中南大学学报（医学版）J Cent South Univ (Med Sci)2021,46(10)迷走神经刺激术治疗难治性癫痫的疗效和安全性杨转移，刘定阳，杨治权，陈晓宇，蔡宇祥，刘涧，张俊美，李苏珊（中南大学湘雅医院神经外科，长沙410008）[摘要]目的：迷走神经刺激术是一种治疗难治性癫痫的神经调控方法，适用于不能切除癫痫病灶或者病灶切除手术失败的难治性癫痫患者。
本研究探讨迷走神经刺激术治疗难治性癫痫的疗效和安全性，并分析影响疗效的因素。
方法：回顾性分析2016年4月至2019年8月在中南大学湘雅医院行迷走神经刺激术的35例难治性癫痫患者的临床及随访资料。
结果：术后随访6~47(平均26个月)，MuHugh 分级I 级7例，II 级13例，III 级8例，IV~V 级7例。
病程短的患者手术效果好于病程长者(分别为77.8%和50.0%，P =0.013)，而不同年龄(P =0.382)、性别(P =0.824)、发作类型(P =0.829)和MRI 表现(P =0.791)的患者疗效差异无统计学意义。
所有患者无永久不良反应发生。
结论：迷走神经刺激术是一种安全、有效的治疗难治性癫痫的辅助方法，病程短的患者疗效好。
[关键词]迷走神经刺激术；难治性癫痫；MuHugh 分级Efficacy and safety of vagus nerve stimulation in thetreatment of refractory epilepsyYANG Zhuanyi,LIU Dingyang,YANG Zhiquan,CHEN Xiaoyu,CAI Yuxiang,LIU Jian,ZHANG Junmei,LI Sushan(Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha 410008,China)ABSTRACT Objective:Vagus nerve stimulation (VNS)is a neuromodulative therapeutic technique for patients with drug-resistant epilepsy who are not suitable for resection or who have experienced a failed resection.This study aims to explore the efficacy and safety of VNS in patients with refractory epilepsy,and to analyze the influential factors for the efficacy.Methods:A retrospective review of clinical data were conducted for 35patients,who were treated for refractory epilepsy through VNS surgery in the Department of Neurosurgery,Xiangya Hospital,Central South University from April 2016to August 2019.All patients were analyzed in terms of the clinical and follow-up data.Results:After a mean follow-up of 26months (6-47months),outcome was as follows:7DOI ：10.11817/j.issn.1672-7347.2021.200209/xbwk/fileup/PDF/2021101096.pdf收稿日期(Date of reception)：2020-03-05第一作者(First author)：杨转移，Email:neuroyzy@,ORCID:0000-0002-2782-9041通信作者(Corresponding author)：杨治权，Email:y66406914@,ORCID:0000-0001-8872-0026基金项目(Foundation item)：国家重点研发计划(2016YFC0105901XYY)。
