颅脑超声评估新生儿脑发育与孕周及出生体质量的相关性殷一铭霍亚玲景丹王丹郑州大学附属儿童医院河南省儿童医院郑州儿童医院超声医学科450000通信作者：殷一铭，Email：【摘要】目的通过颅脑超声评估新生儿脑发育与孕周、出生体质量的相关性，分析其在新生儿脑发育中的临床应用价值。
方法收集本院2017年6月至2019年12月收治的120例新生儿的临床资料，根据出生孕周分为A组20例（29～32周）、B组28例（＞32～34周）、C组32例（＞34～36周）、D组40例（＞36周）。
4组于生后3d内通过超声测量不同区域脑组织平均灰度值、胼胝体和小脑蚓矢状长度，分析其相关性。
结果各组新生儿出生时不同区域脑组织平均灰度值从小到大分别为D组、C 组、B组、A组，胼胝体和小脑蚓平均矢状长度从小到大分别为A组、B组、C组、D组（均P＜0.05）；相关性研究显示，孕周与基底节、额叶、顶叶及枕叶白质平均灰度值均呈负相关（r= -0.673、-0.594、-0.557、-0.521，均P＜0.05），出生体质量与基底节、额叶、顶叶及枕叶白质平均灰度值均呈负相关（r=-0.598、-0.543、-0.526、-0.497，均P＜0.05）。
胼胝体矢状长度与孕周、出生体质量均呈正相关（r=0.466、0.538，均P＜0.05），小脑蚓矢状长度与孕周、出生体质量均呈正相关（r=0.435、0.484，均P＜0.05）。
结论颅脑超声检查费用低、操作方便且可重复性强，可有效评估新生儿脑发育情况，为临床干预提供可靠影像学依据。
【关键词】颅脑超声；新生儿脑发育；孕周；出生体质量基金项目：河南省医学科技攻关计划（联合共建项目）（2018020612）The correlation between neonatal brain development evaluated by craniocerebral ultrasound and gestational age and birth weightYin Yiming,Huo Yaling,Jing Dan,Wang DanDepartment of Ultrasound Medicine,Zhengzhou Children's Hospital,Henan Children's Hospital, Children's Hospital Affiliated of Zhengzhou University,Zhengzhou450000,ChinaCorresponding author:Yin Yiming,Email:【Abstract】Objective To evaluate the correlation between neonatal brain development evaluated by craniocerebral ultrasound and gestational age and birth weight,and to analyze its clinical application value in neonatal brain development.Methods Clinical data of120newbornsin our hospital from June2017to December2019were collected and were divided into group A(20 cases,29-32weeks),group B(28cases,32-34weeks),group C(32cases,34-36weeks),and group D (40cases,>36weeks).The average gray value of brain tissues,sagittal length of callosum and vermis were measured by ultrasound in4groups within3days after birth,and the correlation was analyzed.Results At the time of birth,the average gray value of brain tissues in different regions of each group was from small to large in group D,group C,group B,and group A,the sagittal length of callosum and vermis were from small to large in group A,group B,group C,and group D(all P<0.05). Correlation studies showed that gestational age was negatively correlated with the average gray values of basal ganglia,frontal lobe,parietal lobe,and occipital lobe white matter(r=-0.673,-0.594, -0.557,-0.521,all P<0.05),and birth weight was negatively correlated with the average gray valuesDOI：10.3760/cma.j.issn.1007-1245.2021.02.003收稿日期2020-05-06本文编辑刘玲玲引用本文：殷一铭,霍亚玲,景丹,等.颅脑超声评估新生儿脑发育与孕周及出生体质量的相关性[J].国际医药卫生导报,2021,27(2):170-173.DOI:10.3760/cma.j.issn.1007-1245.2021.02.003.of basal ganglia,frontal lobe,parietal lobe,and occipital lobe white matter(r=-0.598,-0.543,-0.526, -0.497,all P<0.05).The sagittal length of callosum was positively correlated with gestational age and birth weight(r=0.466,0.538,both P<0.05),and the sagittal length of vermis was positively correlated with gestational age and birth weight(r=0.435,0.484,both P<0.05).Conclusion Craniocerebral ultrasonography has the advantages of low cost,easy operation,and high repeatability,which can effectively evaluate the development of neonatal brain and provide reliable imaging basis for clinical intervention.【Key words】Craniocerebral ultrasound;Neonatal brain development;Gestational age;Birth weightFund program:Medical Key Science and Technology Project(Joint Construction)of Henan Province(2018020612)新生儿处于生长发育阶段初期，易受其他因素影响而引起脑发育异常或损伤，遗留脑瘫、癫痫等神经系统后遗症，因此评估新生儿脑发育情况有重要的临床价值［1-2］。
