宝丽亚说明书

1.IDENTIFICATION OF THE SUBSTRANCE/PREPARATION AND THECOMPANY/UNDERTAKINGPOSITION/INFORMATION ON INGREDIENTS3.HAZARDS IDENTIFICATIONMaterial Safety Data SheetRevision Date:February 23,2018Product code LT005,LT006Product name Lenti-Pac™HIV qRT-PCR Titration KitsContact manufacturer GeneCopoeia,Inc.9620Medical Center Drive,Suite 101Rockville,MD 20850USAPhone:301-762-0888Toll free:1-866-360-9531Fax:301-762-3888Chemical Name CAS-No Weight %Phenol108-95-230-60Guanidine isothiocyanate 593-84-015-40Ammonium thiocyanate 1762-95-47-13Glycerol56-81-540-70Contact with acids or bleach liberates toxic gases.DO NOT ADD acids or bleach to any liquid wastes containing this product.We recommend handling all chemicals with caution.GHS –Classification Signal Word DANGERHealth HazardsAcute oral toxicity Category 4Acute dermal toxicityCategory 4Acute Inhalation Toxicity -Vapors Category 4Skin corrosion/irritationCategory 1B Serious eye damage/eye irritationCategory 1Specific target organ systemic toxicity (single exposure)Category 3Specific target organ systemic toxicity(repeated exposure)Category3Mutagenicity Mutagenic category2Physical hazardsNot hazardousHazard StatementsH314-Causes severe skin burns and eye damageH341-Suspected of causing genetic defectsH373-May cause damage to organs through prolonged or repeated exposureH412-Harmful to aquatic life with long lasting effectsH302-Harmful if swallowedH312-Harmful in contact with skinH332-Harmful if inhaledH335-May cause respiratory irritationPrecautionary StatementsP301+P312-IF SWALLOWED:Call a POISON CENTER or doctor/physician if you feel unwellP304+P340-IF INHALED:Remove victim to fresh air and keep at rest in a position comfortable for breathingP301+P330+P331-IF SWALLOWED:rinse mouth.Do NOT induce vomitingP303+P361+P353-IF ON SKIN(or hair):Remove/Take off immediately all contaminated clothing.Rinse skin withwater/showerP305+P351+P338-IF IN EYES:Rinse cautiously with water for several minutes.Remove contact lenses,if present and easy to do.Continue rinsingP310-Immediately call a POISON CENTER or doctor/physicianP308+P313-IF exposed or concerned:Get medical advice/attentionP273-Avoid release to the environmentP280-Wear protective gloves/protective clothing/eye protection/face protectionPrinciple Routes of ExposurePotential Health EffectsEyes Causes burns.Risk of serious damage to eyes.Corrosive to the eyesand may cause severe damage including blindness.Skin Causes burns.Possible risk of irreversible effects.Harmful in contactwith skin.Irritating to skin and mucous membranes.Inhalation Harmful by inhalation.Ingestion Harmful if swallowed.Ingestion causes burns of the upper digestive andrespiratory tracts.Ingestion may cause gastrointestinal irritation,nausea,vomiting and diarrhea.Specific effectsCarcinogenic effects Phenol has been classified by the International Agency for Research onCancer(IARC)as not classifiable as to carcinogenicity to humans(Group3).Mutagenic effects Not ApplicableReproductive toxicity Not ApplicableSensitization Not ApplicableTarget Organ Effects SkinLungsLiverSpleenKidney4.FIRST AID MEASURES5.FIRE-FIGHTING MEASURES6.ACCIDENTAL RELEASE MEASURES7.HANDLING AND STORAGEHMISHealth 3*Chronic HazardFlammability 1ReactivitySkin contact Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes.Call a physician immediately.Eye contactIF IN EYES:Rinse cautiously with water for several minutes.Remove contact lenses,if present and easy to do.Continue rinsing.Rinseimmediately with plenty of water,also under the eyelids,for at least 15minutes.Call a physician immediately.Ingestion Call a physician or poison control center immediately.Rinse mouth.Do not induce vomiting without medical advice.Never give anything by mouth to an unconscious person.InhalationRemove to fresh air.Call a physician or poison control center immediately.Notes to physicianTreat symptomatically.Suitable extinguishing media Dry chemical.Carbon dioxide (CO2).Water spray.Foam.Special protective equipment for firefightersWear self-contained breathing apparatus and protective suit.Australia HazChem Code2XPersonal precautionsELIMINATE all ignition sources (no smoking,flares,sparks or flames in immediate area).Use personal protection equipment.Avoid contact with skin,eyes or clothing.Ensure adequate ventilation.Keep people away from and upwind of spill/leak.Evacuate personnel to safe areas.Methods for cleaning upPrevent product from entering drains.Soak up with inert absorbentmaterial.Neutralize spill with slaked lime,sodium bicarbonate or crushed limestone.Collect powdered material and deposit in sealed containers and dispose of phenol as hazardous waste.Isolate area and deny entry.Environmental precautionsPrevent further leakage or spillage if safe to do so.Prevent product from entering drains.Do not allow material to contaminate ground water system.See Section 12for more information8.EXPOSURE CONTROLS /PERSONAL PROTECTIONHandling Always wear recommended Personal Protective Equipment.Avoid contact with skin,eyes or clothing.Remove all sources of ignition.StorageKeep containers tightly closed in a cool,well-ventilated place.Keep away from heat,sparks,flame and other sources of ignition (i.e.,pilot lights,electric motors and static electricity).Protect from sunlight.Exposure limitsChemical name OSHA PELOSHA PEL (Ceiling)ACGIH OEL (TWA)ACGIH OEL (STEL)Phenol5ppm 19mg/m 3None 5ppm None Guanidine isothiocyanate None None None None Ammonium thiocyanate 5mg/m 3None None None Glycerol15mg/m 3None10mg/m 3NoneEngineering measures Use in a chemical fume hoodPersonal protective equipmentPersonal Protective Equipment requirements are dependent on the user institution's risk assessment and are specific to the risk assessment for each laboratory where this material may be used.Respiratory protection In case of insufficient ventilation wear suitable respiratory equipment RespiratorUp to 50ppmRecommendations,National Institute of Occupational Safety and Health,U.S.(APF =10)Any air-purifying half-mask respirator with organic vaporcartridge(s)in combination with an N95,R95,or P95filter.The following filters may also be used:N99,R99,P99,N100,R100,P100.(APF =10)Any supplied-air respirator Up to 125ppm:(APF =25)Any supplied-air respirator operated in a continuous-flow mode.(APF =25)Any powered air-purifying respirator with an organic vapor cartridge in combination with a high-efficiency particulate filter.Up to 250ppm:(APF =50)Any air-purifying full-facepiece respirator equipped with organic vapor cartridge(s)in combination with an N100,R100,or P100filter.(APF =50)Any air-purifying,full-facepiece respirator (gas mask)with a chin-style,front-or back-mounted organic vapor canister having an N100,R100,or P100filter.(APF =50)Any powered,air-purifying respirator with a tight-fitting facepiece and organic vapor cartridge(s)in combination with a high-efficiency particulate filter.(APF =50)Any self-contained breathing apparatus with a full facepiece.(APF =50)Any supplied-air respirator with a full facepiece.Emergency or planned entry into unknown concentrations or IDLH conditions:(APF =10,000)Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode.9.PHYSICAL AND CHEMICAL PROPERTIES10.STABILITY AND REACTIVITY11.TOXICOLOGICAL INFORMATION(APF =10,000)Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus.Escape:(APF =50)Any air-purifying,full-facepiece respirator (gas mask)with a chin-style,front-or back-mounted organic vapor canister having an N100,R100,or P100filter./Any appropriate escape-type,self-contained breathing apparatus.Hand protectionImpervious gloves.S24-Avoid contact with skin.S36-Wear suitable protective clothing.Eye protectionTight sealing safety goggles.Skin and body protection Impervious clothing.Hygiene measuresContaminated work clothing should not be allowed out of the workplace.Avoid contact with skin,eyes or clothing.Handle in accordance with good industrial hygiene and safety practice.Environmental exposure ControlsPrevent product from entering drains.General information FormLiquid.Appearance Red,maroon.OdorMedicinal,sweet,tar-like.Boiling point/range °C No data available °F No data available Melting point/range °C No data available °F No data available Flash point°C No data available °F No data available Autoignition temperature °C No data available °F No data availableOxidizing properties No information available Water solubilitySolubleStabilityStable under normal conditions.Materials to avoidStrong oxidizing agents.Strong acids.Isocyanates.Heat.Nitriles,Nitrides.Alkaline earth metals.Strong oxidizers,alkali metals and alkaline earth metals may cause fires or explosions.Hazardous decomposition Toxic gas.Sulphur oxides.Hydrogen cyanide (hydrocyanic acid).Carbon oxides,ProductsNitrogen Oxides.PolymerizationHazardous polymerization does not occur.Acute toxicityChemical name LD50(oral,rat/mouse)LD50(dermal,rat/rabbit)LC50(inhalation,rat/mouse)Phenol=317mg/kg (Rat)No data available =316mg/m3(Rat)Guanidine isothiocyanate571mg/kg2000mg/kg5.319mg/L (4H)12.ECOLOGICAL INFORMATIONAmmonium thiocyanate =500mg/kg (Rat)No data available No data available Glycerol =12600mg/kg (Rat)No data available No data availablePrinciple Routes of Exposure Potential Health Effects Eyes Causes burns.Risk of serious damage to eyes Corrosive to the eyes and may cause severe damage including blindness.Skin Causes burns.Possible risk of irreversible effects Harmful in contact with skin.Irritating to skin and mucous membranes.Inhalation Harmful by inhalationIngestionHarmful if swallowed Ingestion causes burns of the upper digestive and respiratory tracts Ingestion may cause gastrointestinal irritation,nausea,vomiting and diarrheaCarcinogenic effects Phenol has been classified by the International Agency for Research on Cancer (IARC)as not classifiable as to carcinogenicity to humans (Group 3).Mutagenic effects No information available.Reproductive toxicity No information available.SensitizationNo information available.Target organ effectsSkin.Lungs.Liver.Spleen.Kidney.EcotoxicityHarmful to aquatic organisms,may cause long-term adverse effects in the aquatic environment.Chronic aquatic toxicity Category 3MobilitySee log PowBiodegradation Inherently biodegradable Bioaccumulation No information availableChemical name Freshwater algae data Water flea data Freshwater fish species dataMicrotox dataLog Pow PhenolDesmodesmusDaphnia magna =316mg/m3(Rat)logPow1.subspicatus EC50187EC5047-279mg/L (72h) 4.24-10.7mg/L Pseudokirchneriella (48subcapitata EC50h)Daphnia 46.42mg/L (96h)magnaEC5010.2-15.5mg/L (48h)13.DISPOSAL CONSIDERATIONS14.TRANSPORT INFORMATION15.REGULATARY INFORMATIONGlycerolDaphnia magna EC50>500mg/L (24h)logPow1.76Dispose of contents/containers in accordance with local regulations.IATAProper shipping name Corrosive liquid,n.o.s.(guanidine thiocyanate-phenol solution).Hazard Class 8Subsidiary class None Packing group II UN-No 1760ERG Code153ComponentTSCA Phenol,108-95-2(30-60)Listed Guanidine isothiocyanate,593-84-0(15-40)Listed Ammonium thiocyanate 1762-95-4(7-13)Listed Glycerol,56-81-5(40-70)ListedUS Federal Regulations SARA 313This product contains the following toxic chemical(s)subject to the notification requirements of section 313of Title III of the Superfund Amendments and Reauthorization Act of 1986.This law requires certain manufacturers to report on annual emissions of specified chemicals and chemical categories.Please note that if you repackage,or otherwise redistribute,this product to industrial customers,a notice similar to this one should be sent to those customers:Chemical name CAS-No.Weight %SARA 313-Threshold values Phenol108-95-230-60 1.0Ammonium thiocyanate1762-95-47-131.0Clean Air Act,Section 112Hazardous Air Pollutants (HAPs)(see 40CFR 61)This product contains the following HAPs:Component CAS-No.Weight %HAPS data Phenol108-95-230-60PresentAmmonium thiocyanate1762-95-47-13Present (XCN where X=H or any16.OTHER INFORMATIONother group where a formal dissociation may occur.For example KCN or Ca[CN]2)US state regulations Chemical name Massachusetts -RTK New Jersey-RTK Pennsylvania-RTK Illinois-RTK Rhode Island-RTK PhenolListed Listed Listed Listed Listed Guanidine isothiocyanate -----Ammonium thiocyanate Listed -Listed Listed Listed GlycerolListed-Listed-ListedCalifornia Proposition 65This product does not contain any Proposition 65chemicals.WHMIS Hazard Class D1A -Very toxic materials E -Corrosive materialThis product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR)and the MSDS contains all the information required by the CPR.Reason for revision Not Applicable.SDS sections updated.For research use only."The above information was acquired by diligent search and/or investigation and the recommendations are based on prudent application of professional judgment.The information shall not be taken as being all inclusive and is to be used only as a guide.All materials and mixtures may present unknown hazards and should be used withcaution.Since the Company cannot control the actual methods,volumes,or conditions of use,the Company shall not be held liable for any damages or losses resulting from the handling or from contact with the product as described herein.THE INFORMATION IN THIS SDS DOES NOT CONSTITUTE A WARRENTY,EXPRESSED OR IMPLIED,INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PUPOSE"End of Safety Data Sheet。

2022年度Q2产品、合规及药物警戒知识考试您的姓名： [填空题] *_________________________________1. 以下哪项合规政策与RDPAC准则的相关规定最贴近？（） [单选题] *A.《合规指导手册》B.《药品推广行为准则》(正确答案)C.《推广活动执行指南》D.《推广活动标准操作流程》2. 下列哪些人员不属于医疗卫生专业人士？（） [单选题] *A.医疗、药剂或护理领域专业人员B.可开具处方的人员C.可推荐、采购、供应药品的人员D.医院的护工(正确答案)3. 新一代喹诺酮西他沙星的Slogan是：（） [单选题] *A.新一代必杀G(正确答案)B.G+感染的理想新选择C.无氟，全新选择D.社区获得性感染治疗经验之选4. 西他沙星给药48小时内，约（）的给药量以原型从尿液中排出 [单选题] *A.100%B.80%C.70%(正确答案)D.50%5. 奈诺沙星（太捷信）批准的适应症包括：（） [单选题] *A.尿路感染B.AECOPDC.CAP(正确答案)D.其他选项都对6. 按常规治疗剂量，西他沙星和奈诺沙星的日治疗费用分别是？（） [单选题] *A.9.8元和16.2元B.19.6元和32.4元(正确答案)C.9.8元和32.4元D.19.6元和16.2元7. 新一代喹诺酮西他沙星的对于AECOPD/支扩感染中哪一类主要致病菌的杀菌效果优于环丙沙星：（） [单选题] *A.肺炎链球菌B.大肠杆菌C.铜绿假单胞菌(正确答案)D.肺炎支原体8. 西他沙星常见的不良反应不包括（） [单选题] *A.腹泻B.QT间期延长(正确答案)C.头痛D.松软便9. 在感染领域，MIC通常指（） [单选题] *A. 最小抑菌浓度(正确答案)B. 最小杀菌浓度C. 最大抑菌浓度D. 最小生长浓度10. 关于乐松®贴剂在人体的药代学情况，说法正确的是（） [单选题] *A.乐松经皮吸收后，无法在皮肤和肌肉组织中转化为活性代谢物B.洛索洛芬钠进入血液循环后，大部分进入肾脏，之后以原型形式排出体外C.洛索洛芬钠及其活性代谢物在骨骼肌中的浓度比例高于皮肤(正确答案)D.治疗剂量下的洛索洛芬钠可能会抑制P450酶底物的代谢11. 关于乐松®贴剂的特殊人群用药，下列说法正确的是（） [单选题] *A.8岁以上儿童可安全使用B.65岁以上老人使用时应密切注意贴敷部位的皮肤情况(正确答案)C.妊娠妇女可安全使用D.哺乳期妇女可安全使用12. 关于洛索洛芬钠，说法不正确的是（） [单选题] *A.洛索洛芬钠为丙酸类前体药物B.洛索洛芬钠为非选择性NSAIDs类药物C.洛索洛芬钠具有抗炎、镇痛、解热等作用，尤其镇痛作用很强D.洛索洛芬钠在体内不经转化就可有抗炎、镇痛、解热等药理作用(正确答案)13. 乐松®的作用机制是在体内通过抑制（）的活性起到镇痛、抗炎、解热作用的[单选题] *A.前列腺素B.环氧化酶(正确答案)C.白介素D.血栓素14. NSAIDs类药物的临床用途包括（） [单选题] *A.风湿性疾病和慢性炎症性关节炎的治疗B.运动性损伤的治疗C.疼痛治疗和解热D.以上都是(正确答案)15. 使用乐松®贴剂1h后，哪种组织内的有效成分的浓度比例最高？ [单选题] *A.皮肤B.真皮C.骨骼肌(正确答案)D.血液16. 以下对于2014 NICE骨关节炎指南描述正确的是（） [单选题] *A.当提供口服NSAIDs药物治疗时，无论是传统NSAIDs还是COX-2I皆可作为首选（依托考昔除外）B.所有NSAIDs药物（包括COX-2）镇痛疗效相仿C.所有NSAIDs药物（包括COX-2）在胃肠道、肝脏、心-肾毒性方面各不相同D.以上都对(正确答案)17. 乐松贴剂的适应症为（） [单选题] *A.骨关节炎B.肌肉痛C.外伤导致的肿胀或疼痛D.以上都是(正确答案)18. 下列关于宝丽亚®的儿童用法用量，正确的是（） [单选题] *A.儿童：单剂量药瓶的一般剂量经雾化器给药，每次0.5支，每日1-3次, 使用前请充分摇匀B.儿童：单剂量药瓶的一般剂量经雾化器给药，每次1支，每日1-3次, 使用前请充分摇匀C.儿童：单剂量药瓶的一般剂量经雾化器给药，每次0.5支，每日1-2次, 使用前请充分摇匀(正确答案)D.儿童：单剂量药瓶的一般剂量经雾化器给药，每次1支，每日1-2次, 使用前请充分摇匀19. 启尔畅®的使用剂量因人而异，当用量为“每日二次 ,每次1或2揿。

新治疗性单抗Prolia（denosumab）注射剂使用说明书一般描述：Prolia (denosumab)是一种人IgG2单克隆抗体，对人RANKL(receptor activator of nuclear factor kappa-B ligand，即核因子κB配体受体激活剂)有亲和力和特异性。

Denosumab的分子量约为147 kDa和是在遗传工程哺乳动物(中国仓鼠卵巢)细胞中生产。

Prolia是一种消毒，无防腐剂，透明，无色至淡黄色溶液。

每1 mL单次-使用预装注射器的Prolia含60 mg denosumab(60 mg/mL溶液)，4.7%山梨糖醇，17 mM醋酸盐， 0.01% 聚山梨醇20，注射用水(美国药典USP)，和氢氧化钠至pH值5.2。

每1 mL单次-使用Prolia小瓶a含60 mg denosumab(60 mg/mL溶液)，4.7%山梨糖醇，17 mM醋酸盐， 0.01% 聚山梨醇20，注射用水(美国药典USP)，和氢氧化钠至pH值5.2。

1.适应证：Prolia是一种RANK配体(RANKL)抑制剂，适用于：治疗有骨质疏松高危骨折的绝经后妇女(1.1)。

2.剂量和给药方法：1) 应由卫生保健专业人员给予Prolia(2.1)。

2)每6个月在上臂、上大腿、或腹部皮下注射给予60 mg (2.1)。

3)指导患者每天服用钙1000 mg和每天至少400 IU维生素D (2.1)。

3.剂型和规格：1)单次使用预装注射器在1 mL溶液中含60 mg (3)。

2)单次使用小瓶在1 mL溶液中含60 mg (3)。

4.禁忌证：低钙血症（4.1,5.1）5. 警告和注意事项：1)低钙血症：开始用Prolia前必须纠正。

特别是肾损伤患者可能恶化。

充分补充患者钙和维生素D(5.1)。

2)严重感染包括皮肤感染：可能发生，包括那些导致住院。

忠告患者如他们发生感染的征象或症状，包括蜂窝织炎，寻求及时就医(5.2)。

2Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLsFAILU RE OR IMPROPER SELECTION OR IMPROPER U CTS AND/OR SYSTEMS DESCRIBED HEREIN OR RELATED ITEMS CAN CAU PROPERTY DAMAGE.This document and other information from Parker Hannifin Corporation, its subsidiaries and authorized distributors provide product and/or system options for further investigation by users having technical expertise. It is important that you analyze all aspects of your application and review the information concerning the product or system in the current product catalog. Due to the variety of operating conditions and applications for these products or systems, the user, through its own analysis and testing, is solely responsible for making the final selection of the products and systems and assuring that all performance, safety and warning requirements of the application are met. The products described herein, including without limitation, product features, specifications, designs, availability and pricing, are subject to change by Parker Hannifin Corporation and its subsidiaries at any time without notice.WARNINGSALE CONDITIONSThe items described in this document are available for sale by Parker Hannifin Corporation, its subsidiaries or its authorized distributors. Any sale contract entered into by Parker will be governed by the provisions stated in Parker’s standard terms and conditions of sale (copy available upon request).Polycarbonate bowls and sight domes, being transparent and tough, are ideal for use with Filters and Lubricators. They are suitable for use in normal industrial environments, but should not be located in areas where they could be subjected to direct sunlight, an impact blow, nor temperatures outside of the rated range. As with most plastics, some chemicals can cause damage. Polycarbonate bowls and sight domes should not be exposed to chlorinated hydro-carbons, ketones, esters and certain alcohols. They should not be used in air systems where compressors are lubricated with fire-resistant fluids such as phosphate ester and di-ester types.Metal bowls are recommended where ambient and/or media conditions are not compatible with polycarbonate bowls. Metal bowls resist the action of most such solvents, but should not be used where strong acids or bases are present or in salt laden atmospheres. Consult the factory for specific recommendations where these conditions exist.TO CLEAN POL Metal bowl guards are recommended for all applications.REGULATOR PRESSURE ADJUSTMENT – the knob is not a limiting device. This is a common characteristic of most industrial regulators, and limiting devices may be obtained only by special design.3Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLsTable of ContentsAir Line FiltersSeries 14F ................................................................................................................................................... 4 - 5Air Line Coalescing FiltersSeries 10F ................................................................................................................................................... 6 - 7Air Line RegulatorsSeries 14R ................................................................................................................................................... 8 - 9Air Line Filter / RegulatorsSeries 14E ............................................................................................................................................... 10 - 11Air Line LubricatorsSeries 04L ............................................................................................................................................... 12 - 13Mounting Bracket Kits . (14)4Parker Hannifin CorporationPneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLs§L/s = 6.2 bar inlet and 0.3 bar pressure drop.‡ For polycarbonate bowl see Caution on page 2.14F FiltersOptions:Symbols• Excellent water removal efficiency.• Unique deflector plate that creates swirling of the air stream ensuring maximum water and dirt separation.• 5 micron element standard.• High Flow: 1/8” – 10 l/s §1/4” – 11 l/s§Manual drainAuto drain14F Series5Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLs4mm 0/D x 0.75 I /D tubingAutomatic drainSpecifications5µ FilterAutomatic pulse drain tube barb 4mm O /D x 0.75 I /DBowl capacity 30 cm 3Operating temperature 0°C to 52°C Max supply pressurePolycarbonate bowl0 to 10.3 bar Automatic pulse drain0.7 to 17.2 barStandard filtration 5 micron Port size G1/8 / G1/4Weight0.180 gmFlow ChartsMaterials of ConstructionDimensionsAccessoriesBodyZincBowl - TransparentPolycarbonateDeflector, Element holder & Baffle Plastic DrainsTwist drainBody & Stem Plastic SealsNitrile Automaticpulse drainPiston & Seals NitrileStem, Seat,Adaptor & WashersAluminiumFilter elements 5 micron(standard)Plastic SealsNitrileBowl kits, Poly bowlAutomatic pulse drain PS408P Twist drainPS404P Filter element kits 5 micron PS403P Mounting bracket kitPS417BP2.4 bar 6.2 bar 10.3 barPrimary Pressure - bar P r e s s u r e d r o p - b a r.1.2.3.4.5.6Flow - dm 3/s2.4 bar 6.2 bar 10.3 barPrimary Pressure - bar P r e s s u r e d r o p - b a rFlow - dm 3/sFlow Characteristics - 1/8 Inch Ports14F01B*Flow Characteristics - 1/4 Inch Ports14F11B*14F Series6Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLs10F Series§L/s = 6.2 bar inlet and 0.3 bar pressure drop.10F Coalescing FiltersOptions:Symbol• Removes liquid aerosols and sub-micron particles.• Liquids gravitate to the bottom of the element and will not re-enter the airstream.• Oil free air for critical applications, such as air gauging and pneumatic instrumentation and controls.• 99.97% DOP efficiency.• High Flow: Grade 6 Element1/8” – 8 l/s§1/4” –9 l/s§7Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLs2.4 bar 6.2 bar 10.3 barPrimary Pressure - bar P r e s s u r e d r o p - b a r.1Flow - dm 3/s10F Series4mm 0/D x 0.75 I /D tubingAutomatic drainSpecificationsGrade 6Automatic pulse drain tube barb 4mm O /D x 0.75 I /DBowl capacity 30 cm 3OperationNormal pressure drop 0.1 bar Maximum recommended pres-sure drop0.7 barOperating temperature 0°C to 52°C Max supply pressure Polycarbonate bowl0 to 10.3 bar Standard filtration 0.01 micron Port size G1/8 / G1/4Weight0.180 gmFlow ChartsMaterials of ConstructionDimensionsAccessoriesBodyZincBowl - Transparent PolycarbonateDrainsTwist drainBody & Stem Plastic SealsNitrile Automaticpulse drainPiston & Seals Nitrile Stem, Seat,Adaptor & WashersAluminiumElement holder PlasticFilter element Borosilicate & felt glass fibers 99.97% DOP efficiencySealsNitrileBowl kits, Poly bowlAutomatic pulse drain PS408P Twist drainPS404P Filter element kits 0.01 micronPS446P Mounting bracket kitPS417BPto remove all bowls regardless of drain option2.4 bar 6.2 bar 10.3 barPrimary Pressure - bar P r e s s u r e d r o p - b a r.1Flow - dm 3/sFlow Characteristics - 1/8 Inch Ports10F01E*Flow Characteristics - 1/4 Inch Ports10F11E*8Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLs14R RegulatorsOptions:• Unbalanced poppet standard.• Solid control piston with lip seal for extended life.• Non-rising adjusting knob.• Compact, 73,2mm high by 42mm wide.• High Flow: 1/8” – 6 l/s §1/4” – 7 l/s §SymbolNote: 31mm dia. hole required for panel mounting.§ L/s = 6.9 bar inlet, 6.2 bar no flow secondary setting and 0.7 barpressure drop.14R Series129Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLsSpecificationsGauge ports G1/8Port sizeG1/8 / G1/4Operating temperature 0°C to 52°CMax supply pressure 0 to 20.7 bar Secondary pressure rangeStandard pressure 0 to 8 bar Medium pressure 0 to 4 bar Medium pressure0 to 2 bar Weight140 gmFlow ChartsMaterials of ConstructionDimensionsAccessoriesAdjusting nutBrass Adjusting stem & spring Steel BodyZinc Bonnet, Seat, Piston & Valve poppet PlasticSealsNitrileS e c o n d a r y p r e s s u r e - b a rFlow - dm 3/s14RMA 1.50B 1.50C 2.36D 0.50E 2.98F 1.188G 0.594H 0.325J 0.725Caution:Regulator pressure adjustment – The working range of knobadjustment is designed to permit outlet pressures within their full range. Pressure adjustment beyond this range is also possible because the knob is not a limiting device. This is a common characteristic of most industrial regulators, and limiting devices may be obtained only by special design.For best performance, regulated pressure should always be set by increasing the pressure up to the desired setting.Relief and Flow Characteristics14R013F*14R SeriesS e c o n d a r y p r e s s u r e - b a rFlow - dm 3/sRelief and Flow Characteristics14R113F*10Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLs§L/s = 6.9 bar inlet, 6.2 bar no flow secondary setting and 0.7 bar pressure drop.‡ For polycarbonate bowl see Caution on page 2.Note: 31mm hole required for panel mounting.14E Filter / RegulatorsOptions:Symbols• Excellent water removal efficiency.• Unbalanced poppet standard.• Solid control piston for extended life.• Space saving package offers both filter and regulator features in one integral unit.• Non-rising adjustment knob.• Two full flow 1/8” gauge ports.• High Flow: 1/8” – 7 l/s §1/4” – 8 l/s§14E Series211Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLsBowl kits, Poly bowlAutomatic pulse drain PS408P Twist drainPS404P Gauges - 1/80 to 2 bar P3D-KAB1AYN 0 to 4 bar P3D-KAB1ALN 0 to 10 barP3D-KAB1ANN Mounting bracket kit(Includes panel mount nut)PS417BP Panel mounts nuts Plastic P78652Service kitsNon-relieving PS422P RelievingPS423P4mm 0/D x 0.75 I /D tubingAutomatic drainregardless of drain optionAutomatic pulse drain tube barb 4mm O /D x 0.75 I /DBowl capacity30 cm 3Gauge ports (2) (can be used for full flow)G1/8Port sizeG1/8 / G1/4Operating temperature 0°C to 52°C Secondary pressure range Standard pressure 0 to 8 bar Medium pressure 0 to 4 bar Medium pressure0 to 2 bar Weight0.180 gm14E SeriesSpecificationsFlow ChartsMaterials of ConstructionDimensionsAccessoriesAdjusting nutBrass Adjusting stem & spring Steel BodyZinc Bonnet, Knob, Seat, Piston, Holder & Deflector PlasticBowl - Transparent PolycarbonateDrainsTwist drain Body & Stem Plastic Seals Nitrile Automatic pulse drainPiston & Seals Nitrile Stem, Seat,Adaptor & WashersAluminiumFilter elements - 5 micron (Standard)Plastic SealsNitrileS e c o n d a r y p r e s s u r e - b a rFlow - dm 3/sCaution:Regulator pressure adjustment – The working range of knobadjustment is designed to permit outlet pressures within their full range. Pressure adjustment beyond this range is also possible because the knob is not a limiting device. This is a common characteristic of most industrial regulators, and limiting devices may be obtained only by special design.For best performance, regulated pressure should always be set by increasing the pressure up to the desired setting.Relief and Flow Characteristics14E01B13F*S e c o n d a r y p r e s s u r e - b a rFlow - dm 3/sRelief and Flow Characteristics14E11B13F*12Parker Hannifin CorporationPneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLs§L/s = 6.2 bar inlet and 0.3 bar pressure drop.‡ For polycarbonate bowl see Caution on page 2.04L Mist LubricatorsOptions:Symbol• Proportional oil delivery over a wide range of air flows.• Precision needle valve assures repeatable oil delivery and provides simple adjustment of delivery rate.• Ideal for low and high flow applications with changing air flow.• Transparent sight dome for 360° visibility.• High Flow: 1/8” – 9 l/s §1/4” – 10 l/s§04L Series13Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLs04L SeriesSpecificationsBowl capacity30 cm 3Minimum flow for lubrication 0.2 l/s at 6.9 barPort sizeG1/8 / G1/4Operating temperature 0°C to 52°C Max supply pressure Polycarbonate bowl0 to 10.3 barWeight0.180 gmFlow ChartsMaterials of ConstructionDimensionsAccessoriesBodyZincBowl - Transparent PolycarbonateSeals NitrileSight domePolycarbonateBowl kits, Poly bowl No drain PS421P Mounting bracket kitPS419Primary Pressure - barP r e s s u r e d r o p - b a rFlow - dm 3/s2.4 bar 6.2 bar 10.3 barPrimary Pressure - barP r e s s u r e d r o p - b a r0.1.2.3.4.5.6Flow - dm 3/sFlow Characteristics - 1/8 Inch Ports04L00G*Flow Characteristics - 1/4 Inch Ports04L10G*14Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLsDimensions (mm)A B C D E F G H J K L M Kit4660233425135311461116PS417BP(10F , 14F , 14R, 14E)4655233425135311461116PS419(04L)PS417BP (Includes Panel Mount Nut)PS419Mounting Bracket KitsK Typ.K Typ.15Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLsCatalogue PDE2591TCUK - V3 - May 2020Your local authorized Parker distributor© 2020 Parker Hannifin Corporation. All rights reserved.Parker Hannifin Ltd. Tachbrook Park Drive Tachbrook Park, Warwick, CV34 6TU United KingdomTel.: +44 (0) 1926 317 878 Fax: +44 (0) 1926 317 855********************Parker WorldwideEurope, Middle East, AfricaAE – United Arab Emirates, DubaiTel: +971 4 8127100 ********************AT – Austria, St. Florian Tel: +43 (0)7224 66201 *************************AZ – Azerbaijan, Baku Tel: +994 50 2233 458****************************BE/NL/LU – Benelux, Hendrik Ido Ambacht Tel: +31 (0)541 585 000 ********************BG – Bulgaria, Sofia Tel: +359 2 980 1344**************************BY – Belarus, Minsk Tel: +48 (0)22 573 24 00 ************************CH – Switzerland, Etoy Tel: +41 (0)21 821 87 00*****************************CZ – Czech Republic, Klecany Tel: +420 284 083 111*******************************DE – Germany, Kaarst Tel: +49 (0)2131 4016 0*************************DK – Denmark, Ballerup Tel: +45 43 56 04 00*************************ES – Spain, Madrid Tel: +34 902 330 001 ***********************FI – Finland, Vantaa Tel: +358 (0)20 753 2500 *************************FR – France, Contamine s/Arve Tel: +33 (0)4 50 25 80 25 ************************GR – Greece, Piraeus Tel: +30 210 933 6450 ************************HU – Hungary, Budaörs Tel: +36 23 885 470*************************IE – Ireland, Dublin Tel: +353 (0)1 466 6370 *************************IL – IsraelTel: +39 02 45 19 21************************IT – Italy, Corsico (MI) Tel: +39 02 45 19 21 ***********************KZ – Kazakhstan, Almaty Tel: +7 7273 561 000****************************NO – Norway, Asker Tel: +47 66 75 34 00************************PL – Poland, Warsaw Tel: +48 (0)22 573 24 00 ************************PT – PortugalTel: +351 22 999 7360**************************RO – Romania, Bucharest Tel: +40 21 252 1382*************************RU – Russia, Moscow Tel: +7 495 645-2156************************SE – Sweden, Borås Tel: +46 (0)8 59 79 50 00 ************************SK – Slovakia, Banská Bystrica Tel: +421 484 162 252**************************SL – Slovenia, Novo Mesto Tel: +386 7 337 6650**************************TR – Turkey, Istanbul Tel: +90 216 4997081 ************************UA – Ukraine, Kiev Tel: +48 (0)22 573 24 00 ************************UK – United Kingdom, Warwick Tel: +44 (0)1926 317 878 ********************ZA – South Africa, Kempton Park Tel: +27 (0)11 961 0700*****************************North AmericaCA – Canada, Milton, Ontario Tel: +1 905 693 3000US – USA, Cleveland Tel: +1 216 896 3000Asia PacificAU – Australia, Castle Hill Tel: +61 (0)2-9634 7777CN – China, Shanghai Tel: +86 21 2899 5000HK – Hong Kong Tel: +852 2428 8008IN – India, MumbaiTel: +91 22 6513 7081-85JP – Japan, Tokyo Tel: +81 (0)3 6408 3901KR – South Korea, Seoul Tel: +82 2 559 0400MY – Malaysia, Shah Alam Tel: +60 3 7849 0800NZ – New Zealand, Mt Wellington Tel: +64 9 574 1744SG – Singapore Tel: +65 6887 6300TH – Thailand, Bangkok Tel: +662 186 7000TW – Taiwan, Taipei Tel: +886 2 2298 8987South AmericaAR – Argentina, Buenos Aires Tel: +54 3327 44 4129BR – Brazil, Sao Jose dos Campos Tel: +55 800 727 5374 CL – Chile, Santiago Tel: +56 2 623 1216MX – Mexico, Toluca Tel: +52 72 2275 4200。

Page 1 of 2 ColiComplete ®AOAC Official Method 992.30General DescriptionColiComplete ® contains 5-bromo-4-chloro-3-indolyl-ß-Dgalactopyranoside (X-Gal) and 4-methyl umbelliferyl-ß-D-glucuronide (MUG). Discs are added to LST inoculated with selected dilutions of samples. Samples are incubated at 35–37 °C and examined after 24 and 48 ±2 h for confirmed total coliforms and after 30 ±2 h for confirmed E. coli results. ß-Galactosidase, from coliforms present in samples, cleaves X-Gal into 5-bromo-4-chloro-indoxyl intermediate which undergoes oxidation to yield water-insoluble blue dimer, visually detectable on disc or in surrounding medium as confirmed positive result for total coliform activity. ß-Glucuronidase, from E. coli present in samples, cleaves MUG into glucuronide and methyl umbelliferone which fluoresces under long wave UV light (366 nm) as confirmed positive result for E. coli presence.NOTE : As E. coli O157:H7 does not produce ß-glucuronidase, ColiComplete ® is not suitable for the detection of E. coli O157:H7.A. Sample PreparationPrepare appropriate serial dilutions as indicated in FDA Bacteriological Analytical Manual (BAM), or AOAC Official Methods of Analysis according to sample type.B. InoculationInoculate LST tubes with appropriate sample dilution series selected to determine MPN levels or presence/absence of total coliforms and E. coli in sample. Aseptically add a single ColiComplete ® disc to each tube. Incubate at 35–37 °C.C. Reading ColiComplete ®a. For total coliforms — After at least 24 h incubation, examine each tube for visually detectable blue color on disc or in surrounding medium. Presence of blue color indicates confirmed positive result for total coliforms.NOTE: A wide range of blue color intensity may be expected, depending on sample composition and microflora. All blue reactions are positive regardless of intensity of color.Reincubate at 35–37 °C. After additional 24 ±2 h re-examine. Continued absence of blue indicates negative result; presence of blue indicates confirmed positive result for total coliforms. Read and record the MPN code or presence/absence of total coliforms in the sample.b. For E.coli — After 30 ±2 h from start of initial incubation, examine tubes under long-wave UV light (366 nm). Fluorescent tubes indicate confirmed positive result for E. coli. Read and record the MPN code or presence/absence of E. coli in the sample.D. CONTROLSPositive and negative controls should be used to facilitate interpretation of MUG fluorescent reaction. Use one known positive E. coli tube and two negative controls - one non -E. coli /coliform tube (e.g., Klebsiella spp.) and one uninoculated media tube.NOTE: Use borosilicate glass tubes, flint glass gives fluorescence that may be misinterpreted for a positive result.Lit. No. MK_UG4655EN Merck KGaAFrankfurter Strasse 25064293 DarmstadtGermanyPage 2 of 2 E. Method Modification for Certain JuicesApplicable to juice products/processors which rely on treatments that do not come into direct contact with all parts of the juice, as contained in 21 CFR Part 120: Rules and Regulations. Hazard Analysis and Critical Control Point (HAACP); Procedures for the Safe and Sanitary Processing and Importing of Juice; Final Rule. Vol 66 No. 13. 6137-6202. Use the modified method “Analysis for Escherichia coli in Citrus Juices - Modifi cation of AOAC Official Method 992.30” as stated in Section 120.25 (a).F. StorageStore unused discs at 2–8 °C (36–46 °F) in a sealed container, with desiccant.G. DisposalAfter use, all tubes must be steam-sterilized at 121 °C for at least 30 min before discarding. For in-vitro diagnostic use only.Manufacturing EntityBioControl Systems, Inc, 12822 SE 32nd St, Bellevue, WA 98005, USA.BioControl Systems, Inc is an affiliate of Merck KGaA, Darmstadt, Germany.。