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[16] 高广佩.被动操对早产儿体格发育和骨发育的效果研究.北京:北京协和医学院,2016．[17] 李月梅.非营养性吸吮对早产低出生体重儿生长发育的影响研究.天津:天津医科大学,2017:12．[18] 张玉侠.实用新生儿护理学.北京:人民卫生出版社,2016:100．[19] Embleton ND. Early nutrition and lateroutcomes in preterm infants. World REV NUTR Diet, 2013,106(1):26-32.[20] 黑明燕,William WH.早产儿营养的最优化.中国当代儿科杂志,2017,19(1):1-21.[21] Ehre nkranz R A. Early, aggressivenutritional management for very low birth weight infants: what is the evidence?.Seminars in Perinatology, 2007,31(2):48-55.[22] 苗晓.音乐疗法在早产儿护理中应用的研究进展.全科护理,2017,15(7):804-806．[23] 张惠芳,张进军,曾珠,等.早期延续母亲声音接触对早产儿神经行为发育的影响.实用预防医学,2020,27(1):76-78．[24] 王丹华.早产儿营养管理面临的挑战.中华儿科杂志,2012,50(5):321-325．[25] Cor peleijn WE, Kouwenhoven SP,Goudoever JV . Optimal growth of preterm infants. World Review Nutrition Dietetics, 2013,106:149-155.[26] Jardri R, Houfflin-Debarge V, DelionP, et al. Assessing fetal response to maternal speech using a noninvasive functional brain imaging technique. International Journal of Developmental Neuroscience, 2012,30(2): 159-161.[27] 李凤妮,李小容,薛伟世,等.母亲声音刺激对早产儿经口喂养的影响.中国护理管理,2016,16(4):481-485．[28] 乐琼,吴丽芬,黄燕,等.母乳口腔运动联合母亲声音刺激对极低出生体重早产儿喂养效果的影响.护理研究,2018, 32(14):2242-2245．[29] 肖冬素,曾水英,刘春红.母亲声音刺激联合母乳口腔护理对极低出生体重儿经口喂养的影响.医学理论与实践,2019,32 (24):4091-4092．[30] Loewy J, Stewart K, Dassler AM, et al.The effects of music therapy on vital signs, feeding, and sleep in premature infants. Pediatrics, 2013,131(5):902-918.[31] Chorna OD, Slaughter JC, Wang LL, et al. Apacifier-activated music player with mother's voice improves oral feeding in preterm infants. Pediatrics, 2014,133(3):462-468.[32] 李娜.影响早产儿宫外生长发育迟缓相关因素的研究进展.蚌埠:蚌埠医学院, 2014．[33] Steward DK, Pridham KF. Growth patternsof extremely Low-Birth-Weight hospitalized preterm infants. Journal of Obstetric Gynecologic & Neonatal Nursing, 2010, 31(1):57-65.[34] 于果,钟以琳,蒙景雯,等.母亲声音刺激对新生儿脑发育的影响.中华现代护理杂志,2019,25(8):1015-1018．[35] 李倩,涂素华,李雨昕,等.早期听觉刺激干预对NICU早产儿影响的研究现状. 中国护理管理,2020,20(1):136-139．[收稿日期：2020-05-15][修回日期：2020-10-16](编辑：王兰兰 英文编辑：季美华)[摘 要] 目前尚缺乏对脑卒中患者治疗负担的相关研究。
基金项目：国家自然科学基金项目（８１５６０７５８）作者简介：袁铁超（１９９４ １０—），男，硕士研究生在读，研究方向：中医药防治脾胃病研究，Ｅ ｍａｉｌ：ｙｔｃ８５１１６６７＠１６３ ｃｏｍ通信作者：陈国忠（１９７０ ０１—），男，博士，主任医师，研究方向：中医药防治脾胃病研究，Ｅ ｍａｉｌ：ｃｈｅｎｉｎｊｐ＠１６３ ｃｏｍ中医多途径治疗重症急性胰腺炎的研究进展袁铁超１ 陈国忠２ 王 婕１ 欧智海１ 易志忠１ 李璐璐１（１广西中医药大学，南宁，５３０００１；２广西中医药大学第一附属医院脾胃科，南宁，５３００２３）摘要 重症急性胰腺炎（ＳｅｖｅｒｅＡｃｕｔｅＰａｎｃｒｅａｔｉｔｉｓ，ＳＡＰ）是临床常见的急腹症之一，其具有起病急，进展迅速，治疗时间长，费用多，病死率较高等特点，其中医病名有“胃心痛”“脾心痛”“结胸”“阳明腑实证”等。
中医认为重症急性胰腺炎的病因是暴饮暴食、嗜食酒甘辛辣肥厚味，情志不遂或食积蛔虫妄动，以致湿热毒瘀互结，壅滞气机。
目前，中医药被认为可有效治疗重症急性胰腺炎的手段之一，多途径给药方式有中药口服、中药高位保留灌肠、中药外敷以及针灸联合中药等。
关键词 重症急性胰腺炎；中医治疗；研究进展；多途径；中药口服；中药灌肠；中药外敷；针灸ＲｅｓｅａｒｃｈＰｒｏｇｒｅｓｓｏｎｔｈｅＴｒｅａｔｍｅｎｔｏｆＳｅｖｅｒｅＡｃｕｔｅＰａｎｃｒｅａｔｉｔｉｓｂｙＭｕｌｔｉｐｌｅＡｐｐｒｏａｃｈｅｓｏｆＴｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅＭｅｄｉｃｉｎｅＹＵＡＮＴｉｅｃｈａｏ１，ＣＨＥＮＧｕｏｚｈｏｎｇ２，ＷＡＮＧＪｉｅ１，ＯＵＺｈｉｈａｉ１，ＹＩＺｈｉｚｈｏｎｇ１，ＬＩＬｕｌｕ１（１ＧｕａｎｇｘｉＵｎｉｖｅｒｓｉｔｙｏｆＣｈｉｎｅｓｅＭｅｄｉｃｉｎｅ，Ｎａｎｎｉｎｇ５３０００１，Ｃｈｉｎａ；２ＦｉｒｓｔＡｆｆｉｌｉａｔｅｄＨｏｓｐｉｔａｌｏｆＧｕａｎｇｘｉＵｎｉｖｅｒｓｉｔｙｏｆＣｈｉｎｅｓｅＭｅｄｉｃｉｎｅ，Ｎａｎｎｉｎｇ５３００２３，Ｃｈｉｎａ）Ａｂｓｔｒａｃｔ Ｓｅｖｅｒｅａｃｕｔｅｐａｎｃｒｅａｔｉｔｉｓｉｓｏｎｅｏｆｔｈｅｃｏｍｍｏｎａｃｕｔｅａｂｄｏｍｉｎａｌｄｉｓｅａｓｅｓｉｎｃｌｉｎｉｃ，ｗｈｉｃｈｈａｓｔｈｅｃｈａｒａｃｔｅｒｉｓｔｉｃｓｏｆｒａｐｉｄｏｎｓｅｔ，ｒａｐｉｄｐｒｏｇｒｅｓｓ，ｌｏｎｇｔｒｅａｔｍｅｎｔｔｉｍｅ，ｈｉｇｈｃｏｓｔａｎｄｈｉｇｈｍｏｒｔａｌｉｔｙｅｔｃ．Ａｍｏｎｇｔｈｅｍ，ｔｈｅｎａｍｅｓｏｆｄｏｃｔｏｒｓａｎｄｐａｔｉｅｎｔｓｉｎｃｌｕｄｅ“ｓｔｏｍａｃｈｈｅａｒｔａｃｈｅ”，“ｓｐｌｅｅｎｈｅａｒｔａｃｈｅ”，“ｋｎｏｔｔｉｎｇｃｈｅｓｔ”，“Ｙａｎｇｍｉｎｇｆｕｅｍｐｉｒｉｃａｌｅｖｉｄｅｎｃｅ”ｅｔｃ．ＴｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅｍｅｄｉｃｉｎｅｂｅｌｉｅｖｅｓｔｈａｔｔｈｅｅｔｉｏｌｏｇｙｏｆｓｅｖｅｒｅａｃｕｔｅｐａｎｃｒｅａｔｉｔｉｓｉｓｏｖｅｒｅａｔｉｎｇ，ｅｘｃｅｓｓｉｖｅｃｏｎｓｕｍｐｔｉｏｎｏｆｗｉｎｅａｎｄｓｗｅｅｔａｎｄｓｐｉｃｙｈｙｐｅｒｔｒｏｐｈｉｃｔａｓｔｅ，ｅｍｏｔｉｏｎａｌｐａｒａｌｙｓｉｓｏｒｆｏｏｄｐｒｏｄｕｃｔａｓｃａｒｉｓｒａｓｈｎｅｓｓ，ｓｏｔｈａｔｄａｍｐｎｅｓｓａｎｄｈｅａｔｄｅｐｏｓｉｔｉｏｎ，ｓｔａｇｎａｔｉｏｎｏｆｑｉ．Ａｔｐｒｅｓｅｎｔ，ｔｒａｄｉ ｔｉｏｎａｌＣｈｉｎｅｓｅｍｅｄｉｃｉｎｅｉｓｃｏｎｓｉｄｅｒｅｄａｓｏｎｅｏｆｔｈｅｅｆｆｅｃｔｉｖｅｍｅａｎｓｔｏｔｒｅａｔｓｅｖｅｒｅａｃｕｔｅｐａｎｃｒｅａｔｉｔｉｓ．Ｍｕｌｔｉｐｌｅｗａｙｓｏｆｄｒｕｇａｄｍｉｎｉｓ ｔｒａｔｉｏｎｉｎｃｌｕｄｅｏｒａｌａｄｍｉｎｉｓｔｒａｔｉｏｎｏｆｔｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅｍｅｄｉｃｉｎｅ，ｅｎｅｍａｗｉｔｈｈｉｇｈｒｅｔｅｎｔｉｏｎｏｆｔｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅｍｅｄｉｃｉｎｅ，ｅｘｔｅｒ ｎａｌａｐｐｌｉｃａｔｉｏｎｏｆｔｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅｍｅｄｉｃｉｎｅａｎｄａｃｕｐｕｎｃｔｕｒｅｃｏｍｂｉｎｅｄｗｉｔｈｔｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅｍｅｄｉｃｉｎｅ．Ｉｎｔｈｉｓｐａｐｅｒ，ｔｈｅｒｅ ｓｅａｒｃｈｐｒｏｇｒｅｓｓｏｆｔｈｅａｂｏｖｅｍｅｎｔｉｏｎｅｄｔｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅｍｅｄｉｃｉｎｅｍｕｌｔｉ ｃｈａｎｎｅｌｔｒｅａｔｍｅｎｔｏｆｓｅｖｅｒｅａｃｕｔｅｐａｎｃｒｅａｔｉｔｉｓｉｓｒｅ ｖｉｅｗｅｄ．Ｋｅｙｗｏｒｄｓ Ｓｅｖｅｒｅａｃｕｔｅｐａｎｃｒｅａｔｉｔｉｓ；ＴｒｅａｔｍｅｎｔｏｆｔｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅｍｅｄｉｃｉｎｅ；Ｒｅｓｅａｒｃｈｐｒｏｇｒｅｓｓ；Ｍｕｌｔｉ ｃｈａｎｎｅｌ；ＯｒａｌＣｈｉｎｅｓｅｍｅｄｉｃｉｎｅ；ＴｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅｍｅｄｉｃｉｎｅｅｎｅｍａ；ＴｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅｍｅｄｉｃｉｎｅｅｘｔｅｒｎａｌｔｒｅａｔｍｅｎｔ；Ａｃｕｐｕｎｃｔｕｒｅ中图分类号：Ｒ２４２；Ｒ５７６文献标识码：Ａｄｏｉ：１０．３９６９／ｊ．ｉｓｓｎ．１６７３－７２０２．２０２０．１６．０３６ 重症急性胰腺炎（ＳｅｖｅｒｅＡｃｕｔｅＰａｎｃｒｅａｔｉｔｉｓ，ＳＡＰ）是临床常见的急腹症之一，其具有发病急，病情进展迅速，治疗时间长，花费多，病死率较高等特点，一旦发病往往需要立即住院治疗［１］，严重病例也与持续性器官衰竭（呼吸，心血管或肾功能衰竭持续超过４８ｈ且不能自行恢复，可累及一个或多ＳＡＰ个脏器）和全身炎性反应综合征（ＳｙｓｔｅｍｉｃＩｎｆｌａｍｍａｔｏｒｙＲｅｓｐｏｎｓｅＳｙｎｄｒｏｍｅ，ＳＩＲＳ）等全身并发症有关，其中医病名有“胃心痛”“脾心痛”“结胸”“阳明腑实证”等。
103第13卷 第5期 2011 年 5 月辽宁中医药大学学报JOURNAL OF LIAONING UNIVERSITY OF TCMVol. 13 No. 5 May，2011慢性心力衰竭属于中医的“心水”、“心悸”、“喘证”、“水肿”等范畴，祖国医学早在《黄帝内经》中便有对慢性心衰的类似症状的描述，如《素问·逆调论》云：“夫不得卧，卧则喘者，是水气客也。
”慢性心力衰竭是各种心脏疾患发展的终末阶段，其发病率高，治疗棘手，预后较差，病死率较高。
美国心脏协会统计委员会[1]报道65岁以上人群该病发病率为1%，且呈逐年增长趋势。
顾东风等[2]对我国人群慢性心衰的流行病学调查结果显示其患病率为0.9%。
该病65岁以上患者80%男性，70%女性生存期不超过8年[1]。
近年来利用中医药治疗该病取得了较大的进展，对于降低再住院率、病死率，及提高生存质量等方面均有较大的贡献。
兹将近5年来中医药治疗慢性心力衰竭的临床概况综述如下。
1 病因病机慢性心力衰竭的病因复杂，病机多样，因果错杂。
《素问·水热穴论》云：“故水病下为跗肿大腹，上为喘呼，不得卧者，标本俱病”。
《金匮要略·水气病脉证并治》云：“心水者，其人身重而少气，不得卧，烦躁，其人阴肿。
”论述多偏重水饮泛滥。
然多数医家倾向于凡外感、劳累、情绪不畅、先天不足或它脏病变等因，而致心气虚亏，心阳不振，鼓动无力，影响心血运行，日久则痰生瘀成，痰凝血瘀又可郁遏心阳而成本病。
基本病机可概括为正虚邪实，即“气（阳）虚”、“血瘀”、“水停”。
虚以“气”、“阳”虚衰为主，实由“水饮”、“痰瘀”滞于心脉，上凌心肺、外溢肌肤为主。
也有不少医家认为气阴两虚为病机关键。
此外，亦不乏少数医家独树一帜，见解独到，以体内气机升降失常、胸中大气不足进而下陷为切入点。
现将各种理论的代表医家总结如下。
陈可冀[3]以“虚”、“瘀”、“水”统领病机，认为慢性心力衰竭的最根本中医病机为内虚，早期心气心阳亏虚，兼肺气亏虚，随病情发展及病机变化，导致血运无力，血流迟缓瘀滞导致瘀血内停；中期脾阳受损，运化失司，复加肺气亏虚，水道失调畅，水湿内停；后期病久及肾，肾阳虚衰，膀胱气化不利，水液代谢紊乱，水饮泛滥。
Advances in Clinical Medicine 临床医学进展, 2023, 13(10), 16792-16796Published Online October 2023 in Hans. https:///journal/acmhttps:///10.12677/acm.2023.13102351中医药治疗黄褐斑的研究进展姜晓涵黑龙江中医药大学研究生院，黑龙江哈尔滨收稿日期：2023年9月25日；录用日期：2023年10月19日；发布日期：2023年10月24日摘要黄褐斑是一种常见的局限性对称面部色素沉着性皮肤病，严重影响当今女性生活，易诊难治，并对患者心理产生不良影响，已成为当今医学界的研究热点。
中医认为，黄褐斑多因肝郁不畅，阻滞肌肤；或肝肾不足，肾水不能上承滋养面部；或饮食不节，损伤脾胃，湿热内生最后导致黄褐斑。
目前，西医对于黄褐斑的治疗主要以口服苯二酚、维甲酸和激光治疗为主，但是单纯应用西医治疗的疗效并不理想。
近年来，中医疗法作为一种被广泛接受的治疗方法，已被众多临床观察有确切的疗效。
本文在大量文献研究的基础上，对近年来中医药治疗黄褐斑进行综述如下。
关键词黄褐斑，病因，病机，中医药治疗Research Progress in the Treatment ofChloasma with Traditional Chinese MedicineXiaohan JiangGraduate School of Heilongjiang University of Chinese Medicine, Harbin HeilongjiangReceived: Sep. 25th, 2023; accepted: Oct. 19th, 2023; published: Oct. 24th, 2023AbstractChloasma is a common localized symmetrical facial pigmentation skin disease that seriously af-fects women’s daily lives, is easy to diagnose but difficult to treat, and has adverse effects on pa-tients’ psychology. It has become a research hotspot in the medical community today. Traditional Chinese medicine believes that chloasma is often caused by liver stagnation, which blocks the skin;or liver and kidney deficiency, kidney water cannot nourish the face; or improper diet can damage the spleen and stomach, resulting in endogenous dampness and heat, ultimately leading to chloasma.At present, Western medicine mainly treats melasma with oral quinone, retinoic acid, and laser姜晓涵therapy, but the efficacy of solely using Western medicine treatment is not ideal. In recent years, traditional Chinese medicine therapy, as a widely accepted treatment method, has been widely observed in clinical practice with definite therapeutic effects. On the basis of extensive literature research, this article reviews the treatment of chloasma with traditional Chinese medicine in re-cent years as follows.KeywordsChloasma, Etiology, Pathogenesis, Traditional Chinese Medicine TreatmentThis work is licensed under the Creative Commons Attribution International License (CC BY 4.0)./licenses/by/4.0/1. 引言黄褐斑是临床常见的一种获得性色素增加性皮肤病，主要表现为面部色素沉着性皮肤病，常对称分布在前额、面颊等处，多呈现黄褐色斑片，无鳞屑，无瘙痒，边界清楚[1]。
随着社会人口老龄化的加剧,各种老年慢性疾病引起了医务工作者和社会各界的重视,其中7.5%的老年性疾病约为骨骼和肌肉类疾病[1]。
骨质疏松症是一种以骨量降低、骨组织微观结构退化和骨脆性增大为特征的,导致机体易发生微创性骨折的全身性骨骼性疾病。
肌肉减少症多发生于老年人,是一种以全身肌量减少、肌力下降和生理功能衰退等为特点的慢性综合征。
骨量在人体30岁时达到巅峰,然后开始下降,绝经后的女性骨量下降尤为快速;肌肉量在25岁时达到峰值, 40岁后每年肌肉质量会以约1%~2%的速度流失,80岁时肌量已流失约30%,其中肌肉力量和强度的下降速度明显大于肌肉质量[2]。
骨质疏松会增加跌倒的风险;而肌量减少和功能下降,会降低力量,导致活动功能受限,也提高了跌倒和骨折的风险[3]。
因此对“肌少-骨质疏松症”及早进行干预可降低跌倒和骨折的风险。
然而目前对“肌少-骨质疏松症”还没有直接有效的治疗方法,运动营养、干细胞治疗以及分子药物治疗等相关研究成为该病治疗的主要方向。
该文就目前老年人骨质DOI:10.16662/ki.1674-0742.2021.09.196老年人骨质疏松症合并肌少症治疗的研究进展陈周韬1,陈光华2,吴新诱2,谭小艳2,黄贵芝21.广东医科大学研究生院,广东湛江524023;2.广东医科大学附属医院骨科,广东湛江524001[摘要]社会人口老龄化导致许多老年慢性病的患病率逐年上升,而骨质疏松症和肌肉减少症正是与增龄明显相关的退行性疾病。
越来越多的研究表明肌肉和骨骼、肌肉减少症和骨质疏松症之间互相影响,它们使老年人的骨脆性增加和虚弱,导致其功能衰退、跌倒、骨折、住院、丧失独立性和死亡的风险升高,并降低了老年人的生活质量。
近年关于两者发病机制的研究取得了重大进展,但针对“肌少-骨质疏松症”共同靶点的治疗方法和药物比较缺乏。
但有文献表明有效的运动营养、干细胞治疗以及一些分子药物可以同时对肌肉和骨骼产生积极的影响,这些治疗方法都能使老年人发生跌倒及骨折的风险大大降低。
左卡尼汀对男性不育症的治疗进展摘要】男性不育症患者近年来逐渐增多，给社会及很多家庭造成了极大困扰。
大量文献报道左卡尼汀在男性不育症治疗方面具有独到疗效，可以通过改善不育症患者精子质量而增加受孕几率。
本文针对左卡尼汀的主要成分、作用机制及对男性不育症的治疗进展进行综述。
【关键词】左卡尼汀；男性不育症；研究进展【中图分类号】R698 【文献标识码】A 【文章编号】2095-1752（2019）18-0018-02Progress of levocarnitine in the treatment of male infertilityWen Qike,Chen Wenxiong(Correspondingn author)Lingshan No.2 People's Hospital,Qinzhou,Guangxi 535400,China【Abstract】Male infertility has increased gradually in recent years,causing great distress to the society and many families. It has been reported that levocarnitine has a unique therapeutic effect in the treatment of male infertility, which can improve the sperm quality of infertile patients and increase the chance of conception.This article reviews the main components of levocarnitine, the mechanism of action and the progress in the treatment of male infertility.【Key words】Levocarnitine;Male sterility;Research progress据相关部门统计心血管疾病和各种肿瘤以及不孕不育症是现代社会影响人类身心健康的三大卫生问题。
Traditional Chinese Medicine 中医学, 2021, 10(6), 828-834 Published Online November 2021 in Hans. /journal/tcm https:///10.12677/tcm.2021.106115针刺“智三针”穴组治疗AD 轻度认知障碍的 研究进展莫静彤，郑晓燕，唐纯志广州中医药大学，广东 广州收稿日期：2021年10月20日；录用日期：2021年11月16日；发布日期：2021年11月29日摘要 人口老龄化的日益加重使高发病率的阿尔兹海默病备受关注。
近年来，对AD 轻度认知障碍的治疗研究中，针灸治疗因其良好治疗效果逐渐被关注。
其中“靳三针疗法”通过针刺“智三针”改善AD 的轻度认知障碍的研究逐步增多。
总结近年来针刺“智三针”的相关文献，并结合目前研究情况，对针刺“智三针”改善AD 轻度认知障碍的研究进展进行综述，以期为后续该病针灸研究提供一定参考。
关键词针灸，痴呆，自噬Research Progress of “Zhi San Zhen” Acupuncture in the Treatment of AD Mild Cognitive ImpairmentJingtong Mo, Xiaoyan Zheng, Chunzhi TangGuangzhou University of Chinese Medicine, Guangzhou Guangdong Received: Oct. 20th , 2021; accepted: Nov. 16th , 2021; published: Nov. 29th , 2021AbstractThe increasing incidence of aging population has attracted much attention in the high incidence rate of Alzheimer’s disease. In recent years, acupuncture and moxibustion have been paid more and more attention because of their good therapeutic effect in the treatment of mild cognitive im-pairment of AD. Among them, “Jin three-needle” therapy through acupuncture “Zhi San Zhen” to莫静彤等improve AD mild cognitive impairment research gradually increased. This paper summarizes the related literature of acupuncture “Zhi San Zhen” in recent years, and combined with the current research situation, summarizes the research progress of acupuncture “Zhi San Zhen” to improve mild cognitive impairment of AD, so as to provide a certain reference for the follow-up study of acupuncture and moxibustion of the disease.KeywordsAcupuncture, Dementia, AutophagyThis work is licensed under the Creative Commons Attribution International License (CC BY 4.0)./licenses/by/4.0/1. 引言随着社会现代化发展，老年人口急剧增长，老龄化现象日趋严重，老年性疾病的防治已经引起全球的重视，其中阿尔兹海默病(Alzheimer’s disease, AD)的患病人数逐渐增加，患病率呈现上升趋势[1]。
慢性萎缩性胃炎的临床治疗研究进展董秋菊，韩佰花，刘增福菏泽市立医院消化内科，山东菏泽274000[摘要]慢性萎缩性胃炎是常见的消化系统疾病，该疾病的出现与许多因素有关，在诸多关联因素中幽门螺杆菌（helicobacter pylori, Hp）占重要比重，会使患者胃部发生感染进而形成炎症疾病，对于病情严重的患者，发生胃癌的概率会大大增加，对其生命健康造成威胁。
随着临床研究对该疾病治疗探索的深入，更多的方法也不断在临床投入使用。
对于此类疾病患者的治疗，需要从疾病的病理与发生原因展开。
[关键词]萎缩性胃炎；幽门螺杆菌；西药；中医[中图分类号]R573.3 [文献标识码]A [文章编号]2096-1782（2023）04(a)-0185-04 Research Progress in Clinical Treatment of Chronic Atrophic Gastritis DONG QiuYu, HAN Baihua, LIU ZengfuDepartment of Gastroenterology, Heze Municipal Hospital, Heze, Shandong Province, 274000 China [Abstract] Chronic atrophic gastritis is a common digestive system disease, which is associated with many factors, among which Helicobacter pylori (Hp) plays an important role, causing the infection of the stomach and forming in⁃flammatory diseases, and for patients with severe disease, the chance of gastric cancer will greatly increase, threaten⁃ing their lives and health. As clinical research into the treatment of this disease progresses, more methods continue to be used in the clinic. The treatment of patients with this disease needs to start from the pathology and causes of the disease.[Key words] Atrophic gastritis; Helicobacter pylori; Western medicine; Traditional Chinese medicine慢性萎缩性胃炎主要发生在胃黏膜局部，此处的肌肉组织出现萎缩样改变，黏膜层变薄，且黏膜肌层增厚。
第2 2卷第1 2期2020年12月辽宁中医药大学学报JOURNAL OF LIAONING UNIVERSITY OF TCMVol. 22 No. 12D ec.，2020DOI： 10.13194/j.issn.1673-842x.2020.12.046膝骨性关节炎中医药治疗研究进展徐志为，韩杰,余绍涌，邢沙沙，章晓云，刘昊(广西中医药大学附属瑞康医院，广西南宁530011 )摘要：膝骨性关节炎是临床的常见病，多发病。
许多学者运用传统中医特色疗法如中药、针刀、针刺、推拿等治 疗方法对膝骨性关节炎患者进行治疗，取得了良好的临床疗效。
该文查阅中医药治疗膝骨性关节炎的相关文献，主 要对现代医家、学者运用中医传统疗法治疗膝骨性关节炎患者的临床疗效进行了总结，综述膝骨性关节炎的中医药 治疗研究进展..关键词：膝骨性关节炎；中医药；进展中图分类号：R684.3 文献标志码：A文章编号：1673-842X(2020) 12-0205-04R esearch P ro g ress o f T ra d itio n a l C hinese M edicine in th e T re a tm e n t o f K nee O ste o a rth ritis XU Zh iw ei,HAN J i e,YU Shaoyong,XIN G Sh ash a,ZH AN G X iaoyun,LIU Hao(Ruikang Hospital Affiliated to Guangxi University of Chinese M edicine,Nanning53001 1,G uangxi,China )A b s tra c t: Knee osteoarthritis is a common and frequently occurring d ise ase.Many scholars have used the traditional Chinese m edicine characteristic therapies such as Chinese m ed icin e,acupotom y, acupuncture and m assage to treat knee osteoarthritis patients,and achieved good clin ical e fficacy.This paper reviews the literature on the treatment of knee osteoarthritis with traditional Chinese m edicine,mainly summarizes the clinical efficacy of modern doctors and scholars in the treatment of knee osteoarthritis with traditional Chinese m edicine,and summarizes the research progress in the treatment of knee osteoarthritis with traditional Chinese medicine.K e y w o rd s：knee osteoarthritis;traditional Chinese m edicine;progress骨性关节炎（osteoarthritis，OA )是一种进彳了性 退行性关节疾病，累及全身各大关节，其病理改变主要表现为关节软骨损伤、骨赘形成、软骨下骨改变、滑膜炎症和关节囊增生等。
P u b l i s h i n g g r o up Research progress in the treatment of colorectal cancer in classicalprescriptionsShi-Yun Shao 1, 2, Qi Li 1, 2,*1Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai 201203, China. 2Cancer Institute, Shuguang Hospital Affiliated to Shanghai University of TCM ，Shanghai 201203, China.*Correspondence : Qi Li, Department of Oncology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, NO. 189 Pu'an Road,TMR Cancer Traditional Chinese medicine is an important tumor-assisted treatment.Classical formula has a good effect in colorectal treatment, but the mechanism is not clear.Highlights Classical Chinese medicine prescriptions are widely used in cancer treatment. Although obvious therapeutic effects have been observed in clinical practice,laboratory evidence is still lacking. Clinically effective prescriptions maybecome the research direction for the development of cancer therapeutic drugs.CommentsCancerShanghan Zabing Lun , an acient book of Chinese medicine that published in Han dynasty (219 C.E.), is the first monograph in China that has the principles ofprescription and treatment. Modernphysicians flexibly applied many classical prescriptions recorded on this acientd book, such as Banxia Xiexin decoction, Da Chengqi decoction, Yiyi Fuzi Bijiang decoction and Wumei pill for the treatment of colorectal cancer and its complications, and made some progress in clinical and experimental research. Studies have shown that classical prescriptions alone or in combination with other therapies can improve immunity, prevent cancer from recurrence and metastasis, reduce the side effects of anticancer drugs, improve quality of life, and prolong the survival of cancer patients. However, the current clinical and mechanistic studies on the treatment of classical prescriptions still need to explore in depth.This study aims to summarize the clinical and research progress in the treatment of colorectal cancer with classical prescriptions in recent years.Keywords: Classical prescription, Colorectal cancer, Traditional Chinese medicineAbstractTMR CancerReviewhttps:///cancerIntroductionThe incidence of colorectal cancer ranks third in the world [1]. In China, the incidence and mortality of colorectal cancer are increasing year by year [2-3]. Although the survival rate of patients with colorectal cancer has improved with the rapid progress of surgery, chemotherapy and biological therapy, patients with advanced colorectal cancer still have a high probability of recurrence, metastasis or drug resistance. Currently, the average survival rate of patients with advanced colorectal cancer is only about 30 months [4-5]. Traditiona Chinese medicine (TCM) is one of the effective methods for comprehensive treatment of colorectal cancer and is supported by clinical evidence. The application of TCM adjuvant therapy can synergistically inhibit tumor growth, significantly reduce complications and side effects caused by surgery, radiotherapy, and chemotherapy, improve chemotherapy tolerance, enhance human immunity, improve patient prognosis, and prevent recurrence and metastasis [6]. The Han dynasty doctor Zhang Zhongjing's Shanghan Zabing Lun( an acient book of China, 219 C.E.) is the first monograph in China that has the principles of prescription and treatment. The book contains a total of 280 prescriptions, and the prescriptions have the characteristics of refining and strict prescription. The symptoms of colorectal cancer and its complications are complicated, and modern medical doctors have applied chemistries to treat colorectal cancer and its complications, often achieving good results. This article will discuss the research progress of the treatment of colorectal cancer and its related complications from the clinical application and mechanism research.TCM understanding of colorectal cancer Ancient Chinese medicine did not directly record the name of colorectal cancer. Combined with its clinical symptoms, colorectal cancer can be attributed to the category of Jiju recorded in TCM theory, both have the same symptoms of abdominal pain and blood in stool. Ancient books of TCM have a long history to discuss this disease. "Huangdi Neijing" (an acient book of China, unknown time) and “Lingshu Wubian” (an acient book of China, unknown time) contain the description of colorectal cancer. The clinical practice of the past doctors believes that the etiology and pathogenesis of colorectal cancer mostly rely on positive Qi (a vital force that form part of living entity in traditional Chinese culture) deficiency as an internal cause and the invasion of external evils is an external cause. The poisonous toxicosis is in the intestinal tract, and the sputum is not scattered for a long time, and thus the tumor is formed. The pathological changes are mainly Yu, Du, Tan, and Xu (some pathological products resulted from disease in TCM theory). During the Ming 1636-1912, C.E.), the theory and practice of TCM in the treatment of colorectal cancer became more mature [7].Such as "Jing Yue Quanshu-Jiju(an acient book of China, 1624 C.E.)" described that patient with low immunity have an increased incidence of cancer. Early colorectal cancer has no obvious symptoms. In the late stage, there is mainly increased the frequency of bowel movements, diarrhea or constipation, bloody or mucusin the stool, abdominal pain, abdominal distension, abdominal mass, and other gastrointestinal symptoms.Research progress in the treatment of colorectal cancer with classical prescriptionsBanxia Xiexin decoction"Shanghan Zabing Lun "( an acient book of China, 219C.E.) described that patient with colorectal cancer generally have bloating, but no symptoms of abdominal pain. Changes in vomiting and bowel sounds can also accompany it. The causes of colorectal cancer are complex, and most of them are cold and hot, and theyare mixed. Banxia Xiexin decoction reflects the combination of cold and heat and Yin and Yang (a concept of dualism that describing opposite forces thatmay be interdependent and give rise to each other inTCM culture) characteristics. It is mainly used in the syndrome of cold and heat, and to regulate the gastrointestinal dysfunction [8]. Clinically, it is oftenused to reduce adverse reactions after surgery and radiotherapy and chemotherapy. Li Yingjie et al. [9] treated 140 patients with colorectal cancer accompaniedby postoperative gastrointestinal dysfuction with Banxia Xiexin decoction, the control group used conventional medical symptomatic supportive treatment. The results showed that the serum CEA level in the treatment groupwas lower than that in the control group, and the difference was statistically significant. The clinicaleffect was better than the control group. Common toxicand side effects after chemotherapy for colorectal cancer include systemic fatigue, limb weakness, gastrointestinal dysfunction, oral mucositis, neurotoxicity, leukopenia, thrombocytopenia, and other myelosuppressive symptoms. The symptoms of gastrointestinal dysfunction caused by it are similar tothe Tan syndrome (a type of pathological products resulted from disease) of Chinese medicine theory. Besides, Banxia Xiexin decoction combined with chemotherapy can prevent and reduce the gastrointestinal toxicity caused by chemotherapy, andalso has a certain effect on chemotherapy-related oral mucositis. Wang Jian et al. [10] used Banxia Xiexin decoction to treat the digestive tract reaction caused by chemotherapy in rectal cancer. The control group received routine vomiting treatment. The treatmentgroup received oral Banxia Xiexin decoction 3 days before chemotherapy based on the control group. The effective rate of the treatment group for nausea and vomiting was 90.3%, which was much higher than thathttps:///cancerTMR Cancer TMR CancerXiexin decoction to prevent chemotherapy-related oral mucositis. The incidence of ≥ grade 2 oral mucositis in the treatment group was 48.8%, and the median duration was 5.5 days. While the incidence was 57.4%, and the median duration was 10.5 days in the control group. This study shows that Banxia Xiexin decoction may shorten the healing time of the oral mucosa. Besides, studies [13] have shown that Banxia Xiexin decoction can resist inflammation and anti-oxidation, and has a good protective and regulating effect on the digestive system. These results indicate that colorectal cancer plays an important role in reducing the toxic and side effects after chemotherapy.Da Chengqi decoctionIntestinal obstruction is a common complication of postoperative colorectal cancer with main symptoms of abdominal distension, abdominal pain, nausea and vomiting, and constipation. Zhu Huanhuan et al. [14] used preoperative Da Chengqi decoction and 5% dextrose sodium chloride injection plus potassium chloride to prevent postoperative intestinal obstruction in patients with colorectal cancer. The control group received traditional bowel preparation before surgery. The results showed that the treatment group had an effective rate of 90.2%, and the average anal exhaust (stomach tube removal) time was significantly shortened. After 72 hours, the peripheral blood CRP treatment group was lower. Wei Nan [15] used the addition and subtraction treatment of 41 patients with acute intestinal obstruction after colon cancer surgery. Compared with Western medicine routine symptomatic treatment of intestinal cancer with acute intestinal obstruction, the results showed that the treatment group gastrointestinal decompression the flow rate was significantly less than the control group. Yu Hailong et al. [16] treated 115 patients with colon cancer who received surgery were randomly divided into Da Chengqi decoction group and control group, and the control group received routine treatment. After one week, the incidence of abdominal distension in Da Chengqi decoction group was 7.94%, which was significantly lower than that of the control group (30.56%). Moreover, the Da Chengqi decoction group recovered faster and had a lower incidence of postoperative complications. Li Zhiju et al. [17] used Da Chengqi decoction in the treatment of colorectal cancer with intestinal obstruction, Da Chengqi decoction group in the improvement of clinical symptoms such as abdominal distension, bloating and defecation were significantly better than the conventional control group. The curative effect was exact, and the total effective rate was 93.94%, which was significantly better than the control group (70.97%). Clinical practice has proved that Da Chengqi decoction may improve the function of intestinal fistula, improve intestinal microenvironment, significantly increase gastrointestinal blood flow, reduce intestinal capillary Chengqi decoction may have the function of reducing adhesion, and relieve postoperative intestinal obstruction in patients with colorectal cancer.Yiyi Fuzi Baijiang decoctionYiyi Fuzi Baijiang decoction has the function of reducing the volume of the mass. Du Yanlin et al. [18] treated 33 patients with colorectal cancer using YiyiFuzi Baijiang decoction combined with FOLFOX4 chemotherapy. Compared with the chemotherapy group,the results showed that the toxic side effects after chemotherapy were significantly reduced combinedwith Yiyi Fuzi Baijiang decoction. Professor Liu Shangyi and Tong Xiaolin [19-20] used this method in clinical practice to treat patients with an abnormal stoolafter bowel cancer surgery. Chen Lingling [21] and others also found that Yiyi Fuzi Baijiang decoctionmight regulate the number of intestinal flora and reducethe levels of inflammatory factors IL-6, thus reducingthe inflammation reaction.Wumei pillWumei pill now is used by clinicians to treat diarrhea, constipation, and bloating in patients with colorectal cancer. Li Zhiming et al. [22] used Wumei pill for the treatment of colorectal cancer during the rehabilitationof gastrointestinal tract dysfunction. Professor Jiang Shiqing et al. [23] summarized that Wumei pill may significantly reduce the occurrence of postoperative complications. Zhang Ran et al. [24] also observed thatin the mouse model of colon cancer, a modified Wumeipill might inhibit the progression of the tumor throughWnt/JNK pathway, and significantly reduce the expression levels of Wnt, JNK protein and mRNA incolon cancer model mice. The Wnt/JNK pathway regulates cytoskeletal rearrangement during embryonic development and participates in gastrulation. Studieshave shown that Wnt and JNK proteins are highly expressed in colonic atypical hyperplasia tissues andcolon cancer tissues, and can be targeted for tumor therapy.Huangqin decoctionHuangqin decoction is widely used in the treatment of nausea and vomiting caused by digestive tract diseases, abdominal pain, and diarrhea. Chemotherapy-associated diarrhea is a common side-effect of the digestive tractafter chemotherapy in patients with colorectal cancer.Yu Yang et al. [25] treat 72 patients with colorectal cancer who received FOLFIRI chemotherapy. The results showed that the incidence of delayed diarrhea inthe Huangqin decoction group was 29.41%, which was significantly lower than that of the chemotherapy alonegroup (57.89%). Moreover, the adverse reactions in the control group also decreased significantly. Liu Dongyanet al. [26] use Huangqin decoction combined with Mengtuoshi (montmorillonite) powder to prevent the treatment of delayed diarrhea caused by irinotecan, 100https:///cancerTMR Cancer TMR Cancerchemotherapy were randomly divided into combination group and chemotherapy group. It was observed that the incidence of diarrhea and the duration of diarrhea in the combination group were lower than those in the chemotherapy group. Chen et al. [27] found that Huangqi decoction might resist oxidation, inhibit the production of inflammatory factors, repair the intestinal mucosal damage of the blind colon, thereby playing a role in the treatment and prevention of diarrhea in the animal models. The research team at Yale University developed the phytopharmaceutical PHY906 based on Huangqi decoction and conducted long-term experimental research. Professor Zheng Yongqi's team [28] studied the mouse model of allograft colon cancer and studied the effect of PHY906 on chemotherapeutic drugs. The mice in the experimental group were intragastrically administered with PHY906 and compared with the mice that were not treated with gavage. The results suggest that PHY906 may enhance the anti-tumor activity of chemotherapy and reduce the side effects of irinotecan. PHY906 works well in Phase I/II clinical trials. Compared with placebo plus chemotherapy, patients with PHY906 combined with chemotherapy had fewer life-threatening (grade 4) adverse events and a lower overall incidence of grade 3 or 4 diarrhea [29-32]. The research of PHY906 provides a good example for Chinese medicine to treat colorectal cancer, which brings new opportunities for Chinese medicine to fight cancer.Xiao Chaihu decoctionXiao Chaihu decoction plays an important role in the treatment of cancer fever. Dai Chunshan [33] et al. used Xiao Chaihu decoction alone to treat 48 cases of cancerous fever in the elderly, including 12 cases of liver cancer, 19 cases of lung cancer, 5 cases of pancreatic cancer, 4 cases of gallbladder cancer, 5 cases of colon cancer, 3 cases of gastric cancer, and the efficient rate was 81.25% and no obvious side effects were observed. Also, Professor Li Qi et al. [34] used Xiao Chaihu decoction and Sini decoction to treat postoperative oral ulcers in rectal cancer. Xu Bin et al.[35] demonstrated that Xiao Chai Hu detoction might increase intestinal alkaline phosphatase activity, promote lipid transport and lipid absorption, and inhibit fat accumulation, thereby inhibiting the proliferation of HCT-116 cancer cells. The mechanisms of Xiao Chaihu decoction immunomodulation and direct tumor suppression are also further clarified.Sini decoctionSini decoction may play an essential role in thrombocytopenia after radiotherapy and chemotherapy of patients with colorectal cancer. Wu Zhanxi et al. [36] demonstrated that the effect of Sini decoction on thrombocytopenia after chemotherapy, 78 patients with colorectal cancer who had thrombocytopenia after chemotherapy were randomly divided into control given recombinant human interleukin-11 treatment, the treatment group was treated with Sini decoction, and the course of treatment was 2 weeks. Results showed thatthe platelet rise, the platelet count and hemoglobin,white blood cell index in the treatment group was significantly higher than the control group. It is confirmed that Sini decoction can increase IL-6 secretion, regulate immunity by promoting the production of antibodies by spleen cells, promote the proliferation of hematopoietic stem cells, and increasethe production of platelets in patients.ConclusionColorectal cancer is a chronic disease that the pathogenic mechanism is not yet clear. It has different manifestations at different stages of disease development. The prescription plays a role in the prevention and treatment of tumors from multiple targets. It is often used alone or in combination withother modern conventional therapies. It has the following advantages: (1) improve immunity and prevent cancer from recurrence and metastasis; (2) to alleviate the toxic side effects of anticancer drugs; (3) to alleviate the symptoms of patients, improve the qualityof life, and prolong the survival of patients with cancer.In recent years, the application of prescription for the treatment of colorectal cancer and its related diseaseshas been extensive and clinically effective. However,the following problems still exist: (1) syndrome differentiation, treatment, and efficacy evaluation of colorectal cancer in TCM are not the same; (2) at present, there are many medical treatments for colorectal cancer, but there is a lack of large-scale randomized, double-blind TCM clinical trials to evaluate and confirm the efficacy of single and combined treatments for colorectal cancer, and lack ofmore reliable medical evidence; (3) lack of safety assessment and efficacy evaluation system for treatment;(4) the study of the mechanism, pharmacology, and compatibility of colorectal cancer is still in the preliminary exploration stage and needs further study. Itis believed that with the continuous deepening of research in the field of anti-tumor, the prescription canfully exert its advantages and overcome its drawbacks.The field of Chinese medicine prevention and treatmentof cancer will also open up a broader road.Reference1.Siegel RL, Miller KD, Jemal A. 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