nanoscale投稿模板

【珍藏版】SCI论文投稿全过程信件模板一览来源：MedSciDear Editors:We would like to submit the enclosed manuscript entitled “Paper Title”, which we wish to be considered for publication in “Journal Name”. No conflict of interest exits in the submission of this manuscript, and manuscript is approved by all authors for publication. I would like to declare on behalf of my co-authors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part. All the authors listed have approved the manuscript that is enclosed.In this work, we evaluated …… (简要介绍一下论文的创新性). I hope this paper is suitable for “Journal Name”.The following is a list of possible reviewers for your consideration:1) Name A E-mail: ××××@××××2) Name B E-mail: ××××@××××We deeply appreciate your consideration of our manuscript, and we look forward to receiving comments from the reviewers. If you have any queries, please don’t hesitate to contact me at the address below.Thank you and best regards.Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××@××××二、催稿信Dear Prof. ×××:Sorry for disturbing you. I am not sure if it is the right time to contact you to inquire about the status of my submitted manuscript titled “Paper Title”. (ID: 文章稿号), although the status of “With Editor” has been lasting for more than two months, since submitted to journal three months ago. I am just wondering that my manuscript has been sent to reviewers or not?I would be greatly appreciated if you could spend some of your time check the status for us. I am very pleased to hear from you on the reviewer’s comments.Thank you very much for your consideration.Best regards!Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××@××××三、修改稿Cover letterDear Dr/ Prof..（写上负责你文章编辑的姓名，显得尊重，因为第一次的投稿不知道具体负责的编辑，只能用通用的Editors）:On behalf of my co- authors, we thank you very much for giving us an opportunity to revise our manuscript, we appreciate editor and reviewers very much for their positive and constructive comments and suggestions on our manuscript entitled “Paper Title”. (ID: 文章稿号).We have studied reviewer’s comments carefully and have made revision which marked in red in the paper. We have tried our best to revise our manuscript according to the comments. Attached please find the revised version, which we would like to submit for your kind consideration.We would like to express our great appreciation to you and reviewers for comments on our paper. Looking forward to hearing from you.Thank you and best regards.Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××@××××四、修改稿回答审稿人的意见（最重要的部分）List of ResponsesDear Editors and Reviewers:Thank you for your letter and for the reviewers’ commentsconcerning our manuscript entitled “Paper Title” (ID: 文章稿号). Those comments are all valuable and very helpful for revising and improving our paper, as well as the important guiding significance to our researches. We have studied comments carefully and have made correction which we hope meet with approval. Revised portion are marked in red in the paper. The main corrections in the paper and the responds to the reviewer’s comments are as flowing:Responds to the reviewer’s comments:Reviewer #1:1. Response to comment: (……简要列出意见……)Response: ××××××2. Response to comment: (……简要列出意见……)Response: ××××××。

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20XX年3月多不饱和脂肪酸不同组分抑制肺腺癌干细胞作用研究胡振东1，尹荣1,2，武雅琴2，李宁2*(*指通讯作者)矚慫润厲钐瘗睞枥庑赖賃軔朧。

(1. 南京大学医学院，南京，210093；2. 江苏省肿瘤医院，南京，210009)摘要：采用图像分析技术对液相中气泡群的粒径分布进行了研究。

首先使用高速摄像机拍摄得到简易反应器内气泡的图片，再通过Matlab平台对图像进行预处理后将其转换为二值图像来提取周长和面积，并依据圆度值对气泡进行分类，分离单个气泡和黏连气泡，以防止分水岭算法对单个气泡的过度分割。

然后利用改进的分水岭算法对黏连气泡进行分割，获得黏连气泡的粒径分布，将单个气泡与黏连气泡的粒径分布汇总得到整个气泡群的粒径分布。

最后，将由气泡群的粒径分布计算得到的气含率与实验测得的气含率进行比较，得到不同表观气速下的测量误差，在此基础上得到了各表观气速下气泡群粒径分布的概率密度图。

结果表明，误差随着表观气速的增大而增大，表观气速在1.2~1.8 cm·s-1之间时，误差在10%以内。

(中文摘要的字数大致如例)聞創沟燴鐺險爱氇谴净祸測樅。

一、投稿时的Cover latter1). Here within enclosed is our paper for consideration to be published on "(Journal name)". The further information about the paper is in the following:The Title: XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXThe Authors: XXXXXXXXXX XXXXXXXXXXXX and XXXXXXXXXXThe authors claim that none of the material in the paper has been published or is under consideration for publication elsewhere.I am the corresponding author and my address and other information is as follows:Address: Department of XXXXXXXXX,College of Chemistry and Enviromental Science, Henan Normal UniversityXinxiang City, Henan Province, 453007,P.R.ChinaE-mail:Tel: +86-XXX-XXXXXXXFax: +86-XXX-XXXXXXXThank you very much for consideration!Sincerely Yours,Dr. XXX2). Dear Dr. A:I am sending a manuscript entitled “ ” by – which I should like to submit for possible publication in the journal of - .Yours sincerely3). Dear Dr. A:Enclosed is a manuscript entitled “” by sb, which we are submitting for publication in the journal of - . We have chosen this journal because it deals with - . We believe that sth would be of interest to the journal’s readers.4). Dear Dr. A:Please find enclosed for your review an origin al research article, “” by sb. All authors have read and approve this version of the article, and due care has been taken to ensure the integrity of the work. No part of this paper has published or submitted elsewhere. No conflict of interest exits in the submission of this manuscript, and we have attached to this letter the signed letter granting us permission to use Figure 1 from another source.We appreciate your consideration of our manuscript, and we look forward to receiving comments from the reviewers.二、询问有无收到稿件Dear Editors,We dispatched our manuscript to your journal on 3 August 2006 but have not, as yet, receive acknowledgement of their safe arrival. We fear that may have been lost and should be grateful if you would let us know whether or not you have received them. If not, we will send our manuscript again. Thank you in advance for your help.三、询问论文审查回音Dear Editors，It is more than 12 weeks since I submitted our manuscript (No: ) for possible publication in your journal. I have not yet received a reply and am wondering whether you have reached a decision. I should appreciated your letting me know what you have decided as soon as possible.四、关于论文的总体审查意见1. This is a carefully done study and the findings are of considerable interest. A few minor revision are list below.2. This is a well-written paper containing interesting results which merit publication. For the benefit of the reader, however, a number of points need clarifying and certain statements require further justification. There are given below.3. Although these observation are interesting, they are rather limited and do not advance our knowledge of the subject sufficiently to warrant publication in PNAS. We suggest that the authors try submitting their findings to specialist journal such as –4. Although this paper is good, it would be ever better if some extra data were added.5. This manuscript is not suitable for publication in the journal of – because the main observation it describe was reported 3 years ago in a reputable journal of - .6. Please ask someone familiar with English language to help you rewrite this paper. As you will see, I have made some correction at the beginning of the paper where some syntax is not satisfactory.7. We feel that this potentially interesting study has been marred by an inability to communicate the finding correctly in English and should like to suggest that the authors seek the advice of someone with a good knowledge of English, preferable native speaker.8. The wording and style of some section, particularly those concerning HPLC, need careful editing. Attention should be paid to the wording of those parts of the Discussion of and Summary which have been underlined.9. Preliminary experiments only have been done and with exception of that summarized in Table 2, none has been repeated. This is clearly unsatisfactory, particularly when there is so much variation between assays.10. The condition of incubation are poorly defined. What is the temperature? Were antibody used?五、给编辑的回信1. In reply to t he referee’s main criticism of paper, it is possible to say that –One minor point raised by the referee concerns of the extra composition of the reaction mixture in Figure 1. This has now been corrected. Further minor changes had been made on page 3, paragraph 1 (line 3-8) and 2 (line 6-11). These do not affect our interpretation of the result.2. I have read the referee’s comments very carefully and conclude that the paper has been rejected on the sole grounds that it lake toxicity data. I admit that I did not include a toxicity table in my article although perhaps I should have done. This was for the sake of brevity rather than an erroror omission.3. Thank you for your letter of –and for the referee’s comments concerning our manuscript entitled “”. We have studied their comments carefully and have made correction which we hope meet with their approval.4. I enclosed a revised manuscript which includes a report of additional experiments done at the referee’s suggestion. You will see that our original fin dings are confirmed.5. We are sending the revised manuscript according to the comments of the reviewers. Revised portion are underlined in red.6. We found the referee’s comments most helpful and have revised the manuscript7. We are pleased to note the favorable comments of reviewers in their opening sentence.8. Thank you for your letter. I am very pleased to learn that our manuscript is acceptable for publication in Cancer Research with minor revision.9. We have therefore completed a further series of experiments, the result of which are summarized in Table 5. From this we conclude that intrinsic factor is not account.10. We deleted the relevant passage since they are not essential to the contents of the paper.11. I feel that the reviewer’s comments c oncerning Figures 1 and 2 result from a misinterpretation of the data.12. We would have include a non-protein inhibitor in our system, as a control, if one had been available.13. We prefer to retain the use of Table 4 for reasons that it should be clear from the new paragraph inserted at the end of the Results section.14. Although reviewer does not consider it is important to measure the temperature of the cells, we consider it essential.15. The running title has been changed to “”.16. The Materials and Methods section now includes details for measuring uptake of isotope and assaying hexokinase.17. The concentration of HA T media (page12 paragraph 2) was incorrectly stated in the original manuscript. This has been rectified. The authors are grateful to the referees for pointing out their error.18. As suggested by both referees, a discussion of the possibility of laser action on chromosome has been included (page16, paragraph 2).19. We included a new set of photographs with better definition than those originally submitted and to which a scale has been added.20. Following the suggestion of the referees, we have redraw Figure 3 and 4.21. Two further papers, published since our original submission, have been added to the text and Reference section. These are:22. We should like to thank the referees for their helpful comments and hope that we have now produced a more balance and better account of our work. We trust that the revised manuscript is acceptable for publication.23. I greatly appreciate both your help and that of the referees concerning improvement to this paper. I hope that the revised manuscript is now suitable for publication.24. I should like to express my appreciation to you and the referees for suggesting how to improve our paper.25. I apologize for the delay in revising the manuscript. This was due to our doing an additional experiment, as suggested by referees转载--SCI期刊投稿状态投稿术语名词解释/s/blog_6763380d01013buh.html1. Submitted to Journal 刚提交的状态2. Manuscript received by Editorial Office 就是你的文章到了编辑手里了，证明投稿成功3. With editor 如果在投稿的时候没有要求选择编辑，就先到主编那，主编会分派给别的编辑。

SCI投稿全过程信件模板与相关容1很好的博客 (2)2SCI 投稿全过程信件模板一览 (2)2.1一、最初投稿Cover letter (2)2.2二、催稿信 (3)2.3三、修改稿Cover letter (3)2.4四、修改稿回答审稿人的意见（最重要的部分） (3)2.5五、文章接受后可以考虑感一下负责你文章的编辑或主编（根据需要） (4)2.6六、询问校稿信件（如果文章接受后时间较长） (5)2.7七、文章校稿信件 (5)3SCI投稿信件的一些套话和模板zz (6)3.1一、投稿信 (6)3.2二、询问有无收到稿件 (6)3.3三、询问论文审查回音 (6)3.4四、关于论文的总体审查意见 (7)3.5五、给编辑的回信(很多方面的套话) (7)4SCI论文投稿常见句型和优美句子1000句 (9)5英文论文投稿前应该进行的28个细节检查 (9)6中科院博士谈SCI论文投稿步骤及经验总结 (11)6.1（一）投稿程序 (12)6.2（二）投稿经验总结 (13)7SCI论文写作实战技巧 (14)8SCI期刊稿件的准备与投送 (15)8.1稿件的准备 (15)8.2首页或投稿函(cover letter) (16)8.2.1著作权声明(authorship responsibility and con-tributions) (16)8.2.2转让许可(license for publication) (17)8.2.3文章类型/栏目(article type) (17)8.2.4基金和资金资助(funding disclosure) (17)8.2.5利益冲突(conflict of interest) (18)8.3电子文档的准备 (20)9一年三篇IF大于7的牛人告诉你怎么写SCI (20)9.1一、研究生必备四本 (20)9.2二、论文写作要点 (21)9.3三、如何撰写实验研究论文（唐朝枢） (21)9.4四、如何写好论文讨论部分：科学论文的讨论需要结构化 (22)9.5五、关于写英文文章的秘诀 (22)9.6六、写论文的技巧 (23)9.6.1优秀论文的要素 (23)9.6.2优秀论文的误区 (23)9.6.3写文章的条件 (23)9.6.4写论文的要点 (23)9.6.5Reviewer Check List (24)9.6.6IEEE Transactions on CSVT Review form (24)9.7七、论文写作技巧 (24)9.8八、优秀论文结构例 (25)9.9处理被拒 (26)9.10常见问题 (26)1很好的博客/?Uid-955-Action-Viewspace-Itemid-74015（含多个连接，“SCI论文投稿常见句型和优美句子1000句”）2SCI 投稿全过程信件模板一览2.1一、最初投稿Cover letterDear Editors:We would like to submit the enclosed manuscript entitled “Paper Title”, which we wish to be considered for publication in “Journal Name”. No conflict of interest exits in the submission of this manuscript, and manuscript is approved by all authors for publication. I would like to declare on behalf of my co-authors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part. All the authors listed have approved the manuscript that is enclosed.In this work, we evaluated …… (简要介绍一下论文的创新性). I hope this paper is suitable For “Journal Name”.The following is a list of possible reviewers for your consideration:1) Name A E-mail: ××××××××2) Name B E-mail: ××××××××We deeply appreciate Your consideration of our manuscript, and we look forward to receiving comments from the reviewers. If you have any queries, please don’t hesitate to contact me at the address below.Thank you and best regards.Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××××××2.2二、催稿信Dear P rof. ×××:Sorry for disturbing you. I am not sure if it is the right time to contact you to inquire about the status of my submitted manuscript titled “Paper Title”. (ID: 文章稿号), although the status of “With Editor” has been lasting for more than two months, since submitted to journal three months ago. I am just wondering that my manuscript has been sent to reviewers or not?I would be greatly appreciated if you could spend some of your time check the status for us. I am very pleased to hear from you on the reviewer’s comments.Thank you very much for your consideration.Best regards!Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××××××2.3三、修改稿Cover letterDear Dr/ Prof..（写上负责你文章编辑的，显得尊重，因为第一次的投稿不知道具体负责的编辑，只能用通用的Editors）:On behalf of my co-authors, we thank you very much for giving us an opportunity to revise our manuscript, we appreciate editor and reviewers very much for their positive a nd constructive comments and suggestions on our manuscript entitled “Paper Title”. (I D: 文章稿号).We have studied reviewer’s comments carefully and have made revision which marked in red in the paper. We have tried our best to revise our manuscript according to the comments. Attached please find the revised version, which we would like to submit for your kind consideration.We would like to express our great appreciation to you and reviewers for comments on our paper. Looking forward to hearing from you.Thank you and best regards.Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××××××2.4四、修改稿回答审稿人的意见（最重要的部分）List of ResponsesDear Editors and Reviewers:Thank you for your letter and for the reviewers’comments concerning our manuscript entitled “Paper Title” (ID: 文章稿号). Those comments are all valuable and very helpful for revising and improving our paper, as well as the important guiding significance to our researches. We have studied comments carefully and have made correction which we hope meet with approval. Revised portion are marked in red in the paper. The main corrections in the pap er and the responds to the reviewer’s comments are as flowing:Responds to the reviewer’s comments:Reviewer #1:1. Response to comment: (……简要列出意见……)Response: ××××××2. Response to comment: (……简要列出意见……)Response: ××××××。

科研必备之SCI投稿7个阶段邮件模板，收藏！Dear Editors:We would like to submit the enclosed manuscript entitled “Paper Title”, which we wish to be considered for publication in “Journal Name”. No conflict of interest exits in the submission of this manuscript, and manuscript is approved by all authors for publication. I would like to declare on behalf of my co-authors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part. All the authors listed have approved the manuscript that is enclosed.In this work, we evaluated …… (简要介绍一下论文的创新性).I hope this paper is suitable for “Journal Name”.The following is a list of possible reviewers for your consideration:1)Name A E-mail: ××××@××××2)Name B E-mail: ××××@××××We deeply appreciate your consideration of our manuscript, and we look forward to receiving comments from the reviewers. If you have anyquerie s, please don’t hesitate to contact me at the address below.Thank you and best regards.Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××@××××二、催稿信Dear Prof. ×××:Sorry for disturbing you. I am not sure if it is the right time to contact you to inquire about the status of my submitted manuscript titled “Paper Title”.(ID:文章稿号), although the status of “With Editor” has been lasting for more than two months, since submitted to journal three months ago. I am just wondering that my manuscript has been sent to reviewers ornot?I would be greatly appreciated if you could spend some ofyour time check the status for us. I am very pleased to hear from you on the reviewer’s comments.Thank you very much for your consideration.Best regards!Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××@××××三、修改稿 Cover letterDear Dr/ Prof..（写上负责你文章编辑的姓名，显得尊重，因为第一次的投稿不知道具体负责的编辑，只能用通用的Editors）: On behalf of my co-authors, we thank you very much for giving us anopportunity to revise our manuscript, we appreciate editor and reviewers very much for their positive and constructive comments and suggestions on our manuscriptentitled “Paper Title”.(ID:文章稿号).We have studied reviewer’s comments carefully and have made revision which marked in red in the paper. We have tried our best to revise our manuscript according to the comments. Attached please find the revised version, which we would like to submit for your kind consideration.We would like to express our great appreciation to you and reviewers for comments on our paper. Looking forward to hearing from you.Thank you and best regards.Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××@××××四、修改稿回答审稿意见（最重要的部分）List of ResponsesDear Editors and Reviewers:Thank you for your letter and for the reviewers’ comments concerning our manuscript entitled “Paper Title” (ID:文章稿号).Those comments are all valuable and very helpful for revising and improving our paper, as well as the important guiding significance to our researches. We have studied comments carefully and have made correction which we hope meet with approval. Revised portion are marked in red in the paper. The main corrections in the paper and the responds to thereviewer’s comments are as flowing:Respon ds to the reviewer’s comments:Reviewer #1:1. Response to comment: (……简要列出意见……)Response:××××××2. Response to comment:(……简要列出意见……)Response:××××××。

SCI投稿全过程信件模板与相关内容1 很好的博客链接 (2)2 SCI 投稿全过程信件模板一览 (2)2.1 一、最初投稿Cover letter (2)2.2 二、催稿信 (3)2.3 三、修改稿Cover letter (3)2.4 四、修改稿回答审稿人的意见（最重要的部分） (3)2.5 五、文章接受后可以考虑感谢一下负责你文章的编辑或主编（根据需要） (5)2.6 六、询问校稿信件（如果文章接受后时间较长） (5)2.7 七、文章校稿信件 (5)3 SCI投稿信件的一些套话和模板zz (6)3.1 一、投稿信 (6)3.2 二、询问有无收到稿件 (6)3.3 三、询问论文审查回音 (7)3.4 四、关于论文的总体审查意见 (7)3.5 五、给编辑的回信(很多方面的套话) (7)4 SCI论文投稿常见句型和优美句子1000句 (9)5 英文论文投稿前应该进行的28个细节检查 (9)6 中科院博士谈SCI论文投稿步骤及经验总结 (11)6.1 （一）投稿程序 (12)6.2 （二）投稿经验总结 (13)7 SCI论文写作实战技巧 (14)8 SCI期刊稿件的准备与投送 (15)8.1 稿件的准备 (16)8.2 首页或投稿函(cover letter) (16)8.2.1 著作权声明(authorship responsibility and con-tributions) (16)8.2.2 版权转让许可(license for publication) (17)8.2.3 文章类型/栏目(article type) (17)8.2.4 基金和资金资助(funding disclosure) (17)8.2.5 利益冲突(conflict of interest) (18)8.3 电子文档的准备 (20)9 一年三篇IF大于7的牛人告诉你怎么写SCI (20)9.1 一、研究生必备四本 (20)9.2 二、论文写作要点 (21)9.3 三、如何撰写实验研究论文（唐朝枢） (21)9.4 四、如何写好论文讨论部分：科学论文的讨论需要结构化 (22)9.5 五、关于写英文文章的秘诀 (22)9.6 六、写论文的技巧 (23)9.6.1 优秀论文的要素 (23)9.6.2 优秀论文的误区 (23)9.6.3 写文章的条件 (23)9.6.4 写论文的要点 (23)9.6.5 Reviewer Check List (24)9.6.6 IEEE Transactions on CSVT Review form (24)9.7 七、论文写作技巧 (24)9.8 八、优秀论文结构范例 (25)9.9 处理被拒 (26)9.10 常见问题 (26)1很好的博客链接/?Uid-955-Action-Viewspace-Itemid-74015（含多个连接，“SCI论文投稿常见句型和优美句子1000句”）2SCI 投稿全过程信件模板一览2.1 一、最初投稿Cover letterDear Editors:We would like to submit the enclosed manuscript entitled “Paper Title”, whic h we wish to be considered for publication in “Journal Name”. No conflict of interest exits in the submission of this manuscript, and manuscript is approved by all authors for publication. I would like to declare on behalf of my co-authors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part. All the authors listed have approved the manuscript that is enclosed.In this work, we evaluated ……(简要介绍一下论文的创新性). I hope this paper is suitable For “Journal Name”.The following is a list of possible reviewers for your consideration:1) Name A E-mail: ××××@××××2) Name B E-mail: ××××@××××We deeply appreciate Your consideration of our manuscript, and we look forward to receiving comments from the reviewers. If you have any queries, please don’t hesitate to contact me at the address below.Thank you and best regards.Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××@××××2.2 二、催稿信Dear Prof. ×××:Sorry for disturbing you. I am not sure if it is the right time to contact you to inquire about the status of my submitted manuscript titled “Paper Title”. (ID: 文章稿号), although the status of “With Editor”has been lasting for more than two months, since submitted to journal three months ago. I am just wondering that my manuscript has been sent to reviewers or not?I would be greatly appreciated if you could spend some of your time check the status for us. I am very pleased to hear from you on t he reviewer’s comments.Thank you very much for your consideration.Best regards!Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××@××××2.3三、修改稿Cover letterDear Dr/ Prof..（写上负责你文章编辑的姓名，显得尊重，因为第一次的投稿不知道具体负责的编辑，只能用通用的Editors）:On behalf of my co-authors, we thank you very much for giving us an opportunity to revise our manuscript, we appreciate editor and reviewers very much for their positive and constructive comments and suggestions on our manuscript entitled “Paper Title”. (I D: 文章稿号).We have studied reviewer’s comments carefully and have made revision which marked in red in the paper. We have tried our best to revise our manuscript according to the comments. Attached please find the revised version, which we would like to submit for your kind consideration.We would like to express our great appreciation to you and reviewers for comments on our paper. Looking forward to hearing from you.Thank you and best regards.Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××@××××2.4 四、修改稿回答审稿人的意见（最重要的部分）List of ResponsesDear Editors and Reviewers:Thank you for your letter and for the reviewers’comments concerning our manuscript entitled “Paper Title”(ID: 文章稿号). Those comments are all valuable and very helpful for revising and improving our paper, as well as the important guiding significance to our researches. We have studied comments carefully and have made correction which we hope meet with approval. Revised portion are marked in red in the paper. The main corrections in the paper and the responds to the reviewer’s comments are as flowing:Responds to the reviewer’s comments:Reviewer #1:1. Response to comment: (……简要列出意见……)Response: ××××××2. Response to comment: (……简要列出意见……)Response: ××××××。

SCI 论文投稿cover letter 投稿信模版4 实例—子午|子午学术论坛Case 1Dear Editor,We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience.GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease.Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I amSincerely yours,case2Dear Editor,We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron.We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release.Sincerely yours,Case 3Sample Cover Letter[the example used is the IJEB]Dear Editor of the [please type in journal title or acronym]:Enclosed is a paper, entitled "Mobile Agents for Network Management." Please accept it as a candidate for publication in the [journal title]. Below are our responses to your submission requirements.1. Title and the central theme of the article.Paper title: "Mobile Agents for Network Management." This study reviews the concepts of mobile agents and distributed network management system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a large network environment.2. Which subject/theme of the Journal the material fitsNew enabling technologies (if no matching subject/theme, enter 'Subject highly related to [subject of journal] but not listed by [please type in journal title or acronym])3. Why the material is important in its field and why the material should be published in [please type in journal title or acronym]?The necessity of having an effective computer network is rapidly growing alongside the implementation of information technology. Finding an appropriate network management system has become increasingly important today's distributed environment. However, the conventional centralized architecture, which routinely requests the status information of local units by the central server, is not sufficient to manage the growing requests. Recently, a new framework that uses mobileagent technology to assist the distributed management has emerged. The mobile agent reduces network traffic, distributes management tasks, and improves operational performance. Given today's bandwidth demand over the Internet, it is important for the [journal title/acronym] readers to understand this technology and its benefits. This study gives a real-life example of how to use mobile agents for distributed network management. It is the first in the literature that reports the analysis of network performance based on an operational prototype of mobile agent-based distributednetwork. We strongly believe the contribution of this study warrants its publication in the [journal title/acronym].4. Names, addresses, and email addresses of four expert referees.Prof. Dr. William GatesChair Professor of Information Technology321 Johnson HallPremier University Lancaster, NY 00012-6666, USAphone: +1-888-888-8888 - fax: +1-888-888-8886 e-mail: wgates@Expertise: published a related paper ("TCP/IP and OSI: Four Strategies for Interconnection") in CACM, 38(3), pp. 188-198.Relationship: I met Dr. Gate only once at a conference in 1999. I didn't know him personally. Assoc Prof. Dr. John AdamsDirector of Network Research CenterCollege of Business Australian University123, Harbor Drive Sydney,Australia 56789phone: +61-8-8888-8888 - fax: +61-8-8888-8886e-mail: jadams@.auExpertise: published a related paper ("Creating Mobile Agents") in IEEE TOSE, 18(8), pp. 88-98. Relationship: None. I have never met Dr. Adams.Assoc Prof. Dr. Chia-Ho ChenChair of MIS DepartmentCollege of ManagementOpen University888, Putong RoadKeelung, Taiwan 100phone: +886-2-8888-8888 - fax: +886-2-8888-8886e-mail: chchen@.twExpertise: published a related paper ("Network Management for E-Commerce") in IJ Electronic Business, 1(4), pp. 18-28.Relationship: Former professor, dissertation chairman.Mr. Frank YoungPartner, ABC Consulting888, Seashore HighwayWon Kok, KowloonHong Kongphone: +852-8888-8888 - fax: +852-8888-8886e-mail: fyoung@Expertise: Mr. Young provides consulting services extensively to his clients regarding network management practices.Relationship: I have worked with Mr. Young in several consulting projects in the past three years.Finally, this paper is our original unpublished work and it has not been submitted to any other journal for reviews.Sincerely,Johnny Smith。

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重组anti-CD20 scFv/CD80/CD28/ζ非复制型逆转录病毒的构建及其在Jurkat细胞株中的表达*胡永仙1，俞康1△，谭映霞2，沈志坚1，钱红兰1，梁彬1，单大铭3(1.温州医学院附属第一医院血液内科，2.医学科学研究所，浙江温州 325000；3.美国华盛顿大学Bio-Rad实验室主任)【摘要】目的：构建表达anti-CD20 scFv/CD80/CD28/ζ重组非复制型逆转录病毒，转染Jurkat 细胞株使其表达目的蛋白。

方法：采用DNA重组技术把pBULLET上的CD28-ζcDNA插入到已含anti-CD20 scFv/CD80的真核逆转录病毒载体pLNCX质粒上，转染PA 317细胞株，收获上清液获非复制型逆转录病毒，感染NIH 3T3细胞株，用PCR、流式细胞术检测目的基因在NIH 3T3细胞的表达情况，确定病毒滴度。

挑取高滴度的包装细胞株收获病毒,感染Jurkat细胞,经G418筛选细胞，用RT-PCR检测目的基因表达情况。

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重组anti-CD20 scFv/CD80/CD28/ζ非复制型逆转录病毒的构建及其在Jurkat细胞株中的表达*胡永仙1，俞康1△，谭映霞2，沈志坚1，钱红兰1，梁彬1，单大铭3(1.温州医学院附属第一医院血液内科，2.医学科学研究所，浙江温州325000；3.美国华盛顿大学Bio-Rad实验室主任)【摘要】目的：构建表达anti-CD20 scFv/CD80/CD28/ζ重组非复制型逆转录病毒，转染Jurkat细胞株使其表达目的蛋白。

方法：采用DNA重组技术把pBULLET上的CD28-ζcDNA 插入到已含anti-CD20 scFv/CD80的真核逆转录病毒载体pLNCX质粒上，转染PA 317细胞株，收获上清液获非复制型逆转录病毒，感染NIH 3T3细胞株，用PCR、流式细胞术检测目的基因在NIH 3T3细胞的表达情况，确定病毒滴度。

挑取高滴度的包装细胞株收获病毒,感染Jurkat细胞,经G418筛选细胞，用RT-PCR检测目的基因表达情况。