnhancerReagent-X 15 °C to 30 °C 30 days 15 °C to 30 °CSample PreparationSample PreparationDefinitions•Specimens—Clinical material collected from a patient and placed in an appropriatetransport system.•Samples—Represents a more generic term to describe any material for testing on thePanther Fusion System including specimens, specimens transferred into a Panther Fusion compatible sample tube and controls.Notes•Refer to the Panther Fusion System Operator’s Manual for complete instructions on how to load samples onto the system.•Handle all specimens as if they contain potentially infectious agents. Use UniversalPrecautions.•Take care to avoid cross-contamination during specimen handling steps. For example,discard used material without passing over tubes.•When testing frozen specimens, allow specimen to reach room temperature prior toprocessing.•The following procedures are provided as guidance. Test specific sample preparationprocedures should be developed and validated by the user.Table 1 lists the minimum sample volumes needed based on the chosen tube type, number of extractions needed, and sample aspiration height.Table 1. Minimum Sample VolumesFCR/FER-XSample Tube PartNumber Sample AspirationHeightCap RequiredDeadVolume(µL)MinimumVolume for aSingleExtraction(µL)AdditionalVolume forEachAdditionalExtraction(µL)Aptima Specimen AliquotTubes (SATs)100 Tubes (tapered)503762Low Pierceable200550350Medium Pierceable8001150350 High-Level Sensing No Cap200550350Transport TubePolypropylene50 per bag401457Low Pierceable9001250350 Medium Pierceable130******** High-Level Sensing No Cap130********Note: The minimum volume may vary by sample type. Each sample type will need to be validated.Sample PreparationPreparation of Working DiluentsSpecimens with high nucleic acid or cellular content will demonstrate greater extractionefficiency if diluted with a diluent (STM, UTM, PBS, or BTM) containing Open Access Diluent Additive.1.Prepare working diluent stocks by pipetting 1.0 mL of Open Access Diluent Additive into80 mL of STM, UTM, and BTM. To prepare a PBS working diluent stock, pipette 1.0 mLof Open Access Diluent Additive into 25 mL of PBS.2.Mix by gently swirling the bottle or gently inverting. Do not vortex.bel the bottle as Working Diluent-XXX where XXX = STM, UTM, PBS, or BTM.4.Once prepared, the working diluents may be stored at room temperature (15°C to 30°C)for up to 30 days.Nasopharyngeal (NP) Swab in VTM and Nasal Swab in Liquid Amies Specimen Processing1.Transfer 500 μL of the NP or nasal swab specimen to an SLT.2.Affix the provided penetrable cap or a new penetrable cap.Alternatively,1.Refer to Table 1 for the minimal volume required for the intended number of extractionsfor the sample tube being used.2.Dilute the NP or nasal swab specimen in a 1:1.56 ratio with STM (e.g. combine 500 µLspecimen with 780 µL of STM).3.Affix the provided penetrable cap or a new penetrable cap.Lower Respiratory Tract (LRT) Specimen Processing1.Transfer 250 μL of the LRT specimen (avoid transferring mucus) and 250 μL of VTM toan SLT.2.Affix the provided penetrable cap or a new penetrable cap.Alternatively,1.Refer to Table 1 for the minimal volume required for the intended number of extractionsfor the sample tube being used.2.Dilute the LRT specimen in a 1:1 ratio with VTM (e.g. combine 250 µL of specimen with250 µL of VTM).3.Dilute the LRT/VTM mixture in a 1:1.56 ratio with STM (e.g. combine 500 µL of themixture with 780 µL of STM).4.Affix the provided penetrable cap or a new penetrable cap.EDTA Plasma and Serum Specimen Processing1.Refer to Table 1 for the minimal volume required for the intended number of extractionsfor the sample tube being used.2.Dilute the plasma or serum specimen in a 1:0.2 ratio with Working Diluent-PBS (e.g.combine 500 µL of plasma or serum with 100 µL of Working Diluent-PBS).3.Add Proteinase K to a final concentration of 0.5 mg/mL.4.Incubate 30 minutes at room temperature (15°C to 30°C).Sample Preparation5.Affix the provided penetrable cap or a new penetrable cap.EDTA Whole Blood Specimen Processing1.Refer to Table 1 for the minimal volume required for the intended number of extractionsfor the sample tube being used.Note: Processing of whole blood requires the use of the medium sample aspirationheight.2.Dilute the whole blood specimen in a 1:2 ratio with Working Diluent-BTM (e.g. combine400 µL of whole blood with 800 µL of Working Diluent-BTM).3.Add Proteinase K to a final concentration of 1 mg/mL.4.Incubate 30 minutes at room temperature (15°C to 30°C).5.Affix the provided penetrable cap or a new penetrable cap.Stool Specimen ProcessingPrior to loading on the Panther Fusion System, stool samples must be transferred to the transport tube of an Aptima Multitest Swab Specimen Collection Kit.1.Partially peel open the swab package. Remove the swab. Do not touch the soft tip or laythe swab down. Submerge the swab in the unformed or liquid stool specimen.2.Uncap the transport tube containing 2.9 mL of STM. Place the swab in the transporttube and gently swirl the swab in the tube for 5 seconds to release material.3.Carefully break the swab shaft at the score line against the side of the tube and discardthe swab shaft.4.Affix the provided penetrable cap or a new penetrable cap.Note: To avoid the aspiration of flocculent material, stool specimen processing requires the use of medium sample aspiration height.Urine Specimen Processing1.Refer to Table 1 for the minimal volume required for the intended number of extractionsfor the sample tube being used.2.Dilute the urine specimen in a 1:1 ratio with Working Diluent-UTM (e.g. combine 300 µLof urine with 300 µL of Working Diluent-UTM).3.Affix the provided penetrable cap or a new penetrable cap.Cerebrospinal Fluid (CSF) Specimen Processing1.Refer to Table 1 for the minimal volume required for the intended number of extractionsfor the sample tube being used.2.Dilute the CSF specimen in a 1:1 ratio with Working Diluent-STM (e.g. combine 300 µLof CSF with 300 µL of Working Diluent-STM).3.Affix the provided penetrable cap or a new penetrable cap.ThinPrep Specimen Processing1.Refer to Table 1 for the minimal volume required for the intended number of extractionsfor the sample tube being used.2.Dilute the ThinPrep specimen in a 1:1 ratio with Working Diluent-STM (e.g. combine300 µL of ThinPrep specimen with 300 µL of Working Diluent-STM.Panther Fusion System Test Procedure3.Affix the provided penetrable cap or a new penetrable cap.Vaginal, Endocervical, Rectal, Throat, and Lesion Swab Specimen Processing Note: Swab collection kits containing STM, VTM, or liquid Amies are acceptable for use.1.Refer to Table 1 for the minimal volume required for the intended number of extractionsfor the sample tube being used.2.Dilute the swab specimen in a 1:1 ratio with Working Diluent-STM (e.g. combine 300 µLof swab specimen with 300 µL of Working Diluent-STM).3.Affix the provided penetrable cap or a new penetrable cap.Lim or Carrot Broth Culture Specimen Processing1.Prior to testing on the Panther Fusion System, resuspend the culture specimen andtransfer 1 mL of the specimen to the Aptima Specimen Transfer Tube containing 2.9 mLof Specimen Transport Medium (STM).2.Affix the provided penetrable cap or a new penetrable cap.Panther Fusion System Test ProcedureNote: Refer to the Panther Fusion System Operator’s Manual for additional proceduralinformation.Work Area Preparation1.Wipe down work surfaces with2.5% to3.5% (0.35 M to 0.5 M) sodium hypochloritesolution. Allow the sodium hypochlorite solution to contact surfaces for at least 1 minuteand follow with a deionized (DI) water rinse. Do not allow the sodium hypochloritesolution to dry. Cover the bench surface with clean, plastic-backed absorbent laboratorybench covers.2.Clean a separate work surface where samples will be prepared using the proceduredescribed in step 1.Reagent Preparation1.Remove the bottles of IC-X, FCR-X and FER-X from storage.2.Open the bottles of IC-X, FCR-X and FER-X, and discard the caps. Open the TCR dooron the upper bay of the Panther Fusion system.3.Place the IC-X, FCR-X and FER-X bottles in the appropriate positions on the TCRcarousel.4.Close the TCR door.Note: The Panther Fusion system adds the IC-X to the FCR-X. After the IC-X is added to the FCR-X, it is referred to as wFCR-X (working FCR-X). If the FCR-X and FER-X areremoved from the system, use new caps and immediately store according to the proper storage conditions.Specimen HandlingNote: Prepare specimens per instructions in the Sample Preparation section beforeloading specimens onto the Panther Fusion system.Limitations1.Do not vortex samples.2.Inspect sample tubes before loading into the rack. If a sample tube contains bubbles orhas a lower volume than is typically observed, gently tap the bottom of the tube to bringcontents to the bottom.System PreparationFor instructions on setting up the Panther Fusion system including loading samples,reagents, assay cartridges and universal fluids, refer to the Panther Fusion SystemOperator’s Manual.LimitationsHologic, Inc.10210 Genetic Center DriveSan Diego, CA 92121 USACustomer Support:+1 800 442 9892***************************Technical Support:For more contact information visit .A.Only use on Panther Fusion system by a trained professional.e of Panther Fusion Extraction Reagents-X for clinical specimen types not mentionedhas not been validated.Hologic, Panther Fusion, ThinPrep, and associated logos are trademarks and/or registered trademarks of Hologic, Inc. and/or its subsidiaries in the United States and/or other countries.All other trademarks that may appear in this package insert are the property of their respective owners.This product may be covered by one or more U.S. patents identified at /patents.© 2018 Hologic, Inc. All rights reserved.AW-18173-001 Rev. 0012018-08+1 888 484 4747****************************。

preparation词组Preparation.Preparation is key to success in any endeavor, whether it's studying for a test, training for a marathon, or launching a new business. By taking the time to prepare, you can increase your chances of achieving your goals and avoiding costly mistakes.There are many different ways to prepare for a task. You may need to gather information, develop a plan, or practice your skills. The best way to prepare will vary depending on the task at hand. However, there are some general tips that can help you prepare for any task:Start early.Don't wait until the last minute to start preparing. Give yourself plenty of time to gather information, develop a plan, and practice your skills.Be organized.Keep track of your notes, materials, and deadlines. This will help you stay on top of your preparations and avoid feeling overwhelmed.Break down the task into smaller steps.This will make the task seem less daunting and more manageable.Set realistic goals.Don't try to do too much at once. Set small, achievable goals that you can build on over time.Practice.The more you practice, the better prepared you will be. Practice your skills, review your notes, and take practice tests.Get feedback.Ask a friend, family member, or teacher to review your work and give you feedback. This can help you identify areas where you need to improve your preparation.Stay positive.Preparing for a task can be challenging, but it's important to stay positive. Believe in yourself and your ability to achieve your goals.Preparation is an essential part of success. By taking the time to prepare, you can increase your chances of achieving your goals and avoiding costly mistakes.中文回答：准备是任何一项事业取得成功的关键，无论是学习考试、参加马拉松比赛还是开创一项新业务。

United States Patent 5,919,486 Ishii , et al.July 6, 1999Powder preparation and a process for preparing the sameAbstractA liquid oil and fat ingredient or others are carried by pores of a porous carrier composed of porous starch grain obtained by reacting an enzyme having raw starch digestive activity onto the starch. With starch being used as porous carrier, the powder preparation according to the present invention is not harmful to the human body, it can be supplied continuously in great volumes, manufactured cheaply without difficult processing, and moreover, being completely biodegradable, this powder preparation does not cause any environmental problems. It can be used in various industrial fields.Inventors: Ishii; Takanori (Aichi, JP), Hasegawa; Nobuhiro (Aichi, JP), Katsuro; Masaaki (Aichi, JP), Suzuki; Kazumasa(Kanagawa, JP), Koishi; Masumi (Hokkaido, JP)Assignee: San-Ei Sucrochemical Co., Ltd. (Aichi, JP)Appl. No.: 08/867,406Filed: June 2, 1997Foreign Application Priority DataDec 27, 1993 [JP] 5-346829Current U.S. Class:424/489 ; 424/490Current International Class:A61K 9/14 (20060101); A61K 47/36 (20060101); A61K 009/14 ()Field of Search: 424/489,490,461,46References Cited [Referenced By]U.S. Patent Documents4443497April 1984 Samejima et al.5190775March 1993 Klose5456985October 1995 Zgoulli et al.Foreign Patent Documents0 182 296 May., 1986 EP2-27944 Jan., 1990 JP5-112469 May., 1993 JPWO/89/04842 Jun., 1989 WO Primary Examiner: Page; Thurman K.Assistant Examiner: Benston, Jr.; William E.Attorney, Agent or Firm: Smith, Gambrell & Russell, LLP Beveridge, DeGrandi, Weilacher & Young Intellectual Property GroupParent Case TextThis application is a continuation of application Ser. No. 08/507,477, filed Oct. 10, 1995, which application is entirely incorporatedherein by reference, which is a 371 of PCT/JP94/02246 Filed Dec. 27, 1994.ClaimsWe claim:1. A powder preparation comprising a porous starch grain carrier formed by reacting a starch grain with an enzyme having starch digestive activity on starch, and a material carried within the pores of said porous starch grain carrier.2. A powder preparation according to claim 1, wherein said materialis a liquid oil and fat ingredient.3. A powder preparation according to claim 1, wherein said materialis dissolved in an aqueous solution.4. A powder preparation according to claim 1, wherein said materialis dissolved in an organic solvent.5. A powder preparation according to claim 1 wherein said carrier and said material are microencapsulated within a coating about thesurface of said carrier.6. A powder preparation according to claim 1, wherein said materialis selected from the group consisting of medicines, agricultural chemicals, fertilizers, pigments, paints, inks, biochemical products, oils and fats, foods, food additives, fragrances, cosmetics and industrial chemicals.7. A process for preparing a powder preparation comprising subjectinga starch grain to an enzyme having starch digestive activity onstarch for a period of time sufficient for said enzyme to form a plurality of pores in said starch grain, mixing said starch grainwith a material and permitting said material to enter said pores on said starch grain whereby said material is carried by said pores of said starch grain.8. A process for preparing a powder preparation according to claim 7, wherein said material is a liquid oil.9. A process for preparing a powder preparation according to claim 7, wherein said Material is dissolved in an aqueous solution.10. A process for preparing a powder preparation according to claim 7, wherein said material is dissolved in an organic solvent.11. A process for preparing a powder preparation according to claim 7, wherein said porous starch grain and material are dispersed in a solvent in which said material does not dissolve, and then removing said solvent whereby said material remains in the pores of saidporous starch grain.12. A process for preparing a powder preparation according to claim 7, wherein the porous starch grain and material are dispersed in asolvent in which said material can dissolve, and then removing said solvent whereby said material remains in said pores of said porous starch grain.13. A process for preparing a powder preparation according to claim 7 comprising the further steps of dispersing said porous starch grain having said material carried by said pores of said starch grain in acoating solution and then drying said coating solution whereby a coating layer is formed on the surface of said porous starch grain to microencapsulate said grain and said material within the pores of said grain.14. A process for preparing a powder preparation according to claim 7 comprising the further steps of emulsifying said porous starch grain having said material carried by said pores of said starch grain in a coating solution and then drying said coating solution whereby a coating layer is formed on the surface of said porous starch grain to microencapsulate said grain and said material within the pores of said grain.15. A process for preparing a powder preparation according to claim 7 comprising the further steps of spraying said porous starch grain having said material carried by said pores of said starch grain with a coating solution and then drying said coating solution whereby a coating layer is formed on the surface of said porous starch grain to microencapsulate said grain and said material within the pores of said grain.16. A process according to claim 7, wherein said material is selected from the group consisting of medicines, agricultural chemicals, fertilizers, pigments, paints, inks, biochemical products, oils and fats, foods, food additives, fragrances, cosmetics and industrial chemicals.17. A process for preparing a powder preparation comprising forming a porous carrier comprising a plurality of porous starch grains,by subjecting said starch grains to an enzyme having a raw starch digestive activity on starch for a period of time sufficient for said enzyme to form a plurality of pores in said starch grains, mixing said porous carrier with a material and permitting said material to enter said pores in said porous carrier whereby said material is carried by said pores of said porous carrier.18. A process according to claim 17, wherein said material is selected from the group consisting of medicines, agricultural chemicals, fertilizers, pigments, paints, inks, biochemical products, oils and fats, foods, food additives, fragrances, cosmetics and industrial chemicals.DescriptionTECHNICAL FIELDThe present invention relates to a powder preparation and a processfor preparing the same and, more particularly, a powder preparation using a porous carrier obtained by making an enzyme having raw starch digestive activity to react on starch and a preparation process thereof.Object substances or materials carried by the porous carrier in the powder preparation of the present invention comprise medicines, agricultural chemicals, fertilizers, pigments, paints, inks, biochemical products, oil and fat, foods, food additives, fragrances, cosmetics and other substances used in various industrial fields.BACKGROUND ARTFor powder preparations wherein a liquid object material is pulverized, there has been one wherein the object material is carried by various pulverizing bases including those based on petroleum.Conventionally, petroleum base materials such as polyethylene glycol, polyvinyl alcohol, etc. have been largely used as pulverizing base.Conventional powder preparations, however, present some inconveniences such as hard processing of pulverizing base, expensive production cost, difficulty of continuous and massive supply of pulverizing base and some faults of poor security of being injurious to the human body when massive pulverizing base is administrated or remaining permanently because they are not biodegradable, so they were far from being used largely and massively in various industrial fields.For the reason of security, especially, the use of petroleum based powder preparations is limited in the field of foods, cosmetics, etc.Hence, a powder preparation which would not be harmful to the human body, whose continuous and massive supply is assured and production cost is cheap, which needs no difficult processing, is completely biodegradable and can be largely used in various industrial fieldshas been desired.DISCLOSURE OF THE INVENTIONThe present inventors have conducted earnest researches on the powder preparations that would meet the conditions mentioned above and have invented the use of a porous carrier composed of porous starch grain wherein an enzyme having raw starch digestive activity is made to react on starch.Then, using the porous carrier, they have tried to pulverize actually various materials that are generally considered hard to pulverize.As the result, they have found that a porous carrier composed of porous starch grain obtained by reacting an enzyme having raw starch digestive activity on starch provides a large porous surface, that perforated starch presents better absorption of both water and oiland that materials of various state get into the pores under appropriate conditions and are carried by said pores, so as to accomplish finally the present invention.Namely, the subject of the present invention can be attained by the following means.First, a powder preparation, wherein a liquid oil and fat ingredientis carried by pores of a porous carrier composed of porous starch grain obtained by reacting an enzyme having raw starch digestive activity on starch.Second, a powder preparation, wherein an aqueous solution ingredientin which an object material is dissolved is carried by pores of a porous carrier composed of porous starch grain obtained by reactingan enzyme having raw starch digestive activity on starch.Third, a powder preparation, wherein an organic solvent ingredient in which an object material is dissolved is carried by pores of a porous carrier composed of porous starch grain obtained by reacting an enzyme having raw starch digestive activity on starch.Fourth, a powder preparation, wherein an object material is carriedby pores of a porous carrier composed of porous starch grain obtained by reacting an enzyme having raw starch digestive activity on starch.Fifth, a powder preparation according to one of the first to fourth means mentioned above, wherein the same is put into a microcapsule by coating its surface.Sixth, a process for preparing a powder preparation, wherein porous starch grain is obtained by reacting an enzyme having raw starch digestive activity on starch, the obtained porous starch grain is mixed with a liquid oil and carried.Seventh, a process for preparing a powder preparation, wherein porous starch grain is obtained by reacting an enzyme having raw starch digestive activity on starch, then the obtained porous starch grainis mixed with an aqueous solution where an object material is dissolved, and carried.Eighth, a process for preparing a powder preparation, wherein porous starch grain is obtained by reacting an enzyme having raw starch digestive activity on starch, then the obtained porous starch grainis mixed with an organic solvent where an object material is dissolved, and carried.Ninth, a process for preparing a powder preparation, wherein a porous carrier composed of porous starch grain is obtained by reacting an enzyme having raw starch digestive activity on starch, the obtained porous carrier and an object material are dispersed in a solvent in which the object material does not dissolve, then the solvent is removed to carry the object material in the pores of the porous carrier.Tenth, a process for preparing a powder preparation, wherein a porous carrier composed of porous starch grain is obtained by reacting an enzyme having raw starch digestive activity on starch, the obtained porous carrier and an object material are dispersed in a solvent in which the object material can dissolve, then the solvent is removed to carry the object material in the pores of the porous carrier.Eleventh, a process for preparing a powder preparation, wherein a porous carrier composed of porous starch grain is obtained by reacting an enzyme having raw starch digestive activity on starch, the obtained porous carrier is mixed with an object material, and carried.Twelfth, a process for preparing a powder preparation for preparing a microcapsule of the powder preparation which comprises the steps of preparing the powder preparation according to one of the sixth to eleventh means mentioned above, dispersing the same in a coating solution and drying and forming a coating layer on the surface.Thirteenth, a process for preparing a powder preparation for preparing microcapsule of the powder preparation which comprises the steps of preparing the powder preparation according to one of the sixth to eleventh means mentioned above, emulsifying the same in a coating solution and drying and forming a coating layer on the surface.Fourteenth, a process for preparing a powder preparation for preparing microcapsule of the powder preparation which comprises the steps of preparing the powder preparation according to one of the sixth to eleventh means mentioned above, spraying a coating agent to form a coating layer on the surface.Fifteenth, a process for preparing a powder preparation, wherein a porous starch grain is obtained by reacting an enzyme having raw starch digestive activity on starch, the obtained porous starch grain is mixed with a solution containing the object material to form a powder preparation, and wherein a coating layer is formed on the surface of the obtained powder preparation.Here, the porous carrier may be prepared according to the process described in the Japanese TOKKAIHEI 5-112469 [TOKKYO-KOKAI-KOHO (18 months Publication of Unexamined Patent Application) HEISEI 5(1993)-112469] by the present inventors.Then, an object material may be microcenapsulated by making pores of a porous carrier carry the object material and coating the surface thereof with a coating agent to form a coating layer.Additionally, the release of the object material can be controlled and the taste can be improved by pulverizing an object material of various industrial fields through blending or other processing with the porous carrier and then microencapsulating the same through the coating process.Zein, hydroxypropylmethylcellulose phthalate or others may be used as coating agent.The coating may be realized by dispersing or emulsifying the powder preparation in a coating solution where coating agent is dissolved and then drying the same through spray drying, lyophilizing or other drying method, or by spray cooling coating agent such as vegetable hardened oil, carnauba wax, etc.With starch being used as porous carrier, the powder preparation according to the present invention is not harmful to the human body. It can be supplied continuously in great volume, manufactured cheaply without difficult processing and moreover, it is completely biodegradable which does not incur any environmental problems. Itwill be used largely in various industrial fields.Best Mode for Carrying Out the InventionHereinbelow, each Example of the present invention will be explained in detail.EXAMPLE 1First, the preparation of the porous carrier will be disclosed.100 g of corn starch and 1.0 g of Dabiase K-27 (Trade name: raw starch digestive enzyme made by Daikin Kogyo Co., Ltd.) were put in 1000 ml of acetic acid buffer solution of 0.25 mM (pH 5.0) and stood overnight at 40.degree. C. while stirring and then washed and dried to obtain porous carrier composed of porous corn starch grain.100 g of the porous carrier obtained by the process mentioned above and 75 g of soybean oil were mixed by Twinmix-08 made by Dalton Co., Ltd.In this manner, an oil and fat having a very fluid powder form was produced.In comparison, 100 g of corn starch and 75 g of soybean oil were mixed by Twinmix-08 made by Dalton Co., Ltd. only to obtain the same product having a paste form.EXAMPLE 2100 g of the porous carrier obtained in the Example 1 and 135 g of soy sauce (dark soy sauce made by Kikkoman Corp.) were mixed using Twinmix-08 of Dalton Co., Ltd. to obtain a fluid, scarcely sticky powder preparation of soy sauce.In comparison, 100 g of corn starch and 135 g of soy sauce were mixed using Twinmix-08 made by Dalton Co., Ltd. only to obtain the same product having a paste form.EXAMPLE 3100 g of the porous carrier obtained in the Example 1 and 80 g of a liquid fragrance ("Meijiya's Essence Orange" made by Meijiya Co., Ltd.) were mixed using Twinmix-08 made by Dalton Co., Ltd. to obtain a fluid, scarcely sticky powder preparation of fragrance.In comparison, 100 g of corn starch and 80 g of fragrance were mixed using Twinmix-08 made by Dalton Co., Ltd. only to obtain the same product having a paste form.EXAMPLE 413.5 g of the porous carrier obtained in the Example 1 and 1.5 g of red pigment powder (Sekishoku No. 102) were mixed (1000 rpm, 10 min.) by Mechanomill (trade name: Okada Seikou Co., Ltd.).When the mixed product obtained was observed through a scanning electron microscope, the Sekishoku No. 102 was carried in the pores of the porous carrier and became powder preparation.9.98 g of corn starch was added to 0.02 g of the mixed product obtained (containing 0.002 g of Sekishoku No. 102) and mixed by Spatula for 30 seconds.In comparison, 9.998 g of corn starch was added to 0.002 g of Sekishoku No. 102 and treated similarly as before.The absolute volume of Sekishoku No. 2 ought to be same in both samples.Each of the two (2) samples was sampled 5 times respectively andtheir absorbance was determined.510 nm was adopted as measuring wave length.An calibration curve showing the relationship between the absorbance and the dilution multiplying factor had been established beforehand and the dilution multiplying factor was calculated from the measured absorbance.The theoretical dilution multiplying factor also was calculated for the sampling volume.The ratio of the theoretical dilution multiplying factor and the dilution multiplying factor obtained from the actual measured value was calculated and the variance of this ratio was compared.If this variance is small, Sekishoku No. 102 may be considered uniformly mixed through the corn starch.As the result, the variance was 0.252 when Sekishoku No. 102 was added and mixed with corn starch while it was 0.004 when the porous carrier obtained in the Example 1 was used.The variance was significantly smaller when the porous carrier obtained in the Example 1 was used and, consequently, Sekishoku No. 102 may be considered to have been mixed uniformly.This fact shows that the porous carrier obtained in the Example 1 may be advantageously used when a trace of additive ingredient should be mixed uniformly.EXAMPLE 5100 g of porous carrier obtained in the Example 1 and 20 g of ground 2,4-D (2,4-Dichlorophenoxy acetic acid) were dispersed in 500 ml of water (2,4-D being hardly dissolved at this moment), the solution was dehydrated by suction filtering and the residue after filtration was dried.The obtained sample was observed by a scanning electron microscope to find that 2,4-D was buried and carried by pores of the porous carrier. When the product was applied to paddy-rice or lawn as herbicide, the release control effect thereof was observed.EXAMPLE 6As the present invention group, 20 g of naphthalene was dissolved in 500 ml of 99% ethanol, and 50 g of porous carrier obtained in the Example 1 was added thereto and the solution was stirred for 1 minute, filtered under the reduced pressure and the residue after filtration was recovered.The residue after filtration was spread over a Petri dish, left at 60.degree. C. in a constant-temperature dryer and the remaining amount of naphthalene was determined with time.Supposing the initial amount was 100, Table 1 shows the result of comparing the remaining amount naphthalene at respective time lapses of the storage with the control group wherein only naphthalene is spread over a Petri dish.TABLE 1 ______________________________________ Initial 1 hour 2 hours 3 hours 24 hours ______________________________________ Control group 100.00 79.39 63.71 47.99 0.00 Invention group 100.00 94.38 88.1683.23 25.42 ______________________________________According to the results of Table 1, the use of a porous carrier obtained in the Example 1 may improve the continuous effect of naphthalene.EXAMPLE 7100 g of porous carrier obtained in the Example 1, 20 g of soybean peptide powder ("Hainyuto PM" made by Fuji Seiyu Co, Ltd.) and 1000 ml (solid concentration of 6%) of corn gluten mill extract by 70% ethanol (zein) were stirred and mixed for 1 (one) minute at 14700 rpm by means of a Warring blender (type 7011G) to obtain a emulsion, then the emulsion was spray-dried by means of a spray-dryer (SD-1 made by Tokyo Rika) to obtain microcapsule wherein soy peptide is carried by pores of the porous carrier and the surface is covered with zein coating layer.1 g of the microcapsule was dispersed in 1 (one) liter of water, the absorbance was determined at 270 nm and the elution rate of soy peptide was estimated, which was found to be 20.3%.Moreover, 10 subjects tasted the microcapsule of the invention and soy peptide powder and all (ten) of them found soy peptide bitter while 8 of them found the microcapsule not bitter.The results mentioned above suggest that bitter substance can be masked by coating with zein through the usage of porous carrier obtained in the Example 1.* * * * *。

Technical Data Sheet Depth FiltrationBECO® PR RangeDepth Filter Sheets for the Pharmaceutical IndustryBECO PR depth filter sheets meet the highdemands of the pharmaceutical industry.Exceptionally pure raw materials and a specialproduction method produce BECO PR depth filtersheets with low endotoxin content. The specialcharacteristic of this range is high endotoxinretention during the filtration of manypharmaceutical products.The specific advantages of BECO PR depth filtersheets:-High endotoxin retention as well as a maximummicrobial retention rate.-The innovative production process guarantees anendotoxin content of less than < 0.125 EU/ml.-Maximum raw material purity for minimummigration of soluble ions.-The ideal combination of various filtrationmechanisms (surface, adsorption, depth filtration)and adsorptive properties ensures maximumreliability.-Comprehensive quality assurance for all raw andauxiliary materials and intensive in-process controlsensure consistent quality of the finished products.-Before delivery, the endotoxin content of< 0.125 EU/ml of all BECO PR depth filter sheets istested with the help of an LAL test. A certificate isavailable on request.- A Validation Guide is available upon request.Microbial Reduction and RemovalBECO PR Steril S 100, PR Steril S 80, PR Steril 40BECO depth filter sheets boast high microbial retentionrates achieved through the tight-pored structure and anelectrokinetic potential with an adsorptive effect.These depth filter sheets are particularly suitable aspre-filters for subsequent membrane filtration becauseof their high capacity to retain endotoxins and colloidalcomponents.Fine FiltrationBECO PR 12BECO depth filter sheets for achieving a high degree of clarification. These depth filter sheets reliably retain ultra-fine particles and provide bioburden reduction.In practice, these depth filter sheets serve as ideal pre-filters for protection of membrane filters, reverse osmosis systems, and to protect chromatography columns. Clarifying Filtration and Coarse FiltrationBECO PR 5, PR 1BECO depth filter sheets with large-volume cavity structure. These depth filter sheets have a high dirt-holding capacity for particles and are very suitable forclarifying filtration applications.Physical DataThis information is intended as a guideline for the selection of BECO depth filter sheets.The water flow is a laboratory value characterizing the different BECO depth filter sheet types.It is not the recommended flow rate.22PR Steril27295 0.1 0.15 (3.9) 58 > 7.3 (50) 0.7 (30) < 0.125 S100PR Steril27280 0.2 0.15 (3.9) 50 > 11.6 (80) 1.1 (46) < 0.125 S80PR Steril27240 0.4 0.15 (3.9) 49 > 7.3 (50) 1.5 (61) < 0.125 40PR 12 27212 0.8 0.15 (3.9) 50 > 18.9 (130) 4.3 (175) < 0.125PR 5 27205 2.0 0.15 (3.9) 50 > 8.7 (60) 8.1 (330) < 0.125PR 1 27200 4.0 0.17 (4.3) 48 > 6.5 (45) 58.4 (2381) < 0.125 * 100 kPa = 1 bar** Endotoxin content analysis after rinsing with 1.23 gal/ft² (50 l/m²) of WFI (Water for Injection)Chemical DataBECO depth filter sheets meet the requirements of LFGB*, Recommendation XXXVI/1 issued by BfR**, and the test criteria of FDA*** Directive CFR 21 § 177.2260.Chemical resistance of the BECO depth filter sheets to different solvents over a contact time of 3 hours at 68 °F (20 °C). The chemical compatibilities listed in the table below are a guide only.Aqueous solutions: Organic solvents:Sugar solution, 10% r nc Hydrochloric acid, 1% r nc Methanol r nc With 1% free chlorine r nc Hydrochloric acid, 3% r nc Ethanol r nc r nc Hydrochloric acid, 5% r nc Isopropanol r nc With 1% hydrogenperoxideWith 30% formaldehyde r nc Hydrochloric acid, 10% r nc Toluene r nc With 10% ethanol r nc Nitric acid, 1% r nc Xylene r nc With 40% ethanol r nc Nitric acid, 3% r nc Acetone r nc With 98% ethanol r nc Nitric acid, 5% r nc Methyl ethyl ketone r nc Caustic soda, 1% r nc Nitric acid, 10% r nc n-hexane r nc Caustic soda, 2% r nc Sulfuric acid, 1% r nc Dioxan r nc Caustic soda, 4% r 0 Sulfuric acid, 3% r nc Cyclohexane r nc Ammonia solution, 1% r nc Sulfuric acid, 5% r nc Tetrachloroethylene r nc Ammonia solution, 3% r nc Sulfuric acid, 10% r nc Ethylene glycol r nc Ammonia solution, 5% r nc Acetic acid, 1% r nc Dimethyl sulfide r ncr ncAcetic acid, 3% r nc N, N-DimethylformamideAcetic acid, 5% r ncAcetic acid, 10% r 0r = resistant nc = no change0 = slight opalescence* = German Food, Commodity, and Feed Act ** = Federal Institute of Risk Assessment *** = Food and Drug Administration; USAPyrogens/EndotoxinsPyrogens are biological or chemical substances whichcan induce a rise in body temperature. One commonexample are endotoxins. These are cell wall components known as lipopolysaccharides, that are embedded in the outer membrane of gram-negativebacteria.Quantitative evidence of endotoxins can be determinedusing the LAL test (L imulus A mebocyte L ysate). This method is an efficient and economical alternative to therabbit fever test. An independent institute examines thedepth filter sheets. The endotoxin content of the specimens examined is specified in EU/ml (E ndotoxin U nits).The measurement is carried out after rinsing with1.23 gal/ft² (50 l/m²) of WFI water.Endotoxin Retention RateTo measure endotoxin retention, a 40% glucose solution containing a defined amount of lipopolysaccharide (LPS)in pyrogen-free water is passed through a depth filter sheet. A defined sample of the filtrate is then measuredby means of the LAL test. Filtration flow rate: 12.3 gal/ft 2/h(500 l/m 2/h)Sampling after: 1.23 gal/ft² and 6.14 gal/ft²(50 l/m 2 and 250 l/m 2)Amount of endotoxin added: 2.2 mg LPS E. Coli 055:B5, this equals 4.4 µg LPS/ml or4.4 x 104 EU/mlThe endotoxin retention rate is indicated in the following graphic.Endotoxin Retention Rate of BECO PR Depth FilterSheets989799100Application Examples:Dialysis concentratexHuman albumin x Photoresist x I-globulin x xCoagulation factors x x Plasmaexpander solutionsx xEnzymeproduction x xHormones x x xAmino acids x x x Infusion solutions x x x Vaccine production x x x Serums from rabbits, sheep,horses, cattle, calves x x xComponentsBECO depth filter sheets are made from particularly pure natural materials, i.e., finely fibrillated cellulosefibers from deciduous and coniferous trees, cationic charge carriers, and high quality, particularly purediatomaceous earth.Instructions for Correct UseBECO depth filter sheets require careful handling when inserting them into the plate and frame filter. Avoid banging, bending, and rubbing the sheets. Do not use damaged depth filter sheets.InsertingEach BECO depth filter sheet has a rough side and a smooth side. The rough side of the depth filter sheet is the unfiltrate side; the smooth side is the filtrate side. Always ensure that the filtrate side is in contact with the clear filtrate plate when inserting the sheets.Sanitizing and Sterilizing (Optional)The wetted BECO depth filter sheets may be sterilized with hot water or saturated steam up to a maximum temperature of 273.2 °F (134 °C). The pressed filter package should be loosened slightly. Make sure to sterilize the entire filter system thoroughly. Do not apply final pressure until after the filter package has cooled down.Sterilizing with Hot WaterThe flow velocity should at least equal the filtration capacity. The water should be softened and free of impurities.Temperature: 185 °F (85 °C)Duration: 30 minutes after the temperature hasreached 185 °F (85 °C) at all valves. Pressure: At least 7.2 psi (50 kPa, 0.5 bar) at thefilter outlet.Sterilizing with SteamSteam quality: The steam must free of foreign particlesand impurities.Temperature: Max. 273.2 °F (134 °C)(saturated steam)Duration: Approx. 20 minutes after steam escapesfrom all filter valves.Rinsing: After sterilizing with 1.23 gal/ft² (50 l/m²)at 1.25 times the flow rate.Filter Preparation and FiltrationUnless already completed after sterilization, Eaton recommends pre-rinsing the closed filter with 1.23 gal/ft² (50 l/m²) of water at 1.25 times the flow rate prior to the first filtration. Depending on the application, this usually equals a rinsing time of 10 to 20 minutes. Test the entire filter for leakage at maximum operating pressure.High-proof alcohol solutions and chemical products that do not allow pre-rinsing with water should be circulated for 10 to 20 minutes. Dispose of the rinsing solution after rinsing.Differential PressureTerminate the filtration process when a differential pressure of 43.5 psi (300 kPa, 3 bar) is reached. For safety reasons, a differential pressure of 21.8 psi(150 kPa, 1.5 bar) should not be exceeded in applications for separating microorganisms.SafetyWhen used and handled correctly, there are no known unfavorable effects associated with this product. Further safety information can be found in the relevant Material Safety Data Sheet, which can be downloaded from our website. Waste DisposalDue to their composition BECO depth filter sheets are biodegradable. Comply with relevant current regulations, depending on the filtered product.StorageBECO depth filter sheets consist of strongly adsorptive materials. The product must be handled carefully during shipping and storage. Store the depth filter sheets in a dry, odor-free, and well-ventilated place. Do not expose the depth filter sheets to direct sunlight. BECO depth filter sheets are intended for immediate use and should be used within 36 months after production date.Available FormatsAll common square or round filter sizes are available for delivery. Special formats are available on request. Quality Assurance According to DIN EN ISO 9001 The Quality Management System of Eaton Technologies GmbH has been certified according to DIN EN ISO 9001.This certification verifies that a fully functioning comprehensive Quality Assurance System covering product development, contract controls, choice of suppliers, receiving inspections, production, final inspection, inventory management, and shipment has been implemented.Extensive quality assurance measures incorporate adherence to technical function criteria and chemical purity and quality recognized as safe under the German legislation governing the production of foods and beverages.All information is given to the best of our knowledge. However, the validity of the information cannot be guaranteed for every application, working practice and operating condition. Misuse of the product will result in all warrantees being voided.Subject to change in the interest of technical progress.North America44 Apple StreetTinton Falls, NJ 07724Toll Free: 800 656-3344(North America only)Tel: +1 732 212-4700Europe/Africa/Middle EastAuf der Heide 253947 Nettersheim, Germany Tel: +49 2486 809-0Friedensstraße 4168804 Altlußheim, Germany Tel: +49 6205 2094-0An den Nahewiesen 2455450 Langenlonsheim, Germany Tel: +49 6704 204-0 ChinaNo. 3, Lane 280,Linhong RoadChangning District, 200335Shanghai, P.R. ChinaTel: +86 21 5200-0099Singapore100G Pasir Panjang Road #07-08Singapore 118523Tel: +65 6825-1668BrazilRua Clark, 2061 - Macuco13279-400 - Valinhos, BrazilTel: +55 11 3616-8400For more information, pleaseemail us at ********************or visit /filtration© 2018 Eaton. All rights reserved. All trademarks andregistered trademarks are the property of their respectiveowners. All information and recommendations appearing inthis brochure concerning the use of products describedherein are based on tests believed to be reliable. However,it is the user’s responsibility to determine the suitability forhis own use of such products. Since the actual use byothers is beyond our control, no guarantee, expressed orimplied, is made by Eaton as to the effects of such use orthe results to be obtained. Eaton assumes no liabilityarising out of the use by others of such products. Nor is theinformation herein to be construed as absolutely complete,since additional information may be necessary or desirablewhen particular or exceptional conditions or circumstancesexist or because of applicable laws or governmentregulations.EN1 A 2.1.6.406-2018。

controlled release preparations -回复[controlled release preparations]In the world of pharmaceuticals, controlled release preparations play a crucial role in ensuring the safe and effective delivery of drugs to patients. These preparations are designed to release the active ingredients of a drug in a controlled and sustained manner, allowing for a steady drug level in the body over an extended period of time. This article will guide you through the step-by-step process of preparing controlled release formulations.Step 1: Formulation DesignThe first step in preparing a controlled release formulation is to carefully consider the properties and requirements of the drug. This includes understanding its pharmacokinetics, therapeutic window, and desired release profile. By analyzing these factors, scientists can choose the right polymers and excipients that will best control the release of the drug.Step 2: Polymer SelectionPolymers play a critical role in controlling the release of drugs. These substances are chosen based on their compatibility with thedrug, their ability to form a matrix or membrane, and their release characteristics. Common polymers used in controlled release preparations include hydrogels, microparticles, and nanoparticles.Step 3: Drug-Polymer CompatibilityBefore proceeding with formulation development, it is essential to ensure the compatibility between the drug and the chosen polymer. Various techniques like solubility tests, thermal analysis, and spectroscopy can be employed to determine this compatibility. If any incompatibility is found, modifications may be made, or alternative polymers may be considered.Step 4: Formulation TechniquesIn developing controlled release preparations, several techniques can be employed. Some common methods include solvent evaporation, hot-melt extrusion, emulsion-solvent evaporation, and solid dispersion. The choice of technique depends on the nature of the drug, the desired release profile, and the properties of the polymer.Step 5: Process OptimizationOnce the initial formulation is prepared, it undergoes rigorousoptimization to ensure the desired release profile is achieved. Factors such as drug loading, polymer concentration, mixing time, and temperature are fine-tuned to achieve the desired outcome. This step involves detailed experimentation, coupled with analytical techniques to measure drug release kinetics.Step 6: Evaluation and CharacterizationAfter formulation and optimization, the controlled release preparations must undergo thorough evaluation and characterization. Physical characteristics like particle size, shape, surface morphology, and drug content uniformity are assessed. Drug release rates are measured using appropriate in vitro and in vivo techniques, ensuring that the controlled release mechanism is effective and reproducible.Step 7: Stability StudiesStability studies are critical to assess the long-term performance and quality of controlled release preparations. These studies involve exposing the formulation to various stress conditions like temperature, humidity, and light, to evaluate its physical and chemical stability over time. Results from stability studies guide manufacturing and storage recommendations.Step 8: Scale-up and CommercializationOnce the controlled release preparation has successfully passed all evaluation and stability studies, it can be scaled up for manufacturing. Parameters established during the optimization process are utilized to develop robust manufacturing protocols. Quality control measures, such as batch-to-batch consistency checks, are implemented to ensure the commercial product meets regulatory standards.In conclusion, the preparation of controlled release formulations involves a systematic approach that includes formulation design, polymer selection, drug-polymer compatibility evaluation, formulation techniques, optimization, evaluation, stability studies, and finally, scale-up and commercialization. Each step is crucial to ensuring the efficacy, safety, and consistency of controlled release preparations, ultimately benefiting patients by providing them with optimal therapeutic outcomes.。

专利名称：PERORALLY APPLICABLE PREPARATIONCONTAINING HISTAMINASE OF VEGETABLEORIGIN, RESISTANT TO PEPSIN ANDTRYPSIN AND A PROCESS FOR PRODUCINGIT发明人：SIPKA, Sándor,GYÖRY, Zoltán,BORBÉLY,Jánosné,KERESZTES, Tamás,VÁRNAI,Péter,BÍRÓ, Tamás申请号：EP10763851.2申请日：20100902公开号：EP2611454B1公开日：20150325专利内容由知识产权出版社提供摘要：The subject of the invention is a perorally applicable preparation of vegetable origin, resistant to pepsin and trypsin, based on histaminase, optionally for the use as an agent for improving digestion, reducing appetite or reducing body weight. The preparation of the invention is a pressed juice - which is optionally in lyophilized form -obtained from seedlings of pea (Pisum sativum L.), lentil (Lens culinaris), chick pea (Cicer arietinum), grass pea (Latirus sativus), bean (Phaseolus vulgaris) or field bean (Vicia faba) or - from a mixture of seedlings of the above mentioned plants - which contains histaminase, catalase and protease inhibitor. The subject as well of the invention is the production of the above preparation. ˙申请人：DEBRECENI EGYETEM地址：HU国籍：HU代理机构：Varnai, Aniko 更多信息请下载全文后查看。