Mycophenolate mofetil_128794-94-5_DataSheet_MedChemExpress
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Product Name:
Mycophenolate mofetil CAS No.:
128794-94-5Cat. No.:
HY-B0199Product Data Sheet
MWt:
433.49Formula:
C23H31NO7Purity :>98%
Solubility:
DMSO 85 mg/mL; Water <1 mg/mL y Mechanisms:
Biological Activity:
Mycophenolate Mofetil is a non competitive selective and reversible inhibitor of inosine
Pathways:Cell Cycle/DNA Damage; Target:DNA/RNA Synthesis g ;g
Mycophenolate Mofetil is a non-competitive, selective and reversible inhibitor of inosine
monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively.
Target: Inosine monophosphate dehydrogenase (IMPDH)Mycophenolate mofetil is an ester prodrug of the active immunosuppressant mycophenolic acid
(MPA). The latter shows a noncompetitive, selective and reversible inhibition activity against inosine monophosphate dehydrogenase type I/II with IC50 of 39 nM and 27 nM, respectively. Moreover,MPA also produces the concentration-dependent inhibition of proliferation of ConA-stimulated T cells, LPS-stimulated B cells and alloantigen-specific T cells with IC50 of 100 nM, 120 nM, and 51nM, respectively [1]. Mycophenolate mofetil with high concentration of 10 g/mL induces a strong References:
[1]. Nakanishi, T., et al., Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-
566419 on rat cardiac allograft rejection. Int Immunopharmacol, 2010. 10(1): p. 91-7.[2]. Dehghani, F., et al., Inhibition of microglial and astrocytic inflammatory responses by the
,p y []y p g μg g apoptosis in microglial cell cultures and increases the number of activated caspase-...
immunosuppressant mycophenolate mofetil. Neuropathol Appl Neurobiol, 2010. 36(7): p. 598-611.[3]. Ozgen, M., et al., Mycophenolate mofetil and daclizumab targeting T lymphocytes in bleomycin-
induced experimental scleroderma. Clin Exp Dermatol, 2012. 37(1): p. 48-54.Caution: Not fully tested. For research purposes only
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