IDO1分子的基本信息
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IFN-γinhibits presentation of atumor/self peptide by CD8α–dendritic cells via potentiation of the CD8α+subset. J. Immunol. 165, 1357–1363 (2000).This report identifies IDO as a mechanism used by mouse regulatory DCs.79. G rohmann, U. et al. CD40 ligation ablates the tolerogenicpotential of lymphoid dendritic cells. J. Immunol. 166,277–283 (2001).80. G rohmann, U. et al. IL-6 inhibits the tolerogenic functionof CD8α+dendritic cells expressing indoleamine 2,3-dioxygenase. J. Immunol. 167, 708–714 (2001).81. G rohmann, U. et al. Functional plasticity of dendriticcell subsets as mediated by CD40 versus B7 activation. J. Immunol. 171, 2581–2587 (2003).This report shows that IDO-mediated suppression can be upregulated or downregulated by signals from the immune system. 82. O’Keeffe, M. et al. Mouse plasmacytoid cells: long-livedcells, heterogeneous in surface phenotype and function,that differentiate into CD8+dendritic cells only after microbial stimulus. J. Exp. 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