1、左心房扩大 2、左心室肥厚 3、左心室扩张
附录:洋地黄和利尿剂效果不理想、 补充辅酶Q10 3月见效。
辅酶Q10-抗降脂药损伤
他汀类副作用:
• • • • 1、横纹肌溶解症 浑身无力,肌肉疼痛 2、心脑功能受损 记忆力功能障碍 2001年8月8日: 美国和欧洲52名患者,因服用辅拜斯亭死亡 ,后来统计,全球有528人死亡于这种药物 的副作用。 • 2002年9月:国际辅酶Q10协会向美国FDA 正式提交声明警告,由于他汀类药物阻断了 体内Q10的生产,造成体内Q10严重下降。 • 2004年3月:美国FDA沉默33月后终于正面 回应了这一警告,将心脑血管病人Q10剂量 猛增4倍(吃降脂药的病人)美国40-60MG ,240MG。 辛伐他汀、洛伐他汀、普伐他汀、氟伐他汀 、阿托伐他、汀西立伐他汀
Tohoku J Exp Med. 1983, 141 Suppl:453
国内的报道也显示,辅酶Q10在与一些药物合用时对改善心律失常有帮助
例数
360 32 60 30 30 58
病情
多型(对照) 病态窭房结综合征 室早(对照) 室颤、房早、房颤、 室上速 室早 难治性室性心律失 常(对照)
剂量
60mg
LETTER TO FDA REGARDING STATIN ISSUE
….. Object: Biochemical and Potential Clinical Consequences of Inhibiting Coenzyme Q10 Biosynthesis by HMG-CoA Reductase Inhibitors: A Critical Opinion by the International Coenzyme Q10 Association. Dear Sirs, Please accept this letter as a position statement on the growing problem of adverse side effects related to the use of HMG-CoA reductase inhibitors. The International Coenzyme Q10 Association is a group of scientists and medical professionals with a research focus on coenzyme Q10, which plays a crucial role in cellular ATP production. It has been demonstrated that HMG-CoA reductase inhibitors, also known as statins, block the biosynthesis of coenzyme Q10 and of dolichol, besides the well known effect on cholesterol synthesis. Several studies have shown that administration of different kinds of statins can lead to a parallel decrease of coenzyme Q10 and cholesterol in plasma (1- 9, 19). …… It is reasonable to suggest that skeletal muscle pathology such as myalgia and rhabdomyolysis is also related to decreases in tissue coenzyme Q10 concentrations. There are some indications of rapid improvement in statin-induced myalgia and fatigue with supplemental CoQ10 (20). In different kinds of muscle disease the beneficial effects of coenzyme Q10 supplementation have been shown to correlate with improvement in oxidative phosphorylation as monitored by NMR techniques (14 - 16). A few cases have already been reported where CoQ10 reverses the condition of cardiac failure in the course of treatment with statins (1). These observations may relate to two Merck & Co., Inc. patents for combining CoQ10 with statin in the same capsule: US Patent 4929437, issued May 29, 1990 and US Patent 4933165, issued June 12, 1990, both titled "Coenzyme Q10 with HMG-CoA Reductase Inhibitors“. …….