Tacrine_hydrochloride_hydrate_LCMS_27440_MedChemExpress

=====================================================================

Acq. Operator : Li Shan(LCMS-02) Seq. Line : 76Acq. Instrument : HY-LCMS-02 Location : P2-E-04

Injection Date : 7/3/2015 6:45:28 PM Inj : 1 Inj Volume : 3.000 µlAcq. Method : D:\AGLIENT 1260\DATA\20150703\20150703 2015-07-03 09-21-12\100-1000MS+3MIN- 1.5_(0.02%FA).MLast changed : 7/3/2015 9:21:12 AM by Li Shan(LCMS-02)Analysis Method : D:\AGLIENT 1260\METHOD\100-1000MS+3MIN-1.5_(0.02%FA).MLast changed : 7/6/2015 11:20:08 AM by Li Shan(LCMS-02) (modified after loading)Method Info : Postive,MS:100-1000,Column ID:A-RP-132,40℃ Catalog No : HY-B0005 Batch#16814 A-RP-134 Additional Info : Peak(s) manually integrated

min0.511.522.53mAU

02004006008001000 DAD1 B, Sig=214,4 Ref=off (D:\AGLIENT...\DATA\20150703\20150703 2015-07-03 09-21-12\BIZ2015-703-DJL9-1.D)

Inhibitors, Agonists, Screening Safety Data SheetRevision Date:May-24-2017Print Date:May-24-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :TacrolimusCatalog No. :HY-13756CAS No. :104987-11-31.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureGHS Classification in accordance with 29 CFR 1910 (OSHA HCS)H301Acute toxicity, Oral (Category 3)2.2 GHS Label elements, including precautionary statementsPictogramSignal word DangerHazard statement(s)H301 Toxic if swallowed.Precautionary statement(s)P264 Wash skin thoroughly after handling.P270 Do not eat, drink or smoke when using this product.P273 Avoid release to the environment.P301+ P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesPage 1 of Synonyms:FK⁻506; Fujimycin; FR900506; FK506; FK 506Formula:C44H69NO12Molecular Weight:804.02CAS No. :104987-11-34. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelidswith fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnelto safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces andequipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaustventilation.Page 2 of 7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months-20°C1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protectionSafety goggles with side-shields.Hand protectionProtective gloves.Skin and body protectionImpervious clothing.Respiratory protectionSuitable respirator.Environmental exposure controlsKeep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearanceWhite to off-white (Solid)OdorNo data availableOdor thresholdNo data availablepHNo data availableMelting/freezing pointNo data availableBoiling point/rangeNo data availableFlash pointNo data availableEvaporation rateNo data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limitsNo data availableVapor pressureNo data availableVapor densityNo data availableRelative densityNo data availableWater SolubilityNo data availablePartition coefficientNo data availableAuto-ignition temperatureNo data availableDecomposition temperatureNo data availablePage 3 of

Inhibitors, Agonists, Screening Certificate of Analysis

PHYSICAL AND CHEMICAL PROPERTIES Molecular Formula:C20H24N2O2Molecular Weight:324.42Storage:Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months-20°C1 monthChemical Structure:

ANALYTICAL DATA Appearance:White to off-white (Solid)1 H NMR Spectrum:Consistent with structureLCMS:Consistent with structurePurity (LCMS):99.59%Conclusion:The product has been tested and complies with the given specifications.Product Name:QuinineCat. No.:HY-D0143CAS No.:130-95-0Batch No.:27672Chemical Name:Cinchonan–9–ol, 6'–methoxy–, (8α,9R)–

Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA

=====================================================================

Acq. Operator : Yang Qian(LCMS-02) Seq. Line : 64Acq. Instrument : HY-LCMS-02 Location : P1-C-03

Injection Date : 12/24/2015 3:46:18 PM Inj : 1 Inj Volume : 3.000 µlAcq. Method : D:\AGLIENT 1260\DATA\20151224\20151224 2015-12-24 09-05-37\100-1000MS+3MIN- 1.5_(0.02%FA)-BD.MLast changed : 12/24/2015 9:05:37 AM by Yang Qian(LCMS-02)Analysis Method : D:\AGLIENT 1260\METHOD\10-80B,25MIN(RP-HPLC)-BD.MLast changed : 12/24/2015 3:54:20 PM by Yang Qian(LCMS-02) (modified after loading)Method Info : MS:100-1000,Column ID:A-RP-108,30℃ Catalog No : HY-13003 Batch#19026 A-RP-134 Additional Info : Peak(s) manually integrated

min0.511.522.53mAU

02505007501000125015001750 DAD1 C, Sig=254,4 Ref=off (D:\AGLIENT 1260\DATA\20151224\20151224 2015-12-24 09-05-37\BIZ2015-D24-WJ2.D)