Tacrolimus-monohydrate抑制剂COA-M6293

Inhibitors, Agonists, Screening Certificate of Analysis

PHYSICAL AND CHEMICAL PROPERTIES Molecular Formula:C44H69NO12Molecular Weight:804.02Storage:Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months-20°C1 monthChemical Structure:

ANALYTICAL DATA Appearance:White to off-white (Solid)1 H NMR Spectrum:Consistent with structureLCMS:Consistent with structurePurity (LCMS):98.46%Conclusion:The product has been tested and complies with the given specifications.Product Name:TacrolimusCat. No.:HY-13756CAS No.:104987-11-3Batch No.:22811Chemical Name:15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-

Inhibitors, Agonists, Screening Safety Data SheetRevision Date:May-24-2017Print Date:May-24-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :TacrolimusCatalog No. :HY-13756CAS No. :104987-11-31.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureGHS Classification in accordance with 29 CFR 1910 (OSHA HCS)H301Acute toxicity, Oral (Category 3)2.2 GHS Label elements, including precautionary statementsPictogramSignal word DangerHazard statement(s)H301 Toxic if swallowed.Precautionary statement(s)P264 Wash skin thoroughly after handling.P270 Do not eat, drink or smoke when using this product.P273 Avoid release to the environment.P301+ P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesPage 1 of Synonyms:FK⁻506; Fujimycin; FR900506; FK506; FK 506Formula:C44H69NO12Molecular Weight:804.02CAS No. :104987-11-34. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelidswith fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnelto safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces andequipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaustventilation.Page 2 of 7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months-20°C1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protectionSafety goggles with side-shields.Hand protectionProtective gloves.Skin and body protectionImpervious clothing.Respiratory protectionSuitable respirator.Environmental exposure controlsKeep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearanceWhite to off-white (Solid)OdorNo data availableOdor thresholdNo data availablepHNo data availableMelting/freezing pointNo data availableBoiling point/rangeNo data availableFlash pointNo data availableEvaporation rateNo data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limitsNo data availableVapor pressureNo data availableVapor densityNo data availableRelative densityNo data availableWater SolubilityNo data availablePartition coefficientNo data availableAuto-ignition temperatureNo data availableDecomposition temperatureNo data availablePage 3 of

检测报告

目录号：M3465

产品名：Triamcinolone

CAS号：124-94-7

物理和化学性质

分子式：CHFO

分子量：394.43

溶解性：DMSO 70 mg/mL长期储存：-20°C 冷藏

结构式：

分析数据

HPLC：纯度 >98%

H-NMR：结构一致

产品信息

产品描述：Triamcinolone是一种糖皮质激素，有游离醇或酯化形式，可以口服，肌肉注射，局部注射，吸入或外用，用于治疗皮质类激素紊乱的各种疾病。

使用建议：我们建议您，将已溶于溶剂的产品封装在密封小瓶内，储存于-20°C或以下环境，并且在一个月内用完。

AbMole中国产品仅供实验室人员研究使用，不对患者出售。21276

分子量275.34

溶解性（25°C）DMSO 55 mg/mL

分子式CHNOWater < 1 mg/mL

CAS号61413-54-5Ethanol 55 mg/mL

储存条件3年 -20°C 粉末状

生物活性PDE4的选择性抑制剂，rolipram，抑制免疫纯化的PDE4B和PDE4D活性，IC50分别为130 nM和240 nM。具有抗炎活性。

不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

小鼠大鼠兔豚鼠仓鼠狗

重量 (kg)0.020.151.80.40.0810

体表面积 (m)0.0070.0250.150.050.020.5

K 系数36128520

动物 A (mg/kg) = 动物 B (mg/kg) × 动物 B的K系数动物 A的K系数例如，依据体表面积折算法，将白藜芦醇用于小鼠的剂量22.4 mg/kg 换算成大鼠的剂量，需要将22.4 mg/kg 乘以小鼠的K系数（3），再除以大鼠的K系数（6），得到白藜芦醇用于大鼠的等效剂量为11.2 mg/kg。

参考文献Effects of rolipram and zaprinast on learning and memory in the Morris water maze and radial arm maze tests in naive mice. Akar F, et al. Drug Res (Stuttg). 2015 Feb;65(2):86-90. PMID: 24764251.Rolipram 目录号M5939

化学数据

16213

2

m

mmmm