Dear Sirs,
Please accept this letter as a position statement on the growing problem of adverse side effects related to the use of HMG-CoA reductase inhibitors. The International Coenzyme Q10 Association is a group of scientists and medical professionals with a research focus on coenzyme Q10, which plays a crucial role in cellular ATP production. It has been demonstrated that HMG-CoA reductase inhibitors, also known as statins, block the biosynthesis of coenzyme Q10 and of dolichol, besides the well known effect on cholesterol synthesis. Several studies have shown that administration of different kinds of statins can lead to a parallel decrease of coenzyme Q10 and cholesterol in plasma (1- 9, 19). ……
补充辅酶Q10能增强调脂治疗效果
•辅酶Q10与他汀合用可以抑制LDL氧化,减少单核细胞粘附,进一步改
• 1958年被称为“辅酶Q10的研 究之父”——卡鲁福鲁卡斯博士 确定其化学结构,并因此获得了 美国化学学会的最高荣誉。他提 出辅酶Q10对心脏机能起着重要 的作用。