DOI：10.16662/ki.1674-0742.2023.29.052维持性血液透析对终末期肾病患者的治疗及临床预后评价王迎春，杨文杰，张智成仙游博爱医院，福建莆田351200［摘要］目的分析终末期肾病患者接受维持性血液透析的治疗效果、临床预后。
方法随机选取2021年1—12月仙游博爱医院收治的80例终末期肾病患者为研究对象，应用随机数表法分为对照组和观察组，包括对照组40例和观察组40例，均接受维持性血液透析治疗，对照组使用低通量血液透析，观察组使用高通量血液透析。
对比两组疗效及预后。
结果观察组临床总疗效（95.00%）高于对照组（77.50%），差异有统计学意义（χ2=5.164，P<0.05）。
两组血肌酐、尿素氮对比，差异无统计学意义（P>0.05）。
治疗后，观察组血清甲状旁腺激素、β2-微球蛋白水平低于对照组，差异有统计学意义（P<0.05）。
两组血钙水平比较，差异无统计学意义（P>0.05）。
治疗后，观察组血磷水平低于对照组，差异有统计学意义（P<0.05）。
观察组并发症发生率为7.50%，低于对照组，差异有统计学意义（χ2=4.500，P<0.05）。
结论应用维持性血液透析治疗终末期肾病患者的临床疗效良好，特别是与低通量血液透析相比，采取高通量血液透析的治疗方式，可以显著提升患者临床预后，改善各种临床指标，降低并发症发生率。
［关键词］终末期肾病；维持性血液透析；临床疗效；钙磷代谢水平；并发症［中图分类号］R5 ［文献标识码］A ［文章编号］1674-0742（2023）10(b)-0052-04Evaluation of the Treatment and Clinical Prognosis of Patients with End-stage Renal Disease by Maintenance HemodialysisWANG Yingchun, YANG Wenjie, ZHANG ZhichengXianyou Boai Hospital, Putian, Fujian Province, 351200 China[Abstract] Objective To analyze the therapeutic effect and clinical prognosis of patients with end-stage renal disease receiving maintenance hemodialysis. Methods A total of 80 patients with end-stage renal disease admitted to Xianyou Boai Hospital from January 2021 to December 2021 were randomly selected as the study objects and divided into con⁃trol group and observation group by random number table method, including 40 cases in the control group and 40 cases in the observation group, all of whom received maintenance hemodialysis treatment. The control group received low-flux hemodialysis, and the observation group received high-flux hemodialysis. The efficacy and prognosis of the two groups were compared. Results The total clinical efficacy of observation group (95.00%) was higher than that of control group (77.50%), and the difference was statistically significant (χ2=5.164, P<0.05). There was no statistically significant difference in serum creatinine and urea nitrogen between two groups after treatment (P>0.05). After treat⁃ment, the serum parathyroid hormone and β2-microglobulin levels in observation group were lower than those in con⁃trol group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in blood calcium level between two groups (P>0.05), After treatment, the blood phosphorus level of the observation group was lower than that of the control group, and the difference was statistically significant (P<0.05). The complication rate of observation group was 7.50%, which was lower than that of control group, and the difference was statistically signifi⁃cant (χ2=4.500, P<0.05). Conclusion The application of maintenance hemodialysis in the treatment of end-stage renal disease patients has good clinical efficacy, especially compared with low-flux hemodialysis, the adoption of high-flux [作者简介] 王迎春（1981-），女，本科，主治医生，研究方向为血液透析。
