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10.in the northern Finland birth cohort

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GeneticDeterminantsofHeightGrowthAssessed

LongitudinallyfromInfancytoAdulthoodinthe

NorthernFinlandBirthCohort1966

UllaSovio1,AmandaJ.Bennett2,IonaY.Millwood1,JohnMolitor1,PaulF.O’Reilly1,NicholasJ.

Timpson3,4,MarikaKaakinen5,6,JaanaLaitinen7,JariHaukka8,9,DemetrisPillas1,IoannaTzoulaki1,Jassy

Molitor1,CliveHoggart1,LachlanJ.M.Coin1,JohnWhittaker10,AnneliPouta11,Anna-Liisa

Hartikainen12,NelsonB.Freimer13,14,15,ElisabethWiden16,LeenaPeltonen17,18,19,PaulElliott1,MarkI.

McCarthy2,3,20,Marjo-RiittaJarvelin1,5,6,11,*

1DepartmentofEpidemiologyandPublicHealth,ImperialCollegeLondon,London,UnitedKingdom,2OxfordCentreforDiabetes,EndocrinologyandMetabolism,

UniversityofOxford,Oxford,UnitedKingdom,3WellcomeTrustCentreforHumanGenetics,UniversityofOxford,Oxford,UnitedKingdom,4TheMRCCentreforCausal

AnalysesinTranslationalEpidemiology,BristolUniversity,Bristol,UnitedKingdom,5InstituteofHealthSciences,UniversityofOulu,Oulu,Finland,6BiocenterOulu,

UniversityofOulu,Oulu,Finland,7FinnishInstituteofOccupationalHealth,Oulu,Finland,8NationalPublicHealthInstitute,Helsinki,Finland,9Biostatisticsand

EpidemiologyCluster,InternationalAgencyforResearchonCancer,Lyon,France,10LondonSchoolofHygieneandTropicalMedicine,UniversityofLondon,London,

UnitedKingdom,11DepartmentofChildandAdolescentHealth,NationalPublicHealthInstitute,Oulu,Finland,12DepartmentofClinicalSciences/Obstetricsand

Gynecology,UniversityofOulu,Oulu,Finland,13CenterforNeurobehavioralGenetics,UniversityofCaliforniaLosAngeles,LosAngeles,California,UnitedStatesof

America,14TheJaneandTerrySemelInstituteforNeuroscienceandHumanBehavior,UniversityofCaliforniaLosAngeles,LosAngeles,California,UnitedStatesof

America,15DepartmentofPsychiatry,UniversityofCaliforniaLosAngeles,LosAngeles,California,UnitedStatesofAmerica,16FinnishGenomeCenter,Universityof

Helsinki,Helsinki,Finland,17InstituteforMolecularMedicine(FIMM),UniversityofHelsinki,Helsinki,Finland,18BroadInstituteofHarvardandMIT,Cambridge,

Massachusetts,UnitedStatesofAmerica,19WellcomeTrustSangerInstitute,Cambridge,UnitedKingdom,20OxfordNIHRBiomedicalResearchCentre,Churchill

Hospital,Oxford,UnitedKingdom

Abstract

Recentgenome-wideassociation(GWA)studieshaveidentifieddozensofcommonvariantsassociatedwithadultheight.

However,itisunknownhowthesevariantsinfluenceheightgrowthduringchildhood.Wederivedpeakheightvelocityin

infancy(PHV1)andpuberty(PHV2)andtimingofpubertalheightgrowthspurtfromparametricgrowthcurvesfittedto

longitudinalheightgrowthdatatotesttheirassociationwithknownheightvariants.ThestudyconsistedofN=3,538

singletonsfromtheprospectiveNorthernFinlandBirthCohort1966withgenotypedataandfrequentheightmeasurements

(onaverage20measurementsperperson)from0–20years.Twenty-sixofthe48variantstestedassociatedwithadult

height(p,0.05,adjustedforsexandprincipalcomponents)inthissample,allinthesamedirectionasinpreviousGWA

scans.SevenSNPsinornearthegenesHHIP,DLEU7,UQCC,SF3B4/SV2A,LCORL,andHIST1H1DassociatedwithPHV1andfive

SNPsinornearSOCS2,SF3B4/SV2A,C17orf67,CABLES1,andDOT1LwithPHV2(p,0.05).Weformallytestedvariantsfor

interactionwithage(infancyversuspuberty)andfoundbiologicallymeaningfulevidenceforanage-dependenteffectfor

theSNPinSOCS2(p=0.0030)andfortheSNPinHHIP(p=0.045).Wedidnothavesimilarpriorevidencefortheassociation

betweenheightvariantsandtimingofpubertalheightgrowthspurtaswehadforPHVs,andnoneoftheassociationswere

statisticallysignificantaftercorrectionformultipletesting.Thefactthatinthissample,lessthanhalfofthevariants

associatedwithadultheighthadameasurableeffectonPHV1orPHV2islikelytoreflectlimitedpowertodetectthese

associationsinthisdataset.Ourstudyisthefirstgeneticassociationanalysisonlongitudinalheightgrowthinaprospective

cohortfrombirthtoadulthoodandgivesgroundingforfutureresearchonthegeneticregulationofhumanheightduring

differentperiodsofgrowth.

Citation:SovioU,BennettAJ,MillwoodIY,MolitorJ,O’ReillyPF,etal.(2009)GeneticDeterminantsofHeightGrowthAssessedLongitudinallyfromInfancyto

AdulthoodintheNorthernFinlandBirthCohort1966.PLoSGenet5(3):e1000409.doi:10.1371/journal.pgen.1000409

Editor:GregGibson,TheUniversityofQueensland,Australia

ReceivedSeptember26,2008;AcceptedFebruary5,2009;PublishedMarch6,2009

Copyright:ß2009Sovioetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermits

unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.

Funding:FinancialsupportwasreceivedfromtheAcademyofFinland(projectgrants104781,120315andCenterofExcellenceinComplexDiseaseGenetics),

UniversityHospitalOulu,Biocenter,UniversityofOulu,Finland,NHLBIgrant5R01HL087679-02throughtheSTAMPEEDprogram(1RL1MH083268-01),ENGAGE

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2019年上海市徐汇区中考英语一模考试试卷 解析版

2019年上海市徐汇区中考英语一模考试试卷 解析版

2019年上海市徐汇区中考英语一模考试试卷 解析版

1 / 32 2019年上海市徐汇区中考英语一模试卷

一、选择题（共20小题，每小题1分，满分20分）

1．（1分）Which of the following underlined parts is different in pronunciation？（ ）

A．team B．pleasant C．repeat D．meaning

2．（1分）Don't worry! The government will look after ________ homeless in freezing

days．（ ）

A．a B．an C．the D．/

3．（1分）As the winter holidays are coming， let's spread ________ wings to travel around the

world．（ ）

A．ourselves B．us C．our D．ours

4．（1分）The first China International Import Expo was held ________ November， 2018 in

Shanghai．（ ）

A．in B．on C．at D．of

5．（1分）Mike recently got a package， ________ he didn't remember buying anything．（ ）

A．so B．or C．for D．but

6．（1分）Some caves can only be visited by boat while ________ are for expert swimmers and

divers．（ ）

A．other B．others C．another D．the others

7．（1分）Rowan was listed in the top 50 ________ people ever by a group of comedians．（ ）

北语网院20春《综合英语(I)》作业_4答案

北语网院20春《综合英语(I)》作业_4答案

北语网院20春《综合英语(I)》作业_4答案

(单选)1：My home is 10 km _____ the School.

A：faraway

B：far away from

C： far from

D： away from

正确答案：D

(单选)2：By making some research, everybody can find the answer ________ the issue.

A：to

B：of

C： about

D： on

正确答案：A

(单选)3：At Yale University, _______ people (all over age 60) took a test of memory.

B：elder

C：elderly

D：older

E：old

正确答案：C

(单选)4：He ______ to Japan, and will be back next week.

A：went

B：has been

C： has gone

D： goes

正确答案：C

(单选)5：Only when you have obtained sufficient data _______ come to a sound

conclusion.

B：you will

C：you can

D：can you

E：would you

正确答案：D

(单选)6：With too much stimulation, students _________ －stop trying.

A：get up

B：show up

C： pick up

D： give up

正确答案：D

(单选)7：Sometimes the movie makers do not translate original titles directly. ______, 北语网院20春《综合英语(I)》作业_4答案

北语18秋《综合英语（I）》作业1234

北语18秋《综合英语（I）》作业1234

北语18秋《综合英语（I）》作业1234

18秋《综合英语（I）》作业_1

一、单选题( 每题4分, 共20道小题, 总分值80分)

1.She spoke so quietly that I could _______ hear her.

A. almost

B. mostly

C. nearly

D. hardly

答案：D 联系“文档贡献者”

2.Advertisements try to _______ the target consumers.

A. amuse at

B. approach

C. serve

D. appeal to

答案：D

3.My home is 10 km _____ the School.

A. faraway

B. far away from

C. far from

D. away from

答案：D

4.The _______ of the show was the group dance.

A. highlight

B. emphasis

C. stress

D. focus

答案：A

5.With too much stimulation, students _________ －stop trying.

A. get up B. show up

C. pick up

D. give up

答案：D

6.He was asked to _______ his concept of cool.

A. define

B. determine

C. demand

D. depend

7.They have the ability for longer eye _______.

A. connection

B. contact

C. stare

D. watch

8.The problem has been _______ me for weeks .

A. bothering

浙江省浙东北联盟2024-2025学年高一上学期期中考试英语试题

浙江省浙东北联盟2024-2025学年高一上学期期中考试英语试题

试卷第1页，共10页 浙江省浙东北联盟2024-2025学年高一上学期期中考试英语试题

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