下载文档原格式
流行病学EPIDEMIOLOGY第五章队列研究Chapter Five Cohort Study卢智泉预防医学教研室2006.03.08第五章队列研究Chapter Five Cohort Study•队列研究 Cohort study 亦称前瞻性研究prospective study，与病例对照研究方法同属分析性流行病学研究中两种重要的方法，广泛地用来探索疾病的危险因素，检验病因假设。
使用这种方法可以直接观察人群暴露于病因的情况及其结局，从而确定危险因素与疾病的关系，在验证假设上是一种介于病例对照研究与人群试验之间的一种研究方法。
本研究方法可在描述性流行病学工作基础上，初步形成病因假设之后，或经病例对照研究初步检验了病因假设之后，再进一步确证该假设的正确性。
•一、基本概念 Basic principle• A study design in which a population cohort is prospectively defined and divided according to the presence or absence of an exposure variable of interest and then followed over time for the occurrence of prespecified outcomes.• A type of study in which investigators begin with a group of subjects without the disease of interest (eg, lung cancer), classify them according to their exposure status (eg, people who smoke a pack of cigarettes a day compared with people who do not smoke), then monitor them over time for subsequent disease development; this is also called a follow-up study.•所谓队列是指具有共同经历，共同暴露于某一种因素或共同具有某一特征的人群。
