CVD 浙大英文课件
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Advanced Organic ChemistryLecture 2Xufeng LinSep., 20092. StereochemistryChirality in ToolsHelixChirality in ArtØDopamine ØL-DOPA ØProdrug ØDecarboxylationL-DOPAIf we consider the biological activities of chiral compounds in general, there are four different behaviors:1)only one enantiomer has the desired biologicalactivity, and the other one does not show signifcantbioactivity;2)both enantiomers have identical or nearly identicalbioactivity;3)the enantiomers have quantitatively different activity;4)the two enantiomers have different kinds of biologicalactivity.天冬酰胺薄荷OH OH OO OHOHOHOO OHS-(+)-Alkannin (R)-(-)-Shikoninv The toxicity of naturally occurring (-)-nicotine is much greater than that of unnatural (+)-nicotine.v Chiral herbicides, pesticides, and plant growth regulators widely used in agriculture also show strong biodiscriminations.Conditions for Asymmetryq Amines with three different substituents are potentially chiral because of the pseudotetrahedral arrangement of the three groups and the lone-pair electrons. Under normal conditions, however, these enantiomers are not separable because of the rapid inversion at the nitrogen center.q In contrast to the amines, inversion of configuration for phosphines is generally negligibly slow at ambient temperature. This property has made it possible for chiral phosphines to be highly useful as ligands in transitionmetalcatalyzed asymmetric syntheses.q As a result of the presence of lone-pair electrons, the configuration of organosulfur species is pyramidal, and the pyramidal reversion is normally slow at ambient temperature. Thus two enantiomers of chiral sulfoxides are possible and separable.In the case of nitrogen compounds, if the inversion at the nitrogen center is prevented by a rigid structural arrangement, chirality also arises.The bridgehead structure completely prevents inversion.In a three-membered heterocyclic ring, the energy barrier for inversion at the nitrogen center is substantially raised.NomenclatureCl多少对enantiomersdiastereomersNO 2COOH NO 2COOH COOHNO NO 2COOH Br I Br XI Br I BrC C C abaCCCHH3C3C C CHCH3H3C EnantiomersCF2 F2C2 F2CF3F2C CF2 F2CF2 F3C(S)(R)Planar chiralityp S p SChiral centerp S构象分析分子将采取能量最低的几何形状,这种几何形状是通过围绕单键的旋转而达到的。
浙大学报英文版排版手册1:页面设置上:4cm;下:2.9cm;左:2.3cm;右:2.3cm;页眉:3cm;页脚:2.8cm2:字体Times New Roman(某些符号在插入的时候,不用标准字体,用西文字体或symbol)。
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浙江大学新编英语教材浙江大学是中国著名的高等学府,拥有丰富的教学资源和优秀的教师队伍。
为了适应时代的发展需求和学生的学习需求,浙江大学近期进行了新编英语教材的开发工作。
本文将从教材的编写目的、内容大纲以及教学方法等方面进行探讨。
一、教材编写目的新编英语教材的编写目的是为了提供一个全面、系统、科学的英语学习材料,以帮助学生打下坚实的英语基础,提升英语综合应用能力。
教材注重培养学生的听、说、读、写能力,注重培养学生的语言实际运用能力和跨文化交际能力,以满足学生日常生活、学习、工作和社交交往等各方面的需求。
二、教材内容大纲浙江大学新编英语教材的内容大纲包含以下几个主要部分:1.基础词汇与语法教材将通过丰富的词汇和语法练习,帮助学生掌握英语的基础词汇和语法知识,从而打下坚实的语言基础。
2.听力和口语教材将提供大量的听力材料和口语训练,培养学生的听力理解和口语表达能力。
同时,教材将设计各种情景对话和口头交际活动,帮助学生提高实际应用能力。
3.阅读理解教材将提供丰富多样的阅读材料,包括新闻报道、学术论文、故事等,培养学生的阅读理解能力和批判思维能力。
教材还将引导学生进行阅读讨论和写作练习,提高学生的综合应用能力。
4.写作能力教材将注重培养学生的写作能力,包括日常交际写作和学术写作。
通过写作练习,学生将提高表达思想和观点的能力,培养独立思考和创造性思维能力。
三、教学方法新编英语教材将采用多种灵活的教学方法,包括任务型教学、小组合作学习、项目学习等。
教材将通过多种不同的教学活动和教学资源,激发学生的学习兴趣,提高学习效果。
此外,教材还将提供在线学习平台和多媒体教学资源,以便学生随时随地进行学习。
学生可以通过在线练习、听力材料和口语对话等方式,巩固和提高自己的英语水平。
总之,浙江大学新编英语教材的开发旨在为学生提供一个全面、系统、科学的英语学习平台。
通过合理的课程设置、丰富的教学内容和灵活的教学方法,教材将帮助学生全面提升英语语言能力,为将来的学习和就业奠定良好基础。
六、通知通知一般分为书面通知和口头通知两种。
其要素常常包括:时间、地点、事件、参与者、活动内容及注意事项等。
要求:言简意赅、措辞得当。
通知常用语:1.通知常用开头语:(1)May I have your attention,please?(2)Attention please,everyone.I have an announcement to make.(3)Be quite.There is something important I have to tell you.(4)I have something important to tell you.(5)I’m glad to tell you something important.2.其他常用语句:(1)Everyone should be there on time.(2)Be sure not to be late.(3)Please be present on time.(4)Everyone is required to be present on time.(5)Be sure to attend it on time.(6)Everybody is expected to attend it on time.(7)All teachers and students are required to...(8)Our school/The Student Union will/is going to hold...(9)A lecture will be given at 7∶00 this evening in...(10)Please take your notebooks with you and be sure on time.(11)Those who are interested in it are warmly welcome.Notice①will organize .②This activity aims to .③This activity is arranged to or so.It is planned to begin on .④The team members will be arranged to .Your main task is to .⑤Anyone who is welcome warmly.⑥Those who are interested can contact for further information.⑦Looking forward to your active participation.为弘扬中国传统文化,学生会将举行“诗歌朗诵大赛”(Poetry Recitation Contest),邀请学校国际部学生参加。
深穿支动脉为出血的主要部位,豆纹动脉是脑出血最好发部位,其外侧支称为出血动脉The mainly hemorrhagic sites are the perforating branches of middle cerebral artery, the most common sites of ICH are lenticulostriate arteries, lateral branches of those are called hemorrhagic arteries.基底节区Basal ganglia 70%脑叶Cerebral lobe 10%脑干Brain stem 10%小脑齿状核区Cerebellar dentate nucleus 10%粟粒状动脉瘤:大脑中动脉深穿支豆纹动脉>基底动脉脑桥支>大脑后动脉丘脑支>小脑上动脉分支>顶枕交界区和颞叶分支Granulous aneurysm : the lenticulostriate arteries > branches of the basilar artery supplying the pons > thalamic branches of the posterior cerebral arteries > branches of the superior cerebellar arteries > some arteries supplying the junctional zone between parietal and occipital lobe and branches of temporal lobe临床表现clinical manifestations (1)年龄50-70岁,男>女Age 50-70 years. The incidence is higher in men than in women冬春季多发Mostly occurrs in winter and spring.多有高血压史Usually with hypertension.活动或情绪激动时发生Occurrs when activities or emotional excitement.数分钟至数小时症状达高峰Neurologic deficits may progress over minutes to hours.全脑症状:头痛、呕吐、意识改变Global cerebral symptom: headache, vomiting, alterd consciousness临床表现clinical manifestions (2)1. 基底节区出血(内囊区出血)占70%,其中壳核(内囊外侧型)60%,丘脑(内囊内侧型)10%。
The most common site of hemorrhage is basal ganglia, which occurs in 70% of patients. It consists of putamen (lateral of the internal capsule) and thalamus (medial of the internal capsule) . (1)壳核出血:三偏,双眼向病灶对侧同向凝视不能,主侧半球有失语。
(1) Putaminal hemorrhage: hemiplegia, hemisensory deficit, hemiopia, impairment of syntropic gaze to the contralateral lesion, aphasia with dominant hemisphere临床表现clinical manifestions (3)(2)丘脑出血:丘脑膝状动脉和丘脑穿通动脉。
三偏,上下肢程度相近,深浅感觉障碍,特征性眼征,意识障碍,中线症状,锥体外系症状,丘脑性失语,精神症状。
(2)Thalamic hemorrhage: the thalamic genual artery and the long penetrating thalamic artery. hemiplegia, hemisensory deficit, hemiopia, hemiplegia affecting the arm and leg to a roughlyequal extent, impairment of superficial and deep sensation, marked ocular sign, impairment of consciousness, symptoms of the median line, the extrapyramidal symptoms, the thalamic aphasia, mentalsymptoms.临床表现clinical manifestions (4)(3)尾状核头部出血:少见。
脑膜刺激征,无明显瘫痪,头痛,呕吐,颈强,Kernig征(+),可有对侧中枢性面、舌瘫(3)Hemorhage in the head of the caudate nucleus: seldom. meningeal irritation sign, unobvious paralysis, headache, vomiting, neck stiffness, positive Kernig’s sign, the facial and hypoglossal paralysis caused by contralateral upper unit opathy.临床表现clinical manifestions(5)2.脑桥出血:10%,多位于脑桥基底与被盖部之间。
2. Pontine hemorrhage: 10%, mostly occurs between the basal pons and the tegmen.大量出血(>5ml):常破入四脑室。
昏迷,针尖样瞳孔,呕吐,中枢性高热,中枢性呼吸困难,眼球浮动,四肢瘫,去大脑强直发作,多在48小时内死亡。
Massive hemorrhage(>5ml): usually ruptures into the fourth ventricle. Coma, pinpoint pupils, vomiting, central fever, central dyspnea, impairment of horizontal eye movements, quadriplegia, decerebrate rigidity, usually leads to death within 48 hours.临床表现clinical manifestions (6)小量出血:交叉性瘫,共济失调性偏瘫,双眼向病灶侧凝视或核间性眼肌麻痹。
Small hemorrhage: crossed paralysis, ataxic-hemiplegia, both eyes gaze to the ipsilateral lesion or internuclear ophthalmoplegia.3.中脑出血:罕见.Hemorrhage in diencephalon: seldom.轻症:一侧或双侧动眼神经不全瘫痪,Weber综合征Mild case: unilateral or bilateral oculomotor nerve partial paralysis, Weber’s syndrome.重症:深昏迷,四肢弛缓性瘫,迅速死亡Severe case: deep coma, flaccid quadriplegia, rapidly go to death临床表现clinical manifestions (7)4.小脑出血:10%,小脑齿状核动脉多发。
发病初期有眩晕,呕吐,枕部头痛,平衡障碍,无肢体瘫痪。
4.Cerebellar hemorrhage: 10%, usually occurs in the artery supplying dentate nucleus.The symptoms including vertigo, vomiting, occipital headache and disorders of equilibrium, but not quadriplegia appear at onset of bleeding.临床表现clinical manifestions (8)轻症:一侧肢体笨拙,行动不稳,共济失调,眼震,无瘫痪。
Mild case: clumsiness of unilateral body, unstable movement, ataxia, nystagmus, no paralysis.重症:双眼向病灶对侧凝视,吞咽发声困难,锥体束征,一侧瞳孔缩小,光反应迟钝,脑干受压表现,甚至枕大孔疝。
Severe case: both eyes gaze at the contralateral lesion, difficulty in swallowing and dysphonia, pyramidal sign, constriction of unilateral pupil , bluntness in response to light, signs of brainstem compression, even foramen magnum herniation.临床表现clinical manifestations (9)5.脑叶出血:10%,以顶叶最常见。
头痛,呕吐,脑膜刺激征,局灶症状,抽搐较多见。
5.Lobar hemorrhage:10%, the most common site is parietal lobe. Headache, vomiting, Meningeal irritation sign, focal brain sign, sizure额叶:偏瘫,Broca失语,摸索。
Frontal lobe: hemiplegia, broca’s aphasia, crocidismus.临床表现clinical manifestations (10)颞叶:Wernicke失语,精神症状。
Temporal lobe: Wernicke’s aphasia, mental symptoms.枕叶:视野缺损。